Majid Zeidi | University of Pennsylvania (original) (raw)

Papers by Majid Zeidi

Research paper thumbnail of Polymorphisms and Serum Level of Mannose-Binding Lectin: An Iranian Survey

Iranian Journal of Allergy Asthma and Immunology, Jul 26, 2014

Mannose-binding lectin (MBL) is a Ca +2 -dependent collagenous lectin, that is produced by liver ... more Mannose-binding lectin (MBL) is a Ca +2 -dependent collagenous lectin, that is produced by liver and mediates innate immune responses by opsonization of pathogens. The serum level of MBL varies widely among healthy individuals, ranging from 0.05µg/ml (or lower) to over 5µg/ml, mainly depending on genetic variations.

Research paper thumbnail of Sebaceous Induction In Dermatofibroma: A Common Feature of Dermatofibromas On The Shoulder

Journal of Cutaneous Pathology

Background: Dermatofibroma (DF) has multiple histopathological variants and overlying acanthosis,... more Background: Dermatofibroma (DF) has multiple histopathological variants and overlying acanthosis, hyperkeratosis and hyperpigmentation are often present. We have frequently observed sebaceous induction in DFs on the shoulder and wanted to assess if this is a site-specific finding. Methods: We prospectively collected 100 DFs and assessed for sebaceous induction, the histopathologic pattern of the DF and any associated-epidermal changes. We retrospectively searched for DFs with sebaceous induction to assess the anatomic site of the biopsy. Results: In the 100 prospectively collected DFs, 49% occurred on the lower extremities, 39% on the upper extremities, 10% on the trunk and 2% on the head. Sebaceous induction was present in 16 DFs, 81% of which occurred on or near the shoulder. The most common variant was fibrocollagenous DF (64%), including in DFs with sebaceous induction. The retrospective search for DFs with sebaceous induction found 19 cases in which 95% occurred on the shoulder area. Sclerotic pattern DFs were most common in this retrospective cohort (47%), and seborrheic keratosis-like hyperplasia occurred in 100% of these cases. Conclusion: DFs occurring on the shoulder have a high incidence of sebaceous induction with seborrheic keratosis-like epidermal hyperplasia and a fibrocollagenous or sclerotic pattern.

Research paper thumbnail of The Study of Total IgE Reference Range in Healthy Adults in Tehran, Iran

Iranian Journal of Public Health

IgE is an antibody class that regarded as an important factor in the pathogenesis of allergic dis... more IgE is an antibody class that regarded as an important factor in the pathogenesis of allergic diseases, asthma, immune responses to parasitic infection and it could be responsible for the late- phase allergic response. The objective of this study was to evaluate total IgE in healthy Iranian adults, establishment of reference range of total IgE and assess helpfulness of this value in clinical diagnosis atopic and allergic diseases. Three hundred sixty six healthy adults from blood transfusion volunteers (18 to 60 years) were selected in this study. A specific questionnaire (including demographic factors, smoking status and …) was filled out for each person. Also, we evaluated effect of race and education on total IgE. These adults had no history of allergic disease. The total serum IgE level using a commercial enzyme immunoassay and CBC (Eosinophil count) was determined in them. Mean of age was 37.32± 10.93 yrs and 219 cases were males and 147 females. The geometric mean of total IgE...

Research paper thumbnail of Hepatitis B Viral DNA Among HBs Antigen Negative Healthy Blood Donors

Hepatitis Monthly, 2013

Background: Presence of occult hepatitis B infection (OBI) renders HBs antigen (HBsAg) undetectab... more Background: Presence of occult hepatitis B infection (OBI) renders HBs antigen (HBsAg) undetectable by ELISA. Therefore it is valuable to evaluate the frequency of OBI among healthy blood donors to improve and perhaps change the strategies of blood screening to reduce the risk of HBV transmission. Objectives: The aim of this study was to determine the presence of HBcAb and HBV DNA among Iranian HBsAg negative healthy blood donors who donated their blood to the Tehran Blood Transfusion Center during 2011. Patients and Methods: 1000 serum specimens negative for HBsAg, HCV antibody and HIV antibody were collected from healthy blood donors and tested for HBcAb. Presence of hepatitis B viral DNA was checked in HBcAb positive samples by nested PCR with two sets of primers to amplify part of HBV S gene. Results: There were 64 women and 936 men in the population under study. The mean ± SD age of the donors was 38 ± 11 years. 80 out of 1000 samples (8%) were found to be positive for HBcAb. HBV DNA was detected in 50% of HBcAb positive specimens. The mean ± SD age of donors without HBV DNA was 37.7 ± 10.5 years and for donors with HBV DNA was 40.9 ± 11.2 years (P = 0.05). Conclusions: OBI was prevalent among 50% of HBcAb positive healthy blood donors. The frequency of positive HBcAb among healthy HBsAg negative blood donors was comparable to previous studies reported from Iran. On the other hand, the frequency of HBV DNA in HBsAg negative blood donors was higher than previous reports.

Research paper thumbnail of Determination of Lymphocyte Subsets Reference Values in Healthy Iranian Men by a Single Platform Flow Cytometric Method

Lymphocyte subsets enumeration is of paramount importance in the management of immunodeficiency d... more Lymphocyte subsets enumeration is of paramount importance in the management of immunodeficiency disorders such as HIV/AIDS. For better interpretation of laboratory findings, reference intervals must be determined in each population. Because of scarcity of published studies from Iranian population, lymphocyte subsets were enumerated in 142 healthy Iranian men by a single platform flow cytometric method. Mean and 95% confidence interval for CD41 T cells, CD81 T cells, CD4/CD8 ratio, B cells, and natural killer cells were 748.8 (351-1207), 409.0 (192-752), 1.96 (0.77-3.70), 238.6 (82-500), and 200.7 (91-393), respectively. We compared our results with other studies and found significant differences with some of them. In conclusion, we endorse determination of lymphocyte subsets reference interval in different populations. '

Research paper thumbnail of Selective immunoglobulin a deficiency in Iranian blood donors: prevalence, laboratory and clinical findings

Copyright© 2008, IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY. All rights reserved. ... ORIG... more Copyright© 2008, IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY. All rights reserved. ... ORIGINAL ARTICLE Iran J Allergy Asthma Immunol September 2008; 7(3): 157-162 ... Selective Immunoglobulin A Deficiency in Iranian Blood Donors: Prevalence, ...

Research paper thumbnail of Polymorphisms and Serum Level of Mannose-Binding Lectin: An Iranian Survey

Iranian Journal of Allergy Asthma and Immunology, Jul 26, 2014

Mannose-binding lectin (MBL) is a Ca +2 -dependent collagenous lectin, that is produced by liver ... more Mannose-binding lectin (MBL) is a Ca +2 -dependent collagenous lectin, that is produced by liver and mediates innate immune responses by opsonization of pathogens. The serum level of MBL varies widely among healthy individuals, ranging from 0.05µg/ml (or lower) to over 5µg/ml, mainly depending on genetic variations.

Research paper thumbnail of Sebaceous Induction In Dermatofibroma: A Common Feature of Dermatofibromas On The Shoulder

Journal of Cutaneous Pathology

Background: Dermatofibroma (DF) has multiple histopathological variants and overlying acanthosis,... more Background: Dermatofibroma (DF) has multiple histopathological variants and overlying acanthosis, hyperkeratosis and hyperpigmentation are often present. We have frequently observed sebaceous induction in DFs on the shoulder and wanted to assess if this is a site-specific finding. Methods: We prospectively collected 100 DFs and assessed for sebaceous induction, the histopathologic pattern of the DF and any associated-epidermal changes. We retrospectively searched for DFs with sebaceous induction to assess the anatomic site of the biopsy. Results: In the 100 prospectively collected DFs, 49% occurred on the lower extremities, 39% on the upper extremities, 10% on the trunk and 2% on the head. Sebaceous induction was present in 16 DFs, 81% of which occurred on or near the shoulder. The most common variant was fibrocollagenous DF (64%), including in DFs with sebaceous induction. The retrospective search for DFs with sebaceous induction found 19 cases in which 95% occurred on the shoulder area. Sclerotic pattern DFs were most common in this retrospective cohort (47%), and seborrheic keratosis-like hyperplasia occurred in 100% of these cases. Conclusion: DFs occurring on the shoulder have a high incidence of sebaceous induction with seborrheic keratosis-like epidermal hyperplasia and a fibrocollagenous or sclerotic pattern.

Research paper thumbnail of The Study of Total IgE Reference Range in Healthy Adults in Tehran, Iran

Iranian Journal of Public Health

IgE is an antibody class that regarded as an important factor in the pathogenesis of allergic dis... more IgE is an antibody class that regarded as an important factor in the pathogenesis of allergic diseases, asthma, immune responses to parasitic infection and it could be responsible for the late- phase allergic response. The objective of this study was to evaluate total IgE in healthy Iranian adults, establishment of reference range of total IgE and assess helpfulness of this value in clinical diagnosis atopic and allergic diseases. Three hundred sixty six healthy adults from blood transfusion volunteers (18 to 60 years) were selected in this study. A specific questionnaire (including demographic factors, smoking status and …) was filled out for each person. Also, we evaluated effect of race and education on total IgE. These adults had no history of allergic disease. The total serum IgE level using a commercial enzyme immunoassay and CBC (Eosinophil count) was determined in them. Mean of age was 37.32± 10.93 yrs and 219 cases were males and 147 females. The geometric mean of total IgE...

Research paper thumbnail of Hepatitis B Viral DNA Among HBs Antigen Negative Healthy Blood Donors

Hepatitis Monthly, 2013

Background: Presence of occult hepatitis B infection (OBI) renders HBs antigen (HBsAg) undetectab... more Background: Presence of occult hepatitis B infection (OBI) renders HBs antigen (HBsAg) undetectable by ELISA. Therefore it is valuable to evaluate the frequency of OBI among healthy blood donors to improve and perhaps change the strategies of blood screening to reduce the risk of HBV transmission. Objectives: The aim of this study was to determine the presence of HBcAb and HBV DNA among Iranian HBsAg negative healthy blood donors who donated their blood to the Tehran Blood Transfusion Center during 2011. Patients and Methods: 1000 serum specimens negative for HBsAg, HCV antibody and HIV antibody were collected from healthy blood donors and tested for HBcAb. Presence of hepatitis B viral DNA was checked in HBcAb positive samples by nested PCR with two sets of primers to amplify part of HBV S gene. Results: There were 64 women and 936 men in the population under study. The mean ± SD age of the donors was 38 ± 11 years. 80 out of 1000 samples (8%) were found to be positive for HBcAb. HBV DNA was detected in 50% of HBcAb positive specimens. The mean ± SD age of donors without HBV DNA was 37.7 ± 10.5 years and for donors with HBV DNA was 40.9 ± 11.2 years (P = 0.05). Conclusions: OBI was prevalent among 50% of HBcAb positive healthy blood donors. The frequency of positive HBcAb among healthy HBsAg negative blood donors was comparable to previous studies reported from Iran. On the other hand, the frequency of HBV DNA in HBsAg negative blood donors was higher than previous reports.

Research paper thumbnail of Determination of Lymphocyte Subsets Reference Values in Healthy Iranian Men by a Single Platform Flow Cytometric Method

Lymphocyte subsets enumeration is of paramount importance in the management of immunodeficiency d... more Lymphocyte subsets enumeration is of paramount importance in the management of immunodeficiency disorders such as HIV/AIDS. For better interpretation of laboratory findings, reference intervals must be determined in each population. Because of scarcity of published studies from Iranian population, lymphocyte subsets were enumerated in 142 healthy Iranian men by a single platform flow cytometric method. Mean and 95% confidence interval for CD41 T cells, CD81 T cells, CD4/CD8 ratio, B cells, and natural killer cells were 748.8 (351-1207), 409.0 (192-752), 1.96 (0.77-3.70), 238.6 (82-500), and 200.7 (91-393), respectively. We compared our results with other studies and found significant differences with some of them. In conclusion, we endorse determination of lymphocyte subsets reference interval in different populations. '

Research paper thumbnail of Selective immunoglobulin a deficiency in Iranian blood donors: prevalence, laboratory and clinical findings

Copyright© 2008, IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY. All rights reserved. ... ORIG... more Copyright© 2008, IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY. All rights reserved. ... ORIGINAL ARTICLE Iran J Allergy Asthma Immunol September 2008; 7(3): 157-162 ... Selective Immunoglobulin A Deficiency in Iranian Blood Donors: Prevalence, ...