Joaquim Mauricio Da Motta Leal Filho | Universidade de São Paulo (original) (raw)
Papers by Joaquim Mauricio Da Motta Leal Filho
Este volume da série INRAD casos clínicos é a continuação do projeto, que divulga e auxilia na fo... more Este volume da série INRAD casos clínicos é a continuação do projeto, que divulga e auxilia na formação dos profissionais da área radiológica. Foi mantido o formato com base na coletânea de casos proveitosos do ponto de vista didático, que acrescentam muito à vivência radiológica. Cada caso é apresentado sob a forma de uma história clínica acompanhada das principais imagens do caso que, em um segundo momento, são discutidas por especialistas na área. A elaboração do livro contou com a participação da equipe médica do instituto de radiologia.
Physiological reports, 2014
Several techniques to induce renal ischemia have been proposed: clamp, PVA particles, and cathete... more Several techniques to induce renal ischemia have been proposed: clamp, PVA particles, and catheter-balloon. We report the development of a controlled, single-insult model of unilateral renal ischemia/reperfusion (I/R) without contralateral nephrectomy, using a suitable model, the pig. This is a ballooncatheter-based model using a percutaneous, interventional radiology procedure. One angioplasty balloon-catheter was placed into the right renal artery and inflated for 120 min and reperfusion over 24 h. Serial serums were sampled from the inferior vena cava and urine was directly sampled from the bladder throughout the experiment, and both kidneys were excised after 24 h of reperfusion. Analyses of renal structure and function were performed by hematoxylin-eosin/periodic Acid-Schiff, serum creatinine (SCr), blood urea nitrogen (BUN), fractional excretion of ions, and glucose, SDS-PAGE analysis of urinary proteins, and serum neutrophil gelatinase-associated lipocalin (NGAL). Total nitrated protein was quantified to characterize oxidative stress. Acute tubular necrosis (ATN) was identified in every animal, but only two animals showed levels of SCr above 150% of baseline values. As expected, I/R increased SCr and BUN. Fractional sodium, potassium, chloride, and bicarbonate excretion were modulated during ischemia. Serum-nitrated proteins and NGAL had two profiles: decreased with ischemia and increased after reperfusion. This decline was associated with increased protein excretion during ischemia and early reperfusion. Altogether, these data show that the renal I/R model can be performed by percutaneous approach in the swine model. This is a suitable translational model to study new early renal ischemic biomarkers and pathophysiological mechanisms in renal ischemia.
CardioVascular and Interventional Radiology, 2015
To report a novel modified occlusion balloon technique to treat biliary leaks. A 22-year-old fema... more To report a novel modified occlusion balloon technique to treat biliary leaks. A 22-year-old female patient underwent liver transplantation with biliary-enteric anastomosis. She developed thrombosis of the common hepatic artery and extensive ischemia in the left hepatic lobe. Resection of segments II and III was performed and a biliary-cutaneous leak originating at the resection plane was identified in the early postoperative period. Initial treatment with percutaneous transhepatic drainage was unsuccessful. Therefore, an angioplasty balloon was coaxially inserted within the biliary drain and positioned close to the leak. The fistula output abruptly decreased after the procedure and stopped on the 7th day. At the 3-week follow-up, cholangiography revealed complete resolution of the leakage. This novel modified occlusion balloon technique was effective and safe. However, greater experience and more cases are necessary to validate the technique.
GED - Gastrenterologia Endoscopia Digestiva
Pediatr. mod, 2002
Base de dados : LILACS. Pesquisa : 501320 [Identificador único]. Referências encontradas : 1 [ref... more Base de dados : LILACS. Pesquisa : 501320 [Identificador único]. Referências encontradas : 1 [refinar]. Mostrando: 1 .. 1 no formato [Detalhado]. página 1 de 1, 1 / 1, LILACS, seleciona. para imprimir. Fotocópia. Texto completo. experimental, Documentos relacionados. ...
Purpose To report a novel modified occlusion balloon technique to treat biliary leaks. Methods A ... more Purpose To report a novel modified occlusion balloon
technique to treat biliary leaks.
Methods A 22-year-old female patient underwent liver
transplantation with biliary-enteric anastomosis. She
developed thrombosis of the common hepatic artery and
extensive ischemia in the left hepatic lobe. Resection of
segments II and III was performed and a biliary-cutaneous
leak originating at the resection plane was identified in the
early postoperative period. Initial treatment with percutaneous
transhepatic drainage was unsuccessful. Therefore,
an angioplasty balloon was coaxially inserted within the
biliary drain and positioned close to the leak.
Results The fistula output abruptly decreased after the
procedure and stopped on the 7th day. At the 3-week follow-up,
cholangiography revealed complete resolution of
the leakage.
Conclusion This novel modified occlusion balloon technique
was effective and safe. However, greater experience
and more cases are necessary to validate the technique.
Vascular medicine (London, England), Jan 24, 2015
The purpose of this study is to describe 10 cases of symptomatic isolated spontaneous celiac trun... more The purpose of this study is to describe 10 cases of symptomatic isolated spontaneous celiac trunk dissection (ISCTD) in order to evaluate the initial clinical presentation, diagnosis, treatment modalities and outcomes. A retrospective search was performed from 2009 to 2014 and 10 patients with ISCTD were included in the study. Patients with associated aortic and/or other visceral artery dissection were excluded. The following information was collected from each case: sex, age, associated risk factors, symptoms, diagnostic method, anatomic dissection pattern, treatment modality and outcome. Most patients were male (90%), with an average age of 44.8 years, and the most common symptom was abdominal pain (100%). Hypertension and vasculitis (polyarteritis nodosa) were the most frequent risk factors (40% and 30%, respectively). Diagnosis was made in all patients with computed tomography. Dissection was limited to the celiac trunk in three patients and extended to celiac branches in the o...
ABSTRACT Este livro aborda os seguintes temas: - generalidades em infectologia; - síndromes infec... more ABSTRACT Este livro aborda os seguintes temas: - generalidades em infectologia; - síndromes infecciosas; - doenças causadas por vírus; - doenças causadas por bactérias; - doenças causadas por protozoários; - doenças causadas por helmintos; - doenças causadas por fungos; - doenças causadas por algas; - animais e plantas de importância médica; - doenças causadas por ectoparasitas; - enfermidades de etiologia desconhecida; - temas correlatos de importância em infectologia.
![Research paper thumbnail of [Lonomia erucism in Teresópolis, Rio de Janeiro State, Brazil: report of a probable case and review]](https://attachments.academia-assets.com/39538826/thumbnails/1.jpg)
](Revista da Sociedade Brasileira de Medicina Tropical
This is a case report of a 44-year-old male living in Teresópolis, RJ, Brazil, probably poisoned ... more This is a case report of a 44-year-old male living in Teresópolis, RJ, Brazil, probably poisoned by contact with a Lonomia caterpillar, who presented hemolytic anemia, decreased platelet count and acute renal insufficiency. Lonomia erucism diagnosis was established by anamnesis and clinical and laboratory manifestations. Therapeutic measures consisting of hemotransfusion and hemodialysis were successful. Physiopathologic and clinical features of erucism by Lonomia are discussed.
A arterite de Takayasu (AT) é uma doença vascular inflamatória crônica de etiologia desconhecida ... more A arterite de Takayasu (AT) é uma doença vascular inflamatória crônica de etiologia desconhecida que se caracteriza por provocar lesões definitivas nos grandes vasos, ramos diretos da aorta, principalmente os supra-aórticos, podendo acometer inclusive a artéria pulmonar. Predomina em mulheres (9:1) jovens (15-25 anos) de descendência asiática. As lesões da aorta e seus ramos podem ser aneurismáticas ou estenótico-oclusivas 1-3 . Das artérias parietais, a mais acometida é a artéria subclávia esquerda e, das viscerais, as artérias renais. Daí a associação da AT com a hipertensão renovascular. O tratamento está baseado: 1) no controle da atividade da doença através dos imunossupressores;
Physiological reports, 2014
Several techniques to induce renal ischemia have been proposed: clamp, PVA particles, and cathete... more Several techniques to induce renal ischemia have been proposed: clamp, PVA particles, and catheter-balloon. We report the development of a controlled, single-insult model of unilateral renal ischemia/reperfusion (I/R) without contralateral nephrectomy, using a suitable model, the pig. This is a balloon-catheter-based model using a percutaneous, interventional radiology procedure. One angioplasty balloon-catheter was placed into the right renal artery and inflated for 120 min and reperfusion over 24 h. Serial serums were sampled from the inferior vena cava and urine was directly sampled from the bladder throughout the experiment, and both kidneys were excised after 24 h of reperfusion. Analyses of renal structure and function were performed by hematoxylin-eosin/periodic Acid-Schiff, serum creatinine (SCr), blood urea nitrogen (BUN), fractional excretion of ions, and glucose, SDS-PAGE analysis of urinary proteins, and serum neutrophil gelatinase-associated lipocalin (NGAL). Total nitr...
The Journal of Vascular Access, 2011
Results: The procedure was successful and no complications occurred. The position of the catheter... more Results: The procedure was successful and no complications occurred. The position of the catheter tip did not alter with arm movement. Conclusion: The implantation of a port reservoir in the arm following venous access via the internal jugular vein is both safe and convenient.
Annales de Chirurgie Vasculaire, 2010
Catheter migration or catheter fracture and consequent migration of a fragment is a rare complica... more Catheter migration or catheter fracture and consequent migration of a fragment is a rare complication that occurs in 1% of the patients. Despite the low incidence, embolization may cause severe and potentially fatal complications, with the mortality rates varying between 24 and 60%. The gold standard treatment for this condition is the extraction of the fragmented catheter by the intravascular percutaneous route, through the common femoral vein. If it is not available, the extraction procedure must be performed through an alternative access. This article describes a fully successful removal of a fragmented catheter by percutaneous intravascular access obtained through the right subclavian vein.
Annals of Vascular Surgery, 2010
Catheter migration or catheter fracture and consequent migration of a fragment is a rare complica... more Catheter migration or catheter fracture and consequent migration of a fragment is a rare complication that occurs in 1% of the patients. Despite the low incidence, embolization may cause severe and potentially fatal complications, with the mortality rates varying between 24 and 60%. The gold standard treatment for this condition is the extraction of the fragmented catheter by the intravascular percutaneous route, through the common femoral vein. If it is not available, the extraction procedure must be performed through an alternative access. This article describes a fully successful removal of a fragmented catheter by percutaneous intravascular access obtained through the right subclavian vein.
Biorheology, 2012
One drawback of in vitro cell culturing is the dedifferentiation process that cells experience. S... more One drawback of in vitro cell culturing is the dedifferentiation process that cells experience. Smooth muscle cells (SMC) also change molecularly and morphologically with long term culture. The main objective of this study was to evaluate if culture passages interfere in vascular SMC mechanical behavior. SMC were obtained from five different porcine arterial beds. Optical magnetic twisting cytometry (OMTC) was used to characterize mechanically vascular SMC from different cultures in distinct passages and confocal microscopy/western blotting, to evaluate cytoskeleton and extracellular matrix proteins. We found that vascular SMC rigidity or viscoelastic complex modulus (G) decreases with progression of passages. A statistically significant negative correlation between G and passage was found in four of our five cultures studied. Phalloidin-stained SMC from higher passages exhibited lower mean signal intensity per cell (confocal microscopy) and quantitative western blotting analysis showed a decrease in collagen I content throughout passages. We concluded that vascular SMC progressively lose their stiffness with serial culture passaging. Thus, limiting the number of passages is essential for any experiment measuring viscoelastic properties of SMC in culture.
Este volume da série INRAD casos clínicos é a continuação do projeto, que divulga e auxilia na fo... more Este volume da série INRAD casos clínicos é a continuação do projeto, que divulga e auxilia na formação dos profissionais da área radiológica. Foi mantido o formato com base na coletânea de casos proveitosos do ponto de vista didático, que acrescentam muito à vivência radiológica. Cada caso é apresentado sob a forma de uma história clínica acompanhada das principais imagens do caso que, em um segundo momento, são discutidas por especialistas na área. A elaboração do livro contou com a participação da equipe médica do instituto de radiologia.
Physiological reports, 2014
Several techniques to induce renal ischemia have been proposed: clamp, PVA particles, and cathete... more Several techniques to induce renal ischemia have been proposed: clamp, PVA particles, and catheter-balloon. We report the development of a controlled, single-insult model of unilateral renal ischemia/reperfusion (I/R) without contralateral nephrectomy, using a suitable model, the pig. This is a ballooncatheter-based model using a percutaneous, interventional radiology procedure. One angioplasty balloon-catheter was placed into the right renal artery and inflated for 120 min and reperfusion over 24 h. Serial serums were sampled from the inferior vena cava and urine was directly sampled from the bladder throughout the experiment, and both kidneys were excised after 24 h of reperfusion. Analyses of renal structure and function were performed by hematoxylin-eosin/periodic Acid-Schiff, serum creatinine (SCr), blood urea nitrogen (BUN), fractional excretion of ions, and glucose, SDS-PAGE analysis of urinary proteins, and serum neutrophil gelatinase-associated lipocalin (NGAL). Total nitrated protein was quantified to characterize oxidative stress. Acute tubular necrosis (ATN) was identified in every animal, but only two animals showed levels of SCr above 150% of baseline values. As expected, I/R increased SCr and BUN. Fractional sodium, potassium, chloride, and bicarbonate excretion were modulated during ischemia. Serum-nitrated proteins and NGAL had two profiles: decreased with ischemia and increased after reperfusion. This decline was associated with increased protein excretion during ischemia and early reperfusion. Altogether, these data show that the renal I/R model can be performed by percutaneous approach in the swine model. This is a suitable translational model to study new early renal ischemic biomarkers and pathophysiological mechanisms in renal ischemia.
CardioVascular and Interventional Radiology, 2015
To report a novel modified occlusion balloon technique to treat biliary leaks. A 22-year-old fema... more To report a novel modified occlusion balloon technique to treat biliary leaks. A 22-year-old female patient underwent liver transplantation with biliary-enteric anastomosis. She developed thrombosis of the common hepatic artery and extensive ischemia in the left hepatic lobe. Resection of segments II and III was performed and a biliary-cutaneous leak originating at the resection plane was identified in the early postoperative period. Initial treatment with percutaneous transhepatic drainage was unsuccessful. Therefore, an angioplasty balloon was coaxially inserted within the biliary drain and positioned close to the leak. The fistula output abruptly decreased after the procedure and stopped on the 7th day. At the 3-week follow-up, cholangiography revealed complete resolution of the leakage. This novel modified occlusion balloon technique was effective and safe. However, greater experience and more cases are necessary to validate the technique.
GED - Gastrenterologia Endoscopia Digestiva
Pediatr. mod, 2002
Base de dados : LILACS. Pesquisa : 501320 [Identificador único]. Referências encontradas : 1 [ref... more Base de dados : LILACS. Pesquisa : 501320 [Identificador único]. Referências encontradas : 1 [refinar]. Mostrando: 1 .. 1 no formato [Detalhado]. página 1 de 1, 1 / 1, LILACS, seleciona. para imprimir. Fotocópia. Texto completo. experimental, Documentos relacionados. ...
Purpose To report a novel modified occlusion balloon technique to treat biliary leaks. Methods A ... more Purpose To report a novel modified occlusion balloon
technique to treat biliary leaks.
Methods A 22-year-old female patient underwent liver
transplantation with biliary-enteric anastomosis. She
developed thrombosis of the common hepatic artery and
extensive ischemia in the left hepatic lobe. Resection of
segments II and III was performed and a biliary-cutaneous
leak originating at the resection plane was identified in the
early postoperative period. Initial treatment with percutaneous
transhepatic drainage was unsuccessful. Therefore,
an angioplasty balloon was coaxially inserted within the
biliary drain and positioned close to the leak.
Results The fistula output abruptly decreased after the
procedure and stopped on the 7th day. At the 3-week follow-up,
cholangiography revealed complete resolution of
the leakage.
Conclusion This novel modified occlusion balloon technique
was effective and safe. However, greater experience
and more cases are necessary to validate the technique.
Vascular medicine (London, England), Jan 24, 2015
The purpose of this study is to describe 10 cases of symptomatic isolated spontaneous celiac trun... more The purpose of this study is to describe 10 cases of symptomatic isolated spontaneous celiac trunk dissection (ISCTD) in order to evaluate the initial clinical presentation, diagnosis, treatment modalities and outcomes. A retrospective search was performed from 2009 to 2014 and 10 patients with ISCTD were included in the study. Patients with associated aortic and/or other visceral artery dissection were excluded. The following information was collected from each case: sex, age, associated risk factors, symptoms, diagnostic method, anatomic dissection pattern, treatment modality and outcome. Most patients were male (90%), with an average age of 44.8 years, and the most common symptom was abdominal pain (100%). Hypertension and vasculitis (polyarteritis nodosa) were the most frequent risk factors (40% and 30%, respectively). Diagnosis was made in all patients with computed tomography. Dissection was limited to the celiac trunk in three patients and extended to celiac branches in the o...
ABSTRACT Este livro aborda os seguintes temas: - generalidades em infectologia; - síndromes infec... more ABSTRACT Este livro aborda os seguintes temas: - generalidades em infectologia; - síndromes infecciosas; - doenças causadas por vírus; - doenças causadas por bactérias; - doenças causadas por protozoários; - doenças causadas por helmintos; - doenças causadas por fungos; - doenças causadas por algas; - animais e plantas de importância médica; - doenças causadas por ectoparasitas; - enfermidades de etiologia desconhecida; - temas correlatos de importância em infectologia.
Revista da Sociedade Brasileira de Medicina Tropical
This is a case report of a 44-year-old male living in Teresópolis, RJ, Brazil, probably poisoned ... more This is a case report of a 44-year-old male living in Teresópolis, RJ, Brazil, probably poisoned by contact with a Lonomia caterpillar, who presented hemolytic anemia, decreased platelet count and acute renal insufficiency. Lonomia erucism diagnosis was established by anamnesis and clinical and laboratory manifestations. Therapeutic measures consisting of hemotransfusion and hemodialysis were successful. Physiopathologic and clinical features of erucism by Lonomia are discussed.
A arterite de Takayasu (AT) é uma doença vascular inflamatória crônica de etiologia desconhecida ... more A arterite de Takayasu (AT) é uma doença vascular inflamatória crônica de etiologia desconhecida que se caracteriza por provocar lesões definitivas nos grandes vasos, ramos diretos da aorta, principalmente os supra-aórticos, podendo acometer inclusive a artéria pulmonar. Predomina em mulheres (9:1) jovens (15-25 anos) de descendência asiática. As lesões da aorta e seus ramos podem ser aneurismáticas ou estenótico-oclusivas 1-3 . Das artérias parietais, a mais acometida é a artéria subclávia esquerda e, das viscerais, as artérias renais. Daí a associação da AT com a hipertensão renovascular. O tratamento está baseado: 1) no controle da atividade da doença através dos imunossupressores;
Physiological reports, 2014
Several techniques to induce renal ischemia have been proposed: clamp, PVA particles, and cathete... more Several techniques to induce renal ischemia have been proposed: clamp, PVA particles, and catheter-balloon. We report the development of a controlled, single-insult model of unilateral renal ischemia/reperfusion (I/R) without contralateral nephrectomy, using a suitable model, the pig. This is a balloon-catheter-based model using a percutaneous, interventional radiology procedure. One angioplasty balloon-catheter was placed into the right renal artery and inflated for 120 min and reperfusion over 24 h. Serial serums were sampled from the inferior vena cava and urine was directly sampled from the bladder throughout the experiment, and both kidneys were excised after 24 h of reperfusion. Analyses of renal structure and function were performed by hematoxylin-eosin/periodic Acid-Schiff, serum creatinine (SCr), blood urea nitrogen (BUN), fractional excretion of ions, and glucose, SDS-PAGE analysis of urinary proteins, and serum neutrophil gelatinase-associated lipocalin (NGAL). Total nitr...
The Journal of Vascular Access, 2011
Results: The procedure was successful and no complications occurred. The position of the catheter... more Results: The procedure was successful and no complications occurred. The position of the catheter tip did not alter with arm movement. Conclusion: The implantation of a port reservoir in the arm following venous access via the internal jugular vein is both safe and convenient.
Annales de Chirurgie Vasculaire, 2010
Catheter migration or catheter fracture and consequent migration of a fragment is a rare complica... more Catheter migration or catheter fracture and consequent migration of a fragment is a rare complication that occurs in 1% of the patients. Despite the low incidence, embolization may cause severe and potentially fatal complications, with the mortality rates varying between 24 and 60%. The gold standard treatment for this condition is the extraction of the fragmented catheter by the intravascular percutaneous route, through the common femoral vein. If it is not available, the extraction procedure must be performed through an alternative access. This article describes a fully successful removal of a fragmented catheter by percutaneous intravascular access obtained through the right subclavian vein.
Annals of Vascular Surgery, 2010
Catheter migration or catheter fracture and consequent migration of a fragment is a rare complica... more Catheter migration or catheter fracture and consequent migration of a fragment is a rare complication that occurs in 1% of the patients. Despite the low incidence, embolization may cause severe and potentially fatal complications, with the mortality rates varying between 24 and 60%. The gold standard treatment for this condition is the extraction of the fragmented catheter by the intravascular percutaneous route, through the common femoral vein. If it is not available, the extraction procedure must be performed through an alternative access. This article describes a fully successful removal of a fragmented catheter by percutaneous intravascular access obtained through the right subclavian vein.
Biorheology, 2012
One drawback of in vitro cell culturing is the dedifferentiation process that cells experience. S... more One drawback of in vitro cell culturing is the dedifferentiation process that cells experience. Smooth muscle cells (SMC) also change molecularly and morphologically with long term culture. The main objective of this study was to evaluate if culture passages interfere in vascular SMC mechanical behavior. SMC were obtained from five different porcine arterial beds. Optical magnetic twisting cytometry (OMTC) was used to characterize mechanically vascular SMC from different cultures in distinct passages and confocal microscopy/western blotting, to evaluate cytoskeleton and extracellular matrix proteins. We found that vascular SMC rigidity or viscoelastic complex modulus (G) decreases with progression of passages. A statistically significant negative correlation between G and passage was found in four of our five cultures studied. Phalloidin-stained SMC from higher passages exhibited lower mean signal intensity per cell (confocal microscopy) and quantitative western blotting analysis showed a decrease in collagen I content throughout passages. We concluded that vascular SMC progressively lose their stiffness with serial culture passaging. Thus, limiting the number of passages is essential for any experiment measuring viscoelastic properties of SMC in culture.