Narsing Rao | University of Southern California (original) (raw)
Papers by Narsing Rao
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Ophthalmic Research, 1982
ABSTRACT
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Ophthalmic Research, 1987
The antioxidants sodium benzoate and 2,3-dihydroxybenzoic acid reduced the inflammatory response ... more The antioxidants sodium benzoate and 2,3-dihydroxybenzoic acid reduced the inflammatory response in experimental phacoanaphylactic endophthalmitis. The 2,3-dihydroxybenzoic acid was by far the more effective antiphlogistic agent. The molecular mechanisms that may have contributed to the observed difference in antiphlogistic activity are discussed.
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PubMed, 1983
Four patients with sympathetic ophthalmia (SO) simulating Vogt-Koyanagi-Harada disease (VKH) were... more Four patients with sympathetic ophthalmia (SO) simulating Vogt-Koyanagi-Harada disease (VKH) were studied. They all had penetrating wounds of the globe and developed bilateral uveitis, as well as two or more extraocular manifestations, e.g., vitiligo, poliosis, dysacousia and/or meningitis. Histopathologically, the enucleated globes revealed features that were identical to those observed in Harada's disease: mainly, a granulomatous choroiditis with formations of chorioretinal adhesions and migration of pigment into the disorganized retina. The study indicated that the only reliable feature that could differentiate SO from VHK disease was the history of a penetrating wound in the former and the absence of such trauma in the latter.
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American Journal of Ophthalmology, Oct 1, 2004
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Archives of Ophthalmology, Mar 1, 2000
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American Journal of Ophthalmology, Oct 1, 2008
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American Journal of Ophthalmology, Jun 1, 1993
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International Ophthalmology, 1992
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American Journal of Ophthalmology, Aug 1, 2005
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Ophthalmic Research, 1979
ABSTRACT
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Ophthalmic Research, 1982
Guinea pigs and mice after immunization with lens proteins were observed to develop a typical for... more Guinea pigs and mice after immunization with lens proteins were observed to develop a typical form of experimental phacoanaphylactic endophthalmitis after lens injury. Sensitization to lens protein elicited a good antibody response in rabbits, however no disease developed after lens injury. This is another example of frequent discrepancies between autoimmune responses and autoimmune disease and indicates the importance of investigating mechanisms of phlogogenicity in autoimmune disease.
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American Journal of Ophthalmology, Dec 1, 2001
To report a case of adenocarcinoma metastatic to the choroid with rupture through the Bruch membr... more To report a case of adenocarcinoma metastatic to the choroid with rupture through the Bruch membrane, thus, simulating a choroidal melanoma. Interventional case report. Evaluation in a university-based clinic, including a complete eye examination, fluorescein angiography, and ultrasonography; oncological evaluation; and eventual enucleation with histopathological study, including immunohistochemical stains. A 62-year-old Hispanic female presented with visual loss, right eye, of short duration because of a choroidal mass with retinal detachment. Ultrasonography showed a dome-shaped lesion with an eccentric collar-button projection and medium internal reflectivity, which suggested a choroidal melanoma. Initial systemic evaluation was negative. Severe pain necessitated enucleation, RE, and histopathology of the choroidal mass demonstrated an adenocarcinoma. Further examination revealed a left, upper lobe, nonsmall cell lung carcinoma. Metastatic choroidal tumors may present, although rarely, with collar-button configurations.
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Cornea, Apr 1, 1990
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Archives of Ophthalmology, Mar 1, 1987
Lens-induced granulomatous uveitis was produced in brown Norway rats. To determine the role of th... more Lens-induced granulomatous uveitis was produced in brown Norway rats. To determine the role of the lipoxygenase and cyclo-oxygenase products of arachidonic acid in the modulation of granulomatous uveitis, one group of experimental animals was treated with nafazatrom, while another group was treated with nordihydroguaiaretic acid (lipoxygenase inhibitors). Both resulted in significant attenuation of granulomatous inflammation, with reduced giant-cell infiltration into the choroid. In contrast, indomethacin (a cyclo-oxygenase inhibitor) therapy resulted in increased giant-cell formation. These findings suggest that the lipoxygenase and cyclo-oxygenase products of arachidonic acid play a role in the development of granulomatous uveitis and that such inflammation can be selectively suppressed by lipoxygenase inhibitors.
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Ophthalmology, Dec 1, 1994
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JAMA Ophthalmology, Jun 1, 2014
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Ophthalmic Research, 1979
The immunopathologic response of guinea pigs to sensitization with retinal ‘s’ antigen has a biph... more The immunopathologic response of guinea pigs to sensitization with retinal ‘s’ antigen has a biphasic character that is dose-dependent. At low dose levels, a non-necrotizing posterior segment inflammation is observed. At high dose levels an acute necrotizing panophthalmitis is observed. Complement depletion markedly modulates the inflammation observed following sensitization with high dose levels but appears to have no effect on
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Survey of Ophthalmology, Nov 1, 1987
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International Ophthalmology, Feb 1, 1982
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Bookmarks Related papers MentionsView impact
Ophthalmic Research, 1982
ABSTRACT
Bookmarks Related papers MentionsView impact
Ophthalmic Research, 1987
The antioxidants sodium benzoate and 2,3-dihydroxybenzoic acid reduced the inflammatory response ... more The antioxidants sodium benzoate and 2,3-dihydroxybenzoic acid reduced the inflammatory response in experimental phacoanaphylactic endophthalmitis. The 2,3-dihydroxybenzoic acid was by far the more effective antiphlogistic agent. The molecular mechanisms that may have contributed to the observed difference in antiphlogistic activity are discussed.
Bookmarks Related papers MentionsView impact
PubMed, 1983
Four patients with sympathetic ophthalmia (SO) simulating Vogt-Koyanagi-Harada disease (VKH) were... more Four patients with sympathetic ophthalmia (SO) simulating Vogt-Koyanagi-Harada disease (VKH) were studied. They all had penetrating wounds of the globe and developed bilateral uveitis, as well as two or more extraocular manifestations, e.g., vitiligo, poliosis, dysacousia and/or meningitis. Histopathologically, the enucleated globes revealed features that were identical to those observed in Harada's disease: mainly, a granulomatous choroiditis with formations of chorioretinal adhesions and migration of pigment into the disorganized retina. The study indicated that the only reliable feature that could differentiate SO from VHK disease was the history of a penetrating wound in the former and the absence of such trauma in the latter.
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American Journal of Ophthalmology, Oct 1, 2004
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Archives of Ophthalmology, Mar 1, 2000
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American Journal of Ophthalmology, Oct 1, 2008
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American Journal of Ophthalmology, Jun 1, 1993
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International Ophthalmology, 1992
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American Journal of Ophthalmology, Aug 1, 2005
Bookmarks Related papers MentionsView impact
Ophthalmic Research, 1979
ABSTRACT
Bookmarks Related papers MentionsView impact
Ophthalmic Research, 1982
Guinea pigs and mice after immunization with lens proteins were observed to develop a typical for... more Guinea pigs and mice after immunization with lens proteins were observed to develop a typical form of experimental phacoanaphylactic endophthalmitis after lens injury. Sensitization to lens protein elicited a good antibody response in rabbits, however no disease developed after lens injury. This is another example of frequent discrepancies between autoimmune responses and autoimmune disease and indicates the importance of investigating mechanisms of phlogogenicity in autoimmune disease.
Bookmarks Related papers MentionsView impact
American Journal of Ophthalmology, Dec 1, 2001
To report a case of adenocarcinoma metastatic to the choroid with rupture through the Bruch membr... more To report a case of adenocarcinoma metastatic to the choroid with rupture through the Bruch membrane, thus, simulating a choroidal melanoma. Interventional case report. Evaluation in a university-based clinic, including a complete eye examination, fluorescein angiography, and ultrasonography; oncological evaluation; and eventual enucleation with histopathological study, including immunohistochemical stains. A 62-year-old Hispanic female presented with visual loss, right eye, of short duration because of a choroidal mass with retinal detachment. Ultrasonography showed a dome-shaped lesion with an eccentric collar-button projection and medium internal reflectivity, which suggested a choroidal melanoma. Initial systemic evaluation was negative. Severe pain necessitated enucleation, RE, and histopathology of the choroidal mass demonstrated an adenocarcinoma. Further examination revealed a left, upper lobe, nonsmall cell lung carcinoma. Metastatic choroidal tumors may present, although rarely, with collar-button configurations.
Bookmarks Related papers MentionsView impact
Cornea, Apr 1, 1990
Bookmarks Related papers MentionsView impact
Archives of Ophthalmology, Mar 1, 1987
Lens-induced granulomatous uveitis was produced in brown Norway rats. To determine the role of th... more Lens-induced granulomatous uveitis was produced in brown Norway rats. To determine the role of the lipoxygenase and cyclo-oxygenase products of arachidonic acid in the modulation of granulomatous uveitis, one group of experimental animals was treated with nafazatrom, while another group was treated with nordihydroguaiaretic acid (lipoxygenase inhibitors). Both resulted in significant attenuation of granulomatous inflammation, with reduced giant-cell infiltration into the choroid. In contrast, indomethacin (a cyclo-oxygenase inhibitor) therapy resulted in increased giant-cell formation. These findings suggest that the lipoxygenase and cyclo-oxygenase products of arachidonic acid play a role in the development of granulomatous uveitis and that such inflammation can be selectively suppressed by lipoxygenase inhibitors.
Bookmarks Related papers MentionsView impact
Ophthalmology, Dec 1, 1994
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JAMA Ophthalmology, Jun 1, 2014
Bookmarks Related papers MentionsView impact
Ophthalmic Research, 1979
The immunopathologic response of guinea pigs to sensitization with retinal ‘s’ antigen has a biph... more The immunopathologic response of guinea pigs to sensitization with retinal ‘s’ antigen has a biphasic character that is dose-dependent. At low dose levels, a non-necrotizing posterior segment inflammation is observed. At high dose levels an acute necrotizing panophthalmitis is observed. Complement depletion markedly modulates the inflammation observed following sensitization with high dose levels but appears to have no effect on
Bookmarks Related papers MentionsView impact
Survey of Ophthalmology, Nov 1, 1987
Bookmarks Related papers MentionsView impact
International Ophthalmology, Feb 1, 1982
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