Guilherme A Marson | Universidade de São Paulo (original) (raw)
Papers by Guilherme A Marson
Journal of Visualized Experiments, 2024
We present a method for real-time recording of human interaction with three-dimensional (3D) virt... more We present a method for real-time recording of human interaction with three-dimensional (3D) virtual objects. The approach consists of associating rotation data of the manipulated object with behavioral measures, such as eye tracking, to make better inferences about the underlying cognitive processes. The task consists of displaying two identical models of the same 3D object (a molecule), presented on a computer screen: a rotating, interactive object (iObj) and a static, target object (tObj). Participants must rotate iObj using the mouse until they consider its orientation to be identical to that of tObj. The computer tracks all interaction data in real time. The participant's gaze data are also recorded using an eye tracker. The measurement frequency is 10 Hz on the computer and 60 Hz on the eye tracker. The orientation data of iObj with respect to tObj are recorded in rotation quaternions. The gaze data are synchronized to the orientation of iObj and referenced using this same system. This method enables us to obtain the following visualizations of the human interaction process with iObj and tObj: (1) angular disparity synchronized with other time-dependent data; (2) 3D rotation trajectory inside what we decided to call a "ball of rotations"; (3) 3D fixation heatmap. All steps of the protocol have used free software, such as GNU Octave and Jmol, and all scripts are available as supplementary material. With this approach, we can conduct detailed quantitative studies of the task-solving process involving mental or physical rotations, rather than only the outcome reached. It is possible to measure precisely how important each part of the 3D models is for the participant in solving tasks, and thus relate the models to relevant variables such as the characteristics of the objects, cognitive abilities of the individuals, and the characteristics of human-machine interface.
DOAJ (DOAJ: Directory of Open Access Journals), 2007
This work focuses on the approach of the EuroVacc e-learning core-team, an interdisciplinary work... more This work focuses on the approach of the EuroVacc e-learning core-team, an interdisciplinary workgroup dedicated to the development of e-learning projects in the medical fields. The group is running three major projects: Immunology Online (IOL), OCTAVE (Online Collaborative Training for AIDS Vaccine Evaluation) and OOL (Oncology Online). IOL is a web-based curriculum that draws expertise from the five Swiss medical faculties and targets medical and graduate students. IOL employs a “blended learning” strategy (face-to-face and e-learning) as an alternative to traditional lectures. OCTAVE is a pilot e-learning program initiated by EuroVacc and the HIV Vaccine Trials Network to deliver training in priority areas such as good clinical and laboratory practices, HIV pathogenesis and vaccinology. OCTAVE targets the need for on-site, face-toface training visits (i.e. training in laboratory methods). Oncology Online aims at integrating clinical and molecular aspects of cancer. IOL, OCTAVE and OOL are hosted by the Bio-med platform (www.bio-med.ch) of the Swiss Virtual Campus program. The platform scaffolds a Learning Management System for creation, updating, revision and delivery of web content. It supports an active and flexible e-learning environment, tailored to the needs of a diverse clientele. Our approach has been tested in multiple contexts, namely problem based learning, article based learning, lectures and, more recently, protocol-based learning. Each project counts with the commitment of experts from a variety of collaborating organizations, whom provide relevant material in basic and applied biomedical sciences.
Journal of Biochemistry Education, Nov 20, 2016
Supported by: CAPES INTRODUCTION: This work presents the following guidelines for developing inte... more Supported by: CAPES INTRODUCTION: This work presents the following guidelines for developing interactive learning objects on the 3D biomolecules: i-identify a relevant educational need; ii-select an appropriate subject; iii-employ interactive 3D molecular structures; iv-simultaneously display animation with related textual information or 2D diagrams; vintegrating different modes of representation of chemical phenomena. Based on these, was constructed the "Photolyase Tutorial". Photolyase is an enzyme that repairs DNA. It recognizes the cyclobutane pyrimidine dimer lesion (CPD) caused by exposure to ultraviolet light. Understanding the repair mechanism requires understanding the structure-activity relationships of the molecules involved. Therefore, this topic is a convenient subject for teaching key aspects of the structure of protein and nucleic acids. There are few interactive 3D DNA repair tutorials available and most of these are in english, therefore not acessible for students that do not domain this language. Besides, these tutorials generally focus only on displaying structural features without make foster correlations between the structure and chemical aspects of repair mechanisms. OBJECTIVES: In order to construct a interactive tutorial that fills these gaps, the 3D structures of a DNA molecule, a DNA with CPD lesion and the photolyase enzyme were manipulated focusing on structural and chemical explanation. MATERIALS AND METHODS: These structures were obtained from PDB (http://www.rcsb.org/pdb/home/home.do) and manipulated to show biochemical and chemical concepts by using the resources from the LABIQ Platform (http://labiq.is.usp.br). DISCUSSION AND RESULTS: Several concepts are covered, i.e., H-bonding, active site, co-factors etc. The tutorial is organized in small conceptual blocks presenting, in a stepwise fashion, how the enzyme recognizes the DNA lesion and proceeds to repair. Each block comprises a trigger button that controls the interactive molecular viewer from the short text information or 2D diagram. CONCLUSION: This way, we developed a interactive tutorial that combines different modes of representation of chemical and structural concepts of biomolecules in a single interface.
Journal of Biochemistry Education, May 18, 2002
of the panel presented at the SBBq annual meeting (see attachament).
Anais do XII EPPEQ, 2023
Com o intuito de enfrentar a crescente produção e circulação de desinformação e se adaptar ao con... more Com o intuito de enfrentar a crescente produção e circulação de desinformação e se adaptar ao contexto da pandemia, no ano de 2020 a disciplina obrigatória do curso de licenciatura em química do Instituto de Química da USP, Instrumentação para o Ensino de Química II (QFL 1703) passou por importantes mudanças. A principal delas foi a criação de um curso de extensão, o Lab Vivo, ministrado pelos licenciandos a estudantes de ensino médio de escola pública. Nele discute-se uma peça de desinformação. A análise dos dados da última aplicação do curso parece indicar sucesso do mesmo na promoção de literacia científica e midiática e na mediação entre desinformação e conhecimento científico.
Química Nova, 2013
offer free quality content for broad audiences. QNInt provides peer-reviewed articles from SBQ jo... more offer free quality content for broad audiences. QNInt provides peer-reviewed articles from SBQ journals on science & society, chemical concepts, classroom activities and educational research. With 3,000,000 visits, QNInt also offers a unique library of interactive molecules. In the International Year of Chemistry QNInt served for distributing pH kits and registering data from IUPAC´s Global Water Experiment, yielding Brazil the largest share of the global pH data set. The portal performance makes QNInt a valuable resource for connecting science to education.
Journal of Chemical Education, Oct 5, 2011
This work presents a convenient framework for developing interactive chemical education software ... more This work presents a convenient framework for developing interactive chemical education software to facilitate the integration of macroscopic, microscopic, and symbolic dimensions of chemical concepts-specifically, via the development of software for gel permeation chromatography. The instructional role of the software was evaluated in a study involving 237 undergraduates. The results suggest that the software fostered transition from lower-to higher-order cognitive reasoning. Common misconceptions regarding microscopic phenomena were also detected and addressed.
Journal of Biochemistry Education, Oct 10, 2017
The tutorial "DNA Structure and Stability" was developed articulating Ausubel's Theory of Meaning... more The tutorial "DNA Structure and Stability" was developed articulating Ausubel's Theory of Meaningful Learning and Mayer's Multimedia principles, in order to favor the DNA structure significant learning through the guided and gradual exploration of the DNA three-dimensional structure interactive animations. In this sense, conceptual units with auxiliary medias have been established, such as texts, diagrams and tables, which assist in the explanation of animations. Several chemical and biochemical concepts are explained in order to favor understanding of DNA as a biopolymer determined by its intra/intermolecular chemical interactions that consequently establish the structure/stability relationships and structure/biological activity. In this way, was developed an interactive tutorial that can be used in several teaching and learning situations in order to favor the construction of knowledge by the learner.
Em primeiro lugar, agradeço, ao Prof. Dr. Bayardo B. Torres, pela mais nca experiência acadêmica ... more Em primeiro lugar, agradeço, ao Prof. Dr. Bayardo B. Torres, pela mais nca experiência acadêmica que já vivi. É um privilégio tê-lo como orientador.
Fundação Carlos Chagas eBooks, 2021
Journal of Biochemistry Education, May 19, 2001
of the panel presented at the SBBq annual meeting (see attachament).
Journal of Biochemistry Education, May 18, 2002
of the panel presented at the SBBq annual meeting (see attachament).
DOAJ (DOAJ: Directory of Open Access Journals), 2013
The Quimica Nova Interativa (QNInt) portal was launched in 2009 by the Brazilian Chemical Society... more The Quimica Nova Interativa (QNInt) portal was launched in 2009 by the Brazilian Chemical Society (SBQ) to offer free quality content for broad audiences. QNInt provides peer-reviewed articles from SBQ journals on science & society, chemical concepts, classroom activities and educational research. With 3,000,000 visits, QNInt also offers a unique library of interactive molecules. In the International Year of Chemistry QNInt served for distributing pH kits and registering data from IUPAC's Global Water Experiment, yielding Brazil the largest share of the global pH data set. The portal performance makes QNInt a valuable resource for connecting science to education.
Journal of Visualized Experiments, 2024
We present a method for real-time recording of human interaction with three-dimensional (3D) virt... more We present a method for real-time recording of human interaction with three-dimensional (3D) virtual objects. The approach consists of associating rotation data of the manipulated object with behavioral measures, such as eye tracking, to make better inferences about the underlying cognitive processes. The task consists of displaying two identical models of the same 3D object (a molecule), presented on a computer screen: a rotating, interactive object (iObj) and a static, target object (tObj). Participants must rotate iObj using the mouse until they consider its orientation to be identical to that of tObj. The computer tracks all interaction data in real time. The participant's gaze data are also recorded using an eye tracker. The measurement frequency is 10 Hz on the computer and 60 Hz on the eye tracker. The orientation data of iObj with respect to tObj are recorded in rotation quaternions. The gaze data are synchronized to the orientation of iObj and referenced using this same system. This method enables us to obtain the following visualizations of the human interaction process with iObj and tObj: (1) angular disparity synchronized with other time-dependent data; (2) 3D rotation trajectory inside what we decided to call a "ball of rotations"; (3) 3D fixation heatmap. All steps of the protocol have used free software, such as GNU Octave and Jmol, and all scripts are available as supplementary material. With this approach, we can conduct detailed quantitative studies of the task-solving process involving mental or physical rotations, rather than only the outcome reached. It is possible to measure precisely how important each part of the 3D models is for the participant in solving tasks, and thus relate the models to relevant variables such as the characteristics of the objects, cognitive abilities of the individuals, and the characteristics of human-machine interface.
DOAJ (DOAJ: Directory of Open Access Journals), 2007
This work focuses on the approach of the EuroVacc e-learning core-team, an interdisciplinary work... more This work focuses on the approach of the EuroVacc e-learning core-team, an interdisciplinary workgroup dedicated to the development of e-learning projects in the medical fields. The group is running three major projects: Immunology Online (IOL), OCTAVE (Online Collaborative Training for AIDS Vaccine Evaluation) and OOL (Oncology Online). IOL is a web-based curriculum that draws expertise from the five Swiss medical faculties and targets medical and graduate students. IOL employs a “blended learning” strategy (face-to-face and e-learning) as an alternative to traditional lectures. OCTAVE is a pilot e-learning program initiated by EuroVacc and the HIV Vaccine Trials Network to deliver training in priority areas such as good clinical and laboratory practices, HIV pathogenesis and vaccinology. OCTAVE targets the need for on-site, face-toface training visits (i.e. training in laboratory methods). Oncology Online aims at integrating clinical and molecular aspects of cancer. IOL, OCTAVE and OOL are hosted by the Bio-med platform (www.bio-med.ch) of the Swiss Virtual Campus program. The platform scaffolds a Learning Management System for creation, updating, revision and delivery of web content. It supports an active and flexible e-learning environment, tailored to the needs of a diverse clientele. Our approach has been tested in multiple contexts, namely problem based learning, article based learning, lectures and, more recently, protocol-based learning. Each project counts with the commitment of experts from a variety of collaborating organizations, whom provide relevant material in basic and applied biomedical sciences.
Journal of Biochemistry Education, Nov 20, 2016
Supported by: CAPES INTRODUCTION: This work presents the following guidelines for developing inte... more Supported by: CAPES INTRODUCTION: This work presents the following guidelines for developing interactive learning objects on the 3D biomolecules: i-identify a relevant educational need; ii-select an appropriate subject; iii-employ interactive 3D molecular structures; iv-simultaneously display animation with related textual information or 2D diagrams; vintegrating different modes of representation of chemical phenomena. Based on these, was constructed the "Photolyase Tutorial". Photolyase is an enzyme that repairs DNA. It recognizes the cyclobutane pyrimidine dimer lesion (CPD) caused by exposure to ultraviolet light. Understanding the repair mechanism requires understanding the structure-activity relationships of the molecules involved. Therefore, this topic is a convenient subject for teaching key aspects of the structure of protein and nucleic acids. There are few interactive 3D DNA repair tutorials available and most of these are in english, therefore not acessible for students that do not domain this language. Besides, these tutorials generally focus only on displaying structural features without make foster correlations between the structure and chemical aspects of repair mechanisms. OBJECTIVES: In order to construct a interactive tutorial that fills these gaps, the 3D structures of a DNA molecule, a DNA with CPD lesion and the photolyase enzyme were manipulated focusing on structural and chemical explanation. MATERIALS AND METHODS: These structures were obtained from PDB (http://www.rcsb.org/pdb/home/home.do) and manipulated to show biochemical and chemical concepts by using the resources from the LABIQ Platform (http://labiq.is.usp.br). DISCUSSION AND RESULTS: Several concepts are covered, i.e., H-bonding, active site, co-factors etc. The tutorial is organized in small conceptual blocks presenting, in a stepwise fashion, how the enzyme recognizes the DNA lesion and proceeds to repair. Each block comprises a trigger button that controls the interactive molecular viewer from the short text information or 2D diagram. CONCLUSION: This way, we developed a interactive tutorial that combines different modes of representation of chemical and structural concepts of biomolecules in a single interface.
Journal of Biochemistry Education, May 18, 2002
of the panel presented at the SBBq annual meeting (see attachament).
Anais do XII EPPEQ, 2023
Com o intuito de enfrentar a crescente produção e circulação de desinformação e se adaptar ao con... more Com o intuito de enfrentar a crescente produção e circulação de desinformação e se adaptar ao contexto da pandemia, no ano de 2020 a disciplina obrigatória do curso de licenciatura em química do Instituto de Química da USP, Instrumentação para o Ensino de Química II (QFL 1703) passou por importantes mudanças. A principal delas foi a criação de um curso de extensão, o Lab Vivo, ministrado pelos licenciandos a estudantes de ensino médio de escola pública. Nele discute-se uma peça de desinformação. A análise dos dados da última aplicação do curso parece indicar sucesso do mesmo na promoção de literacia científica e midiática e na mediação entre desinformação e conhecimento científico.
Química Nova, 2013
offer free quality content for broad audiences. QNInt provides peer-reviewed articles from SBQ jo... more offer free quality content for broad audiences. QNInt provides peer-reviewed articles from SBQ journals on science & society, chemical concepts, classroom activities and educational research. With 3,000,000 visits, QNInt also offers a unique library of interactive molecules. In the International Year of Chemistry QNInt served for distributing pH kits and registering data from IUPAC´s Global Water Experiment, yielding Brazil the largest share of the global pH data set. The portal performance makes QNInt a valuable resource for connecting science to education.
Journal of Chemical Education, Oct 5, 2011
This work presents a convenient framework for developing interactive chemical education software ... more This work presents a convenient framework for developing interactive chemical education software to facilitate the integration of macroscopic, microscopic, and symbolic dimensions of chemical concepts-specifically, via the development of software for gel permeation chromatography. The instructional role of the software was evaluated in a study involving 237 undergraduates. The results suggest that the software fostered transition from lower-to higher-order cognitive reasoning. Common misconceptions regarding microscopic phenomena were also detected and addressed.
Journal of Biochemistry Education, Oct 10, 2017
The tutorial "DNA Structure and Stability" was developed articulating Ausubel's Theory of Meaning... more The tutorial "DNA Structure and Stability" was developed articulating Ausubel's Theory of Meaningful Learning and Mayer's Multimedia principles, in order to favor the DNA structure significant learning through the guided and gradual exploration of the DNA three-dimensional structure interactive animations. In this sense, conceptual units with auxiliary medias have been established, such as texts, diagrams and tables, which assist in the explanation of animations. Several chemical and biochemical concepts are explained in order to favor understanding of DNA as a biopolymer determined by its intra/intermolecular chemical interactions that consequently establish the structure/stability relationships and structure/biological activity. In this way, was developed an interactive tutorial that can be used in several teaching and learning situations in order to favor the construction of knowledge by the learner.
Em primeiro lugar, agradeço, ao Prof. Dr. Bayardo B. Torres, pela mais nca experiência acadêmica ... more Em primeiro lugar, agradeço, ao Prof. Dr. Bayardo B. Torres, pela mais nca experiência acadêmica que já vivi. É um privilégio tê-lo como orientador.
Fundação Carlos Chagas eBooks, 2021
Journal of Biochemistry Education, May 19, 2001
of the panel presented at the SBBq annual meeting (see attachament).
Journal of Biochemistry Education, May 18, 2002
of the panel presented at the SBBq annual meeting (see attachament).
DOAJ (DOAJ: Directory of Open Access Journals), 2013
The Quimica Nova Interativa (QNInt) portal was launched in 2009 by the Brazilian Chemical Society... more The Quimica Nova Interativa (QNInt) portal was launched in 2009 by the Brazilian Chemical Society (SBQ) to offer free quality content for broad audiences. QNInt provides peer-reviewed articles from SBQ journals on science & society, chemical concepts, classroom activities and educational research. With 3,000,000 visits, QNInt also offers a unique library of interactive molecules. In the International Year of Chemistry QNInt served for distributing pH kits and registering data from IUPAC's Global Water Experiment, yielding Brazil the largest share of the global pH data set. The portal performance makes QNInt a valuable resource for connecting science to education.