Falah Hasan Obayes AL-Khikani | Kerbalauniversity (original) (raw)
Papers by Falah Hasan Obayes AL-Khikani
Biomedical and Biotechnology Research Journal (BBRJ)
Dermatophytes are filamentous fungi that survive on keratinous materials. There is a broad preval... more Dermatophytes are filamentous fungi that survive on keratinous materials. There is a broad prevalence of dermatophytes infection among the world. Dermatophytosis is the disease that mainly caused by different species of dermatophytes within the cutaneous layer of the skin. It has contagious properties to spread from person to another and also from the animal to the human. The skin, hair, and nail of all types of mammalian, including human, are under the risk to develop dermatophytosis. A total of 2530 articles have been investigated in PubMed (n = 1525), Medline (n = 705), and Google Scholar (n = 300). From 2530 articles, just 48 studies were included in this review. This study aimed to review available data and current literature as well as information from personal experiments regarding dermatophytes infection to focus on the dermatophytes general features, dermatophytosis, pathogenesis presented by enzymes production, most common factors associated with infection, prevalence, and treatment of dermatophytes infection, and also to yield a clear vision to other researches about this worldwide predominant contiguous fungal disease.
Journal of Medicine in Scientific Research
Matrix Science Medica, 2021
Matrix Science Medica, 2021
Indian Journal of Medical Specialities, 2021
Indian Journal of Medical Specialities, 2020
Because AmB can activate immune modulation by elevating immune response cytokines and pro-inflmma... more Because AmB can activate immune modulation by elevating immune response cytokines and pro-inflmmatory responses, it may have a role as a potential antiviral drug by acting as antiviral therapy and enhancing immune responses.
Hamdan Medical Journal, 2020
Entamoeba moshkovskii is species of the big genus Entamoeba. This type of parasite rarely causes ... more Entamoeba moshkovskii is species of the big genus Entamoeba. This type of parasite rarely causes disease in humans. However, this has been more changed recently. The purpose of the current study was to review all obtainable published data regarding E. moshkovskii infections around the world and provides essential information on the epidemiology, incidence, diagnosis and microbiological information of E. moshkovskii at present, trying to understand if it can be considered as important risk diarrhoeal pathogen. Only studies that depending on polymerase chain reaction as a definitive diagnosis of E. moshkovskii have been included because E. moshkovskii is undistinguished from E. histolytica and E. depress morphologically, so very little information is available concerning the epidemiology and prevalence of E. moshkovskii because few searches have been used molecular diagnostic techniques to identify it. The ability of E. moshkovskii to grow and adapt to the various environmental hard conditions may make its risk of infection higher than the risk of E. histolytica. Reasons beyond E. moshkovskii differentiation from other Entamoeba complexes for stopping dispensable medications in patients infected with nonpathogenic amoebiasis. All E. moshkovskii infections were gastrointestinal tract diseases associated with infectious diarrhea, From available data in this review, E. moshkovskii considered an important and potential risk pathogen with a high rate of residence and prevalence worldwide.
Medical Science of Ukraine (MSU), 2020
Vaginitis is a common problem for women regarding a worldwide health challenge with many side eff... more Vaginitis is a common problem for women regarding a worldwide health challenge with many side effects. Vaginitis is among the most visiting to gynecology clinics. About 75% of all reproductive women had at least one fungal vaginitis infection in their life, and more than 40% will have two or more than two. Candida spp is the most prevalent in fungal vaginitis, while reports for unusual fungi were observed as mucor spp. Amphotericin B (AmB) belongs to the polyene group has a wide spectrum in vitro and in vivo antifungal activity. All of the known available formulas of AmB are administrated via intravenous injection to treat severe systemic fungal infections, while the development of the topical formula of AmB is still under preliminary development including topical vaginal AmB. Due to the revealing of antimicrobial-resistant fungi in recent years, this study explains the role of topical AmB in treating refractory fungi vaginitis that may not a response to other drugs reported in man...
Journal of Nature and Science of Medicine, 2020
Letter to Editor majoR tImelInes of (covId-2019) outbReak The number of confirmed cases of the 20... more Letter to Editor majoR tImelInes of (covId-2019) outbReak The number of confirmed cases of the 2019 novel coronavirus disease (COVID-19) reported to the World Human Organization (WHO) continues to rise worldwide, the outbreak of the novel (COVID-19) is regarding a serious threat to global health. [1] Coronavirus is positive polarity RNA with envelope, it related with the zoonotic infection that belongs to Coronaviridae, there are four known genera of coronavirus, but on January 10, 2020, a modern coronavirus in Wuhan in China have been emerged causing the severe pulmonary outbreak, it is recorded as (COVID-19) by the WHO. [2]
Background: The majority of research has concentrated on H. pylori alone, ignoring the positive o... more Background: The majority of research has concentrated on H. pylori alone, ignoring the positive or negative interactions with other pathogenic microbes. A common herpesvirus that infects 40% to 70% of the general population is cytomegalovirus (CMV). So, the aim of this study was to find this possible correlation. Materials and Methods: This research was conducted in Babylon, Iraq, from January to March, 2022. A total of 90 people suspected with H. pylori as abdominal pain, nausea, loss of appetite, and bloating. These persons were engaged in this study divided to two groups as IgG positive H pylori (positive group) and IgG negative H pylori (negative group). Antibody screening assays on blood samples were used to look for antibodies against H. pylori. IgG antibody titer in blood samples for CMV was detected by mini vidas biomerieux. One-way ANOVA, independent T, and Chi-square tests were used to examine the data using SPSS 23 software. Results: The CMV titer was significantly different between negative group 52.41 ± 24.107 and positive group 70.39 ± 29.048 (P = 0.002) with positive significant correlation was found at the 0.01 level (r = 0.323; P = 0.003) between these two groups regarding CMV. Males (63.16%) were more infected with H. pylori compared to females (38.5%). Thus, the gender of males considered as a risk factor regarding this infection at odds ratio 2.74 (95% CI: 1.15-6.5; P = 0.032). Whereas, no significant difference between males 61 ± 23.85 and females 61.35 ± 30.88 was observed regarding CMV titer. Conclusion: Males considered as a risk factor regarding H. pylori infection at odds ratio 2.74 (P = 0.002). There is strong positive correlation between infection of H. pylori and CMV (r = 0.323; P = 0.003). The question that remains to resolve if H. pylori were favor the reactivation of latent infection by CMV or vice versa.
Background: The majority of research has concentrated on H. pylori alone, ignoring the positive o... more Background: The majority of research has concentrated on H. pylori alone, ignoring the positive or negative interactions with other pathogenic microbes. A common herpesvirus that infects 40% to 70% of the general population is cytomegalovirus (CMV). So, the aim of this study was to find this possible correlation. Materials and Methods: This research was conducted in Babylon, Iraq, from January to March, 2022. A total of 90 people suspected with H. pylori as abdominal pain, nausea, loss of appetite, and bloating. These persons were engaged in this study divided to two groups as IgG positive H pylori (positive group) and IgG negative H pylori (negative group). Antibody screening assays on blood samples were used to look for antibodies against H. pylori. IgG antibody titer in blood samples for CMV was detected by mini vidas biomerieux. One-way ANOVA, independent T, and Chi-square tests were used to examine the data using SPSS 23 software. Results: The CMV titer was significantly different between negative group 52.41 ± 24.107 and positive group 70.39 ± 29.048 (P = 0.002) with positive significant correlation was found at the 0.01 level (r = 0.323; P = 0.003) between these two groups regarding CMV. Males (63.16%) were more infected with H. pylori compared to females (38.5%). Thus, the gender of males considered as a risk factor regarding this infection at odds ratio 2.74 (95% CI: 1.15-6.5; P = 0.032). Whereas, no significant difference between males 61 ± 23.85 and females 61.35 ± 30.88 was observed regarding CMV titer. Conclusion: Males considered as a risk factor regarding H. pylori infection at odds ratio 2.74 (P = 0.002). There is strong positive correlation between infection of H. pylori and CMV (r = 0.323; P = 0.003). The question that remains to resolve if H. pylori were favor the reactivation of latent infection by CMV or vice versa.
Asian Pacific Journal of Reproduction
Biomedical and Biotechnology Research Journal (BBRJ)
Journal of Preventive, Diagnostic and Treatment Strategies in Medicine
Rambam Maimonides Medical Journal
Background: The increasing resistance of many bacterial pathogens against antibiotic measures urg... more Background: The increasing resistance of many bacterial pathogens against antibiotic measures urgently requires new or repurposing therapeutic strategies. Gentian violet is a triarylmethane dye used as a histological stain and for Gram’s method of classifying bacteria. It also exerts an antimicrobial effect against certain pathogens, especially dermatological infections. Safranin is the most popular counterstain used in medical laboratories due to its low cost and safe laboratory usage. However, few studies have been conducted on the antimicrobial activity of safranin. Objective: With the growing prevalence of multidrug-resistant bacteria, this study aimed to evaluate the antibacterial efficacy of gentian violet and safranin against multidrug-resistant Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa). Methods: All tested bacteria were multidrug-resistant (MDR) bacteria isolated from skin infections (abscesses and wounds). Using gentian violet and safranin...
Microbes and Infectious Diseases, 2021
Pharmaceutical and Biomedical Research, 2020
Background: Despite several available topical and systemic antifungal drugs for the treatment of ... more Background: Despite several available topical and systemic antifungal drugs for the treatment of fungal infections, Amphotericin B (AmB) is still one of the most common first-line choices in treating systemic fungal infection for more than seven decades after its discovery. Objectives: Amphotericin B which belongs to the polyene group has a wide spectrum of in vitro and in vivo antifungal activity. Its mechanism of antifungal action is characterized by creating a pore in the fungal plasma membrane leading to cell death. Methods: In addition to the old formula of deoxycholate-Amphotericin B (D-AmB), three lipid formulas have been developed to reduce the adverse effects of conventional AmB (D-AmB) in the human body and increase its therapeutic efficacy. All of the known available formulas of AmB are administrated via intravenous injection to treat severe systemic fungal infections, while the development of the topical formula of AmB is still under preliminary research. Numerous pharm...
Research Results in Pharmacology, 2020
Introduction: Amphotericin B (AmB) which belongs to the polyene group has a wide spectrum in vitr... more Introduction: Amphotericin B (AmB) which belongs to the polyene group has a wide spectrum in vitro and in vivo antimicrobial activity against fungi and parasites, but resistance to AmB is rare despite extensive use. Material and methods: Atotal of 2530 articles were investigated in PubMed (n = 1525), Medline (n = 705), and Google Scholar (n = 300). From 2530 articles, only 61 studies were included in this review. All the short and full articles were searched that were scheduled to be published until April 2020. Results: After its discovery, AmB has been one of the most common first-line choices in treating systemic fungal infection for over seven decades from its discovery. Recently, some studies have focused on the potential antimicrobial action of AmB against some enveloped and non-enveloped viruses, such as human immunodeficiency virus, Japanese encephalitis virus, herpes simplex virus, and Rubella virus. Discussion: Among the invading pathogens, viruses constitute the most com...
International Journal of Current Microbiology and Applied Sciences, 2016
Biomedical and Biotechnology Research Journal (BBRJ)
Dermatophytes are filamentous fungi that survive on keratinous materials. There is a broad preval... more Dermatophytes are filamentous fungi that survive on keratinous materials. There is a broad prevalence of dermatophytes infection among the world. Dermatophytosis is the disease that mainly caused by different species of dermatophytes within the cutaneous layer of the skin. It has contagious properties to spread from person to another and also from the animal to the human. The skin, hair, and nail of all types of mammalian, including human, are under the risk to develop dermatophytosis. A total of 2530 articles have been investigated in PubMed (n = 1525), Medline (n = 705), and Google Scholar (n = 300). From 2530 articles, just 48 studies were included in this review. This study aimed to review available data and current literature as well as information from personal experiments regarding dermatophytes infection to focus on the dermatophytes general features, dermatophytosis, pathogenesis presented by enzymes production, most common factors associated with infection, prevalence, and treatment of dermatophytes infection, and also to yield a clear vision to other researches about this worldwide predominant contiguous fungal disease.
Journal of Medicine in Scientific Research
Matrix Science Medica, 2021
Matrix Science Medica, 2021
Indian Journal of Medical Specialities, 2021
Indian Journal of Medical Specialities, 2020
Because AmB can activate immune modulation by elevating immune response cytokines and pro-inflmma... more Because AmB can activate immune modulation by elevating immune response cytokines and pro-inflmmatory responses, it may have a role as a potential antiviral drug by acting as antiviral therapy and enhancing immune responses.
Hamdan Medical Journal, 2020
Entamoeba moshkovskii is species of the big genus Entamoeba. This type of parasite rarely causes ... more Entamoeba moshkovskii is species of the big genus Entamoeba. This type of parasite rarely causes disease in humans. However, this has been more changed recently. The purpose of the current study was to review all obtainable published data regarding E. moshkovskii infections around the world and provides essential information on the epidemiology, incidence, diagnosis and microbiological information of E. moshkovskii at present, trying to understand if it can be considered as important risk diarrhoeal pathogen. Only studies that depending on polymerase chain reaction as a definitive diagnosis of E. moshkovskii have been included because E. moshkovskii is undistinguished from E. histolytica and E. depress morphologically, so very little information is available concerning the epidemiology and prevalence of E. moshkovskii because few searches have been used molecular diagnostic techniques to identify it. The ability of E. moshkovskii to grow and adapt to the various environmental hard conditions may make its risk of infection higher than the risk of E. histolytica. Reasons beyond E. moshkovskii differentiation from other Entamoeba complexes for stopping dispensable medications in patients infected with nonpathogenic amoebiasis. All E. moshkovskii infections were gastrointestinal tract diseases associated with infectious diarrhea, From available data in this review, E. moshkovskii considered an important and potential risk pathogen with a high rate of residence and prevalence worldwide.
Medical Science of Ukraine (MSU), 2020
Vaginitis is a common problem for women regarding a worldwide health challenge with many side eff... more Vaginitis is a common problem for women regarding a worldwide health challenge with many side effects. Vaginitis is among the most visiting to gynecology clinics. About 75% of all reproductive women had at least one fungal vaginitis infection in their life, and more than 40% will have two or more than two. Candida spp is the most prevalent in fungal vaginitis, while reports for unusual fungi were observed as mucor spp. Amphotericin B (AmB) belongs to the polyene group has a wide spectrum in vitro and in vivo antifungal activity. All of the known available formulas of AmB are administrated via intravenous injection to treat severe systemic fungal infections, while the development of the topical formula of AmB is still under preliminary development including topical vaginal AmB. Due to the revealing of antimicrobial-resistant fungi in recent years, this study explains the role of topical AmB in treating refractory fungi vaginitis that may not a response to other drugs reported in man...
Journal of Nature and Science of Medicine, 2020
Letter to Editor majoR tImelInes of (covId-2019) outbReak The number of confirmed cases of the 20... more Letter to Editor majoR tImelInes of (covId-2019) outbReak The number of confirmed cases of the 2019 novel coronavirus disease (COVID-19) reported to the World Human Organization (WHO) continues to rise worldwide, the outbreak of the novel (COVID-19) is regarding a serious threat to global health. [1] Coronavirus is positive polarity RNA with envelope, it related with the zoonotic infection that belongs to Coronaviridae, there are four known genera of coronavirus, but on January 10, 2020, a modern coronavirus in Wuhan in China have been emerged causing the severe pulmonary outbreak, it is recorded as (COVID-19) by the WHO. [2]
Background: The majority of research has concentrated on H. pylori alone, ignoring the positive o... more Background: The majority of research has concentrated on H. pylori alone, ignoring the positive or negative interactions with other pathogenic microbes. A common herpesvirus that infects 40% to 70% of the general population is cytomegalovirus (CMV). So, the aim of this study was to find this possible correlation. Materials and Methods: This research was conducted in Babylon, Iraq, from January to March, 2022. A total of 90 people suspected with H. pylori as abdominal pain, nausea, loss of appetite, and bloating. These persons were engaged in this study divided to two groups as IgG positive H pylori (positive group) and IgG negative H pylori (negative group). Antibody screening assays on blood samples were used to look for antibodies against H. pylori. IgG antibody titer in blood samples for CMV was detected by mini vidas biomerieux. One-way ANOVA, independent T, and Chi-square tests were used to examine the data using SPSS 23 software. Results: The CMV titer was significantly different between negative group 52.41 ± 24.107 and positive group 70.39 ± 29.048 (P = 0.002) with positive significant correlation was found at the 0.01 level (r = 0.323; P = 0.003) between these two groups regarding CMV. Males (63.16%) were more infected with H. pylori compared to females (38.5%). Thus, the gender of males considered as a risk factor regarding this infection at odds ratio 2.74 (95% CI: 1.15-6.5; P = 0.032). Whereas, no significant difference between males 61 ± 23.85 and females 61.35 ± 30.88 was observed regarding CMV titer. Conclusion: Males considered as a risk factor regarding H. pylori infection at odds ratio 2.74 (P = 0.002). There is strong positive correlation between infection of H. pylori and CMV (r = 0.323; P = 0.003). The question that remains to resolve if H. pylori were favor the reactivation of latent infection by CMV or vice versa.
Background: The majority of research has concentrated on H. pylori alone, ignoring the positive o... more Background: The majority of research has concentrated on H. pylori alone, ignoring the positive or negative interactions with other pathogenic microbes. A common herpesvirus that infects 40% to 70% of the general population is cytomegalovirus (CMV). So, the aim of this study was to find this possible correlation. Materials and Methods: This research was conducted in Babylon, Iraq, from January to March, 2022. A total of 90 people suspected with H. pylori as abdominal pain, nausea, loss of appetite, and bloating. These persons were engaged in this study divided to two groups as IgG positive H pylori (positive group) and IgG negative H pylori (negative group). Antibody screening assays on blood samples were used to look for antibodies against H. pylori. IgG antibody titer in blood samples for CMV was detected by mini vidas biomerieux. One-way ANOVA, independent T, and Chi-square tests were used to examine the data using SPSS 23 software. Results: The CMV titer was significantly different between negative group 52.41 ± 24.107 and positive group 70.39 ± 29.048 (P = 0.002) with positive significant correlation was found at the 0.01 level (r = 0.323; P = 0.003) between these two groups regarding CMV. Males (63.16%) were more infected with H. pylori compared to females (38.5%). Thus, the gender of males considered as a risk factor regarding this infection at odds ratio 2.74 (95% CI: 1.15-6.5; P = 0.032). Whereas, no significant difference between males 61 ± 23.85 and females 61.35 ± 30.88 was observed regarding CMV titer. Conclusion: Males considered as a risk factor regarding H. pylori infection at odds ratio 2.74 (P = 0.002). There is strong positive correlation between infection of H. pylori and CMV (r = 0.323; P = 0.003). The question that remains to resolve if H. pylori were favor the reactivation of latent infection by CMV or vice versa.
Asian Pacific Journal of Reproduction
Biomedical and Biotechnology Research Journal (BBRJ)
Journal of Preventive, Diagnostic and Treatment Strategies in Medicine
Rambam Maimonides Medical Journal
Background: The increasing resistance of many bacterial pathogens against antibiotic measures urg... more Background: The increasing resistance of many bacterial pathogens against antibiotic measures urgently requires new or repurposing therapeutic strategies. Gentian violet is a triarylmethane dye used as a histological stain and for Gram’s method of classifying bacteria. It also exerts an antimicrobial effect against certain pathogens, especially dermatological infections. Safranin is the most popular counterstain used in medical laboratories due to its low cost and safe laboratory usage. However, few studies have been conducted on the antimicrobial activity of safranin. Objective: With the growing prevalence of multidrug-resistant bacteria, this study aimed to evaluate the antibacterial efficacy of gentian violet and safranin against multidrug-resistant Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa). Methods: All tested bacteria were multidrug-resistant (MDR) bacteria isolated from skin infections (abscesses and wounds). Using gentian violet and safranin...
Microbes and Infectious Diseases, 2021
Pharmaceutical and Biomedical Research, 2020
Background: Despite several available topical and systemic antifungal drugs for the treatment of ... more Background: Despite several available topical and systemic antifungal drugs for the treatment of fungal infections, Amphotericin B (AmB) is still one of the most common first-line choices in treating systemic fungal infection for more than seven decades after its discovery. Objectives: Amphotericin B which belongs to the polyene group has a wide spectrum of in vitro and in vivo antifungal activity. Its mechanism of antifungal action is characterized by creating a pore in the fungal plasma membrane leading to cell death. Methods: In addition to the old formula of deoxycholate-Amphotericin B (D-AmB), three lipid formulas have been developed to reduce the adverse effects of conventional AmB (D-AmB) in the human body and increase its therapeutic efficacy. All of the known available formulas of AmB are administrated via intravenous injection to treat severe systemic fungal infections, while the development of the topical formula of AmB is still under preliminary research. Numerous pharm...
Research Results in Pharmacology, 2020
Introduction: Amphotericin B (AmB) which belongs to the polyene group has a wide spectrum in vitr... more Introduction: Amphotericin B (AmB) which belongs to the polyene group has a wide spectrum in vitro and in vivo antimicrobial activity against fungi and parasites, but resistance to AmB is rare despite extensive use. Material and methods: Atotal of 2530 articles were investigated in PubMed (n = 1525), Medline (n = 705), and Google Scholar (n = 300). From 2530 articles, only 61 studies were included in this review. All the short and full articles were searched that were scheduled to be published until April 2020. Results: After its discovery, AmB has been one of the most common first-line choices in treating systemic fungal infection for over seven decades from its discovery. Recently, some studies have focused on the potential antimicrobial action of AmB against some enveloped and non-enveloped viruses, such as human immunodeficiency virus, Japanese encephalitis virus, herpes simplex virus, and Rubella virus. Discussion: Among the invading pathogens, viruses constitute the most com...
International Journal of Current Microbiology and Applied Sciences, 2016