Israr Ali | University Of Peshawar (original) (raw)

Papers by Israr Ali

Research paper thumbnail of Synthesis, Single Crystal X-ray, Hirshfeld and DFT Studies of 1,8-Dichloro-9,10-dihydro-9,10-ethanoanthracene-11-carboxylic Acid

Crystals

In this paper, synthesis, single-crystal X-ray structure, Hirshfeld and DFT studies of 1,8-dichlo... more In this paper, synthesis, single-crystal X-ray structure, Hirshfeld and DFT studies of 1,8-dichloro-9,10-dihydro-9,10-ethanoanthracene-11-carboxylic acid are discussed. Different intermolecular contacts affecting the crystal stability are studied using Hirshfeld calculations. The H…Cl and O…H contacts are the most significant, showing corresponding interaction distances of 2.731 Å (Cl2…H10) and 1.681Å (H1…O1), 2.328 Å (O1…H13), 2.510 Å (O1…H12) based on Hirshfeld calculations. DFT calculations are carried out to study the electronic behavior, as well as the 1H- and 13C-NMR spectra of the synthesized compound. The computed NMR chemical shifts show excellent correlation with the experimental data (R2 = 0.9884–0.9705).

Research paper thumbnail of Novel Maleic Acid, Crosslinked, Nanofibrous Chitosan/Poly (Vinylpyrrolidone) Membranes for Reverse Osmosis Desalination

International Journal of Molecular Sciences

Fresh and clean water is consistently depleting and becoming a serious problem with rapid increas... more Fresh and clean water is consistently depleting and becoming a serious problem with rapid increases in population, so seawater desalination technology has captured global attention. For an efficient desalination process, this work proposes a novel, nanofibrous, thin-film composite membrane (NF-TFC) based on the deposition of the nanofibrous active layer of a blend of chitosan (CS) and poly (vinylpyrrolidone) (PVP) crosslinked with maleic acid on a 3-triethoxysilylpropylamine functionalized cellulose acetate substrate. FTIR analysis demonstrated the development of chemical and physical interactions and confirmed the incorporation of functional groups present in the NF-TFC. Scanning electron microscopy (SEM) micrographs depict the fibrous structure of the active layers. The reverse osmosis (RO) desalination characteristics of NF-TFC membranes are elevated by increasing the concentration of the crosslinker in a CS/PVP blend. Cellulose acetate (CA)-S4 attained an optimal salt rejection ...

Research paper thumbnail of Synthesis of pyrazole acrylic acid based oxadiazole and amide derivatives as antimalarial and anticancer agents

Bioorganic chemistry, Apr 11, 2018

Depravity of malaria in terms of morbidity and mortality in human beings makes it a major health ... more Depravity of malaria in terms of morbidity and mortality in human beings makes it a major health issue in tropical and subtropical areas of the globe. Drug counterfeiting and non-adherence to the treatment regimen have significantly contributed to development and spread of multidrug resistance that has highlighted the need for development of novel and more efficient antimalarial drugs. Complexity associated with cancer disease and prevalence of diversified cell populations vindicates highly specific treatment options for treatment of cancer. Resistance to these anticancer agents has posed a great hindrance in successful treatment of cancer. Pondering this ongoing situation, it was speculated to develop novel compounds targeting malaria and cancer. Moving on the same aisle, we synthesized pyrazole acrylic acid based oxadiazole and amide derivatives using multi-step reaction pathways (6a-x; 6a'-h'). Schizont maturation inhibition assay was employed to determine antimalarial po...

Research paper thumbnail of Lattice Boltzmann analysis of fluid-structure interaction with moving boundaries

This work is concerned with the modelling of the interaction of fluid flow with flexibly supporte... more This work is concerned with the modelling of the interaction of fluid flow with flexibly supported rigid bodies. The fluid flow is modelled by Lattice-Boltzmann Method, coupled to a set of ordinary differential equations describing the dynamics of the solid body in terms its elastic and damping properties. The time discretization of the body dynamics is performed via the Time Discontinuous Galerkin Method. Several numerical examples are presented and highlight the robustness and efficiency of the proposed methodology, by means of comparisons with previously published results. The examples show that the present fluid-structure method is able to capture vortex- induced oscillations of flexibly-supported rigid body.

Research paper thumbnail of Design, Synthesis, and Biological Evaluation of Hydrazone Incorporated 1,2,4-Triazines as Anticonvulsant Agents

Archiv der Pharmazie, 2014

Research paper thumbnail of ChemInform Abstract: Synthesis of Pharmaceutically Important 1,3,4-Thiadiazole and Imidazolinone Derivatives as Antimicrobials

ChemInform, 2010

ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance t... more ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Research paper thumbnail of Synthesis of N1-(3-chloro-4-flourophenyl)-N4-substituted semicarbazones as novel anticonvulsant agents

Indian journal of chemistry. Section B, …, 2010

Abstract: Several 3-chloro-4-flourophenyl substituted semicarbazones have been synthesized in thr... more Abstract: Several 3-chloro-4-flourophenyl substituted semicarbazones have been synthesized in three steps involving aryl urea and aryl semicarbazide formation. The structures have been confirmed by spectral and elemental analyses. Some selected ...

Research paper thumbnail of Novel Approach for the Synthesis of N -Substituted-4-(2-methyl-4-oxo-4 H -quinazolin-3-yl)-butyramides

Synthetic Communications, 2011

A simple and convenient method for the synthesis of N-substituted-4-(2-methyl-4-oxo-4H-quinazolin... more A simple and convenient method for the synthesis of N-substituted-4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-butyramides has been reported. Several aromatic and aliphatic amide derivatives of 4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-butyric acid were prepared in 60–81% yields by refluxing it with different phosphazo compounds in toluene for approximately 1 h.

Research paper thumbnail of Synthesis of benzothiazole derivatives having acetamido and carbothioamido pharmacophore as anticonvulsant agents

Medicinal Chemistry Research, 2012

Abstract A new series of N-(6-chlorobenzothiazol-2-yl)-2-substituted-acetamides (3a–h) and N-(6-c... more Abstract A new series of N-(6-chlorobenzothiazol-2-yl)-2-substituted-acetamides (3a–h) and N-(6-chlorobenzothiazol-2-yl)-2-(substituted-benzylidene) hydrazinecarbothioamides (5a–h) were synthesized and characterized by IR, 1 H NMR, mass and elemental analysis. In vivo ...

Research paper thumbnail of Design and synthesis of novel N-substituted-3-chloro-2-azetidinone derivatives as potential anticonvulsant agents

Medicinal Chemistry Research, 2011

... Zaheen • Iftikhar Ahsan • Danish Mahmood ... Yield 67%; mp: 242–245°C; IR (KBr, cm-1): 3546 (... more ... Zaheen • Iftikhar Ahsan • Danish Mahmood ... Yield 67%; mp: 242–245°C; IR (KBr, cm-1): 3546 (OH), 3447 (NH), 2917 (NCH), 1671 (C=O); 1H NMR (CDCl3), d (ppm): 11.9 (bs, 1H, CONH), 9.31 (s, 1H, OH), 8.52 (s, 1H, N–CH), 8.1–8.4 (m, 4H, pyridine), 7.1–7.69 (m, 4H, Ar–H); MS ...

Research paper thumbnail of Synthesis and biological evaluation of some new quinazolin-4(3H)-ones derivatives as anticonvulsants

Medicinal Chemistry Research, 2013

Research paper thumbnail of Imidazole Incorporated Semicarbazone Derivatives as a New Class of Anticonvulsants: Design, Synthesis and In-Vivo Screening

Medicinal Chemistry, 2013

A series of novel imidazole incorporated semicarbazones was synthesized using an appropriate synt... more A series of novel imidazole incorporated semicarbazones was synthesized using an appropriate synthetic route and characterized by spectral analysis (IR, 1H NMR, 13C NMR and Mass). The anticonvulsant activity of the synthesized compounds was determined using doses of 30, 100, and 300 mg kg-1 against maximal electroshock seizure (MES), subcutaneous pentylenetetrazole (scPTZ) induced seizure and minimal neurotoxicity test. Six compounds exhibited protection in both models and 2-(1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)ethylidene)-N-p-tolylsemicarbazone emerged as the most active compound of the series without any neurotoxicity and significant CNS depressant effect. Liver enzyme estimations (SGOT, SGPT, Alkaline phosphatase) of the compound also showed no significant change in the enzymes levels. Moreover, it caused 80% elevation of γ-amino butyric acid (GABA) levels in the whole mice brain, thus indicating that it could be a promising candidate in designing of a potent anticonvulsant drug.

Research paper thumbnail of Design and synthesis of some new thiophene, thienopyrimidine and thienothiadiazine derivatives of antipyrine as potential antimicrobial agents

European Journal of Medicinal Chemistry, 2011

4-acetamide pyrazolone 2 was synthesized by acetylation of 4-amino antipyrine 1 in excellent yiel... more 4-acetamide pyrazolone 2 was synthesized by acetylation of 4-amino antipyrine 1 in excellent yield. 4acetamide pyrazolone 2 was exploited as a starting material for the syntheses of hitherto unknown different types of new heterocyclic compounds incorporating the antipyrine moiety which expect highly biological activity against various microorganisms. Thus, Claisen condensation of 4-acetamide pyrazolone 2 with diethyl oxalate have been utility to afford new 4-oxaloacetyl antipyrine 3, which upon hydrazinolysis of the ester function to obtain the acetohydrazide derivative 18 which used as starting material to synthesize 1,2,4-triazol 19 and hydrazone 20 derivatives. 4-aminothiophene carboxylate derivatives 6, 7 were synthesized by utility of Gewald reaction. On the other hand, Michael type addition of the enolate ion of acetyl functions in acetamide pyrazolone 2 to the activated double bond in arylidenemalonoester to furnish pyrane derivative 9 was done. Finally, 4-acetamide pyrazolone 2 was treated with aromatic substituted aldehyde to exhibit thiophenacrylamide derivative 10. Compound 6 gave characteristic reaction for enaminonitriles, thus, the behavior of o-aminoester of 4-aminothiophene carboxylate derivative 6 toward electrophilic reagent, one carbon donars, amide and acid was also investigated to afford the correspondence thiophene derivatives 11,12,13,15 and 16. In addition, treatment of carboxamide derivative 16 with thionyl chloride afforded the thienothiadiazine derivative 17. The characterization of all synthesized compounds was done by elemental analysis and spectral studies. Moreover, all the synthesized compounds were tested against antimicrobial activities by the disc diffusion method, which exhibited higher promising biological activities.

Research paper thumbnail of Design and synthesis of some new quinazolin-4-(3H)-ones as anticonvulsant and antidepressant agents

Archives of Pharmacal Research, 2013

A series of 3-[(4-substituted-benzylidene)-amino]-2-phenyl-3H-quinazolin-4-ones (5a-k) were synth... more A series of 3-[(4-substituted-benzylidene)-amino]-2-phenyl-3H-quinazolin-4-ones (5a-k) were synthesized by reacting 3-amino-2-phenyl-1H-quinazolin-4-one with p-hydroxybenzaldehyde, and then further with various alkyl/benzyl halides or substituted phenacyl bromides. The structures of the compounds were confirmed on the basis of IR, NMR, MS and elemental analysis. Anticonvulsant activities were evaluated using the MES and scPTZ tests. Some of the selected compounds were evaluated for antidepressant activity by forced swim pool test. Compound 3-[(4-butoxy-benzylidene)-amino]-2-phenyl-3H-quinazolin-4-one was emerged as the most promising anticonvulsant agent without any motor impairment effect. The whole brain GABA estimation of brain homogenate indicated that the anticonvulsant activity of above mentioned quinazolinone derivatives might be due to an increased GABA concentration.

Research paper thumbnail of Synthesis of pharmaceutically important 1, 3, 4-thiadiazole and imidazolinone derivatives as antimicrobials

Indian J Chem, 2009

Indian Journal of Chemistry Vol. 48B, September 2009, pp. 1288-1293 ... Synthesis of pharmaceutic... more Indian Journal of Chemistry Vol. 48B, September 2009, pp. 1288-1293 ... Synthesis of pharmaceutically important 1,3,4-thiadiazole and imidazolinone ... Mohd Amir*, Arun Kumar, Israr Ali & SA Khan Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New ...

Research paper thumbnail of Design and synthesis of some azole derivatives containing 2, 4, 5-triphenyl imidazole moiety as anti-inflammatory and antimicrobial agents

Indian Journal of …, 2011

Mohd Amir*, Iftikhar Ahsan, Wasim Akhter, SA Khan & Israr Ali Department of Pharmaceutical Chemis... more Mohd Amir*, Iftikhar Ahsan, Wasim Akhter, SA Khan & Israr Ali Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi 110 062, India E-mail: mamir_s2003@yahoo.co.in Received 15 December 2009; accepted (revised) 6 ...

Research paper thumbnail of Design and synthesis of novel N-substituted-3-chloro-2-azetidinone derivatives as potential anticonvulsant agents

Medicinal Chemistry …

... Zaheen • Iftikhar Ahsan • Danish Mahmood ... Yield 67%; mp: 242–245°C; IR (KBr, cm-1): 3546 (... more ... Zaheen • Iftikhar Ahsan • Danish Mahmood ... Yield 67%; mp: 242–245°C; IR (KBr, cm-1): 3546 (OH), 3447 (NH), 2917 (NCH), 1671 (C=O); 1H NMR (CDCl3), d (ppm): 11.9 (bs, 1H, CONH), 9.31 (s, 1H, OH), 8.52 (s, 1H, N–CH), 8.1–8.4 (m, 4H, pyridine), 7.1–7.69 (m, 4H, Ar–H); MS ...

Research paper thumbnail of Synthesis, Single Crystal X-ray, Hirshfeld and DFT Studies of 1,8-Dichloro-9,10-dihydro-9,10-ethanoanthracene-11-carboxylic Acid

Crystals

In this paper, synthesis, single-crystal X-ray structure, Hirshfeld and DFT studies of 1,8-dichlo... more In this paper, synthesis, single-crystal X-ray structure, Hirshfeld and DFT studies of 1,8-dichloro-9,10-dihydro-9,10-ethanoanthracene-11-carboxylic acid are discussed. Different intermolecular contacts affecting the crystal stability are studied using Hirshfeld calculations. The H…Cl and O…H contacts are the most significant, showing corresponding interaction distances of 2.731 Å (Cl2…H10) and 1.681Å (H1…O1), 2.328 Å (O1…H13), 2.510 Å (O1…H12) based on Hirshfeld calculations. DFT calculations are carried out to study the electronic behavior, as well as the 1H- and 13C-NMR spectra of the synthesized compound. The computed NMR chemical shifts show excellent correlation with the experimental data (R2 = 0.9884–0.9705).

Research paper thumbnail of Novel Maleic Acid, Crosslinked, Nanofibrous Chitosan/Poly (Vinylpyrrolidone) Membranes for Reverse Osmosis Desalination

International Journal of Molecular Sciences

Fresh and clean water is consistently depleting and becoming a serious problem with rapid increas... more Fresh and clean water is consistently depleting and becoming a serious problem with rapid increases in population, so seawater desalination technology has captured global attention. For an efficient desalination process, this work proposes a novel, nanofibrous, thin-film composite membrane (NF-TFC) based on the deposition of the nanofibrous active layer of a blend of chitosan (CS) and poly (vinylpyrrolidone) (PVP) crosslinked with maleic acid on a 3-triethoxysilylpropylamine functionalized cellulose acetate substrate. FTIR analysis demonstrated the development of chemical and physical interactions and confirmed the incorporation of functional groups present in the NF-TFC. Scanning electron microscopy (SEM) micrographs depict the fibrous structure of the active layers. The reverse osmosis (RO) desalination characteristics of NF-TFC membranes are elevated by increasing the concentration of the crosslinker in a CS/PVP blend. Cellulose acetate (CA)-S4 attained an optimal salt rejection ...

Research paper thumbnail of Synthesis of pyrazole acrylic acid based oxadiazole and amide derivatives as antimalarial and anticancer agents

Bioorganic chemistry, Apr 11, 2018

Depravity of malaria in terms of morbidity and mortality in human beings makes it a major health ... more Depravity of malaria in terms of morbidity and mortality in human beings makes it a major health issue in tropical and subtropical areas of the globe. Drug counterfeiting and non-adherence to the treatment regimen have significantly contributed to development and spread of multidrug resistance that has highlighted the need for development of novel and more efficient antimalarial drugs. Complexity associated with cancer disease and prevalence of diversified cell populations vindicates highly specific treatment options for treatment of cancer. Resistance to these anticancer agents has posed a great hindrance in successful treatment of cancer. Pondering this ongoing situation, it was speculated to develop novel compounds targeting malaria and cancer. Moving on the same aisle, we synthesized pyrazole acrylic acid based oxadiazole and amide derivatives using multi-step reaction pathways (6a-x; 6a'-h'). Schizont maturation inhibition assay was employed to determine antimalarial po...

Research paper thumbnail of Lattice Boltzmann analysis of fluid-structure interaction with moving boundaries

This work is concerned with the modelling of the interaction of fluid flow with flexibly supporte... more This work is concerned with the modelling of the interaction of fluid flow with flexibly supported rigid bodies. The fluid flow is modelled by Lattice-Boltzmann Method, coupled to a set of ordinary differential equations describing the dynamics of the solid body in terms its elastic and damping properties. The time discretization of the body dynamics is performed via the Time Discontinuous Galerkin Method. Several numerical examples are presented and highlight the robustness and efficiency of the proposed methodology, by means of comparisons with previously published results. The examples show that the present fluid-structure method is able to capture vortex- induced oscillations of flexibly-supported rigid body.

Research paper thumbnail of Design, Synthesis, and Biological Evaluation of Hydrazone Incorporated 1,2,4-Triazines as Anticonvulsant Agents

Archiv der Pharmazie, 2014

Research paper thumbnail of ChemInform Abstract: Synthesis of Pharmaceutically Important 1,3,4-Thiadiazole and Imidazolinone Derivatives as Antimicrobials

ChemInform, 2010

ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance t... more ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Research paper thumbnail of Synthesis of N1-(3-chloro-4-flourophenyl)-N4-substituted semicarbazones as novel anticonvulsant agents

Indian journal of chemistry. Section B, …, 2010

Abstract: Several 3-chloro-4-flourophenyl substituted semicarbazones have been synthesized in thr... more Abstract: Several 3-chloro-4-flourophenyl substituted semicarbazones have been synthesized in three steps involving aryl urea and aryl semicarbazide formation. The structures have been confirmed by spectral and elemental analyses. Some selected ...

Research paper thumbnail of Novel Approach for the Synthesis of N -Substituted-4-(2-methyl-4-oxo-4 H -quinazolin-3-yl)-butyramides

Synthetic Communications, 2011

A simple and convenient method for the synthesis of N-substituted-4-(2-methyl-4-oxo-4H-quinazolin... more A simple and convenient method for the synthesis of N-substituted-4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-butyramides has been reported. Several aromatic and aliphatic amide derivatives of 4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-butyric acid were prepared in 60–81% yields by refluxing it with different phosphazo compounds in toluene for approximately 1 h.

Research paper thumbnail of Synthesis of benzothiazole derivatives having acetamido and carbothioamido pharmacophore as anticonvulsant agents

Medicinal Chemistry Research, 2012

Abstract A new series of N-(6-chlorobenzothiazol-2-yl)-2-substituted-acetamides (3a–h) and N-(6-c... more Abstract A new series of N-(6-chlorobenzothiazol-2-yl)-2-substituted-acetamides (3a–h) and N-(6-chlorobenzothiazol-2-yl)-2-(substituted-benzylidene) hydrazinecarbothioamides (5a–h) were synthesized and characterized by IR, 1 H NMR, mass and elemental analysis. In vivo ...

Research paper thumbnail of Design and synthesis of novel N-substituted-3-chloro-2-azetidinone derivatives as potential anticonvulsant agents

Medicinal Chemistry Research, 2011

... Zaheen • Iftikhar Ahsan • Danish Mahmood ... Yield 67%; mp: 242–245°C; IR (KBr, cm-1): 3546 (... more ... Zaheen • Iftikhar Ahsan • Danish Mahmood ... Yield 67%; mp: 242–245°C; IR (KBr, cm-1): 3546 (OH), 3447 (NH), 2917 (NCH), 1671 (C=O); 1H NMR (CDCl3), d (ppm): 11.9 (bs, 1H, CONH), 9.31 (s, 1H, OH), 8.52 (s, 1H, N–CH), 8.1–8.4 (m, 4H, pyridine), 7.1–7.69 (m, 4H, Ar–H); MS ...

Research paper thumbnail of Synthesis and biological evaluation of some new quinazolin-4(3H)-ones derivatives as anticonvulsants

Medicinal Chemistry Research, 2013

Research paper thumbnail of Imidazole Incorporated Semicarbazone Derivatives as a New Class of Anticonvulsants: Design, Synthesis and In-Vivo Screening

Medicinal Chemistry, 2013

A series of novel imidazole incorporated semicarbazones was synthesized using an appropriate synt... more A series of novel imidazole incorporated semicarbazones was synthesized using an appropriate synthetic route and characterized by spectral analysis (IR, 1H NMR, 13C NMR and Mass). The anticonvulsant activity of the synthesized compounds was determined using doses of 30, 100, and 300 mg kg-1 against maximal electroshock seizure (MES), subcutaneous pentylenetetrazole (scPTZ) induced seizure and minimal neurotoxicity test. Six compounds exhibited protection in both models and 2-(1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)ethylidene)-N-p-tolylsemicarbazone emerged as the most active compound of the series without any neurotoxicity and significant CNS depressant effect. Liver enzyme estimations (SGOT, SGPT, Alkaline phosphatase) of the compound also showed no significant change in the enzymes levels. Moreover, it caused 80% elevation of γ-amino butyric acid (GABA) levels in the whole mice brain, thus indicating that it could be a promising candidate in designing of a potent anticonvulsant drug.

Research paper thumbnail of Design and synthesis of some new thiophene, thienopyrimidine and thienothiadiazine derivatives of antipyrine as potential antimicrobial agents

European Journal of Medicinal Chemistry, 2011

4-acetamide pyrazolone 2 was synthesized by acetylation of 4-amino antipyrine 1 in excellent yiel... more 4-acetamide pyrazolone 2 was synthesized by acetylation of 4-amino antipyrine 1 in excellent yield. 4acetamide pyrazolone 2 was exploited as a starting material for the syntheses of hitherto unknown different types of new heterocyclic compounds incorporating the antipyrine moiety which expect highly biological activity against various microorganisms. Thus, Claisen condensation of 4-acetamide pyrazolone 2 with diethyl oxalate have been utility to afford new 4-oxaloacetyl antipyrine 3, which upon hydrazinolysis of the ester function to obtain the acetohydrazide derivative 18 which used as starting material to synthesize 1,2,4-triazol 19 and hydrazone 20 derivatives. 4-aminothiophene carboxylate derivatives 6, 7 were synthesized by utility of Gewald reaction. On the other hand, Michael type addition of the enolate ion of acetyl functions in acetamide pyrazolone 2 to the activated double bond in arylidenemalonoester to furnish pyrane derivative 9 was done. Finally, 4-acetamide pyrazolone 2 was treated with aromatic substituted aldehyde to exhibit thiophenacrylamide derivative 10. Compound 6 gave characteristic reaction for enaminonitriles, thus, the behavior of o-aminoester of 4-aminothiophene carboxylate derivative 6 toward electrophilic reagent, one carbon donars, amide and acid was also investigated to afford the correspondence thiophene derivatives 11,12,13,15 and 16. In addition, treatment of carboxamide derivative 16 with thionyl chloride afforded the thienothiadiazine derivative 17. The characterization of all synthesized compounds was done by elemental analysis and spectral studies. Moreover, all the synthesized compounds were tested against antimicrobial activities by the disc diffusion method, which exhibited higher promising biological activities.

Research paper thumbnail of Design and synthesis of some new quinazolin-4-(3H)-ones as anticonvulsant and antidepressant agents

Archives of Pharmacal Research, 2013

A series of 3-[(4-substituted-benzylidene)-amino]-2-phenyl-3H-quinazolin-4-ones (5a-k) were synth... more A series of 3-[(4-substituted-benzylidene)-amino]-2-phenyl-3H-quinazolin-4-ones (5a-k) were synthesized by reacting 3-amino-2-phenyl-1H-quinazolin-4-one with p-hydroxybenzaldehyde, and then further with various alkyl/benzyl halides or substituted phenacyl bromides. The structures of the compounds were confirmed on the basis of IR, NMR, MS and elemental analysis. Anticonvulsant activities were evaluated using the MES and scPTZ tests. Some of the selected compounds were evaluated for antidepressant activity by forced swim pool test. Compound 3-[(4-butoxy-benzylidene)-amino]-2-phenyl-3H-quinazolin-4-one was emerged as the most promising anticonvulsant agent without any motor impairment effect. The whole brain GABA estimation of brain homogenate indicated that the anticonvulsant activity of above mentioned quinazolinone derivatives might be due to an increased GABA concentration.

Research paper thumbnail of Synthesis of pharmaceutically important 1, 3, 4-thiadiazole and imidazolinone derivatives as antimicrobials

Indian J Chem, 2009

Indian Journal of Chemistry Vol. 48B, September 2009, pp. 1288-1293 ... Synthesis of pharmaceutic... more Indian Journal of Chemistry Vol. 48B, September 2009, pp. 1288-1293 ... Synthesis of pharmaceutically important 1,3,4-thiadiazole and imidazolinone ... Mohd Amir*, Arun Kumar, Israr Ali & SA Khan Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New ...

Research paper thumbnail of Design and synthesis of some azole derivatives containing 2, 4, 5-triphenyl imidazole moiety as anti-inflammatory and antimicrobial agents

Indian Journal of …, 2011

Mohd Amir*, Iftikhar Ahsan, Wasim Akhter, SA Khan & Israr Ali Department of Pharmaceutical Chemis... more Mohd Amir*, Iftikhar Ahsan, Wasim Akhter, SA Khan & Israr Ali Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi 110 062, India E-mail: mamir_s2003@yahoo.co.in Received 15 December 2009; accepted (revised) 6 ...

Research paper thumbnail of Design and synthesis of novel N-substituted-3-chloro-2-azetidinone derivatives as potential anticonvulsant agents

Medicinal Chemistry …

... Zaheen • Iftikhar Ahsan • Danish Mahmood ... Yield 67%; mp: 242–245°C; IR (KBr, cm-1): 3546 (... more ... Zaheen • Iftikhar Ahsan • Danish Mahmood ... Yield 67%; mp: 242–245°C; IR (KBr, cm-1): 3546 (OH), 3447 (NH), 2917 (NCH), 1671 (C=O); 1H NMR (CDCl3), d (ppm): 11.9 (bs, 1H, CONH), 9.31 (s, 1H, OH), 8.52 (s, 1H, N–CH), 8.1–8.4 (m, 4H, pyridine), 7.1–7.69 (m, 4H, Ar–H); MS ...