jawaria idrees | University Of Peshawar (original) (raw)

Papers by jawaria idrees

Malaysian Journal of Microbiology, 2012

Bangladesh Journal of Medical Science, 2014

Objectives: To study the association of attention-deficit hyperactivity disorder (ADHD) with hero... more Objectives: To study the association of attention-deficit hyperactivity disorder (ADHD) with heroin addiction. Study design: A cross-sectional, hospital based study. Place and duration of study: The study was carried out at Lady Reading Hospital and Khyber Teaching Hospital, Peshawar, Pakistan from 4th April 2012 to 13th September 2012. Subjects and Methods: A sample of 137 adult heroin addicts were analyzed that whether they were ADHD and that childhood problem continues to manifest symptoms in adults. For retrospective assessment of childhood ADHD, the Wender Utah Rating Scale (WURS) as well as the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) symptom checklist for ADHD was used. The Conners’ Adult ADHD Rating Scales (CAARS) was used to assess the persisting symptoms of ADHD in adults. Inclusion criteria: Patient diagnosed with heroin addiction according to ICD-9 and DSM-IV. Exclusion criteria: Patient has co-morbid with any other mental illnesses. Results: The di...

1 residents of two highly affected regions of Pakistan 2 3 4 Muhammad Umair Khan, a Akram Ahmad, ... more 1 residents of two highly affected regions of Pakistan 2 3 4 Muhammad Umair Khan, a Akram Ahmad, a Talieha Aqeel, b Saad Salman, c Qamer 5 Ibrahim, Jawaria Idrees , Muhammad Ubaid Khan d* 6 7 * Corresponding Author 8 9 a Department of Clinical Pharmacy, UCSI University, Kuala Lumpur, Malays ia 10 Department of Pharmacy Practice, Faculty of Pharmacy, Univers ity of Baluchistan, 11 Quetta, Pakistan 12 Department of Pharmacy, University of Peshawar, Peshawar, Pakistan 13 Sindh Government Hospital, New Karachi, Karachi, Pakistan 14 15 Acknowledgement 16 17 Nil 18 19 Contact Details 20 Muhammad Umair Khan: umair104@yahoo.com 21 Akram Ahmad: akrampharma67@gmail.com 22 Talieha Aqeel: Taliehaaqeel004@gmail.com 23 Saad Salman: saadirph@gmail.com 24 Qamer Ibrahim: qamerzehri@gmail.com 25 Jawaria Idrees: jawaria_drs@yahoo.com 26 *Muhammad Ubaid Khan: ubaiddmu@yahoo.com 27

In this chapter we examine the relationship of attention deficit hyperactivity disorder (ADHD) wi... more In this chapter we examine the relationship of attention deficit hyperactivity disorder (ADHD) with substance use disorder (SUD) and with SUD narrowed down to heroin addiction disorder (HD). This chapter investigates findings of comorbidity. A pool of studies established that stimulant medication not only improves the symptoms of ADHD but also helps in remittance from SUD and HD. There are genetic and neurobiological pathways involved in SUD, HD, and ADHD. Higher rates of SUD and HD among children with ADHD-affected parents are observed and vice versa. Some clinical studies showed that one-fourth of HD patients were comorbid with adult ADHD. Children of HD parents have a risk of ADHD that is three times higher and rates of SUD that are about 16 times higher than those of the offspring of controls. Prenatal maternal and paternal smoking is considered to be the largest risk factor for development of ADHD in children. However, early assessment of comorbidity of ADHD and HD, as well as ...

$Research paper thumbnail of Refractory Myasthenia Gravis$

The Professional Medical Journal

Myasthenia gravis (MG) is prototypical neurological autoimmune disorder,characterized by limb and... more Myasthenia gravis (MG) is prototypical neurological autoimmune disorder,characterized by limb and occulo-bulbular fragility. Our case study will facilitate the practitionersas well as the scientific community to consider other therapy plans with patients presented withacute respiratory failure due to the use of rituximab.A 25-year-old man presented with acuterespiratory failure This case reporte sheds light on the importance of differential diagnoses ofrefractory myasthenia gravis for inexplicable acute respiratory failure upon rituximab treatment.The case study demonstrates the problems associated with use of rituximab in refractorymyasthenia gravis. It can cause acute respiratory failure among the patients with relapsespecially. Our case study will facilitate the practitioners as well as the scientific community toconsider other therapy plans with patients presented with acute respiratory failure due to theuse of rituximab.

Future Science OA

Aim: To evaluate the inhibitory interaction of thymohydroquinone against blood–brain barrier (BBB... more Aim: To evaluate the inhibitory interaction of thymohydroquinone against blood–brain barrier (BBB)-associated neuropsychiatric and neurodegenerative disorders. Materials & methods: An elaborated in silico study was designed to evaluate the interaction of thymohydroquinone with BBB-disrupting proteins and to highlight its pharmacokinetic and safety attributes. Results: Thymohydroquinone demonstrated stable interaction with BBB-disrupting protein active site with Ki (inhibition constant) ranges of (2.71 mM–736.15 μM), binding energy (-4.3 to 5.6 Kcal/mol), ligand efficiency (-0.36 to 0.42 Kcal/mol) and root mean square deviation value of (0.80–2.59 Å). Conclusion: Further pharmacokinetic analysis revealed that thymohydroquinone is BBB and central nervous system (CNS) permeant with high acute toxicity and could be a candidate drug for the treatment of these neurological conditions.

Current Medical Science

Glioblastoma multiforme, an intrusive brain cancer, has the lowest survival rate of all brain can... more Glioblastoma multiforme, an intrusive brain cancer, has the lowest survival rate of all brain cancers. The chemotherapy utilized to prevent their proliferation and propagation is limited due to modulation of complex cancer signalling pathways. These complex pathways provide infiltrative and drug evading properties leading to the development of chemotherapy resistance. Therefore, the development and discovery of such interventions or therapies that can bypass all these resistive barriers to ameliorate glioma prognosis and survival is of profound importance. Medicinal plants are comprised of an exorbitant range of phytochemicals that have the broad-spectrum capability to target intrusive brain cancers, modulate anti-cancer pathways and immunological responses to facilitate their eradication, and induce apoptosis. These phytocompounds also interfere with several oncogenic proteins that promote cancer invasiveness and metastasis, chemotherapy resistance and angiogenesis. These plants are extremely vital for promising anti-glioma therapy to avert glioma proliferation and recurrence. In this review, we acquired recent literature on medicinal plants whose extracts/bioactive ingredients are newly exploited in glioma therapeutics, and also highlighted their mode of action and pharmacological profile.

Aim: Severe acute respiratory syndrome coronavirus-2 (SARS-COV-2), a pernicious viral disease, ca... more Aim: Severe acute respiratory syndrome coronavirus-2 (SARS-COV-2), a pernicious viral disease, causes acute respiratory distress responsible for mortality and morbidity worldwide. To screen different im-munomodulatory medicinal compounds to unravel their interaction with SARS-COV-2 viral proteins. Materials & methods: A library of immunomodulatory medicinal compounds with antiviral capability were analyzed against SARS proteases, spike protein and nonstructural proteins (NSP-9, 15) using Autodock vina. Results: Out of more than 300 medicinal compounds, only six compounds: arzanol, ferulic acid, genis-tein, resveratrol, rosmanol and thymohydroquinone showed significant interaction with the SARS viral proteins by forming hydrogen bonds with the active site residues with low binding energy. Further AD-MET (absorption, distribution, metabolism, excretion and toxicity) analysis showed good pharmacokinetic properties and low acute toxicity of these compounds. Conclusion: The current study...

Suicide and self-harm are very common among adolescents, especially females in western and Asian ... more Suicide and self-harm are very common among adolescents, especially females in western and Asian countries. The Psychosocial predictors, along with hopelessness and non-suicidal harm, have not been studied properly before. Therefore, there is a need to address these issues. The objective of the study was to ascertain the psychosocial and clinical features predicting suicide attempts and non-suicidal self-injury (NSSI) in adolescents with major depression in Pakistan. The Methodology comprised of Adolescent patients (n = 121) with major depressive disorder who were hospitalized in the LRH (Lady Reading Hospital), Peshawar. The patient’s clinical symptoms, family role (family responsibilities), quality of life, physical health and relationship with friends and family members were evaluated. Participants’ suicidal thoughts and behaviors and NSSI (self-inflicted, deliberate self-harm with no intent of suicide) were analyzed and assessed during hospitalization and followed up for 28 week...

Pakistan journal of pharmaceutical sciences, 2016

Harmine, Harmaline, Nicotine and its various complexes synthesized have been characterized by phy... more Harmine, Harmaline, Nicotine and its various complexes synthesized have been characterized by physical, spectral and analytical methods and curtained for in-vitro antimicrobial activity against different bacterial and fungal species at two different concentrations i.e.100μ/100µl and 200μ/100µl dose level respectively. Analysis showed that Nicotine, Zinc-Nico, Cd-Nico, Hg-Nico, Ni-Nico, Cu-Nico, Co-Nico, Harmine, and Harmaline having conc. of 100ug/ 100ul had antibacterial activity on zero, 5, 4, 10, zero, 5, 7, zero, zero strain of bacteria having an average of zero (SD=0.0000), 15.2000 (SD=1.30384), 18.2500 (SD=3.30404), 20.2000 (SD=1.39841), zero (SD=0.0000), 14.6000 (SD=0.89443), 15.8571 (SD=1.34519), zero (SD=0.0000), zero (SD=0.0000) respectively. Zinc (II) chloride, Cadmium (II) Iodide, Mercury (II) chloride, Nickel (II) chloride, Copper (II) chloride, Cobalt (II) chloride, Mercury (II) chloride, Mercury (II) harmine, Mercury (II) harmaline at 100ug/100ul is valid for 7, 8, 9,...

Journal of Pharmacy Practice and Community Medicine, 2016

$Research paper thumbnail of Refractory Myasthenia Gravis; Patient on Rituximab with Acute Respiratory Failure: A Case Report$

ABSTRACT… Myasthenia gravis (MG) is prototypical neurological autoimmune disorder, characterized ... more ABSTRACT… Myasthenia gravis (MG) is prototypical neurological autoimmune disorder, characterized by limb and occulo-bulbular fragility. Our case study will facilitate the practitioners as well as the scientific community to consider other therapy plans with patients presented with acute respiratory failure due to the use of rituximab.A 25-year-old man presented with acute respiratory failure This case reporte sheds light on the importance of differential diagnoses of refractory myasthenia gravis for inexplicable acute respiratory failure upon rituximab treatment. The case study demonstrates the problems associated with use of rituximab in refractory myasthenia gravis. It can cause acute respiratory failure among the patients with relapse specially. Our case study will facilitate the practitioners as well as the scientific community to consider other therapy plans with patients presented with acute respiratory failure due to the use of rituximab.