Dominique McMahon | University of Toronto (original) (raw)
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Papers by Dominique McMahon
Few studies in developing countries have examined innovation in an emerging field such as regener... more Few studies in developing countries have examined innovation in an emerging field such as regenerative medicine (RM). Here, we compare case studies of the RM sectors in Brazil, China and India to help understand RM innovation from a systemic perspective. Innovation in developing countries is usually described as a process of reverse engineering carried out by firms, but we argue that this description is not well suited to innovation in an emerging field such as RM. We show here that innovation in new emerging fields can occur in developing countries by diverse processes not yet discussed in the literature. We introduce the main types of actors in RM innovation, look at the interactions between users and producers, and discuss the advantages and challenges of innovating in RM that are faced by the emerging economies. We find that RM innovation in these countries is demand-driven and occurs under conditions unique to countries with lower-resources. We also find that firms play a smaller role in RM innovation at this stage, showing the importance of considering wider innovation actors in the study of novel innovation dynamics.► We examined regenerative medicine (RM) innovation across China, India and Brazil. ► Many actors are involved in RM innovation, a globally immature high-tech field. ► RM innovation is not reverse engineered; new Southern innovation models are needed. ► RM innovation is demand-driven and can be locally appropriate. ► Characteristics of RM innovation are unique from those describing latecomers.
Regenerative medicine (RM) has the potential to develop new treatments for chronic disease and in... more Regenerative medicine (RM) has the potential to develop new treatments for chronic disease and injury that are desperately needed in developing countries. Several emerging economies are actively participating in RM, producing new knowledge and initiating ...
ungs.edu.ar
Few studies in developing countries have examined innovation in an emerging field such as regener... more Few studies in developing countries have examined innovation in an emerging field such as regenerative medicine (RM). Here, we compare case studies of RM in China, India and Brazil to help understand RM innovation from a systemic perspective. In this paper, we introduce the main types of actor in RM innovation, look at the interactions between users and producers, and discuss the advantages and challenges of innovating in RM faced by the emerging economies. Innovation in developing countries is usually described as a process of reverse engineering, but this description may not be well suited to describing innovation in an emerging field such as RM. We find that RM innovation is demand-driven and occurs under conditions unique to countries with lower-resources.
Regenerative Medicine, Jan 1, 2011
Few studies in developing countries have examined innovation in an emerging field such as regener... more Few studies in developing countries have examined innovation in an emerging field such as regenerative medicine (RM). Here, we compare case studies of the RM sectors in China, India and Brazil to help understand RM innovation from a systemic perspective. We introduce the main types of actors in RM innovation, look at the interactions between users and producers, and discuss the advantages and challenges of innovating in RM that are faced by the emerging economies. Innovation in developing countries is usually described as a process of reverse engineering, but this description may not be well suited to innovation in an emerging field such as RM. We find that RM innovation in these countries is demand-driven and occurs under conditions unique to countries with lower-resources. We also find that firms play a smaller role in RM innovation at this stage of its development instead of a large central role, showing the importance of considering wider innovation actors in the study of novel innovation dynamics. 1 Email addresses: dominique.mcmahon@utoronto.ca (D. McMahon) halla.thorsteinsdottir@utoronto.ca (H. Thorsteinsdóttir) 2 Tel.: +1 416 978 6873
The American Journal of …, Jan 1, 2010
Regenerative …, Jan 1, 2010
Aims: Although Brazil has received attention for conducting one of the world's largest stem cell ... more Aims: Although Brazil has received attention for conducting one of the world's largest stem cell clinical trials for heart disease, little has been published regarding Brazil's regenerative medicine (RM) sector. Here we present a comprehensive case study of RM in Brazil, including ana lysis of the current activity, the main motivations for engaging in RM and the remaining challenges to development in this field. Methods: Our case study is primarily based on semi-structured interviews with experts on RM in Brazil, including researchers, policymakers, clinicians, representatives of firms and regulators. Results: Driven by domestic health needs and strategic government support, Brazil is producing innovative RM research, particularly for clinical research in cardiology, orthopedics, diabetes and neurology. We describe the main RM research currently taking place in Brazil, as well as some of the economic, regulatory and policy events that have created a favorable environment for RM development. Brazilian RM researchers need to overcome several formidable challenges to research: research funding is inconsistent, importation of materials is costly and slow, and weak linkages between universities, hospitals and industry impede translational research. Conclusions: Although Brazil's contribution to the RM sector is small, its niche emphasis on clinical applications may become of global importance, particularly if Brazil manages to address the challenges currently impinging on RM innovation. keywoRds: Brazil n clinical trial n gene therapy n health needs n innovation n regenerative medicine n regulation n stem cell n tissue engineering
Regenerative …, Jan 1, 2010
Science, Jan 1, 2005
Transport of pollutants by migratory species, such as salmon, is known to affect contaminant dist... more Transport of pollutants by migratory species, such as salmon, is known to affect contaminant distributions in Alaskan nursery lakes (1, 2). Arctic seabirds may also be transporting industrial and agricultural contaminants from the ocean to land. Most of these seabirds are pelagic feeders with populations concentrated in very large breeding colonies of more than 20,000 individuals (3). Local nutrient enrichment from guano has been documented, but the possibility of contamination in areas near seabird nesting sites has been largely overlooked. In a recent study on Bear Island, the presence of seabird colonies adjacent to one lake coincided with elevated polychlorinated biphenyl concentrations in fish (4). Here we show that persistent organic pollutants and mercury concentrations in high arctic pond sediments are closely related to the varying influences of seabird populations in ponds on Devon Island, in the Canadian Arctic , and that the combined effects of biomagnification and biological transport of contaminants dwarf the amount transported from atmospheric pathways.
Few studies in developing countries have examined innovation in an emerging field such as regener... more Few studies in developing countries have examined innovation in an emerging field such as regenerative medicine (RM). Here, we compare case studies of the RM sectors in Brazil, China and India to help understand RM innovation from a systemic perspective. Innovation in developing countries is usually described as a process of reverse engineering carried out by firms, but we argue that this description is not well suited to innovation in an emerging field such as RM. We show here that innovation in new emerging fields can occur in developing countries by diverse processes not yet discussed in the literature. We introduce the main types of actors in RM innovation, look at the interactions between users and producers, and discuss the advantages and challenges of innovating in RM that are faced by the emerging economies. We find that RM innovation in these countries is demand-driven and occurs under conditions unique to countries with lower-resources. We also find that firms play a smaller role in RM innovation at this stage, showing the importance of considering wider innovation actors in the study of novel innovation dynamics.► We examined regenerative medicine (RM) innovation across China, India and Brazil. ► Many actors are involved in RM innovation, a globally immature high-tech field. ► RM innovation is not reverse engineered; new Southern innovation models are needed. ► RM innovation is demand-driven and can be locally appropriate. ► Characteristics of RM innovation are unique from those describing latecomers.
Regenerative medicine (RM) has the potential to develop new treatments for chronic disease and in... more Regenerative medicine (RM) has the potential to develop new treatments for chronic disease and injury that are desperately needed in developing countries. Several emerging economies are actively participating in RM, producing new knowledge and initiating ...
ungs.edu.ar
Few studies in developing countries have examined innovation in an emerging field such as regener... more Few studies in developing countries have examined innovation in an emerging field such as regenerative medicine (RM). Here, we compare case studies of RM in China, India and Brazil to help understand RM innovation from a systemic perspective. In this paper, we introduce the main types of actor in RM innovation, look at the interactions between users and producers, and discuss the advantages and challenges of innovating in RM faced by the emerging economies. Innovation in developing countries is usually described as a process of reverse engineering, but this description may not be well suited to describing innovation in an emerging field such as RM. We find that RM innovation is demand-driven and occurs under conditions unique to countries with lower-resources.
Regenerative Medicine, Jan 1, 2011
Few studies in developing countries have examined innovation in an emerging field such as regener... more Few studies in developing countries have examined innovation in an emerging field such as regenerative medicine (RM). Here, we compare case studies of the RM sectors in China, India and Brazil to help understand RM innovation from a systemic perspective. We introduce the main types of actors in RM innovation, look at the interactions between users and producers, and discuss the advantages and challenges of innovating in RM that are faced by the emerging economies. Innovation in developing countries is usually described as a process of reverse engineering, but this description may not be well suited to innovation in an emerging field such as RM. We find that RM innovation in these countries is demand-driven and occurs under conditions unique to countries with lower-resources. We also find that firms play a smaller role in RM innovation at this stage of its development instead of a large central role, showing the importance of considering wider innovation actors in the study of novel innovation dynamics. 1 Email addresses: dominique.mcmahon@utoronto.ca (D. McMahon) halla.thorsteinsdottir@utoronto.ca (H. Thorsteinsdóttir) 2 Tel.: +1 416 978 6873
The American Journal of …, Jan 1, 2010
Regenerative …, Jan 1, 2010
Aims: Although Brazil has received attention for conducting one of the world's largest stem cell ... more Aims: Although Brazil has received attention for conducting one of the world's largest stem cell clinical trials for heart disease, little has been published regarding Brazil's regenerative medicine (RM) sector. Here we present a comprehensive case study of RM in Brazil, including ana lysis of the current activity, the main motivations for engaging in RM and the remaining challenges to development in this field. Methods: Our case study is primarily based on semi-structured interviews with experts on RM in Brazil, including researchers, policymakers, clinicians, representatives of firms and regulators. Results: Driven by domestic health needs and strategic government support, Brazil is producing innovative RM research, particularly for clinical research in cardiology, orthopedics, diabetes and neurology. We describe the main RM research currently taking place in Brazil, as well as some of the economic, regulatory and policy events that have created a favorable environment for RM development. Brazilian RM researchers need to overcome several formidable challenges to research: research funding is inconsistent, importation of materials is costly and slow, and weak linkages between universities, hospitals and industry impede translational research. Conclusions: Although Brazil's contribution to the RM sector is small, its niche emphasis on clinical applications may become of global importance, particularly if Brazil manages to address the challenges currently impinging on RM innovation. keywoRds: Brazil n clinical trial n gene therapy n health needs n innovation n regenerative medicine n regulation n stem cell n tissue engineering
Regenerative …, Jan 1, 2010
Science, Jan 1, 2005
Transport of pollutants by migratory species, such as salmon, is known to affect contaminant dist... more Transport of pollutants by migratory species, such as salmon, is known to affect contaminant distributions in Alaskan nursery lakes (1, 2). Arctic seabirds may also be transporting industrial and agricultural contaminants from the ocean to land. Most of these seabirds are pelagic feeders with populations concentrated in very large breeding colonies of more than 20,000 individuals (3). Local nutrient enrichment from guano has been documented, but the possibility of contamination in areas near seabird nesting sites has been largely overlooked. In a recent study on Bear Island, the presence of seabird colonies adjacent to one lake coincided with elevated polychlorinated biphenyl concentrations in fish (4). Here we show that persistent organic pollutants and mercury concentrations in high arctic pond sediments are closely related to the varying influences of seabird populations in ponds on Devon Island, in the Canadian Arctic , and that the combined effects of biomagnification and biological transport of contaminants dwarf the amount transported from atmospheric pathways.