Ariyanti Dewi - Profile on Academia.edu (original) (raw)

Papers by Ariyanti Dewi

Natural Product Communications, 2016

Five new diterpenes (1-5), each with a highly oxygenated spongian framework, were characterized f... more Five new diterpenes (1-5), each with a highly oxygenated spongian framework, were characterized from an organic extract of a specimen of the nudibranch Goniobranchus splendidus collected from Eastern Australia. The new diterpene 7α-hydroxydendrillol-3 (6) was identified from specimens of Ardeodoris egretta. The structures and relative configurations of the six new metabolites have been elucidated by analysis of their spectroscopic data.

Australian Journal of Chemistry, 2018

A rearranged spongian diterpene chromolactol was obtained from the mantle extract of the Indo-Pac... more A rearranged spongian diterpene chromolactol was obtained from the mantle extract of the Indo-Pacific nudibranch Goniobranchus coi. The structure of chromolactol, either 1a or 1b, which was investigated by extensive NMR experiments and by data comparison as well as by molecular modelling studies and density functional calculations, has a different relative configuration of the 2,8-dioxabicyclo-[3.3.0]-octane ring compared with the co-metabolite norrisolide (2). A biosynthetic pathway leading to the preferred diastereomer of chromolactol (1a) is presented.

Distribution of Defensive Metabolites in Nudibranch Molluscs

Journal of chemical ecology, Jan 19, 2018

Many plants and animals store toxic or unpalatable compounds in tissues that are easily encounter... more Many plants and animals store toxic or unpalatable compounds in tissues that are easily encountered by predators during attack. Defensive compounds can be produced de novo, or obtained from dietary sources and stored directly without selection or modification, or can be selectively sequestered or biotransformed. Storage strategies should be optimized to produce effective defence mechanisms but also prevent autotoxicity of the host. Nudibranch molluscs utilize a diverse range of chemical defences, and we investigated the accumulation and distribution of defensive secondary metabolites in body tissues of 19 species of Chromodorididae nudibranchs. We report different patterns of distribution across tissues, where: 1) the mantle had more or different (but structurally related) compounds than the viscera; 2) all compounds in the mantle were also in the viscera; and 3) the mantle had fewer compounds than the viscera. We found no further examples of species that selectively store a single ...

Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan, 2009

Penelitian isolasi senyawa sitotoksik dari spons Crella papilata telah dilakukan. Spons Crella pa... more Penelitian isolasi senyawa sitotoksik dari spons Crella papilata telah dilakukan. Spons Crella papilata diambil dari Taman Nasional Kepulauan Seribu. Ekstraksi senyawa sitotoksik dilakukan dengan metode maserasi menggunakan metanol dan ekstrak kasar yang dihasilkan difraksinasi dengan kromatografi kolom fase balik. Pemisahan lebih lanjut dilakukan dengan kromatografi kolom fase normal dengan eluen campuran n-heksana/EtOAc (etil asetat) dan EtOAc/MeOH (etil asetat/metanol) secara gradien. Fraksi yang paling aktif diisolasi dengan kromatografi lapis tipis preparatif dan diidentifikasi dengan ¹H NMR (Nuclear Magnetic Resonance) dan LCMS (Liquid Chromatography Mass Spectrophotometry). Interpretasi terhadap data spektra yang dihasilkan memperlihatkan bahwa senyawa bioaktif tersebut merupakan golongan tiol yang mengandung cincin aromatik serta alkil sebagai gugus samping dengan berat molekul sebesar 291. Uji MTT [3-(4,5 dimethylthiazol-2yl)-2,5-diphenyl tetrazolium bromida)] menunjukkan b...

Biomedical benefits of algal glycoproteins

Marine Glycobiology, 2016

Prospective Utilization of Fishery By-products in Indonesia

Seafood Processing By-Products, 2013

Fisheries industry activities generate by-products which have economic potential and can be utili... more Fisheries industry activities generate by-products which have economic potential and can be utilized as a raw material to produce various value-added products. Fisheries by-products can be as follows: (a) by-products from the utilization of fisheries resources, (b) by-products from processing industries, (c) by-products as secondary products in addition to the main products, (d) by-products from surplus during the fishing season, (e) by-products as the remainder of distribution or marketing. By-products from the utilization of fisheries resources can be processed into minced fish, surimi and surimi-based products, food-grade fish flour, fish meal, fish silage, and several traditional products. By-products from shrimp processing industries have been explored to produce sticky shrimp extract, fermented shrimp paste, shrimp crackers, protein hydrolysate, shrimp meal, shrimp silage, chitin, chitosan, chitooligosaccharide, and flavoring agent. Meanwhile, by-products from fish processing, such as canned fish, tuna loin, red snapper fillet, frog legs, and some processed freshwater fish, have the potential to be processed into fish meal, flavoring agent, tanned fish skin, gelatin, fish balls, fish sausage, and fermented products. By-products as secondary products, such as fish oil, can be utilized for pharmaceutical, food, feed, and non-food purposes. Some processing technologies have been developed for the utilization of underutilized fish, especially sharks and rays.

Marine Drugs, 2016

A series of oxy-polybrominated diphenyl ethers (O-PBDEs) has been isolated from the extracts of M... more A series of oxy-polybrominated diphenyl ethers (O-PBDEs) has been isolated from the extracts of Miamira magnifica and Miamira miamirana collected from Queensland, Australia. M. magnifica sequesters the new OH-PBDE 1 and six known OH-PBDEs containing four to six bromines (2-7). M. miamirana also accumulates known tribromo-and tetrabromo OMe-PBDEs 8-10 in both mantle and viscera tissues. To date, Miamira is the only genus of the family Chromodorididae that is known to incorporate O-PBDEs, rather than terpenes, in the mantle where the metabolites may play a putative role in chemical defense. The extract of M. magnifica was tested in a brine shrimp lethality assay and exhibited an LD 50 of 58 µg/mL.

Figure 3 from: Nursid M, Patantis G, Dewi AS, Achmad MJ, Sembodo PM, Estuningsih S (2021) Immunnostimulatory activity of Holothuria atra sea cucumber. Pharmacia 68(1): 121-127. https://doi.org/10.3897/pharmacia.68.e58820

Immunostimulant is a substance that can stimulate the immune system against pathogenic microbes. ... more Immunostimulant is a substance that can stimulate the immune system against pathogenic microbes. Natural products produced by sea cucumbers have the potential to be developed as immunostimulants. This study was aimed to evaluate the imunostimulatory activity of Holothuria atra extract using the phagocytocyte assay of macrophage cells and the differentiation of leukocyte in rats. The samples of H. atra were taken from Halmahera waters, North Maluku, Indonesia. Extraction was carried out with 96% ethanol. Phagocytocyte activity assay was carried out using macrophage cells isolated from Balb/c mice (Mus musculus) using a series of doses 0.5; 1.0; 2.0; 4.0; 8.0; 16.0 and 32.0 mg/kg body weight. Leukocyte differentiation test in vivo was conducted using Rattus norvegicus rat treated with H. atra extract for 90 days with the following series of doses: 0, 25, 50, 100, and 200 mg/kg body weight. The results showed that the highest phagocytosis activity was reached at a concentration of 4.0 ...

When East meets West: the chemistry of Indonesian sponges and Australian nudibranchs

Indonesia is worldwide recognized as being the richest in the world in term of diversity and numb... more Indonesia is worldwide recognized as being the richest in the world in term of diversity and number of marine organisms. These resources are massive supplies for food and medicine. A large variety of biologically active compounds with great biomedical interest such as anticancer, antibiotic, antioxidant, anti-AIDS, anti-TBC and anti-Alzheimer have recently been discovered from Indonesian marine invertebrates including microorganisms associated with them. However, drug development from the sea is often hampered by the difficulty of obtaining sufficient supply. In the other hand, long term exploitation in coastal and coastal and marine resources has caused severe environmental degradation. Hence, maintaining a sustainable capacity for the ecosystem is an urgency need. Integrating efforts on sustainable utilization of marine natural products, diversity conservation and economic development as well as strengthening relationship among government, public and stakeholders into one program ...

Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan

Teripang merupakan komoditas penting di Indonesia yang bermanfaat bagi kesehatan, namun eksploras... more Teripang merupakan komoditas penting di Indonesia yang bermanfaat bagi kesehatan, namun eksplorasi terhadap kandungan nutrisinya masih terbatas. Penelitian ini bertujuan untuk mengetahui jenis, kandungan asam amino, dan asam lemak teripang segar asal perairan Indonesia. Sebanyak enam jenis teripang segar diperoleh dari berbagai lokasi yaitu Lampung, Gorontalo, Maluku Utara, dan Bali. Identifikasi spesies teripang dilakukan secara molekuler dengan metode Polymerase Chain Reaction (PCR), dan hasil sekuensing dibandingkan dengan basis data Basic Local Alignment Search Tool (BLAST). Analisis profil asam amino dan asam lemak berturut-turut dilakukan menggunakan Ultra High-Performance Liquid Chromatography (UPLC) dan Gas Chromatography-Flame Ionization Detector (GC-FID). Hasil identifikasi menunjukkan bahwa teripang alolo, cera merah, lolosong, cera hitam, dan pasir berturut-turut adalah Bohadschia marmorata, Holothuria edulis, H. impatiens, H. atra, dan H. scabra (alam dan budidaya). Kandungan asam amino non esensial (AANE) pada keenam sampel teripang didominasi oleh glisina dan asam glutamat, sedangkan asam amino esensial (AAE) tertinggi adalah treonina. Total asam amino tertinggi pada H. edulis yaitu 8,87 g/100g. Nilai rasio lisina/arginina pada semua sampel teripang <1,00. Asam lemak total tertinggi pada H. scabra alam dan budidaya (0,41%). H. atra, H. scabra alam, dan B. marmorata didominasi oleh asam lemak jenuh (ALJ), sedangkan H. scabra budidaya, H. edulis dan H. impatiens didominasi oleh asam lemak tak jenuh ganda (ALTJG). Rasio ALTJG/ALJ pada H. edulis, H. scabra budidaya, dan H. impatiens >1,00, sedangkan pada H. atra, H. scabra alam, dan B. marmorata sebesar <1,00. Berdasarkan hasil penelitian ini, dapat disimpulkan bahwa H. edulis dan H. impatiens memenuhi persyaratan nutrasetika. KATA KUNCI : teripang, asam amino, asam lemak, rasio lisina/arginina, rasio ALTJG/ALJ

Penyakit kanker adalah permasalahan kesehatan global yang mengancam setiap individu baik di negar... more Penyakit kanker adalah permasalahan kesehatan global yang mengancam setiap individu baik di negara maju maupun di negara berkembang. Penanganan kanker sejauh ini dilakukan berdasarkan metode konvensional yang cenderung menurunkan kualitas hidup para penderitanya. Pendekatan imunoterapi kanker adalah suatu metode pengobatan kanker dengan cara menstimulasi sistem kekebalan hidup pasien untuk melawan tumor melalui regulasi enzim-enzim yang berperan penting pada jalur molekuler tertentu dengan tujuan untuk meminimalisasi terjadinya efek samping yang tidak diinginkan yang umumnya terjadi pada terapi konvensional. Beberapa target molekuler telah dikembangkan saat ini, diantaranya adalah penghambatan enzim Indoleamine-2,3-dioxygenase (IDO) dan pengaktifan enzim SHIP (SH2-containing-inositol-5-phosphatase). Senyawa-senyawa bioaktif dari bahan alam laut yang telah dilaporkan sebagai regulator kedua enzim di atas akan dijabarkan.

Biodiversitas Journal of Biological Diversity, Feb 17, 2019

Sea cucumbers have been commercially traded around the world due to their nutritional values and ... more Sea cucumbers have been commercially traded around the world due to their nutritional values and health benefits. Sea cucumbers are marketed as processed sea cucumber, also known as beche de mer, teripang, haisen or gamat. Due to the high global demand of beche-de-mers, there have been several cases of fraud due to the visual shape and color similarities of processed sea cucumbers. Additionally, the local name diversity of Indonesian sea cucumbers making the identification of beche-de-mers difficult. Therefore, this study aimed to identify commercial sea cucumbers from selected locations in Indonesia by molecular approach. The targeted Cytochrome c oxidase subunit I (COI) was used in this research. A total of 25 beche-de-mers was purchased from local markets in Indonesia, i.e. Boalemo (17 local names), Pesawaran (5), Surabaya (2) and West Lombok (1). Results showed that 22 species of beche-de-mer were successfully identified, ie.

Angiotensin-Converting Enzyme (ACE) Inhibitory Activities of Protein Hydrolysates from Indonesian Sea Cucumbers

International Journal of Peptide Research and Therapeutics

Stress response in sponges and their potential applications to biomonitor stressors in coral reef ecosystem

Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology, Jan 12, 2010

Application of docking method to assess the activity of hydrocarbonoclastic bacteria (HCB) from marine origin in bioremediation process

Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology, Jan 8, 2010

Biologically active secondary metabolites from tropical marine invertebrates

Prospective Utilization of Fishery By-products in Indonesia

Seafood Processing By-Products, 2013

Jurnal Pascapanen Dan Bioteknologi Kelautan Dan Perikanan, Jun 12, 2012

Penelitian ini dilakukan untuk mengeksplorasi potensi ekstrak Streptomyces sp. dan Exserohilum ro... more Penelitian ini dilakukan untuk mengeksplorasi potensi ekstrak Streptomyces sp. dan Exserohilum rostratum sebagai agen antibakteri dan antioksidan. Kedua isolat tersebut merupakan hasil isolasi dari penelitian terdahulu. Eksplorasi bioaktivitas kedua mikroba dikaji dengan menggunakan tiga macam media pertumbuhan yaitu Malt Extract Agar (MEA), Minimal Fungal Medium (MFM) dan Glucose Pepton Yeast extract (GPY). Analisis produksi bahan aktif dilakukan setiap 2 minggu selama 10 minggu kultivasi. Hasil penelitian menunjukkan bahwa kedua isolat tersebut memiliki potensi untuk digunakan sebagai bahan untuk mempertahankan bakteri patogen agar tidak meningkat atau berkembang, atau sebagai bahan anti quorum sensing. Kemampuan penghambatan bakteri uji sebesar 2-3 siklus log. Ekstrak kedua mikroba tidak memiliki potensi sebagai penghasil antioksidan. Identifikasi pendahuluan terhadap jenis senyawa aktif yang terkandung dalam ekstrak pekat Streptomyces sp. dan Exserohilum rostratum berdasarkan spektra NMR berturut-turut diduga termasuk dalam golongan alkaloid dan peptida.

Natural Product Communications, 2016

Five new diterpenes (1-5), each with a highly oxygenated spongian framework, were characterized f... more Five new diterpenes (1-5), each with a highly oxygenated spongian framework, were characterized from an organic extract of a specimen of the nudibranch Goniobranchus splendidus collected from Eastern Australia. The new diterpene 7α-hydroxydendrillol-3 (6) was identified from specimens of Ardeodoris egretta. The structures and relative configurations of the six new metabolites have been elucidated by analysis of their spectroscopic data.

Australian Journal of Chemistry, 2018

A rearranged spongian diterpene chromolactol was obtained from the mantle extract of the Indo-Pac... more A rearranged spongian diterpene chromolactol was obtained from the mantle extract of the Indo-Pacific nudibranch Goniobranchus coi. The structure of chromolactol, either 1a or 1b, which was investigated by extensive NMR experiments and by data comparison as well as by molecular modelling studies and density functional calculations, has a different relative configuration of the 2,8-dioxabicyclo-[3.3.0]-octane ring compared with the co-metabolite norrisolide (2). A biosynthetic pathway leading to the preferred diastereomer of chromolactol (1a) is presented.

Distribution of Defensive Metabolites in Nudibranch Molluscs

Journal of chemical ecology, Jan 19, 2018

Many plants and animals store toxic or unpalatable compounds in tissues that are easily encounter... more Many plants and animals store toxic or unpalatable compounds in tissues that are easily encountered by predators during attack. Defensive compounds can be produced de novo, or obtained from dietary sources and stored directly without selection or modification, or can be selectively sequestered or biotransformed. Storage strategies should be optimized to produce effective defence mechanisms but also prevent autotoxicity of the host. Nudibranch molluscs utilize a diverse range of chemical defences, and we investigated the accumulation and distribution of defensive secondary metabolites in body tissues of 19 species of Chromodorididae nudibranchs. We report different patterns of distribution across tissues, where: 1) the mantle had more or different (but structurally related) compounds than the viscera; 2) all compounds in the mantle were also in the viscera; and 3) the mantle had fewer compounds than the viscera. We found no further examples of species that selectively store a single ...

Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan, 2009

Penelitian isolasi senyawa sitotoksik dari spons Crella papilata telah dilakukan. Spons Crella pa... more Penelitian isolasi senyawa sitotoksik dari spons Crella papilata telah dilakukan. Spons Crella papilata diambil dari Taman Nasional Kepulauan Seribu. Ekstraksi senyawa sitotoksik dilakukan dengan metode maserasi menggunakan metanol dan ekstrak kasar yang dihasilkan difraksinasi dengan kromatografi kolom fase balik. Pemisahan lebih lanjut dilakukan dengan kromatografi kolom fase normal dengan eluen campuran n-heksana/EtOAc (etil asetat) dan EtOAc/MeOH (etil asetat/metanol) secara gradien. Fraksi yang paling aktif diisolasi dengan kromatografi lapis tipis preparatif dan diidentifikasi dengan ¹H NMR (Nuclear Magnetic Resonance) dan LCMS (Liquid Chromatography Mass Spectrophotometry). Interpretasi terhadap data spektra yang dihasilkan memperlihatkan bahwa senyawa bioaktif tersebut merupakan golongan tiol yang mengandung cincin aromatik serta alkil sebagai gugus samping dengan berat molekul sebesar 291. Uji MTT [3-(4,5 dimethylthiazol-2yl)-2,5-diphenyl tetrazolium bromida)] menunjukkan b...

Biomedical benefits of algal glycoproteins

Marine Glycobiology, 2016

Prospective Utilization of Fishery By-products in Indonesia

Seafood Processing By-Products, 2013

Fisheries industry activities generate by-products which have economic potential and can be utili... more Fisheries industry activities generate by-products which have economic potential and can be utilized as a raw material to produce various value-added products. Fisheries by-products can be as follows: (a) by-products from the utilization of fisheries resources, (b) by-products from processing industries, (c) by-products as secondary products in addition to the main products, (d) by-products from surplus during the fishing season, (e) by-products as the remainder of distribution or marketing. By-products from the utilization of fisheries resources can be processed into minced fish, surimi and surimi-based products, food-grade fish flour, fish meal, fish silage, and several traditional products. By-products from shrimp processing industries have been explored to produce sticky shrimp extract, fermented shrimp paste, shrimp crackers, protein hydrolysate, shrimp meal, shrimp silage, chitin, chitosan, chitooligosaccharide, and flavoring agent. Meanwhile, by-products from fish processing, such as canned fish, tuna loin, red snapper fillet, frog legs, and some processed freshwater fish, have the potential to be processed into fish meal, flavoring agent, tanned fish skin, gelatin, fish balls, fish sausage, and fermented products. By-products as secondary products, such as fish oil, can be utilized for pharmaceutical, food, feed, and non-food purposes. Some processing technologies have been developed for the utilization of underutilized fish, especially sharks and rays.

Marine Drugs, 2016

A series of oxy-polybrominated diphenyl ethers (O-PBDEs) has been isolated from the extracts of M... more A series of oxy-polybrominated diphenyl ethers (O-PBDEs) has been isolated from the extracts of Miamira magnifica and Miamira miamirana collected from Queensland, Australia. M. magnifica sequesters the new OH-PBDE 1 and six known OH-PBDEs containing four to six bromines (2-7). M. miamirana also accumulates known tribromo-and tetrabromo OMe-PBDEs 8-10 in both mantle and viscera tissues. To date, Miamira is the only genus of the family Chromodorididae that is known to incorporate O-PBDEs, rather than terpenes, in the mantle where the metabolites may play a putative role in chemical defense. The extract of M. magnifica was tested in a brine shrimp lethality assay and exhibited an LD 50 of 58 µg/mL.

Figure 3 from: Nursid M, Patantis G, Dewi AS, Achmad MJ, Sembodo PM, Estuningsih S (2021) Immunnostimulatory activity of Holothuria atra sea cucumber. Pharmacia 68(1): 121-127. https://doi.org/10.3897/pharmacia.68.e58820

Immunostimulant is a substance that can stimulate the immune system against pathogenic microbes. ... more Immunostimulant is a substance that can stimulate the immune system against pathogenic microbes. Natural products produced by sea cucumbers have the potential to be developed as immunostimulants. This study was aimed to evaluate the imunostimulatory activity of Holothuria atra extract using the phagocytocyte assay of macrophage cells and the differentiation of leukocyte in rats. The samples of H. atra were taken from Halmahera waters, North Maluku, Indonesia. Extraction was carried out with 96% ethanol. Phagocytocyte activity assay was carried out using macrophage cells isolated from Balb/c mice (Mus musculus) using a series of doses 0.5; 1.0; 2.0; 4.0; 8.0; 16.0 and 32.0 mg/kg body weight. Leukocyte differentiation test in vivo was conducted using Rattus norvegicus rat treated with H. atra extract for 90 days with the following series of doses: 0, 25, 50, 100, and 200 mg/kg body weight. The results showed that the highest phagocytosis activity was reached at a concentration of 4.0 ...

When East meets West: the chemistry of Indonesian sponges and Australian nudibranchs

Indonesia is worldwide recognized as being the richest in the world in term of diversity and numb... more Indonesia is worldwide recognized as being the richest in the world in term of diversity and number of marine organisms. These resources are massive supplies for food and medicine. A large variety of biologically active compounds with great biomedical interest such as anticancer, antibiotic, antioxidant, anti-AIDS, anti-TBC and anti-Alzheimer have recently been discovered from Indonesian marine invertebrates including microorganisms associated with them. However, drug development from the sea is often hampered by the difficulty of obtaining sufficient supply. In the other hand, long term exploitation in coastal and coastal and marine resources has caused severe environmental degradation. Hence, maintaining a sustainable capacity for the ecosystem is an urgency need. Integrating efforts on sustainable utilization of marine natural products, diversity conservation and economic development as well as strengthening relationship among government, public and stakeholders into one program ...

Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan

Teripang merupakan komoditas penting di Indonesia yang bermanfaat bagi kesehatan, namun eksploras... more Teripang merupakan komoditas penting di Indonesia yang bermanfaat bagi kesehatan, namun eksplorasi terhadap kandungan nutrisinya masih terbatas. Penelitian ini bertujuan untuk mengetahui jenis, kandungan asam amino, dan asam lemak teripang segar asal perairan Indonesia. Sebanyak enam jenis teripang segar diperoleh dari berbagai lokasi yaitu Lampung, Gorontalo, Maluku Utara, dan Bali. Identifikasi spesies teripang dilakukan secara molekuler dengan metode Polymerase Chain Reaction (PCR), dan hasil sekuensing dibandingkan dengan basis data Basic Local Alignment Search Tool (BLAST). Analisis profil asam amino dan asam lemak berturut-turut dilakukan menggunakan Ultra High-Performance Liquid Chromatography (UPLC) dan Gas Chromatography-Flame Ionization Detector (GC-FID). Hasil identifikasi menunjukkan bahwa teripang alolo, cera merah, lolosong, cera hitam, dan pasir berturut-turut adalah Bohadschia marmorata, Holothuria edulis, H. impatiens, H. atra, dan H. scabra (alam dan budidaya). Kandungan asam amino non esensial (AANE) pada keenam sampel teripang didominasi oleh glisina dan asam glutamat, sedangkan asam amino esensial (AAE) tertinggi adalah treonina. Total asam amino tertinggi pada H. edulis yaitu 8,87 g/100g. Nilai rasio lisina/arginina pada semua sampel teripang <1,00. Asam lemak total tertinggi pada H. scabra alam dan budidaya (0,41%). H. atra, H. scabra alam, dan B. marmorata didominasi oleh asam lemak jenuh (ALJ), sedangkan H. scabra budidaya, H. edulis dan H. impatiens didominasi oleh asam lemak tak jenuh ganda (ALTJG). Rasio ALTJG/ALJ pada H. edulis, H. scabra budidaya, dan H. impatiens >1,00, sedangkan pada H. atra, H. scabra alam, dan B. marmorata sebesar <1,00. Berdasarkan hasil penelitian ini, dapat disimpulkan bahwa H. edulis dan H. impatiens memenuhi persyaratan nutrasetika. KATA KUNCI : teripang, asam amino, asam lemak, rasio lisina/arginina, rasio ALTJG/ALJ

Penyakit kanker adalah permasalahan kesehatan global yang mengancam setiap individu baik di negar... more Penyakit kanker adalah permasalahan kesehatan global yang mengancam setiap individu baik di negara maju maupun di negara berkembang. Penanganan kanker sejauh ini dilakukan berdasarkan metode konvensional yang cenderung menurunkan kualitas hidup para penderitanya. Pendekatan imunoterapi kanker adalah suatu metode pengobatan kanker dengan cara menstimulasi sistem kekebalan hidup pasien untuk melawan tumor melalui regulasi enzim-enzim yang berperan penting pada jalur molekuler tertentu dengan tujuan untuk meminimalisasi terjadinya efek samping yang tidak diinginkan yang umumnya terjadi pada terapi konvensional. Beberapa target molekuler telah dikembangkan saat ini, diantaranya adalah penghambatan enzim Indoleamine-2,3-dioxygenase (IDO) dan pengaktifan enzim SHIP (SH2-containing-inositol-5-phosphatase). Senyawa-senyawa bioaktif dari bahan alam laut yang telah dilaporkan sebagai regulator kedua enzim di atas akan dijabarkan.

Biodiversitas Journal of Biological Diversity, Feb 17, 2019

Sea cucumbers have been commercially traded around the world due to their nutritional values and ... more Sea cucumbers have been commercially traded around the world due to their nutritional values and health benefits. Sea cucumbers are marketed as processed sea cucumber, also known as beche de mer, teripang, haisen or gamat. Due to the high global demand of beche-de-mers, there have been several cases of fraud due to the visual shape and color similarities of processed sea cucumbers. Additionally, the local name diversity of Indonesian sea cucumbers making the identification of beche-de-mers difficult. Therefore, this study aimed to identify commercial sea cucumbers from selected locations in Indonesia by molecular approach. The targeted Cytochrome c oxidase subunit I (COI) was used in this research. A total of 25 beche-de-mers was purchased from local markets in Indonesia, i.e. Boalemo (17 local names), Pesawaran (5), Surabaya (2) and West Lombok (1). Results showed that 22 species of beche-de-mer were successfully identified, ie.

Angiotensin-Converting Enzyme (ACE) Inhibitory Activities of Protein Hydrolysates from Indonesian Sea Cucumbers

International Journal of Peptide Research and Therapeutics

Stress response in sponges and their potential applications to biomonitor stressors in coral reef ecosystem

Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology, Jan 12, 2010

Application of docking method to assess the activity of hydrocarbonoclastic bacteria (HCB) from marine origin in bioremediation process

Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology, Jan 8, 2010

Biologically active secondary metabolites from tropical marine invertebrates

Prospective Utilization of Fishery By-products in Indonesia

Seafood Processing By-Products, 2013

Jurnal Pascapanen Dan Bioteknologi Kelautan Dan Perikanan, Jun 12, 2012

Penelitian ini dilakukan untuk mengeksplorasi potensi ekstrak Streptomyces sp. dan Exserohilum ro... more Penelitian ini dilakukan untuk mengeksplorasi potensi ekstrak Streptomyces sp. dan Exserohilum rostratum sebagai agen antibakteri dan antioksidan. Kedua isolat tersebut merupakan hasil isolasi dari penelitian terdahulu. Eksplorasi bioaktivitas kedua mikroba dikaji dengan menggunakan tiga macam media pertumbuhan yaitu Malt Extract Agar (MEA), Minimal Fungal Medium (MFM) dan Glucose Pepton Yeast extract (GPY). Analisis produksi bahan aktif dilakukan setiap 2 minggu selama 10 minggu kultivasi. Hasil penelitian menunjukkan bahwa kedua isolat tersebut memiliki potensi untuk digunakan sebagai bahan untuk mempertahankan bakteri patogen agar tidak meningkat atau berkembang, atau sebagai bahan anti quorum sensing. Kemampuan penghambatan bakteri uji sebesar 2-3 siklus log. Ekstrak kedua mikroba tidak memiliki potensi sebagai penghasil antioksidan. Identifikasi pendahuluan terhadap jenis senyawa aktif yang terkandung dalam ekstrak pekat Streptomyces sp. dan Exserohilum rostratum berdasarkan spektra NMR berturut-turut diduga termasuk dalam golongan alkaloid dan peptida.