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4S59 les patients ont présenté une amélioration objective et subjective. Radiologiquement, la fus... more 4S59 les patients ont présenté une amélioration objective et subjective. Radiologiquement, la fusion est obtenue pour tous les patients sans subsidence ni migration de l'implant. 65 Intérêt prédictif du test du corset hémibermuda pour la prise en charge thérapeutique des lomboradiculalgies par instabilité dégénérative du rachis lombaire et lombosacré par stabilisation souple ou rigide Martin LISSARRAGUE *, Patrick CHATELLIER, Jean-Louis HUSSON INTRODUCTION. Nous utilisons une immobilisation thoraco-lombo-sacrée dite « corset hémibermuda » dont l'intérêt est de réaliser un test thérapeutique dans la prise en charge des instabilités dégénératives lombaires et lombo-sacrées, afin de sélectionner les patients à une stabilisation chirurgicale. Le but de cette étude rétrospective est d'évaluer l'intérêt prédictif de ce corset.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, Jan 30, 2016

The aim of this work was to evaluate the predictors of mortality in a group of end-stage kidney d... more The aim of this work was to evaluate the predictors of mortality in a group of end-stage kidney disease (ESRD) patients under dialysis, by performing a three-year follow-up study. From the 236 patients included in this study, 54 patients died during the three-year follow-up period. Our data showed that the risk of death was higher in patients presenting lower levels of mean cell hemoglobin concentration, transferrin, and albumin. Our study showed that poor nutritional status and an inflammatory-induced iron depleted erythropoiesis are important factors for mortality in these patients.

Persistent urinary tract infections (UTI) are often caused by E. coli adhered to urothelium. This... more Persistent urinary tract infections (UTI) are often caused by E. coli adhered to urothelium. This type of cells is generally recognized as very tolerant to antibiotics which renders difficult the treatment of chronic UTI. This study investigates the use of lytic bacteriophages as alternative antimicrobial agents, particularly the interaction of phages with E. coli adhered to urothelium and specifically determines their efficiency against this type of cells. The bacterial adhesion to urothelium was performed varying the bacterial cell concentrations and the period and conditions (static, shaken) of adhesion. Three collection bacteriophages (T1, T4, and phiX174 like phages) were tested against clinical E. coli isolates and only one was selected for further infection experiments. Based on the lytic spectrum against clinical isolates and its ability to infect the highest number of antibiotic resistant strains, the T1-like bacteriophage was selected. This bacteriophage caused nearly a 45% reduction of the bacterial population after 2 h of treatment. This study provides evidence that bacteriophages are effective in controlling suspended and adhered cells and therefore can be a viable alternative to antibiotics to control urothelium- adhered bacteria.

Purpose Patients' perception of health-related quality of life (HRQOL) is a consistent and powerf... more Purpose Patients' perception of health-related quality of life (HRQOL) is a consistent and powerful predictor of the outcome of end-stage renal disease (ESRD) patients under dialysis. This study aims to identify factors that could affect the HRQOL of ESRD patients under online hemo-diafiltration (OL-HDF). Methods We evaluated 322 ESRD patients under OL-HDF (59.63 % males; 64.9 ± 14.3 years old) from five dialysis units in the north of Portugal. Socio-demographic data, comorbidities, hematological data, iron status, dialy-sis adequacy, nutritional and inflammatory markers were collected from patients records. Patient's reported HRQOL score was assessed by using the Kidney Disease Quality of Life-Short Form (KDQOL-SF). Results ESRD patients showed a mean (±SD) of 53.17 % (±15.31 %) in SF-36 total score, 50.17 % (±9.51 %) in the SF-36 mental component summary (MCS) and 49.75 % (±9.44 %) in the SF-36 physical component summary (PCS). Red cell distribution width (RDW), feminine gender and diabetes were found as significant predictors of SF-36 total score of HRQOL, which accounts for 12 % of the total explained variance. Patient satisfaction, RDW, body mass index and gender were identified as predictors for the PCS, which accounts for 22 % of total explained variance. Furthermore , patient satisfaction and dry weight were found as predictors for MCS. These predictors accounted for 28 % of the total explained variance. Conclusions Our results showed that the coexistence of diabetes, gender and erythropoietic disturbances are pre-dictors of HRQOL in patients under OL-HDF and suggest that more attention should be given to woman patients, to the improvement of anemia and to diabetic patients, who are more prone to perceive a worst HRQOL.

In a time when conventional antibiotics are becoming increasingly less effective for treatment of... more In a time when conventional antibiotics are becoming increasingly less effective
for treatment of infections, the relationship between bacteria and antimicrobial
resistance is becoming more and more complicated. This paper provides a current
review of studies reported in the literature pertaining to the antibiotherapy
of human urinary tract infections (UTI), in a way that helps the reader direct a
bibliographic search and develop an integrated perspective of the subject. Highlights
are given to (bio)pathogenesis of uncomplicated cystitis. Features associated
with the antibiotherapy of UTI such as development of resistance are
presented in the text systematically. This review discusses recent advances in
the understanding of how the predominant uropathogen Escherichia coli interacts
with its host and leads to infection; so one can understand some of the
reasons behind antibiotherapy failures.

This work aimed to evaluate how aging could influence patients' perception of health quality of l... more This work aimed to evaluate how aging could influence patients' perception of health quality of life (HRQOL), as well as, the effect of aging on dialysis adequacy and in hematological, iron status, inflammatory and nutritional markers. In this transversal study were enrolled 305 ESRD patients under online-hemodiafiltration (OL-HDF) (59.67% males; 64.9 ± 14.3 years old). Data about comorbidities, hematological data, iron status, dialysis adequacy, nutritional and inflammatory markers were collected from patient's records. Moreover, HRQOL score, by using the Kidney Disease Quality of Life-Short Form (KDQOL-SF), was assessed. Analyzing the results according to quartiles of age, significant differences were found for some parameters evaluated by the KDQOL-SF instrument, namely for work status, physical functioning and role-physical, which decreased with increasing age. We also found a higher proportion of diabetic patients, a decrease in creatinine, iron, albumin serum levels, transferrin saturation and nPCR, with increasing age. Moreover, significant negative correlations were found between age and mean cell hemoglobin concentration, iron, transferrin saturation, albumin, nPCR, work status, physical functioning and role-physical. In conclusion, our results showed that aging is associated with a decreased work status, physical functioning and role-physical, with a decreased dialysis adequacy, iron availability and nutritional status, and with an increased proportion of diabetic patients and of patients using central venous catheter, as the vascular access. The knowledge of these changes associated with aging, which have impact in the quality of life of the patients, could be useful in their management. End-stage renal disease (ESRD) patients present high mortality rate [1,2] that far exceeds the mortality rate for the general population [3]. In the past half century, the widespread use of dialysis to prolong life of ESRD patients has been a remarkable achievement, preventing death from uremia in these patients. Nowadays, this therapy has expanded widely and is particularly used by an increased elderly population, leading to significant economic consequences to patients and to healthcare systems. Although some evidence may suggest that mortality rate among dialysis patients have decreased over the last few years, actually, patient's survival is still low.

Purpose: The aim of this work is to evaluate the patient-reported health-related quality of life ... more Purpose: The aim of this work is to evaluate the patient-reported health-related quality of life (HRQOL), according to the
type and location of vascular access used for dialysis procedure.
Methods: In this transversal study, 322 end-stage renal disease (ESRD) patients under online hemodiafiltration (OL-HDF,
59.63% males; 64.9±14.3 years) were enrolled. Arteriovenous fistula (AVF) was used by 252 patients (78.3%), whereas
70 patients (21.7%) had a central venous catheter (CVC). Besides AVF location, data on comorbidities, hematological
data, iron status, dialysis adequacy, nutritional and inflammatory markers were collected. Moreover, the patients’ reported
HRQOL score, using the Kidney Disease Quality of Life-Short Form, was evaluated.
Results: ESRD patients using CVC as vascular access presented a decrease in four SF-36 domain scores, namely physical functioning,
emotional well-being, role-emotional and energy/fatigue when compared with those using AVF as vascular access.
Additionally, these patients also showed significant differences in ESRD target areas, namely decline in cognitive function
and quality of social interaction domains. When comparing the variables according to the localization of the AVF, significant
differences were found in three SF-36 domain scores, namely physical functioning, pain and general health. Moreover, we
also found significant differences in ESRD target areas, namely symptoms/problem list, effects of kidney disease and quality
of social interaction domains.
Conclusions: Our results showed that ESRD patients under OL-HDF using AVF as vascular access had higher HRQOL scores
in several domains when compared with those using CVC. Additionally, we also found that dialysis patients using AVF in the
left forearm presented with higher HRQOL scores.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, Jan 30, 2016