L. Delgado | Universidade do Porto (original) (raw)

Papers by L. Delgado

Revista Portuguesa de Endocrinologia, Diabetes e Metabolismo, 2012

Journal of investigational allergology & clinical immunology, 2012

Guided self-management is an important component of asthma care. Most trials have evaluated paper... more Guided self-management is an important component of asthma care. Most trials have evaluated paper-based strategies. The effectiveness of new communication technologies remains uncertain. To compare the feasibility and clinical outcomes of a standard paper-based asthma self-management strategy with web-based strategies. In a crossover trial, 21 patients using inhaled corticosteroids and long-acting B2-agonists (mean [SD] age 29 [10] years) were randomly assigned to use a sequence of web-based and paper-based diary and action plan. Quality of life, asthma control, lung function, and airway inflammation were assessed using the Asthma Life Quality Questionnaire (ALQ), Asthma Control Questionnaire (ACQ-5), Mini Asthma Quality of Life Questionnaire (Mini AQLQ), and office spirometry. The ratio of forced expiratory volume in the first second of expiration (FEV1) to peak expiratory flow (PEF) rate (PiKo-1) and fraction of exhaled nitric oxide (FE(NO)) were monitored. The main clinical outco...

Journal of investigational allergology & clinical immunology, 2011

Sputum induction is a noninvasive method for the assessment of airway inflammation. To evaluate t... more Sputum induction is a noninvasive method for the assessment of airway inflammation. To evaluate the safety of the procedure and the clinical predictors of successful induction, and to analyze the relationship between sputum cell counts and clinical features in asthmatic and nonasthmatic children. We reviewed sputum inductions performed in our department between 2006 and 2008 in individuals under 18 years; 34 asthmatic and 24 nonasthmatic children were included. Sputum induction was performed with 4.5% saline for 5-minute periods with salbutamol pretreatment. The most viscid portions were selected for processing. Inductions which were tolerated for less than 4 minutes or which produced a sample volume of less than 1 mL or a sample with a squamous cell percentage of over 80% were considered unsuccessful. Sputum induction was successful in 43 (74%) of the 58 children studied.The total median induction time was 15 minutes (interquartile range, 10-15 minutes). Only 7 individuals (12%) ex...

Journal of Allergy and Clinical Immunology, 2006

Dermatology, 2001

Background: Graft-versus-host disease (GvHD) remains the major toxicity of allogeneic bone marrow... more Background: Graft-versus-host disease (GvHD) remains the major toxicity of allogeneic bone marrow transplantation (BMT). In the acute form of the disease, the differential diagnosis includes viral rash and drug eruptions. Methods: We report two patients with chronic myeloid leukemia submitted to allogeneic BMT who developed a severe form of acute cutaneous GvHD, with clinical and histological pictures mimicking toxic epidermal necrolysis (TEN). Results: We found a predominance of peripheral CD8+ T lymphocytes and, at the same time, studying the cellular profile of the blister fluid, just in the beginning of blister eruption, we also found a high proportion of CD8+ T lymphocytes, mainly CD8+CD57–. Conclusion: These data are in agreement with previous reports of the presence of CD8+ T cells in the blister fluid of patients with TEN, further emphasizing similar immunoinflammatory pathways in both diseases.

Archives of Dermatology, 1994

1. Arch Dermatol. 1994 Jun;130(6):808-9. Bullous photodermatosis after lomefloxacin. Correia O, D... more 1. Arch Dermatol. 1994 Jun;130(6):808-9. Bullous photodermatosis after lomefloxacin. Correia O, Delgado L, Barros MA. PMID: 8002662 [PubMed - indexed for MEDLINE] Publication Types: Case Reports; Letter. MeSH Terms: ...

American Journal of Rhinology & Allergy, 2010

Background Elite swimmers are at increased risk of asthma, which has been related to chronic effe... more Background Elite swimmers are at increased risk of asthma, which has been related to chronic effects of pool chlorine environment. However acute effects of swimming on rhinitis remain unknown. Objective We aimed to assess the nasal response to exercise in competitive swimmers compared with competitive runners. Methods Measurements of nasal symptoms, peak nasal inspiratory flow, lung function, dyspnea, and of airway inflammation were obtained before and after a training session of 19 international-level swimmers and 13 professional runners. Exercise-induced rhinitis was defined as a fall in peak nasal inspiratory flow above 20% from baseline and atopy by positivity to skin-prick testing. Changes within groups were compared using paired t test and differences compared by analysis of covariance. Results Prevalence of exercise-induced rhinitis was similar between swimmers and runners, respectively 21% and 23%. Contrary to runners, swimmers experienced a decrease in nasal inspiratory flo...

Allergy & Clinical Immunology International - Journal of the World Allergy Organization, 2006

Background: This paper reviews the recent literature on rhinitis in athletes and the relationship... more Background: This paper reviews the recent literature on rhinitis in athletes and the relationship of nasal and exercise physiology with environmental factors with a negative impact on sport performance, including the relationship between allergic rhinitis and ...

Revista Portuguesa de Pneumologia, 2004

PLOS ONE, 2018

Background Endurance swimming exercises coupled to disinfection by-products exposure has been ass... more Background
Endurance swimming exercises coupled to disinfection by-products exposure has been associated with increased airways dysfunction and neurogenic inflammation in elite swimmers. However, the impact of swimming pool exposure at a recreational level on autonomic
activity has never been explored. Therefore, this study aimed to investigate how swimming pool attendance is influencing lung and autonomic function in school-aged children.
Methods
A total of 858 children enrolled a cross sectional survey. Spirometry and airway reversibility to beta-2 agonist, skin-prick-tests and exhaled nitric oxide measurements were performed. Pupillometry was used to evaluate autonomic nervous function. Children were classified as
current swimmers (CS), past swimmers (PS) and non-swimmers (NS), according to the amount of swimming practice.
Results
Current swimmers group had significantly lower maximum and average pupil constriction velocities when compared to both PS and NS groups (3.8 and 5.1 vs 3.9 and 5.3 vs 4.0 and 5.4 mm/s, p = 0.03 and p = 0.01, respectively). Moreover, affinity to the beta-2 agonist and
levels of exhaled nitric oxide were significantly higher in CS when compared to NS (70 vs 60 mL and 12 vs 10 ppb, p<0.01 and p = 0.03, respectively). A non-significant trend for a higher risk of asthma, atopic eczema and allergic rhinitis was found with more years of swimming
practice, particularly in atopic individuals (β = 1.12, 1.40 and 1.31, respectively). After case analysis, it was possible to observe that results were not influenced by the inclusion of individuals with asthma.
Conclusions
Concluding, swimming pool attendance appears to be associated with autonomic changes and increased baseline airway smooth muscle constriction even in children without asthma.

Int Arch Allergy Immunol, 2018

Ann Allergy Asthma Immunol, 2018

Curr Treat Options Allergy, 2018

Background: Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and erythema multiforme... more Background: Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and erythema multiforme (EM) are immunologically‑mediated dermatological disorders commonly triggered by drug exposure and/or other external agents. We aimed to characterise SJS/TEN‑ and EM‑drug‑related hospitalisations in a nationwide administrative data‑ base, focusing on demographic and clinical characteristics, and in the most frequently implicated drug classes. Methods: We analysed all drug‑related hospitalisations with associated diagnosis of SJS/TEN or EM in Portuguese hospitals between 2009 and 2014. We compared gender, age, comorbidities, length of stay, and in‑hospital mortality and estimated the number of episodes per million packages sold of drug classes. Predictors of in‑hospital mortality were investigated in both conditions by logistic regression. Results: There were 132 SJS/TEN‑related and 122 EM‑related hospitalisations. Incidence and in‑hospital mortality of SJS/TEN episodes (24.2%) were consistent with previous studies. HIV co‑infection was more common among SJS/ TEN hospitalisations (9 vs. 2% with EM; P = 0.009). Liver disease, advanced age, and a TEN diagnosis, were significantly associated with higher risk of mortality in patients with SJS/TEN. The highest numbers of SJS/TEN and EM episodes per million drug packages sold were observed for antivirals (8.7 and 1.5, respectively), antineoplastic/immunosuppres‑ sive drugs (5.6 and 3.9, respectively) and hypouricaemic drugs (5.0 and 2.4, respectively). Conclusions: SJS/TEN in‑hospital mortality is high, and its risk factors include advanced age, liver disease, and TEN diagnosis. The drug classes most frequently associated with these conditions include antivirals, hypouricaemic drugs and antineoplastic/immunosuppressive drugs. Administrative databases seem useful in the study of SJS/TEN drug‑ related hospitalisations, yielding results consistent with previous studies and on a nationwide basis.

The evidence of exercise-induced bronchoconstriction (EIB) without asthma (EIBw A) occurring in a... more The evidence of exercise-induced bronchoconstriction (EIB) without asthma (EIBw A) occurring in athletes led to speculate about different endotypes inducing respiratory symptoms within athletes. Classical postulated mechanisms for bronchial obstruction in this population include the osmotic and the thermal hypotheses. More recently, the presence of epithelial injury and inflammation in the airways of athletes was demonstrated. In addition, neuronal activation has been suggested as a potential modulator of bronchoconstriction. Investigation of these emerging mechanisms is of major importance as EIB is a significant problem for both recreational and competitive athletes and is the most common chronic condition among Olympic athletes, with obvious implications for their competing performance, health and quality of life. Hereby, we summarize the latest achievements in this area and identify the current gaps of knowledge so that future research heads toward better defining the etiologic factors and mechanisms involved in development of EIB in elite athletes as well as essential aspects to ultimately propose preventive and therapeutic measures.

Ocular allergy (OA) includes a group of common and less frequent hypersensitivity disorders frequ... more Ocular allergy (OA) includes a group of common and less frequent hypersensitivity disorders frequently misdiagnosed and not properly managed. The diagnosis of OA is usually based on clinical history and signs and symptoms, with the support of in vivo and in vitro tests when identification of the specific allergen is required. To date, no specific test is available for the diagnosis of the whole spectrum of the different forms of OA. The lack of recommendations on diagnosis of OA is considered a medical need not only for allergists but also for ophthalmologists. This position paper aims to provide a comprehensive overview of the currently available tools for diagnosing OA to promote a common nomenclature and procedures to be used by different specialists. Questionnaires, sign and symptom grading scales, tests, and potential biomarkers for OA are reviewed. We also identified several unmet needs in the diagnostic tools to generate interest, increase understanding, and inspire further investigations. Tools, recommendations, and algorithms for the diagnosis of OA are proposed for use by both allergists and ophthalmologists. Several unmet needs in the diagnostic tools should be further improved by specific clinical research in OA.

We hypothesize that oxidative stress induced by trichloramine exposure during swimming could be r... more We hypothesize that oxidative stress induced by trichloramine exposure during swimming could be related to etiopathogenesis of asthma among elite swimmers. Aim: To investigate the effect of a swimming training session on oxidative stress markers of asthmatic compared to non-asthmatic elite swimmers using exhaled breath (EB) metabolomics. Methods: Elite swimmers annually screened in our department (n=27) were invited and those who agreed to participate (n=20, of which 9 with asthma) had EB collected (Tedlar ® bags) before and after a swimming training session. SPME fiber (DVB/CAR/PDMS) was used to extract EB metabolites followed by a multidimen-sional gas chromatography analysis (GC×GC-ToFMS). Dataset comprises eight me-tabolites end products of lipid peroxidation: five aliphatic alkanes (nonane, 2,2,4,6,6-pentamethylheptane, decane, dodecane, and tetradecane) and three alde-hydes (nonanal, decanal, and dodecanal). To assess exercise impact on lipid peroxida-tion markers, data were analyzed using principle component analysis (PCA), which was run on the original data set and on the data set constructed using differences in the metabolite total areas before and after exercise session.