Yasir Khayyat | Umm Al-Qura University, Makkah, Saudi Arabia (original) (raw)

Papers by Yasir Khayyat

Current traditional medicine, Feb 27, 2024

Saudi Medical Journal

To examine the potential therapeutic effects of ursodeoxycholic acid (UDCA) on diseases of the es... more To examine the potential therapeutic effects of ursodeoxycholic acid (UDCA) on diseases of the esophagus, stomach, and duodenum. Methods: A search was conducted using EBSCO, Medline, PubMed, Google Scholar and Web of Science as well as international guidelines using MESH terms for treatment of UDCA for diseases of the upper gastrointestinal disorders in adult humans without regard to publication language or date restrictions. Results: A total of 256 articles and 22 guidelines were initially identified, and 221 were excluded. Final Systematic Review revision of 13 articles and 22 guidelines confirmed that UDCA is found to have a cytoprotective role in Barret's esophagus within esophageal disorders, improves abdominal pain in functional dyspepsia, and does not alter Helicobacter pylori colonization or inflammation. Conflicting results are noted regarding the role of UDCA in the duodenum as chemopreventive treatment for familial adenomatous polyposis, with polyps regressing and their growth characteristics improving with low doses (10-25 mg/ kg/day). On the contrary, no positive effect was noted upon the combination with Celecoxib and with doses of 1000-2000 mg or 20-30 mg/kg/d. Gastrointestinal side effects were predominantly reported. No side effects necessitated hospitalization or ICU admission. Conclusion: Ursodeoxycholic acid has a limited therapeutic role in functional dyspepsia. There is promising evidence that it may serve as a chemopreventive for Familial adenomatous polyposis and Barret's esophagus, although further research is needed to confirm these findings.

Journal of the Canadian Association of Gastroenterology, 2018

Background: Irritable bowel syndrome (IBS) is a common clinical problem in several age groups in ... more Background: Irritable bowel syndrome (IBS) is a common clinical problem in several age groups in Saudi Arabia ,reached about 9 % in adult students and up to 40 % in teachers .Effort is needed to correctly manage IBS and identify any coexistent condition that mimic the symptoms especially gluten sensitivity (GS). It is considered of low prevalence in Asian and Middle Eastern countries compared to high prevalent regions in Europe and North America. Aims: This prospective study aims to estimate the prevalence of different subtypes of IBS, celiac disease positive serology and possible association that may exist, in an area of high IBS diagnosis and relatively low prevalence of celiac disease. Methods: A Prospective study at a tertiary care private hospital at the western region of Saudi Arabia over the period of August 2013 to August 2016. Adults above the age of 15 year invited to participate in the study.ROME 3 criteria was used to identify and diagnose different subtypes of IBS as IBS-Pain ,IBS-constipation ,IBS-Diarrhea and IBS-Mixed. Basic demographic data collected. The patients filled questionnaire that outline questions related to these subtypes. Laboratory work included CBC, Electrolytes, urea, creatinine, TSH, Tissue transglutaminase antibody (TTG) Ig A and Ig G collected. Patients with Positive serology for TTG invited to undergo upper endoscopy and duodenal biopsies to verify features of Gluten sensitivity according to Modified Marsh classification.A Control group done as a healthy blood donors who are symptom free of irritable bowel syndrome. Serum TTG IgA and IgA levels measured. Results: A 305 patients with IBS of mixed subtypes according to ROME 3 criteria recruited. Predominantly IBS with mixed features 293 patients (96 %), Demographic data to be presented in (table 1). There is 17 patients (5.6%) with positive TTG serology. Duodenal biopsies obtained for only 4 patients (2 patients of Marsh 0 and 2 patients of Marsh 3b classification respectively).There is statistically significant correlation between IBS with diarrhea predominant subtype,Age of the patient population and positive TTG-IgA. There is no significant association between the level of TTG IgA of the GS patients in the study and their modified marsh histological stage.Control group is 204 individuals , Males are 122 (24%).There is no statistically significant difference between the age and gender of the cases and control groups.Three Positive cases detected among the control group (Blood donors) 1.47 %.No IgA deficiencies detected. Conclusions: Gluten sensitivity is prevalent in IBS patients especially diarrhea predominant subtype in the area of the study as compared to the healthy control. Performing serological tests and duodenal biopsies for positive cases will aid in detecting a large group of undiagnosed celiac patients and hence would improve the overall management of irritable bowel syndrome.

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

Background Dysphagia is associated with depression and anxiety due to the severity, impact of sym... more Background Dysphagia is associated with depression and anxiety due to the severity, impact of symptoms itself or secondary to the underlying cause. This is more recognizable to brain diseases that has consequences common to the neural supply of the swallowing act and the cognition and behavior. Limited data are available to explore, quantitate and monitor these neurological outcomes. Our aim of this research to review the literature pertinent to depressive disorders, anxiety, and/or the quality of life (QoL) and psychological well-being. Search of Medline and Google Scholar databases for relevant articles had revealed a total of 1568 citations; 30 articles met the inclusion and exclusion criteria. Results Data about the direct effect of dysphagia on psychiatric aspects are limited. Studies of the relationship between severity of dysphagia and depressive symptoms demonstrated that several evaluation tools are available for objective and subjective assessment. The severity and progres...

American Journal of Gastroenterology

Supplemental material, sj-docx-1-cmg-10.1177_26317745211073411 for Therapeutic utility of percuta... more Supplemental material, sj-docx-1-cmg-10.1177_26317745211073411 for Therapeutic utility of percutaneous cecostomy in adults: an updated systematic review by Yasir Mohammed Khayyat in Therapeutic Advances in Gastrointestinal Endoscopy

Background: Dengue fever is prevalent in several areas in Saudi Arabia; however, information on t... more Background: Dengue fever is prevalent in several areas in Saudi Arabia; however, information on the prediction of disease severity and progression to liver failure is lacking. Aim: To identify the possible associations between liver chemistry and clinical presentation. Methods: This was a retrospective chart review of patients admitted to Al-Noor Specialist Hospital, a tertiary facility with a large referral area. We identified patients with the ICD-10 codes for dengue fever and dengue hemorrhagic fever. Data collected included liver chemistry and other blood work for secondary liver diseases. Statistical analysis involved descriptive data and correlation data analyzed using Mann-Whitney and KruskalWallis tests. Results: A total of 535 patients met the selection criteria. There were 388 male patients (72.5%), 512 with dengue fever (95.7%), 21(3.9%) with dengue hemorrhagic fever, and two (0.4%) with dengue shock syndrome. Gastrointestinal symptoms were predominant in 312 patients (58...

Journal of Umm Al-Qura University for Medical Sciences, 2020

Aim: To evaluate the association between symptomatic abdominal bloating among Saudi patients and ... more Aim: To evaluate the association between symptomatic abdominal bloating among Saudi patients and diagnosis of irritable bowel syndrome (IBS) and patient characteristics that may be affecting their perception of the symptom. Methods: Patients with IBS symptoms presenting to the Gastroenterology Clinic at the International Medical Centre (Jeddah, Saudi Arabia) between August 2013 and July 2016 were recruited using the ROME III criteria for IBS diagnosis. Bowel symptoms and abdominal bloating were collected for statistical comparison with the patient gender, age, and body mass index (BMI). Results: Among the total 305 patients who presented complaining of IBS symptoms, abdominal bloating was predominant, being reported by 257 (84.3%; 122 males and 135 females); the remaining patients either reported no experience of this symptom (n = 22) or no response (n=26). However, among the total patient population only 230 (75.4%) received an IBS subtype diagnosis that is statistically significan...

Therapeutic Advances in Gastrointestinal Endoscopy, 2022

Objective: Percutaneous cecostomy is a minimally invasive procedure that provides access to the c... more Objective: Percutaneous cecostomy is a minimally invasive procedure that provides access to the colon for therapeutic interventions. This review aimed to update and summarize the existing information on the use and application of percutaneous endoscopic cecostomy in the field of therapeutic gastroenterology. Data Sources: A systematic review of the literature was performed without any restrictions on the year of publication from the date of inception in 1986 to January 2021. Methods: The review was performed using the medical subject heading keywords in the following search engines: MEDLINE, EMBASE, Cochrane, and Google Scholar. Results: A total of 29 articles were subjected to final data extraction. The review included a total of 174 patients who underwent percutaneous cecostomy. Most of the included studies were conducted in the United States ( n = 14). The most common comorbidity was cancer ( n = 10) and the major indication for performing percutaneous cecostomy was colonic pseud...

American Journal of Gastroenterology, 2010

The American Journal of GASTROENTEROLOGY Abstracts S89 evaluated with enzyme-linked immunoassay. ... more The American Journal of GASTROENTEROLOGY Abstracts S89 evaluated with enzyme-linked immunoassay. Other studies included upper endoscopy with histological study for H. Pylori; abdominal ultrasound; complete biochemical panel; and hepatitis panel. Results: It was found that patients with chronic Helicobacter gastroduodenitis had relatively frequent changes in clinical and laboratory data, specifi cally increased liver echogenicity, wall thickness of extrahepatic biliary ducts and changes in hepatic transaminases. Most of the patients had a minimal to moderate elevation of transaminases. Majority of the patients (82.5 percent) had elevated levels of anti-Helicobacter IgG and 24.4 percent of the patients had elevated levels of anti-Helicobacter IgM. Total 44 percent of the patients had high anti-Helicobacter IgG levels with concomitant alanine aminotrasferase elevation. However, only a small number of patients with low anti-Helicobacter IgG levels (2.5 percent) had elevation of transminases. Non-specifi c ultrasound fi ndings included thickening of the gall bladder wall in 89.8 percent of the patients and common bile duct in 33.7 percent. About half of the patients with chronic Helicobacter gastroduodenitis had increased liver echogenicity and elevated specifi c IgG levels at the same time. Conclusion: Patients with chronic Helicobacter infection that was confi rmed by histological and immunological studies were found to have elevation of specifi c anti-Helicobacter IgG levels that were associated with ALT elevation and increased liver echogenicity as well as sonographic evidence of thickening of the gall bladder wall and extrahepatic bile ducts, indicating possible involvement of hepatobiliary system into the pathological process. Th ere is no clear explanation of these fi ndings, thus, subsequent larger studies are warranted in the future to explore the signifi cance of anti-Helicobacter spp. antibody levels or a role of particular enterohepatic Helicobacter sp. in the pathogenesis of chronic changes in the hepatobiliary system.

Qatar Medical Journal, 2014

Background: Screening for colon cancer aims at early detection and prompt treatment of the diseas... more Background: Screening for colon cancer aims at early detection and prompt treatment of the disease. Prior knowledge of the disease will contribute to increased participation. However, barriers to performing screening are not known. Methods: A survey using a questionnaire was presented to patients attending the Outpatient Department of a tertiary hospital in the Western Region of Saudi Arabia, to evaluate the background knowledge of colon cancer screening, the diagnostic methods used for that purpose, and the barriers that may resist the implementation of screening. Results: Six hundred and nineteen questionnaires were distributed. Completed questionnaires that were included in the final analysis numbered 321 (51.9%). Age and gender had no statistically significant association with increased awareness of screening options (p = 0.526 and p = 0.2). However, education played a significant role (p = 0.045). Among the group that agreed to undergo screening, there were 55.3% who were willi...

Case Reports in Internal Medicine, 2014

Colonoscopy is a daily procedure that has limited risk if carried out by skilled endoscopists. Un... more Colonoscopy is a daily procedure that has limited risk if carried out by skilled endoscopists. Unexpected turn of events during the procedure requires careful consideration of the patient's underlying medical or surgical history. Here, we present a case of inability to withdraw the colonoscope after the completion of distal colonic intubation owing to an overseen surgical defect related to inguinal hernia in which entrapment of the colonoscope took place.

Saudi Journal of Gastroenterology, 2012

Background/Aim: To identify the prevalence of gluten sensitivity in a healthy adult Saudi populat... more Background/Aim: To identify the prevalence of gluten sensitivity in a healthy adult Saudi population within a low endemic area of celiac disease using IgA tissue transglutaminase antibody. The study was conducted as a prospective pilot study for Saudi attendees of a blood donation centre at King Faisal Specialist Hospital & Research Centre in Jeddah, Saudi Arabia. Patients and Methods: Individuals were invited to participate in the study and screened for gluten sensitivity using immunoglobulin A tissue transglutaminase antibody (IgA TTG) along with serum IgA level. Descriptive data was presented and expressed as mean value; correlation between variables was estimated using Pearson correlation, and nonparametric data using Pearson rho correlation (level of P value <0.05 is considered to be statistically significant). Results: Two hundred and four individuals (122 males and 82 females, mean age 35 years) attending the blood donation centre were screened. Three individuals tested positive for IgA TTG showing normal IgA level (1 female and 2 males) with a 1.5% prevalence in the cohort. Conclusions: Positive celiac screening is present at a low prevalence rate in our adult population, in which the individuals' age and their serum IgA levels are not associated with the positivity level. A study on a larger scale with the application of histologic confirmation of positive cases is needed.

Hepatogastroenterology, 2012

To identify prevalent causes and determine survival rates of patients with portal vein thrombosis... more To identify prevalent causes and determine survival rates of patients with portal vein thrombosis (PVT) in the Western Saudi Arabia. Retrospective chart review of patients diagnosed with chronic liver disease and portal vein thrombosis in two major cities in Western Saudi Arabia during the period 2000-2009. Among 1349 patients screened, 109 patients met the inclusion criteria, 67 patients had acute PVT and 42 patients had chronic PVT. The relative risk of developing PVT is higher in males in whom acute PVT is 1.32 vs. 0.68 in females (95% CI: 090-1.94). Mean survival age of acute and chronic PVT (Kaplan-Meier) is 5.61 years (95% CI: 4.52-6.70). Univariate and multivariate regression analysis identified several variables in which international normalized ratio (INR) level on presentation was found to be a significant variable in survival. Mean survival for acute or chronic PVT is about five years. The first determination of INR level is a useful predictor of survival.

Emergency Medicine International, 2013

Background. Soft esophageal bolus impaction is an emergency that requires skilled endoscopic remo... more Background. Soft esophageal bolus impaction is an emergency that requires skilled endoscopic removal if persistent obstructive symptoms do not resolve spontaneously after careful observation. Expedited care of these patients is crucial to avoid respiratory and mechanical complications. Other possible options for management include medical agents used to manage it prior to performing endoscopy if access to endoscopy was not available or declined by the patient.Aim. To review the available pharmacological and other nonmedicinal options and their mechanism of relief for soft esophageal impaction.Method. Pubmed, Medline and Ovid were used for search of MESH terms pertinent including “foreign body, esophageal, esophageal bolus and medical” for pharmacological and non medicinial agents used for management of esophageal soft bolus impaction as well as manual review of the cross-references.Results. Several agents were identified including Buscopan, Glucagon, nitrates, calcium channel blocke...

Background: Screening for colon cancer aims at early detection and prompt treatment of the diseas... more Background: Screening for colon cancer aims at early detection and prompt treatment of the disease. Prior knowledge of the disease will contribute to increased participation. However, barriers to performing screening are not known. Methods: A survey using a questionnaire was presented to patients attending the Outpatient Department of a tertiary hospital in the Western Region of Saudi Arabia, to evaluate the background knowledge of colon cancer screening, the diagnostic methods used for that purpose, and the barriers that may resist the implementation of screening. Results: Six hundred and nineteen questionnaires were distributed. Completed questionnaires that were included in the final analysis numbered 321 (51.9%). Age and gender had no statistically significant association with increased awareness of screening options ( p 0.526 and p 0.2). However, education played a significant role (p 0.045). Among the group that agreed to undergo screening, there were 55.3 % who were willing t...

License, which permits unrestricted use, distribution, and reproduction in any medium, provided t... more License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. Soft esophageal bolus impaction is an emergency that requires skilled endoscopic removal if persistent obstructive symptoms do not resolve spontaneously after careful observation. Expedited care of these patients is crucial to avoid respiratory and mechanical complications. Other possible options for management include medical agents used to manage it prior to performing endoscopy if access to endoscopy was not available or declined by the patient. Aim. To review the available pharmacological and other nonmedicinal options and their mechanism of relief for soft esophageal impaction.Method. Pubmed,Medline andOvid were used for search of MESH terms pertinent including “foreign body, esophageal, esophageal bolus and medical ” for pharmacological and nonmedicinial agents used formanagement of esophageal soft bolus impaction aswell asmanual revi...

World Journal of Hepatology

Egyptian Liver Journal, 2021

Background The prevention of portal hypertensive complications, including upper gastrointestinal ... more Background The prevention of portal hypertensive complications, including upper gastrointestinal bleeding, is critically important and achieved only through the use of upper endoscopy for the management of oesophageal gastric varices (EGVs). There is a paucity of data and limited utilization of non-invasive predictive parameters to guide the selection of patients who may benefit from endoscopic surveillance, especially in cirrhotic patients with coexistent portal vein thrombosis. Results The study was conducted in eight hospitals in the western region of Saudi Arabia over the period of 2015–2017. Among 1349 chronic liver disease patients, eighty-five patients with complete endoscopic findings were included in the study. Twenty-eight patients were diagnosed with non-malignant PVT. Twenty-five patients (89%) developed oesophageal varices, compared with 57 patients with cirrhosis without PVT. A predictive factor for the development of oesophageal varices of statistical significance was...

Non‐alcoholic liver disease (NAFLD) is a metabolic liver disease associated with visceral adiposi... more Non‐alcoholic liver disease (NAFLD) is a metabolic liver disease associated with visceral adiposity and insulin resistance. Recently, NAFLD has been described in lean individuals who additionally have impaired metabolic parameters similar to their non‐lean counterparts. We aimed to explore this further in Saudi Arabia. From 2016 to 2019, we prospectively studied a group of newly diagnosed NAFLD patients at a tertiary hospital in Saudi Arabia. Patients were classified into three groups: lean (body mass index [BMI] <25), overweight (BMI ≥25 and <30), and obese (BMI ≥30). We made comparisons between these groups on basic clinical, demographic, and laboratory parameters. In total, 1753 patients were recruited and 1262 patients met the inclusion criteria. Altogether, 159 (12.6%), 365 (29%), and 737 (58.4%) patients were in the lean, overweight, and obese categories, respectively. Lean NAFLD patients were, on average, younger than those in the overweight group (mean 49.95 ± 15.3) an...

Current traditional medicine, Feb 27, 2024

Saudi Medical Journal

To examine the potential therapeutic effects of ursodeoxycholic acid (UDCA) on diseases of the es... more To examine the potential therapeutic effects of ursodeoxycholic acid (UDCA) on diseases of the esophagus, stomach, and duodenum. Methods: A search was conducted using EBSCO, Medline, PubMed, Google Scholar and Web of Science as well as international guidelines using MESH terms for treatment of UDCA for diseases of the upper gastrointestinal disorders in adult humans without regard to publication language or date restrictions. Results: A total of 256 articles and 22 guidelines were initially identified, and 221 were excluded. Final Systematic Review revision of 13 articles and 22 guidelines confirmed that UDCA is found to have a cytoprotective role in Barret's esophagus within esophageal disorders, improves abdominal pain in functional dyspepsia, and does not alter Helicobacter pylori colonization or inflammation. Conflicting results are noted regarding the role of UDCA in the duodenum as chemopreventive treatment for familial adenomatous polyposis, with polyps regressing and their growth characteristics improving with low doses (10-25 mg/ kg/day). On the contrary, no positive effect was noted upon the combination with Celecoxib and with doses of 1000-2000 mg or 20-30 mg/kg/d. Gastrointestinal side effects were predominantly reported. No side effects necessitated hospitalization or ICU admission. Conclusion: Ursodeoxycholic acid has a limited therapeutic role in functional dyspepsia. There is promising evidence that it may serve as a chemopreventive for Familial adenomatous polyposis and Barret's esophagus, although further research is needed to confirm these findings.

Journal of the Canadian Association of Gastroenterology, 2018

Background: Irritable bowel syndrome (IBS) is a common clinical problem in several age groups in ... more Background: Irritable bowel syndrome (IBS) is a common clinical problem in several age groups in Saudi Arabia ,reached about 9 % in adult students and up to 40 % in teachers .Effort is needed to correctly manage IBS and identify any coexistent condition that mimic the symptoms especially gluten sensitivity (GS). It is considered of low prevalence in Asian and Middle Eastern countries compared to high prevalent regions in Europe and North America. Aims: This prospective study aims to estimate the prevalence of different subtypes of IBS, celiac disease positive serology and possible association that may exist, in an area of high IBS diagnosis and relatively low prevalence of celiac disease. Methods: A Prospective study at a tertiary care private hospital at the western region of Saudi Arabia over the period of August 2013 to August 2016. Adults above the age of 15 year invited to participate in the study.ROME 3 criteria was used to identify and diagnose different subtypes of IBS as IBS-Pain ,IBS-constipation ,IBS-Diarrhea and IBS-Mixed. Basic demographic data collected. The patients filled questionnaire that outline questions related to these subtypes. Laboratory work included CBC, Electrolytes, urea, creatinine, TSH, Tissue transglutaminase antibody (TTG) Ig A and Ig G collected. Patients with Positive serology for TTG invited to undergo upper endoscopy and duodenal biopsies to verify features of Gluten sensitivity according to Modified Marsh classification.A Control group done as a healthy blood donors who are symptom free of irritable bowel syndrome. Serum TTG IgA and IgA levels measured. Results: A 305 patients with IBS of mixed subtypes according to ROME 3 criteria recruited. Predominantly IBS with mixed features 293 patients (96 %), Demographic data to be presented in (table 1). There is 17 patients (5.6%) with positive TTG serology. Duodenal biopsies obtained for only 4 patients (2 patients of Marsh 0 and 2 patients of Marsh 3b classification respectively).There is statistically significant correlation between IBS with diarrhea predominant subtype,Age of the patient population and positive TTG-IgA. There is no significant association between the level of TTG IgA of the GS patients in the study and their modified marsh histological stage.Control group is 204 individuals , Males are 122 (24%).There is no statistically significant difference between the age and gender of the cases and control groups.Three Positive cases detected among the control group (Blood donors) 1.47 %.No IgA deficiencies detected. Conclusions: Gluten sensitivity is prevalent in IBS patients especially diarrhea predominant subtype in the area of the study as compared to the healthy control. Performing serological tests and duodenal biopsies for positive cases will aid in detecting a large group of undiagnosed celiac patients and hence would improve the overall management of irritable bowel syndrome.

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

Background Dysphagia is associated with depression and anxiety due to the severity, impact of sym... more Background Dysphagia is associated with depression and anxiety due to the severity, impact of symptoms itself or secondary to the underlying cause. This is more recognizable to brain diseases that has consequences common to the neural supply of the swallowing act and the cognition and behavior. Limited data are available to explore, quantitate and monitor these neurological outcomes. Our aim of this research to review the literature pertinent to depressive disorders, anxiety, and/or the quality of life (QoL) and psychological well-being. Search of Medline and Google Scholar databases for relevant articles had revealed a total of 1568 citations; 30 articles met the inclusion and exclusion criteria. Results Data about the direct effect of dysphagia on psychiatric aspects are limited. Studies of the relationship between severity of dysphagia and depressive symptoms demonstrated that several evaluation tools are available for objective and subjective assessment. The severity and progres...

American Journal of Gastroenterology

Supplemental material, sj-docx-1-cmg-10.1177_26317745211073411 for Therapeutic utility of percuta... more Supplemental material, sj-docx-1-cmg-10.1177_26317745211073411 for Therapeutic utility of percutaneous cecostomy in adults: an updated systematic review by Yasir Mohammed Khayyat in Therapeutic Advances in Gastrointestinal Endoscopy

Background: Dengue fever is prevalent in several areas in Saudi Arabia; however, information on t... more Background: Dengue fever is prevalent in several areas in Saudi Arabia; however, information on the prediction of disease severity and progression to liver failure is lacking. Aim: To identify the possible associations between liver chemistry and clinical presentation. Methods: This was a retrospective chart review of patients admitted to Al-Noor Specialist Hospital, a tertiary facility with a large referral area. We identified patients with the ICD-10 codes for dengue fever and dengue hemorrhagic fever. Data collected included liver chemistry and other blood work for secondary liver diseases. Statistical analysis involved descriptive data and correlation data analyzed using Mann-Whitney and KruskalWallis tests. Results: A total of 535 patients met the selection criteria. There were 388 male patients (72.5%), 512 with dengue fever (95.7%), 21(3.9%) with dengue hemorrhagic fever, and two (0.4%) with dengue shock syndrome. Gastrointestinal symptoms were predominant in 312 patients (58...

Journal of Umm Al-Qura University for Medical Sciences, 2020

Aim: To evaluate the association between symptomatic abdominal bloating among Saudi patients and ... more Aim: To evaluate the association between symptomatic abdominal bloating among Saudi patients and diagnosis of irritable bowel syndrome (IBS) and patient characteristics that may be affecting their perception of the symptom. Methods: Patients with IBS symptoms presenting to the Gastroenterology Clinic at the International Medical Centre (Jeddah, Saudi Arabia) between August 2013 and July 2016 were recruited using the ROME III criteria for IBS diagnosis. Bowel symptoms and abdominal bloating were collected for statistical comparison with the patient gender, age, and body mass index (BMI). Results: Among the total 305 patients who presented complaining of IBS symptoms, abdominal bloating was predominant, being reported by 257 (84.3%; 122 males and 135 females); the remaining patients either reported no experience of this symptom (n = 22) or no response (n=26). However, among the total patient population only 230 (75.4%) received an IBS subtype diagnosis that is statistically significan...

Therapeutic Advances in Gastrointestinal Endoscopy, 2022

Objective: Percutaneous cecostomy is a minimally invasive procedure that provides access to the c... more Objective: Percutaneous cecostomy is a minimally invasive procedure that provides access to the colon for therapeutic interventions. This review aimed to update and summarize the existing information on the use and application of percutaneous endoscopic cecostomy in the field of therapeutic gastroenterology. Data Sources: A systematic review of the literature was performed without any restrictions on the year of publication from the date of inception in 1986 to January 2021. Methods: The review was performed using the medical subject heading keywords in the following search engines: MEDLINE, EMBASE, Cochrane, and Google Scholar. Results: A total of 29 articles were subjected to final data extraction. The review included a total of 174 patients who underwent percutaneous cecostomy. Most of the included studies were conducted in the United States ( n = 14). The most common comorbidity was cancer ( n = 10) and the major indication for performing percutaneous cecostomy was colonic pseud...

American Journal of Gastroenterology, 2010

The American Journal of GASTROENTEROLOGY Abstracts S89 evaluated with enzyme-linked immunoassay. ... more The American Journal of GASTROENTEROLOGY Abstracts S89 evaluated with enzyme-linked immunoassay. Other studies included upper endoscopy with histological study for H. Pylori; abdominal ultrasound; complete biochemical panel; and hepatitis panel. Results: It was found that patients with chronic Helicobacter gastroduodenitis had relatively frequent changes in clinical and laboratory data, specifi cally increased liver echogenicity, wall thickness of extrahepatic biliary ducts and changes in hepatic transaminases. Most of the patients had a minimal to moderate elevation of transaminases. Majority of the patients (82.5 percent) had elevated levels of anti-Helicobacter IgG and 24.4 percent of the patients had elevated levels of anti-Helicobacter IgM. Total 44 percent of the patients had high anti-Helicobacter IgG levels with concomitant alanine aminotrasferase elevation. However, only a small number of patients with low anti-Helicobacter IgG levels (2.5 percent) had elevation of transminases. Non-specifi c ultrasound fi ndings included thickening of the gall bladder wall in 89.8 percent of the patients and common bile duct in 33.7 percent. About half of the patients with chronic Helicobacter gastroduodenitis had increased liver echogenicity and elevated specifi c IgG levels at the same time. Conclusion: Patients with chronic Helicobacter infection that was confi rmed by histological and immunological studies were found to have elevation of specifi c anti-Helicobacter IgG levels that were associated with ALT elevation and increased liver echogenicity as well as sonographic evidence of thickening of the gall bladder wall and extrahepatic bile ducts, indicating possible involvement of hepatobiliary system into the pathological process. Th ere is no clear explanation of these fi ndings, thus, subsequent larger studies are warranted in the future to explore the signifi cance of anti-Helicobacter spp. antibody levels or a role of particular enterohepatic Helicobacter sp. in the pathogenesis of chronic changes in the hepatobiliary system.

Qatar Medical Journal, 2014

Background: Screening for colon cancer aims at early detection and prompt treatment of the diseas... more Background: Screening for colon cancer aims at early detection and prompt treatment of the disease. Prior knowledge of the disease will contribute to increased participation. However, barriers to performing screening are not known. Methods: A survey using a questionnaire was presented to patients attending the Outpatient Department of a tertiary hospital in the Western Region of Saudi Arabia, to evaluate the background knowledge of colon cancer screening, the diagnostic methods used for that purpose, and the barriers that may resist the implementation of screening. Results: Six hundred and nineteen questionnaires were distributed. Completed questionnaires that were included in the final analysis numbered 321 (51.9%). Age and gender had no statistically significant association with increased awareness of screening options (p = 0.526 and p = 0.2). However, education played a significant role (p = 0.045). Among the group that agreed to undergo screening, there were 55.3% who were willi...

Case Reports in Internal Medicine, 2014

Colonoscopy is a daily procedure that has limited risk if carried out by skilled endoscopists. Un... more Colonoscopy is a daily procedure that has limited risk if carried out by skilled endoscopists. Unexpected turn of events during the procedure requires careful consideration of the patient's underlying medical or surgical history. Here, we present a case of inability to withdraw the colonoscope after the completion of distal colonic intubation owing to an overseen surgical defect related to inguinal hernia in which entrapment of the colonoscope took place.

Saudi Journal of Gastroenterology, 2012

Background/Aim: To identify the prevalence of gluten sensitivity in a healthy adult Saudi populat... more Background/Aim: To identify the prevalence of gluten sensitivity in a healthy adult Saudi population within a low endemic area of celiac disease using IgA tissue transglutaminase antibody. The study was conducted as a prospective pilot study for Saudi attendees of a blood donation centre at King Faisal Specialist Hospital & Research Centre in Jeddah, Saudi Arabia. Patients and Methods: Individuals were invited to participate in the study and screened for gluten sensitivity using immunoglobulin A tissue transglutaminase antibody (IgA TTG) along with serum IgA level. Descriptive data was presented and expressed as mean value; correlation between variables was estimated using Pearson correlation, and nonparametric data using Pearson rho correlation (level of P value <0.05 is considered to be statistically significant). Results: Two hundred and four individuals (122 males and 82 females, mean age 35 years) attending the blood donation centre were screened. Three individuals tested positive for IgA TTG showing normal IgA level (1 female and 2 males) with a 1.5% prevalence in the cohort. Conclusions: Positive celiac screening is present at a low prevalence rate in our adult population, in which the individuals' age and their serum IgA levels are not associated with the positivity level. A study on a larger scale with the application of histologic confirmation of positive cases is needed.

Hepatogastroenterology, 2012

To identify prevalent causes and determine survival rates of patients with portal vein thrombosis... more To identify prevalent causes and determine survival rates of patients with portal vein thrombosis (PVT) in the Western Saudi Arabia. Retrospective chart review of patients diagnosed with chronic liver disease and portal vein thrombosis in two major cities in Western Saudi Arabia during the period 2000-2009. Among 1349 patients screened, 109 patients met the inclusion criteria, 67 patients had acute PVT and 42 patients had chronic PVT. The relative risk of developing PVT is higher in males in whom acute PVT is 1.32 vs. 0.68 in females (95% CI: 090-1.94). Mean survival age of acute and chronic PVT (Kaplan-Meier) is 5.61 years (95% CI: 4.52-6.70). Univariate and multivariate regression analysis identified several variables in which international normalized ratio (INR) level on presentation was found to be a significant variable in survival. Mean survival for acute or chronic PVT is about five years. The first determination of INR level is a useful predictor of survival.

Emergency Medicine International, 2013

Background. Soft esophageal bolus impaction is an emergency that requires skilled endoscopic remo... more Background. Soft esophageal bolus impaction is an emergency that requires skilled endoscopic removal if persistent obstructive symptoms do not resolve spontaneously after careful observation. Expedited care of these patients is crucial to avoid respiratory and mechanical complications. Other possible options for management include medical agents used to manage it prior to performing endoscopy if access to endoscopy was not available or declined by the patient.Aim. To review the available pharmacological and other nonmedicinal options and their mechanism of relief for soft esophageal impaction.Method. Pubmed, Medline and Ovid were used for search of MESH terms pertinent including “foreign body, esophageal, esophageal bolus and medical” for pharmacological and non medicinial agents used for management of esophageal soft bolus impaction as well as manual review of the cross-references.Results. Several agents were identified including Buscopan, Glucagon, nitrates, calcium channel blocke...

Background: Screening for colon cancer aims at early detection and prompt treatment of the diseas... more Background: Screening for colon cancer aims at early detection and prompt treatment of the disease. Prior knowledge of the disease will contribute to increased participation. However, barriers to performing screening are not known. Methods: A survey using a questionnaire was presented to patients attending the Outpatient Department of a tertiary hospital in the Western Region of Saudi Arabia, to evaluate the background knowledge of colon cancer screening, the diagnostic methods used for that purpose, and the barriers that may resist the implementation of screening. Results: Six hundred and nineteen questionnaires were distributed. Completed questionnaires that were included in the final analysis numbered 321 (51.9%). Age and gender had no statistically significant association with increased awareness of screening options ( p 0.526 and p 0.2). However, education played a significant role (p 0.045). Among the group that agreed to undergo screening, there were 55.3 % who were willing t...

License, which permits unrestricted use, distribution, and reproduction in any medium, provided t... more License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. Soft esophageal bolus impaction is an emergency that requires skilled endoscopic removal if persistent obstructive symptoms do not resolve spontaneously after careful observation. Expedited care of these patients is crucial to avoid respiratory and mechanical complications. Other possible options for management include medical agents used to manage it prior to performing endoscopy if access to endoscopy was not available or declined by the patient. Aim. To review the available pharmacological and other nonmedicinal options and their mechanism of relief for soft esophageal impaction.Method. Pubmed,Medline andOvid were used for search of MESH terms pertinent including “foreign body, esophageal, esophageal bolus and medical ” for pharmacological and nonmedicinial agents used formanagement of esophageal soft bolus impaction aswell asmanual revi...

World Journal of Hepatology

Egyptian Liver Journal, 2021

Background The prevention of portal hypertensive complications, including upper gastrointestinal ... more Background The prevention of portal hypertensive complications, including upper gastrointestinal bleeding, is critically important and achieved only through the use of upper endoscopy for the management of oesophageal gastric varices (EGVs). There is a paucity of data and limited utilization of non-invasive predictive parameters to guide the selection of patients who may benefit from endoscopic surveillance, especially in cirrhotic patients with coexistent portal vein thrombosis. Results The study was conducted in eight hospitals in the western region of Saudi Arabia over the period of 2015–2017. Among 1349 chronic liver disease patients, eighty-five patients with complete endoscopic findings were included in the study. Twenty-eight patients were diagnosed with non-malignant PVT. Twenty-five patients (89%) developed oesophageal varices, compared with 57 patients with cirrhosis without PVT. A predictive factor for the development of oesophageal varices of statistical significance was...

Non‐alcoholic liver disease (NAFLD) is a metabolic liver disease associated with visceral adiposi... more Non‐alcoholic liver disease (NAFLD) is a metabolic liver disease associated with visceral adiposity and insulin resistance. Recently, NAFLD has been described in lean individuals who additionally have impaired metabolic parameters similar to their non‐lean counterparts. We aimed to explore this further in Saudi Arabia. From 2016 to 2019, we prospectively studied a group of newly diagnosed NAFLD patients at a tertiary hospital in Saudi Arabia. Patients were classified into three groups: lean (body mass index [BMI] <25), overweight (BMI ≥25 and <30), and obese (BMI ≥30). We made comparisons between these groups on basic clinical, demographic, and laboratory parameters. In total, 1753 patients were recruited and 1262 patients met the inclusion criteria. Altogether, 159 (12.6%), 365 (29%), and 737 (58.4%) patients were in the lean, overweight, and obese categories, respectively. Lean NAFLD patients were, on average, younger than those in the overweight group (mean 49.95 ± 15.3) an...