Uwitije Rongin | University of Science and Technology of China (original) (raw)
Papers by Uwitije Rongin
Communications in Mathematics and Statistics
In this paper, we introduce a new averaging rule, the nonlinear weighted averaging rule. As an ap... more In this paper, we introduce a new averaging rule, the nonlinear weighted averaging rule. As an application, this averaging rule is used to replace the midpoint averaging in the de Casteljau evaluation algorithm and with this scheme we can also generate transcendental functions which cannot be generated by the classical de Casteljau algorithm. We also investigate the properties of the curves of the functions generated by blossoming, where the results show that these curves and the classical Bézier curves have some similar properties, including variation diminishing property and endpoint interpolation. However, the curves obtained by blossoming using nonlinear weighted averaging rules induced by certain functions violate some properties like convex hull property.
BioMed research international, 2016
The malaria-infected red blood cells experience a significant decrease in cell deformability and ... more The malaria-infected red blood cells experience a significant decrease in cell deformability and increase in cell membrane adhesion. Blood hemodynamics in microvessels is significantly affected by the alteration of the mechanical property as well as the aggregation of parasitized red blood cells. In this study, we aim to numerically study the connection between cell-level mechanobiological properties of human red blood cells and related malaria disease state by investigating the transport of multiple red blood cell aggregates passing through microchannels with symmetric stenosis. Effects of stenosis magnitude, aggregation strength, and cell deformability on cell rheology and flow characteristics were studied by a two-dimensional model using the fictitious domain-immersed boundary method. The results indicated that the motion and dissociation of red blood cell aggregates were influenced by these factors and the flow resistance increases with the increase of aggregating strength and c...
Blood exhibits a heterogeneous nature of hematocrit, velocity, and effective viscosity in microca... more Blood exhibits a heterogeneous nature of hematocrit, velocity, and effective viscosity in microcapillaries. Microvascular bifurcations have a significant influence on the distribution of the blood cells and blood flow behavior. This paper presents a simulation study performed on the two-dimensional motions and deformation of multiple red blood cells in microvessels with diverging and converging bifurcations. Fluid dynamics and membrane mechanics were incorporated. Effects of cell shape, hematocrit, and deformability of the cell membrane on rheological behavior of the red blood cells and the hemodynamics have been investigated. It was shown that the blood entering the daughter branch with a higher flow rate tended to receive disproportionally more cells. The results also demonstrate that red blood cells in microvessels experienced lateral migration in the parent channel and blunted velocity profiles in both straight section and daughter branches, and this effect was influenced by the shape and the initial position of the cells, the hematocrit, and the membrane deformability. In addition, a cell free region around the tip of the confluence was observed. The simulation results are qualitatively consistent with existing experimental findings. This study may provide fundamental knowledge for a better understanding of hemodynamic behavior of micro-scale blood flow. Microvascular system is a network of microvessels connected by irregular short bifurcated segments. The local blood flow behavior at the vicinity of the apexes of the diverging and converging bifurcation significantly affects the hemodynamics in microcirculation, such as the heterogeneous distribution of red blood cells throughout the microvasculature, the effective viscosity, and blood flow velocity 1. The direct influence of this nonuniform distribution is on the microvascular oxygen transportation. Therefore, detailed investigation and deeper understanding of rheological property of red blood cells in micro-bifurcations are extremely important. Blood flow in microcirculation can be affected by many factors. One of the most crucial factors is hematocrit, which is the volumetric percentage of red blood cells in whole blood, and it ranges from 37% to 52% for adults. Due to the Fahraeus-Lindqvist effect, the tube hematocrit in smaller branches can be as low as 10–20%, much lower than the hematocrit in the main vessels. The variation in hematocrit may cause fluctuation in blood effective viscosity which is a primary measure of blood flow resistance and a crucial factor of friction against the vessel walls. Thus, an increase in the blood viscosity will lead to decreasing oxygen transported to tissues and organs and will cause problems with blood circulation. Another important factor that affects the microscopic blood flow is the deformability of the red blood cell. Under normal conditions, red blood cells deform into various shapes to compensate the flow resistance. The cell membrane can be significantly altered under some disease conditions. For example, the malaria infected red blood cells could be much more rigid in comparison with healthy ones 2,3. The ability that red blood cells possess to deform themselves influences the aggregation of the cells, the cell free layer, as well as the velocity of the cells to transit the vessels. The mechanical property of the red blood cell membrane has been modeled and the effects on blood flow have been extensively studied 4–6. Due to the complexity of the microvascular system, a detailed in vivo study of blood flow in the microcircula-tion is a challenging task. Nowadays, in vitro data 7,8 utilize idealised geometries and simplified dynamics for the
Scientific reports, Jan 2, 2016
Blood exhibits a heterogeneous nature of hematocrit, velocity, and effective viscosity in microca... more Blood exhibits a heterogeneous nature of hematocrit, velocity, and effective viscosity in microcapillaries. Microvascular bifurcations have a significant influence on the distribution of the blood cells and blood flow behavior. This paper presents a simulation study performed on the two-dimensional motions and deformation of multiple red blood cells in microvessels with diverging and converging bifurcations. Fluid dynamics and membrane mechanics were incorporated. Effects of cell shape, hematocrit, and deformability of the cell membrane on rheological behavior of the red blood cells and the hemodynamics have been investigated. It was shown that the blood entering the daughter branch with a higher flow rate tended to receive disproportionally more cells. The results also demonstrate that red blood cells in microvessels experienced lateral migration in the parent channel and blunted velocity profiles in both straight section and daughter branches, and this effect was influenced by the...
The malaria-infected red blood cells experience a significant decrease in cell deformability and ... more The malaria-infected red blood cells experience a significant decrease in cell deformability and increase in cell membrane adhesion. Blood hemodynamics in microvessels is significantly affected by the alteration of the mechanical property as well as the aggregation of parasitized red blood cells. In this study, we aim to numerically study the connection between cell-level mechanobiological properties of human red blood cells and related malaria disease state by investigating the transport of multiple red blood cell aggregates passing through microchannels with symmetric stenosis. Effects of stenosis magnitude, aggregation strength, and cell deformability on cell rheology and flow characteristics were studied by a two-dimensional model using the fictitious domain-immersed boundary method. The results indicated that the motion and dissociation of red blood cell aggregates were influenced by these factors and the flow resistance increases with the increase of aggregating strength and cell stiffness. Further, the roughness of the velocity profile was enhanced by cell aggregation, which considerably affected the blood flow characteristics. The study may assist us in understanding cellular-level mechanisms in disease development.
Communications in Mathematics and Statistics
In this paper, we introduce a new averaging rule, the nonlinear weighted averaging rule. As an ap... more In this paper, we introduce a new averaging rule, the nonlinear weighted averaging rule. As an application, this averaging rule is used to replace the midpoint averaging in the de Casteljau evaluation algorithm and with this scheme we can also generate transcendental functions which cannot be generated by the classical de Casteljau algorithm. We also investigate the properties of the curves of the functions generated by blossoming, where the results show that these curves and the classical Bézier curves have some similar properties, including variation diminishing property and endpoint interpolation. However, the curves obtained by blossoming using nonlinear weighted averaging rules induced by certain functions violate some properties like convex hull property.
BioMed research international, 2016
The malaria-infected red blood cells experience a significant decrease in cell deformability and ... more The malaria-infected red blood cells experience a significant decrease in cell deformability and increase in cell membrane adhesion. Blood hemodynamics in microvessels is significantly affected by the alteration of the mechanical property as well as the aggregation of parasitized red blood cells. In this study, we aim to numerically study the connection between cell-level mechanobiological properties of human red blood cells and related malaria disease state by investigating the transport of multiple red blood cell aggregates passing through microchannels with symmetric stenosis. Effects of stenosis magnitude, aggregation strength, and cell deformability on cell rheology and flow characteristics were studied by a two-dimensional model using the fictitious domain-immersed boundary method. The results indicated that the motion and dissociation of red blood cell aggregates were influenced by these factors and the flow resistance increases with the increase of aggregating strength and c...
Blood exhibits a heterogeneous nature of hematocrit, velocity, and effective viscosity in microca... more Blood exhibits a heterogeneous nature of hematocrit, velocity, and effective viscosity in microcapillaries. Microvascular bifurcations have a significant influence on the distribution of the blood cells and blood flow behavior. This paper presents a simulation study performed on the two-dimensional motions and deformation of multiple red blood cells in microvessels with diverging and converging bifurcations. Fluid dynamics and membrane mechanics were incorporated. Effects of cell shape, hematocrit, and deformability of the cell membrane on rheological behavior of the red blood cells and the hemodynamics have been investigated. It was shown that the blood entering the daughter branch with a higher flow rate tended to receive disproportionally more cells. The results also demonstrate that red blood cells in microvessels experienced lateral migration in the parent channel and blunted velocity profiles in both straight section and daughter branches, and this effect was influenced by the shape and the initial position of the cells, the hematocrit, and the membrane deformability. In addition, a cell free region around the tip of the confluence was observed. The simulation results are qualitatively consistent with existing experimental findings. This study may provide fundamental knowledge for a better understanding of hemodynamic behavior of micro-scale blood flow. Microvascular system is a network of microvessels connected by irregular short bifurcated segments. The local blood flow behavior at the vicinity of the apexes of the diverging and converging bifurcation significantly affects the hemodynamics in microcirculation, such as the heterogeneous distribution of red blood cells throughout the microvasculature, the effective viscosity, and blood flow velocity 1. The direct influence of this nonuniform distribution is on the microvascular oxygen transportation. Therefore, detailed investigation and deeper understanding of rheological property of red blood cells in micro-bifurcations are extremely important. Blood flow in microcirculation can be affected by many factors. One of the most crucial factors is hematocrit, which is the volumetric percentage of red blood cells in whole blood, and it ranges from 37% to 52% for adults. Due to the Fahraeus-Lindqvist effect, the tube hematocrit in smaller branches can be as low as 10–20%, much lower than the hematocrit in the main vessels. The variation in hematocrit may cause fluctuation in blood effective viscosity which is a primary measure of blood flow resistance and a crucial factor of friction against the vessel walls. Thus, an increase in the blood viscosity will lead to decreasing oxygen transported to tissues and organs and will cause problems with blood circulation. Another important factor that affects the microscopic blood flow is the deformability of the red blood cell. Under normal conditions, red blood cells deform into various shapes to compensate the flow resistance. The cell membrane can be significantly altered under some disease conditions. For example, the malaria infected red blood cells could be much more rigid in comparison with healthy ones 2,3. The ability that red blood cells possess to deform themselves influences the aggregation of the cells, the cell free layer, as well as the velocity of the cells to transit the vessels. The mechanical property of the red blood cell membrane has been modeled and the effects on blood flow have been extensively studied 4–6. Due to the complexity of the microvascular system, a detailed in vivo study of blood flow in the microcircula-tion is a challenging task. Nowadays, in vitro data 7,8 utilize idealised geometries and simplified dynamics for the
Scientific reports, Jan 2, 2016
Blood exhibits a heterogeneous nature of hematocrit, velocity, and effective viscosity in microca... more Blood exhibits a heterogeneous nature of hematocrit, velocity, and effective viscosity in microcapillaries. Microvascular bifurcations have a significant influence on the distribution of the blood cells and blood flow behavior. This paper presents a simulation study performed on the two-dimensional motions and deformation of multiple red blood cells in microvessels with diverging and converging bifurcations. Fluid dynamics and membrane mechanics were incorporated. Effects of cell shape, hematocrit, and deformability of the cell membrane on rheological behavior of the red blood cells and the hemodynamics have been investigated. It was shown that the blood entering the daughter branch with a higher flow rate tended to receive disproportionally more cells. The results also demonstrate that red blood cells in microvessels experienced lateral migration in the parent channel and blunted velocity profiles in both straight section and daughter branches, and this effect was influenced by the...
The malaria-infected red blood cells experience a significant decrease in cell deformability and ... more The malaria-infected red blood cells experience a significant decrease in cell deformability and increase in cell membrane adhesion. Blood hemodynamics in microvessels is significantly affected by the alteration of the mechanical property as well as the aggregation of parasitized red blood cells. In this study, we aim to numerically study the connection between cell-level mechanobiological properties of human red blood cells and related malaria disease state by investigating the transport of multiple red blood cell aggregates passing through microchannels with symmetric stenosis. Effects of stenosis magnitude, aggregation strength, and cell deformability on cell rheology and flow characteristics were studied by a two-dimensional model using the fictitious domain-immersed boundary method. The results indicated that the motion and dissociation of red blood cell aggregates were influenced by these factors and the flow resistance increases with the increase of aggregating strength and cell stiffness. Further, the roughness of the velocity profile was enhanced by cell aggregation, which considerably affected the blood flow characteristics. The study may assist us in understanding cellular-level mechanisms in disease development.