Godwins Echejoh | The University of Queensland, Australia (original) (raw)

Papers by Godwins Echejoh

as "Chemodectoma: three case-series with review of literature" by Echejoh et al. Upon s... more as "Chemodectoma: three case-series with review of literature" by Echejoh et al. Upon submission of their manuscript to Biomedicine International, the authors verified that "the submission has not been previously published, nor is it under simultaneous considerations for publication by any other journal". Duplicate submissions are academically inappropriate and the practice is prohibited internationally. Review and publication of a manuscript take a substantial amount of reviewers' and editors' time and publishers' money. A duplicate submission therefore wastes academic resources. We hereby retract this published article. We hope Dr. Echejoh and his colleagues will avoid any such duplicate submission in the future. BI BI BI BI

Rhabdomyosarcoma is one of the most frequent soft tissue sarcomas in children. It is found mostly... more Rhabdomyosarcoma is one of the most frequent soft tissue sarcomas in children. It is found mostly in children, primarily infants, toddlers, and pre-school pupils. However, pure testicular rhabdomyosarcoma is a very rare tumor and few cases have been reported in literature. The tumor usually presents as a painless testicular enlargement with early dissemination via the blood stream and lymphatics. The origin of this tumor is presumed to be from overgrowth of a sarcomatous area of the teratoma. Here, we present a case of testicular rhabdomyosarcoma in a 15-year-old student with a fatal outcome during chemotherapy. This is actually the first case of pure testicular rhabdomyosarcoma diagnosed in this centre after over 10 years.

Journal of Clinical Pathology

ObjectiveTo compare the whole genomes sequencing (WGS) results in the 100K Genomes project with t... more ObjectiveTo compare the whole genomes sequencing (WGS) results in the 100K Genomes project with the results of routine molecular diagnostics in precision medicine.Materials and methodsWe analysed 374 cancers including a high tumour mutational burden (TMB-high) subgroup, defined as >10 non-synonymous single nucleotide variations per megabase. Colon cancers were evaluated for microsatellite instability (MSI), mismatch repair (MMR) genes and NRAS, KRAS and BRAF mutations using routine molecular diagnostics. Fluorescence in-situ hybridisation/immunohistochemistry was used to evaluate the Her2Neu status in breast cancers.ResultsThere was high correlation between WGS and routine diagnostic testing results irrespective of TMB status in colon cancers. Her2Neu status was discordant in 3 out of the 5 TMB-high breast cancers (p=0.049). The presence of ductal carcinoma in-situ correlated significantly with discordance (p=0.04). There were 3 (5%) discordant colorectal cases, all in the KRAS g...

… Journal of Medicine …, 2009

Adenocarcinoma of the prostate is the commonest form of cancer in men and the second leading caus... more Adenocarcinoma of the prostate is the commonest form of cancer in men and the second leading cause of cancer death. Not much is known about the aetiology of prostatic cancer. We report a rare case of prostatic adenocarcinoma coexisting with schistosomiasis of the prostate, and review of literature. The association between schistosomiasis and cancer has been well documented in bladder cancer, implicating the genotoxic effect of chronic inflammatory process from the generation of reactive oxygen species (ROS) and the nitrosating action of bacterial infection. There are no data yet proving the association of this disease with prostate neoplasia. The theory of the genotoxic effect of chronic inflammatory process may explain a "cause and effect" association between prostate cancer and schistosomiasis. A pertinent question therefore is, does schistosomiasis cause tumorigenesis in all tissues affected? This is the first record of prostatic schistosomiasis in association with prostatic cancer in our centre.

International Journal of STD & AIDS

Nigerian journal of clinical practice, 2008

To determine the relation of Helicobacter pylori infection with chronic inflammation, atrophy, ac... more To determine the relation of Helicobacter pylori infection with chronic inflammation, atrophy, activity level and intestinal metaplasia. A cross-sectional study of 100 consecutive patients with dyspepsia. These patients were fasted for 12 hours and gastroscopic biopsy specimens were obtained from their gastric mucosae. The specimens were histologically evaluated for H. pylori, inflammatory activity, chronic inflammation, gastric atrophy and intestinal metaplasia. There were 50 (50%) females and 50 (50%) males. The average ages of women and men were 36.3 +/- 11.5 and 42.9 +/- 12.8 respectively. Helicobacter pylori was found in 79%. Neutrophil activity was observed in 83%. Inflammation was found in 95%, glandular atrophy in 38%, intestinal metaplasia in 28% of the cases. Incidental (early gastric) cancer was found in 3%, dysplasia in 2% and reactive gastropathy in 7% of the cases. A statistically significant relationship was found between Helicobacter pylori colonization intensity and...

Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria

Dyspepsia is a common disease worldwide. It is a cause of great absenteeism from work with a lot ... more Dyspepsia is a common disease worldwide. It is a cause of great absenteeism from work with a lot of economic loss. In Jos, it is one of the most common complaints encountered in both general outpatient and specialist clinics. To evaluate the histopathological changes in gastric mucosa of patients presenting with symptoms of dyspepsia. Cross sectional study. Gastric endoscopic biopsy specimens from 100 consecutive patients with symptoms of dyspepsia were histologically evaluated using the criteria of the updated Sydney system. There were 50 males and 50 females. Their overall mean age was 39.6 +/- 12.2 (S.D). The prevalence of Helicobacter pylori colonization was 79%. Males were 53.2% and females 46.8% respectively giving a sex ratio of 1.4:1. Gastritis, neutrophil activity, glandular atrophy and intestinal metaplasia were observed in 95%, 83%, 38% and 28% respectively. Gastric carcinoma was found in 3% ofthe patients. From our study, we conclude that the majority of our patients wit...

Nigerian Journal of Medicine, 2010

Gastric cancer believed to be rare in the past in Africa, is now one of the leading cancer morbid... more Gastric cancer believed to be rare in the past in Africa, is now one of the leading cancer morbidity and mortality. It is now known gastric cancer is 2-3 times higher in males than females living in the same environment. We aim to describe the comprehensive histological characteristics of gastric cancer with age and sex distribution. The study site was Jos University Teaching Hospital situated in the capital of Plateau State. The hospital has a bed capacity of 530. The study materials were obtained from all stained specimens of gastric cancer recorded in the histopathology laboratory of the teaching hospital between 1985 to 2004. The biopsy site was noted. These were divided into the following groups: Cardia, body and an thrum/pyloric regions respectively. Or the information included age and sex of the patients. There were a total of 205 gastric cancer histological confirmed, out of 5705 malignant tumours recorded in the same period. There were a total of 145 cases in male and 60 in females giving a male: female ratio 2.4:1. The highest frequencies of gastric cancers were located in the anthral and cardia regions which accounted for 79% of all the tumours. Well differentiated adenocarcinoma (intestinal type) was the most frequent histological subtypes 51.2%), this was followed by poorly and diffusely infiltrating carcinoma. Other cancers included signet ring carcinoma, Non-Hodgkin's lymphoma and leiomyosarcoma in that order. The study has also demonstrated H pylori at the background of intestinal type adenocarcinoma which was seen in the body and an thrum. The study has shown that gastric cancer is not only common but it occur more males than females. The high proportion of H pylori in our environment might indicate a possible aetiological association. Therefore eradication of H pylori might reduce the prevalence of gastric carcinoma.

Nigerian Journal of Medicine, 2008

Background: Hepatocellular carcinoma (HCC) is the most common abdominal malignancy, representing ... more Background: Hepatocellular carcinoma (HCC) is the most common abdominal malignancy, representing 80-90% of primary liver malignancies around the world. There is a disturbing trend of increased incidence of HCC around the world. We therefore, determined the trend of HCC in Jos. Methods: A ten-year retrospective review was done of all cases of HCC which diagnoses were histologically confirmed as recorded in the Cancer Registry of Jos University Teaching Hospital. The patients' clinical case notes (including surgical and radiological findings) were also reviewed. Results: A total of 71 cases of HCC (31.3% 0f 227 liver biopsies in the same period) were diagnosed within the 10-year period. There were 46 males and 25 females with a male/female ratio of 1.8:1. The age range of the patients was 23 years to 75 years, with a mean age of 45.4±13.1 years. Seventy two percent (72%) of them were between ages 21 years and 50 years. Only 28% were between 51 years and 80 years. The highest rate of 12(17.1%) was seen in the year 2004. Conclusion: The study showed that there was a high prevalence of HCC in Jos, and that HCC was more prevalent in the younger age group compared to what obtains in developed nations.

Highland Medical Research Journal, 2010

ABSTRACT In endemic areas multi-organ involvement by schistosomiasis includingkidney, prostate, l... more ABSTRACT In endemic areas multi-organ involvement by schistosomiasis includingkidney, prostate, liver, intestine and pancreas has been documented. Sometimes this mimics neoplastic growth. Histopathology of tissues or organs affected usually show chronic granulomatous inflammatory reaction surrounding the schistosome egg(s). We are reporting a rare case of pancreatic schistosomiasis presenting as gastric outlet obstruction. An exploratory laparotomy revealed a granular, firm grayish mass in the head of the pancreas with some fibrosis impinging on the duodenum. The obstruction was relieved and a biopsy taken for histology which showed benign pancreatic tissue with several granulomas comprising aggregates of eosinophils, epithelioid cells and centrally placed schistosome ova. This case mimicked a pancreatic tumour with features of gastric outlet obstruction.

Journal of the …, 2008

Rhinosporidiosis is a rare chronic granulomatous infection caused by Rhinosporidium seeberi. It a... more Rhinosporidiosis is a rare chronic granulomatous infection caused by Rhinosporidium seeberi. It affects mainly the mucosa of the nose, nasopharynx, palate, conjunctiva and the urethra. A seven-year-old girl presented with intranasal polypoid growth with recurrent ...

Histopathology, 2012

... be graded and a comment added that if there is any residual gross lesion, a repeat biopsy ma... more ... be graded and a comment added that if there is any residual gross lesion, a repeat biopsy may be warranted and, if not, then close follow-up is recommended. There are 8 histologic variants of squamous cell carcinoma: conventional, verrucous, spindle cell, papillary, basaloid ...

Objective: To determine the prevalence of cirrhosis in Jos Central Nigeria, and to discuss the ae... more Objective: To determine the prevalence of cirrhosis in Jos Central Nigeria, and to discuss the aetiopathogenesis of cirrhosis. Methods: The record of histological diagnoses of liver biopsies was reviewed. Fresh sections (3-5μ) of archival paraffin embedded tissue were taken and routinely stained with haematoxylin and eosin (H&E), and special stains such as Perls, Masson trichrome, Orcein and Periodic Acid Schiff (PAS). Archival slides of fine needle aspirations were retrieved. Four pathologists viewed the slides independently for a consensus diagnosis and levels of disparity assessed. The clinical data were obtained from the accompanying request forms. Results: The results of a total of 73 cases of liver cirrhosis were analysed. This constituted 28% of the total liver biopsies in this centre within the study period. Isolated cases of cirrhosis were 53 (72.6%) while cirrhosis coexisting with hepatocellular carcinoma (HCC) was 20 (27.4%). The frequency of cirrhosis per year was relatively higher in the earlier years; 1995-1999 (38; 52%). However, gradual decline was noticed from year 2000-2005 except for the sharp rise in 2004 (11 cases; 15%). There were 56 (77%) males and 17 (23%) females, with a male to female ratio of 3.3:1. The age range of the cases of cirrhosis was five months to 70 years with a mean SD of 41.2±14.9 years. Majority of cases (52; 71.2%) were within ages 21-50 years. Conclusion: This study shows that there is a high prevalence of liver cirrhosis in Jos, North Central Nigeria, and it is more prevalent in relatively younger age group.

Background: The incidence of adenocarcinoma of the cervix is on the increase in many parts of the... more Background: The incidence of adenocarcinoma of the cervix is on the increase in many parts of the world. There is paucity of information regarding this in our setting. Objective: To describe the histopathological pattern of cervical adenocarcinomas and to highlight the role of immunohistochemistry in diagnostic dilemmas. Method: This is a descriptive analysis of consecutive adenocarcinomas of the cervix as seen in the histopathology department of Jos University Teaching Hospital (JUTH), Jos over a six year period, between January 2005 and December 2010. Result: Of the 240 cervical surgical specimens received over the period of study, 44 (18.3%) were cervical malignancies. Of these 13 (30%) were adenocarcinoma and 31(70.5%) squamous cell carcinoma. The percentages for the different histologic subtypes of the adenocarcinomas were, pure adenocarcinoma (53.8%), adenosquamous carcinoma (23.1%) small cell carcinoma (15.4%) and metastatic adenocarcinoma (7.7%). Conclusion: Cervical adenoca...

Annals of African …, 2006

Studies from various part of Africa including Nigeria have shown that road traffic accidents are ... more Studies from various part of Africa including Nigeria have shown that road traffic accidents are on the increase and are responsible for the high rate of deaths in most cities of Nigeria and other African cities. 1-7 In some teaching hospitals in Nigeria, trauma from accidents is ...

Medical Principles and Practice

Objective: To measure the transcript levels of Aurora kinases and compare them to their immunorea... more Objective: To measure the transcript levels of Aurora kinases and compare them to their immunoreactivity patterns in prostate tumors. Materials and Methods: A total of 26 cases of prostate cancer (PCa) and 38 cases of benign nodular hyperplasia (BPH) were sampled from archived formalin-fixed paraffin-embedded tissues. Tissue sections were lysed, total RNA extracted and cDNA made by random hexamer priming while slide sections were immunostained for the kinases. Normalized relative quantitation was performed for all the kinases using real-time PCR on TaqMan chemistry. Results: The immunoreactivity profile showed 15.4, 53.8 and 30.7% positivity for Aurora kinases A, B and C in PCa cases, respectively, while the positivity was 76.3, 73.7 and 84.2% for the same kinases in BPH cases. The immunoreactivity was preponderant on epithelial tissue compared to stromal component. Conclusion: Aurora kinases were significantly overexpressed in BPH cases compared to PCa cases. At the transcript leve...