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Papers by kitjanit neranon

This thesis focuses on the design, synthesis and development of dynamic multivalent nanostructure... more This thesis focuses on the design, synthesis and development of dynamic multivalent nanostructures such as supramolecular dendrimers, liposomes and gold-functionalized nanostructures. These structures can be used for drug delivery and molecular sensing applications. This thesis is divided into three parts:In part one, a general introduction to self-assembly, dynamic systems, metalligand exchange, nanostructured dendritic scaffolds, liposomes and gold nanostructures is given.In part two, a microwave approach is presented as an efficient method for the regioselective deuteration of bipyridine scaffolds. Dynamic systems based on transition metal-bipyridine coordination complexes were investigated. The compositional self-adaptation and kinetics of these dynamic systems were successfully assessed by ESI-MS. Based on this amphiphilic dendrimers/metallodendrimers were also designed and synthesized via a convergent strategy. Their ability to self-assemble into supramolecular assemblies and ...

This thesis focuses on the design, synthesis and development of dynamic multivalent nanostructure... more This thesis focuses on the design, synthesis and development of dynamic multivalent nanostructures such as supramolecular dendrimers, liposomes and gold-functionalized nanostructures. These structu ...

This thesis focuses on the design, synthesis and development of dynamic multivalent nanostructure... more This thesis focuses on the design, synthesis and development of dynamic multivalent nanostructures such as supramolecular dendrimers, liposomes and gold-functionalized nanostructures. These structures can be used for drug delivery and molecular sensing applications. This thesis is divided into three parts:In part one, a general introduction to self-assembly, dynamic systems, metalligand exchange, nanostructured dendritic scaffolds, liposomes and gold nanostructures is given.In part two, a microwave approach is presented as an efficient method for the regioselective deuteration of bipyridine scaffolds. Dynamic systems based on transition metal-bipyridine coordination complexes were investigated. The compositional self-adaptation and kinetics of these dynamic systems were successfully assessed by ESI-MS. Based on this amphiphilic dendrimers/metallodendrimers were also designed and synthesized via a convergent strategy. Their ability to self-assemble into supramolecular assemblies and ...

This thesis focuses on the design, synthesis and development of dynamic multivalent nanostructure... more This thesis focuses on the design, synthesis and development of dynamic multivalent nanostructures such as supramolecular dendrimers, liposomes and gold-functionalized nanostructures. These structures can be used for drug delivery and molecular sensing applications. This thesis is divided into three parts:In part one, a general introduction to self-assembly, dynamic systems, metalligand exchange, nanostructured dendritic scaffolds, liposomes and gold nanostructures is given.In part two, a microwave approach is presented as an efficient method for the regioselective deuteration of bipyridine scaffolds. Dynamic systems based on transition metal-bipyridine coordination complexes were investigated. The compositional self-adaptation and kinetics of these dynamic systems were successfully assessed by ESI-MS. Based on this amphiphilic dendrimers/metallodendrimers were also designed and synthesized via a convergent strategy. Their ability to self-assemble into supramolecular assemblies and ...

This thesis focuses on the design, synthesis and development of dynamic multivalent nanostructure... more This thesis focuses on the design, synthesis and development of dynamic multivalent nanostructures such as supramolecular dendrimers, liposomes and gold-functionalized nanostructures. These structures can be used for drug delivery and molecular sensing applications. This thesis is divided into three parts:In part one, a general introduction to self-assembly, dynamic systems, metalligand exchange, nanostructured dendritic scaffolds, liposomes and gold nanostructures is given.In part two, a microwave approach is presented as an efficient method for the regioselective deuteration of bipyridine scaffolds. Dynamic systems based on transition metal-bipyridine coordination complexes were investigated. The compositional self-adaptation and kinetics of these dynamic systems were successfully assessed by ESI-MS. Based on this amphiphilic dendrimers/metallodendrimers were also designed and synthesized via a convergent strategy. Their ability to self-assemble into supramolecular assemblies and ...

Functionalized gold nanostructures with efficient, broadband absorption properties are of interes... more Functionalized gold nanostructures with efficient, broadband absorption properties are of interest for a variety of biomedical applications. In this study, we report a plasmon-enhanced functionalization methodology that results in selective surface conjugation of a fluorescent probe via two-photon excitation under visible-wavelength laser irradiation. The fluorescent probe was designed to incorporate a thiolated 4-piperidinyl-1,8-naphthalimide (SNaph) entity, carrying a photolabile 6-nitroveratryl (NV) protecting group, straightforwardly synthesized in a few steps in good yield. Efficient plasmon-enhanced photodeprotection of the NV-group, followed by thiol-gold bond formation on gold nanoisland substrates was recorded upon exposure to 650 nm laser light, supported by confocal laser scanning microscopy (CLSM). Photolysis of the labile NV-group, thereby efficiently exposing the free mercapto group of the thiolated 1,8-naphthalimide, was recorded upon UV-irradiation at 350 nm, whereas...

European Journal of Inorganic Chemistry, 2016

Tetrahedron Letters

Thiophene end-capped aromatic analogues, that is, naphthothiophenes, naphthodithiophenes, pyrenot... more Thiophene end-capped aromatic analogues, that is, naphthothiophenes, naphthodithiophenes, pyrenothiophene, and benzotrithiophene, can be prepared from commercially available hydroxyarenes in two steps, including (1) a consecutive acid-mediated nucleophilic aromatic substitution of hydroxyarenes with 2-mercaptoethanol, followed by cyclization to form an arene-fused dihydrothiophene, and (2) oxidation of the dihydrothiophene unit to thiophene.

Biosensors and Bioelectronics, 2015

Nanomaterials constitute a class of structures that have unique physiochemical properties and are... more Nanomaterials constitute a class of structures that have unique physiochemical properties and are excellent scaffolds for presenting carbohydrates, important biomolecules that mediate a wide variety of important biological events. The fabrication of carbohydrate-presenting nanomaterials, glyconanomaterials, is of high interest and utility, combining the features of nanoscale objects with biomolecular recognition. The structures can also produce strong multivalent effects, where the nanomaterial scaffold greatly enhances the relatively weak affinities of single carbohydrate ligands to the corresponding receptors, and effectively amplifies the carbohydrate-mediated interactions. Glyconanomaterials are thus an appealing platform for biosensing applications. In this review, we discuss the chemistry for conjugation of carbohydrates to nanomaterials, summarize strategies, and tabulate examples of applying glyconanomaterials in in vitro and in vivo sensing applications of proteins, microbes, and cells. The limitations and future perspectives of these emerging glyconanomaterials sensing systems are furthermore discussed.

This thesis focuses on the design, synthesis and development of dynamic multivalent nanostructure... more This thesis focuses on the design, synthesis and development of dynamic multivalent nanostructures such as supramolecular dendrimers, liposomes and gold-functionalized nanostructures. These structures can be used for drug delivery and molecular sensing applications. This thesis is divided into three parts:In part one, a general introduction to self-assembly, dynamic systems, metalligand exchange, nanostructured dendritic scaffolds, liposomes and gold nanostructures is given.In part two, a microwave approach is presented as an efficient method for the regioselective deuteration of bipyridine scaffolds. Dynamic systems based on transition metal-bipyridine coordination complexes were investigated. The compositional self-adaptation and kinetics of these dynamic systems were successfully assessed by ESI-MS. Based on this amphiphilic dendrimers/metallodendrimers were also designed and synthesized via a convergent strategy. Their ability to self-assemble into supramolecular assemblies and ...

This thesis focuses on the design, synthesis and development of dynamic multivalent nanostructure... more This thesis focuses on the design, synthesis and development of dynamic multivalent nanostructures such as supramolecular dendrimers, liposomes and gold-functionalized nanostructures. These structu ...

This thesis focuses on the design, synthesis and development of dynamic multivalent nanostructure... more This thesis focuses on the design, synthesis and development of dynamic multivalent nanostructures such as supramolecular dendrimers, liposomes and gold-functionalized nanostructures. These structures can be used for drug delivery and molecular sensing applications. This thesis is divided into three parts:In part one, a general introduction to self-assembly, dynamic systems, metalligand exchange, nanostructured dendritic scaffolds, liposomes and gold nanostructures is given.In part two, a microwave approach is presented as an efficient method for the regioselective deuteration of bipyridine scaffolds. Dynamic systems based on transition metal-bipyridine coordination complexes were investigated. The compositional self-adaptation and kinetics of these dynamic systems were successfully assessed by ESI-MS. Based on this amphiphilic dendrimers/metallodendrimers were also designed and synthesized via a convergent strategy. Their ability to self-assemble into supramolecular assemblies and ...

This thesis focuses on the design, synthesis and development of dynamic multivalent nanostructure... more This thesis focuses on the design, synthesis and development of dynamic multivalent nanostructures such as supramolecular dendrimers, liposomes and gold-functionalized nanostructures. These structures can be used for drug delivery and molecular sensing applications. This thesis is divided into three parts:In part one, a general introduction to self-assembly, dynamic systems, metalligand exchange, nanostructured dendritic scaffolds, liposomes and gold nanostructures is given.In part two, a microwave approach is presented as an efficient method for the regioselective deuteration of bipyridine scaffolds. Dynamic systems based on transition metal-bipyridine coordination complexes were investigated. The compositional self-adaptation and kinetics of these dynamic systems were successfully assessed by ESI-MS. Based on this amphiphilic dendrimers/metallodendrimers were also designed and synthesized via a convergent strategy. Their ability to self-assemble into supramolecular assemblies and ...

This thesis focuses on the design, synthesis and development of dynamic multivalent nanostructure... more This thesis focuses on the design, synthesis and development of dynamic multivalent nanostructures such as supramolecular dendrimers, liposomes and gold-functionalized nanostructures. These structures can be used for drug delivery and molecular sensing applications. This thesis is divided into three parts:In part one, a general introduction to self-assembly, dynamic systems, metalligand exchange, nanostructured dendritic scaffolds, liposomes and gold nanostructures is given.In part two, a microwave approach is presented as an efficient method for the regioselective deuteration of bipyridine scaffolds. Dynamic systems based on transition metal-bipyridine coordination complexes were investigated. The compositional self-adaptation and kinetics of these dynamic systems were successfully assessed by ESI-MS. Based on this amphiphilic dendrimers/metallodendrimers were also designed and synthesized via a convergent strategy. Their ability to self-assemble into supramolecular assemblies and ...

Functionalized gold nanostructures with efficient, broadband absorption properties are of interes... more Functionalized gold nanostructures with efficient, broadband absorption properties are of interest for a variety of biomedical applications. In this study, we report a plasmon-enhanced functionalization methodology that results in selective surface conjugation of a fluorescent probe via two-photon excitation under visible-wavelength laser irradiation. The fluorescent probe was designed to incorporate a thiolated 4-piperidinyl-1,8-naphthalimide (SNaph) entity, carrying a photolabile 6-nitroveratryl (NV) protecting group, straightforwardly synthesized in a few steps in good yield. Efficient plasmon-enhanced photodeprotection of the NV-group, followed by thiol-gold bond formation on gold nanoisland substrates was recorded upon exposure to 650 nm laser light, supported by confocal laser scanning microscopy (CLSM). Photolysis of the labile NV-group, thereby efficiently exposing the free mercapto group of the thiolated 1,8-naphthalimide, was recorded upon UV-irradiation at 350 nm, whereas...

European Journal of Inorganic Chemistry, 2016

Tetrahedron Letters

Thiophene end-capped aromatic analogues, that is, naphthothiophenes, naphthodithiophenes, pyrenot... more Thiophene end-capped aromatic analogues, that is, naphthothiophenes, naphthodithiophenes, pyrenothiophene, and benzotrithiophene, can be prepared from commercially available hydroxyarenes in two steps, including (1) a consecutive acid-mediated nucleophilic aromatic substitution of hydroxyarenes with 2-mercaptoethanol, followed by cyclization to form an arene-fused dihydrothiophene, and (2) oxidation of the dihydrothiophene unit to thiophene.

Biosensors and Bioelectronics, 2015

Nanomaterials constitute a class of structures that have unique physiochemical properties and are... more Nanomaterials constitute a class of structures that have unique physiochemical properties and are excellent scaffolds for presenting carbohydrates, important biomolecules that mediate a wide variety of important biological events. The fabrication of carbohydrate-presenting nanomaterials, glyconanomaterials, is of high interest and utility, combining the features of nanoscale objects with biomolecular recognition. The structures can also produce strong multivalent effects, where the nanomaterial scaffold greatly enhances the relatively weak affinities of single carbohydrate ligands to the corresponding receptors, and effectively amplifies the carbohydrate-mediated interactions. Glyconanomaterials are thus an appealing platform for biosensing applications. In this review, we discuss the chemistry for conjugation of carbohydrates to nanomaterials, summarize strategies, and tabulate examples of applying glyconanomaterials in in vitro and in vivo sensing applications of proteins, microbes, and cells. The limitations and future perspectives of these emerging glyconanomaterials sensing systems are furthermore discussed.