Ru En How | UPM - Universiti Putra Malaysia (original) (raw)

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Research paper thumbnail of Suboptimal Biochemical Riboflavin Status Is Associated with Lower Hemoglobin and Higher Rates of Anemia in a Sample of Canadian and Malaysian Women of Reproductive Age

BACKGROUND Riboflavin is required for several redox reactions. Clinical riboflavin deficiency occ... more BACKGROUND Riboflavin is required for several redox reactions. Clinical riboflavin deficiency occurs mainly in low-income countries, where it is associated with anemia. The functional significance of suboptimal riboflavin status in different populations and its role in anemia is not well understood. OBJECTIVES We assessed the biomarker status of riboflavin and its association with hemoglobin concentration and anemia in women living in Vancouver, Canada, and Kuala Lumpur, Malaysia. METHODS Healthy nonpregnant, nonbreastfeeding women (19-45 y) were recruited from Canada ( n = 206) and Malaysia (n = 210) via convenience sampling. Fasting blood was collected to assess riboflavin status [erythrocyte glutathione reductase activity coefficient (EGRac)], hematological indicators, soluble transferrin receptor (sTfR), ferritin, vitamin A, folate, and vitamin B-12 concentrations. Linear and logistic regression models were used to assess the association of riboflavin status with hemoglobin conc...

Research paper thumbnail of Suboptimal Biochemical Riboflavin Status Is Associated with Lower Hemoglobin and Higher Rates of Anemia in a Sample of Canadian and Malaysian Women of Reproductive Age

BACKGROUND Riboflavin is required for several redox reactions. Clinical riboflavin deficiency occ... more BACKGROUND Riboflavin is required for several redox reactions. Clinical riboflavin deficiency occurs mainly in low-income countries, where it is associated with anemia. The functional significance of suboptimal riboflavin status in different populations and its role in anemia is not well understood. OBJECTIVES We assessed the biomarker status of riboflavin and its association with hemoglobin concentration and anemia in women living in Vancouver, Canada, and Kuala Lumpur, Malaysia. METHODS Healthy nonpregnant, nonbreastfeeding women (19-45 y) were recruited from Canada ( n = 206) and Malaysia (n = 210) via convenience sampling. Fasting blood was collected to assess riboflavin status [erythrocyte glutathione reductase activity coefficient (EGRac)], hematological indicators, soluble transferrin receptor (sTfR), ferritin, vitamin A, folate, and vitamin B-12 concentrations. Linear and logistic regression models were used to assess the association of riboflavin status with hemoglobin conc...

Research paper thumbnail of Validity and reproducibility of an interviewer-administered food frequency questionnaire for the assessment of riboflavin intake in Malaysian women in Selangor

Introduction: The aim of this study was to assess the validity and reproducibility of a food freq... more Introduction: The aim of this study was to assess the validity and reproducibility of a food frequency questionnaire (FFQ) specifically developed for the assessment of riboflavin intake among Malaysian women in Selangor. Methods: The study was carried out in Universiti Putra Malaysia (UPM), which consisted of 204 healthy women (102 Chinese and 102 Malay) aged between 19 and 45 years. The FFQs were interviewer-administered, which were completed twice; at the beginning of the study (FFQ-1) and two weeks thereafter (FFQ-2). A two-day 24-hour dietary recall (24DR) was interviewer-administered as the standard criteria method. Data were analyzed using Wilcoxon signed ranks test, Spearman correlation coefficient (SCC), intra-class correlation coefficient (ICC) and Bland-Altman plots to determine the validity and reproducibility. Results: Median riboflavin intake derived from 24DRs was significantly higher than FFQ-2 (p<0.01). Both FFQ-1 and FFQ-2 correlated significantly (p<0.01) wit...

Research paper thumbnail of Suboptimal Biochemical Riboflavin Status Is Associated with Lower Hemoglobin and Higher Rates of Anemia in a Sample of Canadian and Malaysian Women of Reproductive Age

BACKGROUND Riboflavin is required for several redox reactions. Clinical riboflavin deficiency occ... more BACKGROUND Riboflavin is required for several redox reactions. Clinical riboflavin deficiency occurs mainly in low-income countries, where it is associated with anemia. The functional significance of suboptimal riboflavin status in different populations and its role in anemia is not well understood. OBJECTIVES We assessed the biomarker status of riboflavin and its association with hemoglobin concentration and anemia in women living in Vancouver, Canada, and Kuala Lumpur, Malaysia. METHODS Healthy nonpregnant, nonbreastfeeding women (19-45 y) were recruited from Canada ( n = 206) and Malaysia (n = 210) via convenience sampling. Fasting blood was collected to assess riboflavin status [erythrocyte glutathione reductase activity coefficient (EGRac)], hematological indicators, soluble transferrin receptor (sTfR), ferritin, vitamin A, folate, and vitamin B-12 concentrations. Linear and logistic regression models were used to assess the association of riboflavin status with hemoglobin conc...

Research paper thumbnail of Suboptimal Biochemical Riboflavin Status Is Associated with Lower Hemoglobin and Higher Rates of Anemia in a Sample of Canadian and Malaysian Women of Reproductive Age

BACKGROUND Riboflavin is required for several redox reactions. Clinical riboflavin deficiency occ... more BACKGROUND Riboflavin is required for several redox reactions. Clinical riboflavin deficiency occurs mainly in low-income countries, where it is associated with anemia. The functional significance of suboptimal riboflavin status in different populations and its role in anemia is not well understood. OBJECTIVES We assessed the biomarker status of riboflavin and its association with hemoglobin concentration and anemia in women living in Vancouver, Canada, and Kuala Lumpur, Malaysia. METHODS Healthy nonpregnant, nonbreastfeeding women (19-45 y) were recruited from Canada ( n = 206) and Malaysia (n = 210) via convenience sampling. Fasting blood was collected to assess riboflavin status [erythrocyte glutathione reductase activity coefficient (EGRac)], hematological indicators, soluble transferrin receptor (sTfR), ferritin, vitamin A, folate, and vitamin B-12 concentrations. Linear and logistic regression models were used to assess the association of riboflavin status with hemoglobin conc...

Research paper thumbnail of Validity and reproducibility of an interviewer-administered food frequency questionnaire for the assessment of riboflavin intake in Malaysian women in Selangor

Introduction: The aim of this study was to assess the validity and reproducibility of a food freq... more Introduction: The aim of this study was to assess the validity and reproducibility of a food frequency questionnaire (FFQ) specifically developed for the assessment of riboflavin intake among Malaysian women in Selangor. Methods: The study was carried out in Universiti Putra Malaysia (UPM), which consisted of 204 healthy women (102 Chinese and 102 Malay) aged between 19 and 45 years. The FFQs were interviewer-administered, which were completed twice; at the beginning of the study (FFQ-1) and two weeks thereafter (FFQ-2). A two-day 24-hour dietary recall (24DR) was interviewer-administered as the standard criteria method. Data were analyzed using Wilcoxon signed ranks test, Spearman correlation coefficient (SCC), intra-class correlation coefficient (ICC) and Bland-Altman plots to determine the validity and reproducibility. Results: Median riboflavin intake derived from 24DRs was significantly higher than FFQ-2 (p<0.01). Both FFQ-1 and FFQ-2 correlated significantly (p<0.01) wit...

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