William Denney - Profile on Academia.edu (original) (raw)

Papers by William Denney

Research paper thumbnail of ggtibble: Create Tibbles and Lists of 'ggplot' Figures for Reporting

ggtibble: Create Tibbles and Lists of 'ggplot' Figures for Reporting

Research paper thumbnail of geboes.score: Evaluate the Geboes Score for Histology in Ulcerative Colitis

geboes.score: Evaluate the Geboes Score for Histology in Ulcerative Colitis

Research paper thumbnail of equil2: Calculate Urinary Saturation with the EQUIL2 Algorithm

equil2: Calculate Urinary Saturation with the EQUIL2 Algorithm

Research paper thumbnail of pmxTools: Pharmacometric and Pharmacokinetic Toolkit

pmxTools: Pharmacometric and Pharmacokinetic Toolkit

Research paper thumbnail of nlmixr2lib: A Model Library for 'nlmixr2

nlmixr2lib: A Model Library for 'nlmixr2

Research paper thumbnail of PKNCA: Perform Pharmacokinetic Non-Compartmental Analysis

PKNCA: Perform Pharmacokinetic Non-Compartmental Analysis

Research paper thumbnail of babelmixr2: Use 'nlmixr2' to Interact with Open Source and Commercial Software

babelmixr2: Use 'nlmixr2' to Interact with Open Source and Commercial Software

Research paper thumbnail of formulops: Mathematical Operations on R Formula

formulops: Mathematical Operations on R Formula

Research paper thumbnail of SYNB8802 Lowers Urinary Oxalate During a Diet-Controlled Study in Patients with Roux-en-Y Gastric Bypass

SYNB8802 Lowers Urinary Oxalate During a Diet-Controlled Study in Patients with Roux-en-Y Gastric Bypass

Journal of the American Society of Nephrology, Nov 1, 2023

Research paper thumbnail of First‐in‐human safety, tolerability, and pharmacokinetic results of DFV890, an oral low‐molecular‐weight NLRP3 inhibitor

First‐in‐human safety, tolerability, and pharmacokinetic results of DFV890, an oral low‐molecular‐weight NLRP3 inhibitor

Clinical and translational science, May 1, 2024

Research paper thumbnail of Proof-of-Concept Study of Oxalate-Consuming Synthetic Biotic Medicine SYNB8802 in Enteric Hyperoxaluria after Roux-en-Y Surgery

Proof-of-Concept Study of Oxalate-Consuming Synthetic Biotic Medicine SYNB8802 in Enteric Hyperoxaluria after Roux-en-Y Surgery

Journal of the American Society of Nephrology, Oct 1, 2021

Research paper thumbnail of The live biotherapeutic SYNB1353 decreases plasma methionine via directed degradation in animal models and healthy volunteers

The live biotherapeutic SYNB1353 decreases plasma methionine via directed degradation in animal models and healthy volunteers

Cell host & microbe, Feb 1, 2024

Research paper thumbnail of Pharmacokinetics and pharmacodynamics across infusion rates of intravenously administered nipocalimab: results of a phase 1, placebo-controlled study

Frontiers in neuroscience, Feb 1, 2024

Pharmacokinetics and pharmacodynamics across infusion rates of intravenously administered nipocal... more Pharmacokinetics and pharmacodynamics across infusion rates of intravenously administered nipocalimab: results of a phase 1, placebo-controlled study.

Research paper thumbnail of circulating tissue factor requires flow coagulation at venous and arterial shear rates: amplification of 100 fM Determination of surface tissue factor thresholds that trigger

Protein microarrays presenting spots of collagen and lipidated tissue factor (TF) allowed a deter... more Protein microarrays presenting spots of collagen and lipidated tissue factor (TF) allowed a determination of the critical surface concentration of TF required to trigger coagulation under flow. Whole blood supplemented with corn trypsin inhibitor (to inhibit factor XIIa) was perfused over microarrays for 5 minutes. Immunofluorescence staining of platelet glycoprotein GPIb␣ and fibrin(ogen) revealed a critical TF concentration (EC50) of 3.6, 8.4, and 10.2 molecules-TF/m 2 at wall shear rates of 100, 500, and 1000 s ؊1 , respectively. For collagen arrays where only the center lane of spots (in the direction of flow) contained TF, a downstream distance of 14 mm was required for the thrombus to widen enough to reach across a 300-micrometer gap to the adjacent TF-free lanes of collagen spots, in agreement with numerical simulation. To investigate the effect of low levels of circulating TF, whole blood (؎ 100 fM added TF) was tested under static and flow conditions. After 5 minutes, the addition of 100 fM TF to whole blood had negligible effect under static conditions, but caused a 2.5-fold increase in fibrin formation under flow. This report defines the threshold concentrations of surface TF required to trigger coagulation under flow.

Research paper thumbnail of Efficacy and safety of a synthetic biotic for treatment of phenylketonuria: a phase 2 clinical trial

Efficacy and safety of a synthetic biotic for treatment of phenylketonuria: a phase 2 clinical trial

Nature Metabolism

Research paper thumbnail of Reproducibility of a battery of human evoked pain models to detect pharmacological effects of analgesic drugs

Reproducibility of a battery of human evoked pain models to detect pharmacological effects of analgesic drugs

European Journal of Pain, 2019

BackgroundAlthough reproducibility is considered essential for any method used in scientific rese... more BackgroundAlthough reproducibility is considered essential for any method used in scientific research, it is investigated only rarely; thus, strikingly little has been published regarding the reproducibility of evoked pain models involving human subjects. Here, we studied the reproducibility of a battery of evoked pain models for demonstrating the analgesic effects of two analgesic compounds.MethodsA total of 81 healthy subjects participated in four studies involving a battery of evoked pain tests in which mechanical, thermal and electrical stimuli were used to measure pain detection and tolerance thresholds. Pharmacodynamic outcome variables were analysed using a mixed model analysis of variance, and a coefficient of variation was calculated by dividing the standard deviation by the least squares means.ResultsA total of 76 subjects completed the studies. After being administered pregabalin, the subjects’ pain tolerance thresholds in the cold pressor and pressure stimulation tests w...

Research paper thumbnail of Blockade of Capsaicin-Induced Dermal Vasodilatation (CIDV) by MK-3207, a Calcitonin-Gene Related Peptide (CGRP) Receptor Antagonist for Acute Treatment of Migraine

Blockade of Capsaicin-Induced Dermal Vasodilatation (CIDV) by MK-3207, a Calcitonin-Gene Related Peptide (CGRP) Receptor Antagonist for Acute Treatment of Migraine

Research paper thumbnail of Publisher Correction: Safety and pharmacodynamics of an engineered E. coli Nissle for the treatment of phenylketonuria: a first-in-human phase 1/2a study

Nature Metabolism

In the version of this article initially published, in the Fig. 3a,b y-axis unit labels now readi... more In the version of this article initially published, in the Fig. 3a,b y-axis unit labels now reading "(h μmol l-1), " there was an error originally where "-1 " followed "h. " The labels have been replaced in the HTML and PDF versions of the article.

Research paper thumbnail of Comparison of Phenylalanine Absorption in Healthy Volunteers and Pku Patients in the SYNPHENY-1 Study

Comparison of Phenylalanine Absorption in Healthy Volunteers and Pku Patients in the SYNPHENY-1 Study

Molecular Genetics and Metabolism, 2022

Research paper thumbnail of Tolerabilityand kinetics of SYNB1020 in a Phase 1, first-in-Human, healthy adult volunteer study

Journal of Hepatology, 2018

SAT-285): SYNB1020 genetic modifications. (1) argR repressor gene deleted, (2) argA gene replaced... more SAT-285): SYNB1020 genetic modifications. (1) argR repressor gene deleted, (2) argA gene replaced with a feedback-resistant version, (3) Control of argA gene by anaerobic promoter (fnr), (4) thyA gene deleted to confer auxotrophy.

Research paper thumbnail of ggtibble: Create Tibbles and Lists of 'ggplot' Figures for Reporting

ggtibble: Create Tibbles and Lists of 'ggplot' Figures for Reporting

Research paper thumbnail of geboes.score: Evaluate the Geboes Score for Histology in Ulcerative Colitis

geboes.score: Evaluate the Geboes Score for Histology in Ulcerative Colitis

Research paper thumbnail of equil2: Calculate Urinary Saturation with the EQUIL2 Algorithm

equil2: Calculate Urinary Saturation with the EQUIL2 Algorithm

Research paper thumbnail of pmxTools: Pharmacometric and Pharmacokinetic Toolkit

pmxTools: Pharmacometric and Pharmacokinetic Toolkit

Research paper thumbnail of nlmixr2lib: A Model Library for 'nlmixr2

nlmixr2lib: A Model Library for 'nlmixr2

Research paper thumbnail of PKNCA: Perform Pharmacokinetic Non-Compartmental Analysis

PKNCA: Perform Pharmacokinetic Non-Compartmental Analysis

Research paper thumbnail of babelmixr2: Use 'nlmixr2' to Interact with Open Source and Commercial Software

babelmixr2: Use 'nlmixr2' to Interact with Open Source and Commercial Software

Research paper thumbnail of formulops: Mathematical Operations on R Formula

formulops: Mathematical Operations on R Formula

Research paper thumbnail of SYNB8802 Lowers Urinary Oxalate During a Diet-Controlled Study in Patients with Roux-en-Y Gastric Bypass

SYNB8802 Lowers Urinary Oxalate During a Diet-Controlled Study in Patients with Roux-en-Y Gastric Bypass

Journal of the American Society of Nephrology, Nov 1, 2023

Research paper thumbnail of First‐in‐human safety, tolerability, and pharmacokinetic results of DFV890, an oral low‐molecular‐weight NLRP3 inhibitor

First‐in‐human safety, tolerability, and pharmacokinetic results of DFV890, an oral low‐molecular‐weight NLRP3 inhibitor

Clinical and translational science, May 1, 2024

Research paper thumbnail of Proof-of-Concept Study of Oxalate-Consuming Synthetic Biotic Medicine SYNB8802 in Enteric Hyperoxaluria after Roux-en-Y Surgery

Proof-of-Concept Study of Oxalate-Consuming Synthetic Biotic Medicine SYNB8802 in Enteric Hyperoxaluria after Roux-en-Y Surgery

Journal of the American Society of Nephrology, Oct 1, 2021

Research paper thumbnail of The live biotherapeutic SYNB1353 decreases plasma methionine via directed degradation in animal models and healthy volunteers

The live biotherapeutic SYNB1353 decreases plasma methionine via directed degradation in animal models and healthy volunteers

Cell host & microbe, Feb 1, 2024

Research paper thumbnail of Pharmacokinetics and pharmacodynamics across infusion rates of intravenously administered nipocalimab: results of a phase 1, placebo-controlled study

Frontiers in neuroscience, Feb 1, 2024

Pharmacokinetics and pharmacodynamics across infusion rates of intravenously administered nipocal... more Pharmacokinetics and pharmacodynamics across infusion rates of intravenously administered nipocalimab: results of a phase 1, placebo-controlled study.

Research paper thumbnail of circulating tissue factor requires flow coagulation at venous and arterial shear rates: amplification of 100 fM Determination of surface tissue factor thresholds that trigger

Protein microarrays presenting spots of collagen and lipidated tissue factor (TF) allowed a deter... more Protein microarrays presenting spots of collagen and lipidated tissue factor (TF) allowed a determination of the critical surface concentration of TF required to trigger coagulation under flow. Whole blood supplemented with corn trypsin inhibitor (to inhibit factor XIIa) was perfused over microarrays for 5 minutes. Immunofluorescence staining of platelet glycoprotein GPIb␣ and fibrin(ogen) revealed a critical TF concentration (EC50) of 3.6, 8.4, and 10.2 molecules-TF/m 2 at wall shear rates of 100, 500, and 1000 s ؊1 , respectively. For collagen arrays where only the center lane of spots (in the direction of flow) contained TF, a downstream distance of 14 mm was required for the thrombus to widen enough to reach across a 300-micrometer gap to the adjacent TF-free lanes of collagen spots, in agreement with numerical simulation. To investigate the effect of low levels of circulating TF, whole blood (؎ 100 fM added TF) was tested under static and flow conditions. After 5 minutes, the addition of 100 fM TF to whole blood had negligible effect under static conditions, but caused a 2.5-fold increase in fibrin formation under flow. This report defines the threshold concentrations of surface TF required to trigger coagulation under flow.

Research paper thumbnail of Efficacy and safety of a synthetic biotic for treatment of phenylketonuria: a phase 2 clinical trial

Efficacy and safety of a synthetic biotic for treatment of phenylketonuria: a phase 2 clinical trial

Nature Metabolism

Research paper thumbnail of Reproducibility of a battery of human evoked pain models to detect pharmacological effects of analgesic drugs

Reproducibility of a battery of human evoked pain models to detect pharmacological effects of analgesic drugs

European Journal of Pain, 2019

BackgroundAlthough reproducibility is considered essential for any method used in scientific rese... more BackgroundAlthough reproducibility is considered essential for any method used in scientific research, it is investigated only rarely; thus, strikingly little has been published regarding the reproducibility of evoked pain models involving human subjects. Here, we studied the reproducibility of a battery of evoked pain models for demonstrating the analgesic effects of two analgesic compounds.MethodsA total of 81 healthy subjects participated in four studies involving a battery of evoked pain tests in which mechanical, thermal and electrical stimuli were used to measure pain detection and tolerance thresholds. Pharmacodynamic outcome variables were analysed using a mixed model analysis of variance, and a coefficient of variation was calculated by dividing the standard deviation by the least squares means.ResultsA total of 76 subjects completed the studies. After being administered pregabalin, the subjects’ pain tolerance thresholds in the cold pressor and pressure stimulation tests w...

Research paper thumbnail of Blockade of Capsaicin-Induced Dermal Vasodilatation (CIDV) by MK-3207, a Calcitonin-Gene Related Peptide (CGRP) Receptor Antagonist for Acute Treatment of Migraine

Blockade of Capsaicin-Induced Dermal Vasodilatation (CIDV) by MK-3207, a Calcitonin-Gene Related Peptide (CGRP) Receptor Antagonist for Acute Treatment of Migraine

Research paper thumbnail of Publisher Correction: Safety and pharmacodynamics of an engineered E. coli Nissle for the treatment of phenylketonuria: a first-in-human phase 1/2a study

Nature Metabolism

In the version of this article initially published, in the Fig. 3a,b y-axis unit labels now readi... more In the version of this article initially published, in the Fig. 3a,b y-axis unit labels now reading "(h μmol l-1), " there was an error originally where "-1 " followed "h. " The labels have been replaced in the HTML and PDF versions of the article.

Research paper thumbnail of Comparison of Phenylalanine Absorption in Healthy Volunteers and Pku Patients in the SYNPHENY-1 Study

Comparison of Phenylalanine Absorption in Healthy Volunteers and Pku Patients in the SYNPHENY-1 Study

Molecular Genetics and Metabolism, 2022

Research paper thumbnail of Tolerabilityand kinetics of SYNB1020 in a Phase 1, first-in-Human, healthy adult volunteer study

Journal of Hepatology, 2018

SAT-285): SYNB1020 genetic modifications. (1) argR repressor gene deleted, (2) argA gene replaced... more SAT-285): SYNB1020 genetic modifications. (1) argR repressor gene deleted, (2) argA gene replaced with a feedback-resistant version, (3) Control of argA gene by anaerobic promoter (fnr), (4) thyA gene deleted to confer auxotrophy.