Prof.Dr.Waleed H A S S A N Almalki - Profile on Academia.edu (original) (raw)

Papers by Prof.Dr.Waleed H A S S A N Almalki

Additive Manufacturing and Printing Approaches for the Development of Pharmaceutical Dosage Forms with Improved Biopharmaceutical Attributes

Recent Advances in Nanotechnology-Based Targeted Therapeutics for Breast Cancer Management

Itraconazole and Difluorinated-Curcumin Containing Chitosan Nanoparticle Loaded Hydrogel for Amelioration of Onychomycosis

Molecular exploration of hidden pleiotropic activities of azoles on dermatophytes in human tinea corporis infection

Protective effects of menthol against sepsis-induced hepatic injury: Role of mediators of hepatic inflammation, apoptosis, and regeneration

Microbial surfactants: A journey from fundamentals to recent advances

Advances in Nematode Identification: A Journey from Fundamentals to Evolutionary Aspects

Environmental DNA Metabarcoding: A Novel Contrivance for Documenting Terrestrial Biodiversity

Role of Medicinal plant-derived Nutraceuticals as a potential target for the treatment of breast cancer

Sepsis triggered oxidative stress‑inflammatory axis: the pathobiology of reprogramming in the normal sleep–wake cycle

Effects of the Anthocyanin Hirsutidin on Gastric Ulcers: Improved Healing through Antioxidant Mechanisms

Oligonucleotides: A novel area of interest for drug delivery in neurodegenerative diseases

Potential role of nutraceuticals via targeting a Wnt/β-catenin and NF-κB pathway in treatment of osteoarthritis

Active pharmaceutical ingredients (APIs) in ionic liquids: An effective approach for API physiochemical parameter optimization

Cold-Active Enzymes and Their Potential Industrial Applications—A Review

More than 70% of our planet is covered by extremely cold environments, nourishing a broad diversi... more More than 70% of our planet is covered by extremely cold environments, nourishing a broad diversity of microbial life. Temperature is the most significant parameter that plays a key role in the distribution of microorganisms on our planet. Psychrophilic microorganisms are the most prominent inhabitants of the cold ecosystems, and they possess potential cold-active enzymes with diverse uses in the research and commercial sectors. Psychrophiles are modified to nurture, replicate, and retain their active metabolic activities in low temperatures. Their enzymes possess characteristics of maximal activity at low to adequate temperatures; this feature makes them more appealing and attractive in biotechnology. The high enzymatic activity of psychrozymes at low temperatures implies an important feature for energy saving. These enzymes have proven more advantageous than their mesophilic and thermophilic counterparts. Therefore, it is very important to explore the efficiency and utility of different psychrozymes in food processing, pharmaceuticals, brewing, bioremediation, and molecular biology. In this review, we focused on the properties of cold-active enzymes and their diverse uses in different industries and research areas. This review will provide insight into the areas and characteristics to be improved in cold-active enzymes so that potential and desired enzymes can be made available for commercial purposes.

A narrative review on the biology of piezo1 with platelet-rich plasma in cardiac cell regeneration

Chemico-Biological Interactions, 2022

Cardiomyocyte regeneration following cardiac damage is challenging to study because of the inflam... more Cardiomyocyte regeneration following cardiac damage is challenging to study because of the inflammatory
process, the multiplication of cells in the stroma, and the creation of scar tissue. In addition to the initial damage,
the subsequent decrease in cardiac myocytes adds to heart failure. Piezo1 is remarkably understudied in the
heart, which may be related to its recent discovery. Despite this, Piezo1 is expressed in a variety of cardiovascular
cell populations, notably epithelial cells (EC), cardiac fibroblasts (CF), and cardiac myocytes (CM), in both animal and human samples, with fibroblasts expressing more than myocytes. Researchers have recently shown that
disrupting Piezo1 signaling causes defects in zebrafish developing the outflow tract (OFT) and aortic valves.
Platelet plasma membranes may provide lipid substrates, such as phosphatidylinositol bisphosphate, that aid in
activating the piezo 1 ion channel in the cardiovascular system. In addition, CXC chemokine ligand 8/CXC
chemokine receptor 1/2 (CXCL8-CXCR1/2) signaling was identified to establish the proliferation of coronary
endothelial cells during cardiac regeneration. Notably, all these pathways are calcium-dependent, and cell
proliferation and angiogenesis were necessary to recover myocardial cells. This review will examine the most
current findings to understand further how platelet-rich plasma (PRP) and the piezo 1 channel might aid in
cardiomyocyte regeneration.

Wearable smart devices in cancer diagnosis and remote clinical trial monitoring: Transforming the healthcare applications

Drug Discovery Today, 2022

During the past two decades, the era of digitalization in pharmaceutical device manufacturing has... more During the past two decades, the era of digitalization in
pharmaceutical device manufacturing has gained significant momentum for maintaining human health. From
various available technologies, internet of things (IoT)
sensors are being increasingly used as wearable devices
(e.g., smart watches, wrist bands, mobile phones, tablets,
implantable pumps, etc.) that enable real-time monitoring
of data. Such devices are integrated with smart materials
that typically monitor the real-time data (blood pressure,
blood sugar, heart and pulse rate, cytokine levels, etc.) to
advise patients and physicians. Hence, there has been a
great demand for wearable devices as potential tools for
remote clinical trial monitoring in cancers and other
diseases and they are proving to be very cost-effective.

Nutraceuticals are dietary supplements that are used to improve health, postpone aging, prevent i... more Nutraceuticals are dietary supplements that are used to improve health, postpone aging, prevent illnesses, and maintain the human body's correct functioning. Nutraceuticals are now garnering a lot of interest because of their nutritional and therapeutic benefits. The research indicating the relevance of nutraceuticals as a possible therapeutic candidate against inflammatory lung disease was covered in this review. Nowadays, inflammatory lung diseases such as chronic obstructive pulmonary disease (COPD), pulmonary fibrosis, asthma, pneumonia, lung cancer, becoming highly dreadful because of their associated fatality. Inflammation is one of the cores and common factors of these diseases which is mainly associated with nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation, NF-κB p65 and nuclear factor of kappa light polypeptide gene enhancer in Bcells inhibitor, alpha (IκBα) phosphorylation, and initiation of the signaling pathway of the NF-κB. The secondary metabolites from natural sources are the active component that attenuates NF-κB and the associated pathway that inhibits inflammation in lung diseases. Nutraceuticals belonging to the chemical category polyphenols, alkaloids, terpenoids, flavonoids, tannins have the potential to combat the NF-κB pathway. Accordingly, this review discusses the medical value of nutraceuticals briefly and their ability to mitigate various inflammatory lung diseases through targeting inhibition of NF-κB.

Biocompatible Phospholipid‐based nanovesicular drug delivery system of ketoprofen: Systematic development, optimization and preclinical evaluation

Biotechnology and Applied Biochemistry, 2022

The sepsis induced defective aggravation of immune cells: a translational science underling chemico-biological interactions from altered bioenergetics and/or cellular metabolism to organ dysfunction

Molecular and Cellular Biochemistry, 2021

Sepsis is described as a systemic immune response of the body to an infectious process that might... more Sepsis is described as a systemic immune response of the body to an infectious process that might result in dysfunctional organs that may lead to death. In clinical practice, sepsis is considered a medical emergency. The initial event in sepsis caused by a deregulated host response towards harmful microorganisms that leads to an aggravated systemic inflammatory response syndrome (SIRS) to tackle with pathogen invasion and a compensatory anti-inflammatory response syndrome (CARS) that lasts for several days. The inflammatory response and the cellular damage as well as the risk of an organ dysfunction are in direct proportion. Even though, the pathogenesis of sepsis remains unclear, many studies have shown evidence of role of oxidants and antioxidants in sepsis. The altered innate and adaptive immune cell and upregulated production and release of cytokines and chemokines most probably due to involvement of JAK-STAT pathway, disturbance in redox homeostasis due to low clearance of lactate and other oxidative stressors, contributes to sepsis process to organ dysfunction which contribute to increase rates of mortality among these patients. Hence, the treatment strategies for sepsis include antibiotics, ventilator and blood glucose management and other strategies for resuscitation are rapidly progressing. In the current review, we mainly concentrate on throwing light on the main molecular aspects and chemico-biological interactions that shows involvement in pathways manipulating alteration in physiology of immune cells (innate and adaptive) that change the bioenergetics/cellular metabolism to organ dysfunction and correlation of these altered pathway, improve the understating for new therapeutic target for sepsis.