Raul Eduardo Ovando Jurado | Universidad Rafael Landivar (original) (raw)
Address: Guatemala City, Departamento de Guatemala, Guatemala
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Papers by Raul Eduardo Ovando Jurado
Revista Argentina de Reumatología, 2016
La artritis reumatoidea incrementa el riesgo de muerte en pacientes que la padecen, ya sea por la... more La artritis reumatoidea incrementa el riesgo de muerte en pacientes que la padecen, ya sea por las comorbilidades como enfermedades cardiovasculares y las infecciones, como así también por una mayor frecuencia de desórdenes linfoproliferativos asociados a la enfermedad de base. Se presenta el caso de un paciente de sexo masculino de 74 años de edad, con artritis reumatoidea poliarticular y nodular de larga data. Tratado con DMARs, etanercept y abatacept con poca eficacia, por lo que inició rituximab con excelente respuesta, recibiendo luego como mantenimiento tofacitinib 5 mg/ día. En abril de este año presenta lesiones nodulares y eritematosas en ambos miembros inferiores que luego se necrotizan y esfacelan. Se suspende tratamiento inmunosupresor. Se indica biopsia de piel que muestra linfoma T cutáneo con compromiso dérmico e hipodérmico. Se inició quimioterapia CHOP pero luego del segundo ciclo el paciente presenta aplasia medular y fallece.
Arthritis & rheumatology (Hoboken, N.J.), Jan 12, 2018
Inhibitory receptors (IRs) are essential to regulate effector immune responses and may play criti... more Inhibitory receptors (IRs) are essential to regulate effector immune responses and may play critical roles during autoimmune diseases. In Rheumatoid Arthritis (RA), we evaluated whether IR expression on T cells showed correlation with immune activation, disease activity and response to treatment as well as if IR-mediated pathways were functional. By flow cytometry, we performed extensive phenotypic and functional evaluation of CD4 and CD8 T cells from blood and synovial fluid of RA patients ex vivo and after culture. All the parameters were correlated with disease activity score (DAS28) and response to treatment. In RA patients with low activation of T cells, IRs expression showed an inverse relationship with DAS28. Frequencies of T cells expressing multiple IRs were reduced in untreated RA patients but recovered normal levels in treated patients. RA patients that responded to treatment, showed augmented frequency of IRs-expressing T cells that correlated with reduced inflammatory c...
Revista De La Svr Sociedad Valenciana De Reumatologia, 2013
This document is part of a collection of programme evaluations available from Oxfam GB in accorda... more This document is part of a collection of programme evaluations available from Oxfam GB in accordance with its evaluation policy. This document was originally written for internal accountability and learning purposes, rather than for external publication. The information included was correct to the evaluator's best knowledge at the date the evaluation took place. The views expressed in this report are those of the author(s) and do not necessarily reflect Oxfam's views. The text may be used free of charge for the purposes of advocacy, campaigning, education, and research, provided that the source is acknowledged in full. The copyright holder requests that all such use be registered with them for impact assessment purposes. For copying in any other circumstances, or for reuse in other publications, or for translation or adaptation, permission must be secured and a fee may be charged.
Revista Argentina de Reumatología, 2016
La artritis reumatoidea incrementa el riesgo de muerte en pacientes que la padecen, ya sea por la... more La artritis reumatoidea incrementa el riesgo de muerte en pacientes que la padecen, ya sea por las comorbilidades como enfermedades cardiovasculares y las infecciones, como así también por una mayor frecuencia de desórdenes linfoproliferativos asociados a la enfermedad de base. Se presenta el caso de un paciente de sexo masculino de 74 años de edad, con artritis reumatoidea poliarticular y nodular de larga data. Tratado con DMARs, etanercept y abatacept con poca eficacia, por lo que inició rituximab con excelente respuesta, recibiendo luego como mantenimiento tofacitinib 5 mg/ día. En abril de este año presenta lesiones nodulares y eritematosas en ambos miembros inferiores que luego se necrotizan y esfacelan. Se suspende tratamiento inmunosupresor. Se indica biopsia de piel que muestra linfoma T cutáneo con compromiso dérmico e hipodérmico. Se inició quimioterapia CHOP pero luego del segundo ciclo el paciente presenta aplasia medular y fallece.
Arthritis & rheumatology (Hoboken, N.J.), Jan 12, 2018
Inhibitory receptors (IRs) are essential to regulate effector immune responses and may play criti... more Inhibitory receptors (IRs) are essential to regulate effector immune responses and may play critical roles during autoimmune diseases. In Rheumatoid Arthritis (RA), we evaluated whether IR expression on T cells showed correlation with immune activation, disease activity and response to treatment as well as if IR-mediated pathways were functional. By flow cytometry, we performed extensive phenotypic and functional evaluation of CD4 and CD8 T cells from blood and synovial fluid of RA patients ex vivo and after culture. All the parameters were correlated with disease activity score (DAS28) and response to treatment. In RA patients with low activation of T cells, IRs expression showed an inverse relationship with DAS28. Frequencies of T cells expressing multiple IRs were reduced in untreated RA patients but recovered normal levels in treated patients. RA patients that responded to treatment, showed augmented frequency of IRs-expressing T cells that correlated with reduced inflammatory c...
Revista De La Svr Sociedad Valenciana De Reumatologia, 2013
This document is part of a collection of programme evaluations available from Oxfam GB in accorda... more This document is part of a collection of programme evaluations available from Oxfam GB in accordance with its evaluation policy. This document was originally written for internal accountability and learning purposes, rather than for external publication. The information included was correct to the evaluator's best knowledge at the date the evaluation took place. The views expressed in this report are those of the author(s) and do not necessarily reflect Oxfam's views. The text may be used free of charge for the purposes of advocacy, campaigning, education, and research, provided that the source is acknowledged in full. The copyright holder requests that all such use be registered with them for impact assessment purposes. For copying in any other circumstances, or for reuse in other publications, or for translation or adaptation, permission must be secured and a fee may be charged.