مؤمل العزاوي | University Of Mosul (original) (raw)

Papers by مؤمل العزاوي

Research paper thumbnail of Microwave Assisted Synthesis of some New Chromene Derivatives

Rafidain Journal of Science, 2010

An efficient synthesis of some new 4-(benzo [d]-1,3-dioxo-5-yl)-[2,3-c]-N-aryl pyrolo-1,3-dione-3... more An efficient synthesis of some new 4-(benzo [d]-1,3-dioxo-5-yl)-[2,3-c]-N-aryl pyrolo-1,3-dione-3,4,5,6-tetrahydro-2H-benzo[h] chromene derivatives (4a-h) via Diels-Alder reaction of 2-piperonylidene-1-tetralone (1) and N-aryl maleimides (3a-h) under microwave irradiation was described. The yield have been improved (-84 92%) and the reaction time reduced from hours to few minutes through the use of dichloromethane as solvent and aluminum chloride as catalyst. All prepared compounds were confirmed by the available physical and spectral methods.

Research paper thumbnail of Synthesis of some New Fused Pyrimidine Compounds

Rafidain Journal of Science, 2017

Research paper thumbnail of Synthesis of Some 6-Aryl-1,2,4,5-Tetrazine-3-thione Compounds Derived from Thiocarbohydrazide

Carbon disulfide was reacted with hydrazine hydrate (80%) to obtained thiocarbohydrazide (1) and ... more Carbon disulfide was reacted with hydrazine hydrate (80%) to obtained thiocarbohydrazide (1) and the latter reacted with different substituted benzaldehyde to afford 6-aryl-1,2,4,5-tetrahydro tetrazine-3-thione(2-6) via condensation reaction. Compounds 6-aryl-1,2,4,5-tetrazine-3-thione (7-11) were also obtained directly through the oxidation reaction of compounds (2-6) in presence of hydrogen peroxide (4%). The structure of the newly compounds were confirmed by available spectroscopic methods.

Research paper thumbnail of One- Pot Synthesis of New Pyranopyrazoles Via Domino Multicomponent Reaction

Egyptian Journal of Chemistry, 2022

Research paper thumbnail of Synthesis of some New Spiro 1,3,4-Oxadiazolines Derived from Azlactone

Rafidain Journal of Science

In this work a mixture of hippuric acid (N-benzoyl glycine) (1) and substituted benzaldehyde unde... more In this work a mixture of hippuric acid (N-benzoyl glycine) (1) and substituted benzaldehyde undergone Erlenmeyer and Perkin reactions respectively to afford the 4-aryl methylidene-2-phenyl oxazole-5-one (2a-d). This reaction proceeded under acidic media using acetic anhydride and sodium acetate. The azlactones (2a-d) used as starting material to prepare the imidazolone derivatives. New 4-aryl methylidene-5-oxo-2-phenyl-N'-(substituted cyclohexylidene)-4,5-dihydro imidazole-1-carbohydrazide(3a-j) were prepared from reactions the azlactones (2a-d) with Schiff's bases which prepared through condensation reaction of semicarbazide with substituted cyclo hexanone. Finally, the preparation of new 1-(4-acetyl-5-spiro substituted cyclohexyl-1,3,4-oxadiazol-2-yl)-4-aryl methylidene-2phenyl-1H-imidazol-5-one (4a-j) via intracyclization reaction of imidazolones (3a-j) in the presence of acetic anhydride as suitable cyclizing agent. The structure of the synthesized compounds were illustrated by the available physical and spectral analysis (M.

Research paper thumbnail of The Use of 3-Bezylidene Phthalide as Synthon in Synthesis of Heterocyclic Compounds

Rafidain Journal of Science

2-(α-Phenylacetyl) benzohydrazide (1) was prepared through the reaction of (Z)-3benzylidene phtha... more 2-(α-Phenylacetyl) benzohydrazide (1) was prepared through the reaction of (Z)-3benzylidene phthalide and hydrazine hydrate. Treatment of compound (1) with substituted benzoyl chloride yielded N'-aroyl-2-(α-phenyl acetyl) benzohydrazide (2a-e) which upon reaction with ammonium acetate provided the corresponding 2-phenyl-1-(2-(5-aryl-1,2,4triazole-3-yl)phenyl)ethanones (3a-e). While the reaction of compound (1) with substituted benzaldehyde gave the hydrazones represented by N'-arylidene-2-(α-phenylacetyl) benzohydrazide derivatives (4a-f). Intramolecule cyclization of the latter compounds by means of acetic anhydride yielded 2-(α-phenylacetyl)phenyl-4-acetyl-4,5-dihydro-5-aryl-1,3,4oxadiazoles (5a-f). Compounds 2-(α-phenylacetyl)-N-(3,6-diphenyl-5-aryl-5,6-dihydro-1,2,4-triazine-4yl) benzamide (6a-f) were also obtained from the direct Diel-Alder reaction between dibenzylidine hydrazine as diene and compounds (4a-f) as dienophile enhanced by microwave irradiation. The assigned structure of the prepared compounds were corroborated by available physical and spectral methods.

Research paper thumbnail of Synthesis of some New 1,2,4,5-Tetrazine Derivatives Via Diels-Alder Reaction

Rafidain Journal of Science

A rapid, sufficiency and economic with no pollution method was adopted to synthesize several 1-ar... more A rapid, sufficiency and economic with no pollution method was adopted to synthesize several 1-aryl-2,5-dione pyrrolidino[3,4-d]-3,6-diphenyl-3,4,5,6-tetrahydro pyridazino [1,2-a]-3,6-diaryl-1,2,3,6-tetrahydro-1,2,4,5-tetrazine compounds (4a-f) and (5af) using a solid phase (solvent-free) microwave irradiation technique. The reaction of dibenzylidine hydrazine (1a) as diaza-heterodiene with N-aryl maleimide compounds (2a-f) as cyclic dienophile yielded the corresponding 1-aryl-2,5dione pyrrolidino[3,4-d]-3,6-diphenyl-3,4,5,6-tetrahydro pyridazine derivatives (3a-f) via Diels-Alder reaction that proceeded through intermolecular 1,4-cycloaddition mechanism and induced by microwave irradiation. Similarly, compounds (3a-f) as cyclic hetero dienophile have been converted directly to the 1,2,3,6-tetrahydro-1,2,4,5-tetrazine derivatives (4a-f) and (5a-f) in presence of diarylidine hydrazines (1b-c) as diaza-heterodiene by means of Diels-Alder reaction induced by microwave irradiation and through intermolecular 1,4-cycloaddition mechanism too. The reaction time has been brought down from hours to few minutes in this technique as compared with the conventional method. This method was, also, efficient, fast economic and environmental friendly. All the prepared compounds were confirmed by the available physical and spectral methods.

Research paper thumbnail of Microwave Assisted Synthesis of some New Chromene Derivatives

Rafidain Journal of Science, 2010

An efficient synthesis of some new 4-(benzo [d]-1,3-dioxo-5-yl)-[2,3-c]-N-aryl pyrolo-1,3-dione-3... more An efficient synthesis of some new 4-(benzo [d]-1,3-dioxo-5-yl)-[2,3-c]-N-aryl pyrolo-1,3-dione-3,4,5,6-tetrahydro-2H-benzo[h] chromene derivatives (4a-h) via Diels-Alder reaction of 2-piperonylidene-1-tetralone (1) and N-aryl maleimides (3a-h) under microwave irradiation was described. The yield have been improved (-84 92%) and the reaction time reduced from hours to few minutes through the use of dichloromethane as solvent and aluminum chloride as catalyst. All prepared compounds were confirmed by the available physical and spectral methods.

Research paper thumbnail of Synthesis of some New Fused Pyrimidine Compounds

Rafidain Journal of Science, 2017

Research paper thumbnail of Synthesis of Some 6-Aryl-1,2,4,5-Tetrazine-3-thione Compounds Derived from Thiocarbohydrazide

Carbon disulfide was reacted with hydrazine hydrate (80%) to obtained thiocarbohydrazide (1) and ... more Carbon disulfide was reacted with hydrazine hydrate (80%) to obtained thiocarbohydrazide (1) and the latter reacted with different substituted benzaldehyde to afford 6-aryl-1,2,4,5-tetrahydro tetrazine-3-thione(2-6) via condensation reaction. Compounds 6-aryl-1,2,4,5-tetrazine-3-thione (7-11) were also obtained directly through the oxidation reaction of compounds (2-6) in presence of hydrogen peroxide (4%). The structure of the newly compounds were confirmed by available spectroscopic methods.

Research paper thumbnail of One- Pot Synthesis of New Pyranopyrazoles Via Domino Multicomponent Reaction

Egyptian Journal of Chemistry, 2022

Research paper thumbnail of Synthesis of some New Spiro 1,3,4-Oxadiazolines Derived from Azlactone

Rafidain Journal of Science

In this work a mixture of hippuric acid (N-benzoyl glycine) (1) and substituted benzaldehyde unde... more In this work a mixture of hippuric acid (N-benzoyl glycine) (1) and substituted benzaldehyde undergone Erlenmeyer and Perkin reactions respectively to afford the 4-aryl methylidene-2-phenyl oxazole-5-one (2a-d). This reaction proceeded under acidic media using acetic anhydride and sodium acetate. The azlactones (2a-d) used as starting material to prepare the imidazolone derivatives. New 4-aryl methylidene-5-oxo-2-phenyl-N'-(substituted cyclohexylidene)-4,5-dihydro imidazole-1-carbohydrazide(3a-j) were prepared from reactions the azlactones (2a-d) with Schiff's bases which prepared through condensation reaction of semicarbazide with substituted cyclo hexanone. Finally, the preparation of new 1-(4-acetyl-5-spiro substituted cyclohexyl-1,3,4-oxadiazol-2-yl)-4-aryl methylidene-2phenyl-1H-imidazol-5-one (4a-j) via intracyclization reaction of imidazolones (3a-j) in the presence of acetic anhydride as suitable cyclizing agent. The structure of the synthesized compounds were illustrated by the available physical and spectral analysis (M.

Research paper thumbnail of The Use of 3-Bezylidene Phthalide as Synthon in Synthesis of Heterocyclic Compounds

Rafidain Journal of Science

2-(α-Phenylacetyl) benzohydrazide (1) was prepared through the reaction of (Z)-3benzylidene phtha... more 2-(α-Phenylacetyl) benzohydrazide (1) was prepared through the reaction of (Z)-3benzylidene phthalide and hydrazine hydrate. Treatment of compound (1) with substituted benzoyl chloride yielded N'-aroyl-2-(α-phenyl acetyl) benzohydrazide (2a-e) which upon reaction with ammonium acetate provided the corresponding 2-phenyl-1-(2-(5-aryl-1,2,4triazole-3-yl)phenyl)ethanones (3a-e). While the reaction of compound (1) with substituted benzaldehyde gave the hydrazones represented by N'-arylidene-2-(α-phenylacetyl) benzohydrazide derivatives (4a-f). Intramolecule cyclization of the latter compounds by means of acetic anhydride yielded 2-(α-phenylacetyl)phenyl-4-acetyl-4,5-dihydro-5-aryl-1,3,4oxadiazoles (5a-f). Compounds 2-(α-phenylacetyl)-N-(3,6-diphenyl-5-aryl-5,6-dihydro-1,2,4-triazine-4yl) benzamide (6a-f) were also obtained from the direct Diel-Alder reaction between dibenzylidine hydrazine as diene and compounds (4a-f) as dienophile enhanced by microwave irradiation. The assigned structure of the prepared compounds were corroborated by available physical and spectral methods.

Research paper thumbnail of Synthesis of some New 1,2,4,5-Tetrazine Derivatives Via Diels-Alder Reaction

Rafidain Journal of Science

A rapid, sufficiency and economic with no pollution method was adopted to synthesize several 1-ar... more A rapid, sufficiency and economic with no pollution method was adopted to synthesize several 1-aryl-2,5-dione pyrrolidino[3,4-d]-3,6-diphenyl-3,4,5,6-tetrahydro pyridazino [1,2-a]-3,6-diaryl-1,2,3,6-tetrahydro-1,2,4,5-tetrazine compounds (4a-f) and (5af) using a solid phase (solvent-free) microwave irradiation technique. The reaction of dibenzylidine hydrazine (1a) as diaza-heterodiene with N-aryl maleimide compounds (2a-f) as cyclic dienophile yielded the corresponding 1-aryl-2,5dione pyrrolidino[3,4-d]-3,6-diphenyl-3,4,5,6-tetrahydro pyridazine derivatives (3a-f) via Diels-Alder reaction that proceeded through intermolecular 1,4-cycloaddition mechanism and induced by microwave irradiation. Similarly, compounds (3a-f) as cyclic hetero dienophile have been converted directly to the 1,2,3,6-tetrahydro-1,2,4,5-tetrazine derivatives (4a-f) and (5a-f) in presence of diarylidine hydrazines (1b-c) as diaza-heterodiene by means of Diels-Alder reaction induced by microwave irradiation and through intermolecular 1,4-cycloaddition mechanism too. The reaction time has been brought down from hours to few minutes in this technique as compared with the conventional method. This method was, also, efficient, fast economic and environmental friendly. All the prepared compounds were confirmed by the available physical and spectral methods.