Hilary Whyte | University of Toronto (original) (raw)

Papers by Hilary Whyte

Research paper thumbnail of Characteristics and short-term outcomes of neonates with mild hypoxic-ischemic encephalopathy treated with hypothermia

Journal of Perinatology, 2019

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Research paper thumbnail of Evaluating the feasibility of a multicenter teleneonatology clinical effectiveness trial

Pediatric Research, May 19, 2023

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Research paper thumbnail of Non-immune Hydrops Fetalis and Hepatic Dysfunction in a Preterm Infant With Congenital Syphilis

Frontiers in Pediatrics, Dec 11, 2019

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Research paper thumbnail of Accuracy of Simulated Research Tasks by Community Hospitals Participating in a Multicenter Telemedicine Trial

Telemedicine Journal and E-health, Oct 1, 2022

Background/Aims: Clinical trials evaluating facility-to-facility telemedicine may include sites t... more Background/Aims: Clinical trials evaluating facility-to-facility telemedicine may include sites that have limited research experience. For the trial to be successful, these sites must correctly perform research-related tasks. This study aimed to determine whether health care professionals at community hospitals could accurately identify simulated study eligible patients and submit data to a research coordinating center. Methods: Twenty-seven community hospitals in the United States and Canada participated in this study. An electronic survey was sent to one designated health care professional at each site. The survey included a description of trial eligibility criteria and five written neonatal resuscitation scenarios. For each scenario, the participant determined whether the neonate was study eligible. One scenario required participants to submit 14 data elements to the coordinating center. Accuracy of study eligibility and data submission was summarized using standard descriptive statistics. Results: The survey response rate was 100% (27/27). Overall accuracy in determining study eligibility was 89% (120/135), and accuracy varied across the five scenarios (range 82-93%). Overall accuracy of data submission was 92% (310/336). Data were >95% accurate for 9 of the 14 data elements, with 100% accuracy achieved for 6 data elements. These results were used to clarify eligibility criteria, inform database design, and improve training materials for the subsequent clinical trial. Conclusions: Health care professionals at community hospitals accurately determined trial eligibility and submitted study data based on written clinical scenarios. Research teams conducting telemedicine trials with community hospitals should consider completing pre-trial simulation activities to identify opportunities for improving trial processes and materials.

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Research paper thumbnail of Therapeutic hypothermia for hypoxic-ischemic encephalopathy after perinatal sentinel events: less brain injury on MRI and improved neurodevelopmental outcome at 18–36 months

Journal of Perinatology, Feb 12, 2020

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Research paper thumbnail of Outcomes of Preterm Infants Differ Based on Level of Care for Birth and Where Medical Care Received

Paediatrics and Child Health, Jun 1, 2012

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Research paper thumbnail of White Blood Cell Counts (WBC) in Newborns Born After Prelabour Rupture of the Membranes at Term (PROM). 182

Pediatric Research, Sep 1, 1996

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Research paper thumbnail of 134 Changes in Visual Evoked Potentials with Arousal States in Preterm Neonates

Pediatric Research, Oct 1, 1986

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Research paper thumbnail of Whole-body vibration in neonatal transport: a review of current knowledge and future research challenges

Early Human Development, Jul 1, 2020

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Research paper thumbnail of Abnormal corpus callosum in neonates after hypoxic-ischemic injury

Pediatric Radiology, Sep 21, 2011

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Research paper thumbnail of Barriers to High Risk Maternal Transfer < 32 Weeks Gestation

Paediatrics and Child Health, May 1, 2010

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Research paper thumbnail of Outcome of Infants 23–26 Weeks’ Gestation Pre and Post Surfactant

Obstetrical & Gynecological Survey, Apr 1, 2001

To describe mortality and neurodevelopmental outcome before and after the introduction of rescue ... more To describe mortality and neurodevelopmental outcome before and after the introduction of rescue therapy with natural surfactant in two neonatal units in Toronto, Canada, a retrospective cohort study of 891 liveborn 23-26 wk gestational age infants, 421 presurfactant (1982-1987) and 470 postsurfactant (1990-1994) was performed. Overall mortality was stable over time (41% vs 35%, p = 0.077), but declined for inborn 24 (71% vs 43%, p = 0.03) and 26 wk (26% vs 13%, p = 0.01) gestational age infants and was higher in surfactant-treated infants (p &amp;amp;lt; 0.0001). Chronic lung disease (61% vs 34%, p &amp;amp;lt; 0.0001) and bilateral blindness (8% vs 4%, p = 0.004) declined over time, with stable rates of cerebral palsy (12% vs 15%), cognitive deficit (27% vs 26%) and aided sensorineural hearing loss (5% vs 4%). Sixty-five percent of surviving infants in both eras were free from neurodevelopmental impairment, and severe impairment declined over time (p = 0.035). This study shows no secular change in overall mortality in a large cohort of 23-26 wk gestational age infants since the introduction of rescue therapy with natural surfactant. However, it does suggest that maternal transfer to and delivery of all extremely preterm infants in high risk perinatal centres is justified.

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Research paper thumbnail of Outcomes of children at 2 years after planned cesarean section versus planned vaginal birth for breech presentation at term : The internal randomized Term Breech Trial

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Research paper thumbnail of Index of suspicion in the nursery

Neoreviews, Apr 1, 2005

A 2,216-g baby boy is born at 37 weeks’ gestation to a 34-year-old gravida 2, para 1 female. The ... more A 2,216-g baby boy is born at 37 weeks’ gestation to a 34-year-old gravida 2, para 1 female. The pregnancy was uncomplicated until the day prior to delivery, when a biophysical profile score of 4/8 was obtained on assessment. Fetal heart rate decelerations to 80 beats/min and multiple late decelerations were noted the evening of delivery, and an emergent cesarean section is planned. The male infant is delivered precipitously prior to entering the operating room. Placental abruption is evident after delivery. At birth, the baby is limp but has spontaneous respirations, with a respiratory rate of 60 breaths/min. Mild intercostal retractions are evident. Femoral pulses are weak, but the heart rate is detected at 130 beats/min. On auscultation, heart sounds are not audible. Apgar scores are 7, 7, and 8 at 1, 5, and 10 minutes, respectively. Shortly after initial assessment, continuous positive airway pressure (CPAP) is applied at 4 to 5 cm H2O, and the baby is transported to the neonatal intensive care unit where the blood pressure is 44/16 mm Hg (mean, 27 mm Hg) and the oxygen saturation is 98% (with CPAP). Color and tone are poor, and the baby subsequently receives bag-and-mask ventilation and a bolus of 10 mL/kg normal saline via a peripheral intravenous …

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Research paper thumbnail of Imaging Case of the Month

American Journal of Perinatology, Jul 1, 1988

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Research paper thumbnail of Mortality Rates and Nicu Outcomes of Neonates Born at the Limits of Viability in in born Vs Outborn Centres

Paediatrics and Child Health, 2010

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Research paper thumbnail of The interfacility transport of critically ill newborns

Paediatrics & Child Health, 2015

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Research paper thumbnail of Comparison of Findings on Head Ultrasound Scans (U/S) With Early Advanced Magnetic Resonance Imaging (Mri) in Preterm Brains

Paediatrics and Child Health, May 1, 2010

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Research paper thumbnail of Periventricular Hemorrhagic Infarction in Very Preterm Infants: Characteristic Sonographic Findings and Association with Neurodevelopmental Outcome at Age 2 Years

The Journal of Pediatrics, Feb 1, 2020

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Research paper thumbnail of Resilience and Vulnerability: Neurodevelopment of Very Preterm Children at Four Years of Age

Frontiers in Human Neuroscience, Jul 14, 2020

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Research paper thumbnail of Characteristics and short-term outcomes of neonates with mild hypoxic-ischemic encephalopathy treated with hypothermia

Journal of Perinatology, 2019

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Evaluating the feasibility of a multicenter teleneonatology clinical effectiveness trial

Pediatric Research, May 19, 2023

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Non-immune Hydrops Fetalis and Hepatic Dysfunction in a Preterm Infant With Congenital Syphilis

Frontiers in Pediatrics, Dec 11, 2019

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Accuracy of Simulated Research Tasks by Community Hospitals Participating in a Multicenter Telemedicine Trial

Telemedicine Journal and E-health, Oct 1, 2022

Background/Aims: Clinical trials evaluating facility-to-facility telemedicine may include sites t... more Background/Aims: Clinical trials evaluating facility-to-facility telemedicine may include sites that have limited research experience. For the trial to be successful, these sites must correctly perform research-related tasks. This study aimed to determine whether health care professionals at community hospitals could accurately identify simulated study eligible patients and submit data to a research coordinating center. Methods: Twenty-seven community hospitals in the United States and Canada participated in this study. An electronic survey was sent to one designated health care professional at each site. The survey included a description of trial eligibility criteria and five written neonatal resuscitation scenarios. For each scenario, the participant determined whether the neonate was study eligible. One scenario required participants to submit 14 data elements to the coordinating center. Accuracy of study eligibility and data submission was summarized using standard descriptive statistics. Results: The survey response rate was 100% (27/27). Overall accuracy in determining study eligibility was 89% (120/135), and accuracy varied across the five scenarios (range 82-93%). Overall accuracy of data submission was 92% (310/336). Data were >95% accurate for 9 of the 14 data elements, with 100% accuracy achieved for 6 data elements. These results were used to clarify eligibility criteria, inform database design, and improve training materials for the subsequent clinical trial. Conclusions: Health care professionals at community hospitals accurately determined trial eligibility and submitted study data based on written clinical scenarios. Research teams conducting telemedicine trials with community hospitals should consider completing pre-trial simulation activities to identify opportunities for improving trial processes and materials.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Therapeutic hypothermia for hypoxic-ischemic encephalopathy after perinatal sentinel events: less brain injury on MRI and improved neurodevelopmental outcome at 18–36 months

Journal of Perinatology, Feb 12, 2020

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Outcomes of Preterm Infants Differ Based on Level of Care for Birth and Where Medical Care Received

Paediatrics and Child Health, Jun 1, 2012

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Research paper thumbnail of White Blood Cell Counts (WBC) in Newborns Born After Prelabour Rupture of the Membranes at Term (PROM). 182

Pediatric Research, Sep 1, 1996

Bookmarks Related papers MentionsView impact

Research paper thumbnail of 134 Changes in Visual Evoked Potentials with Arousal States in Preterm Neonates

Pediatric Research, Oct 1, 1986

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Whole-body vibration in neonatal transport: a review of current knowledge and future research challenges

Early Human Development, Jul 1, 2020

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Research paper thumbnail of Abnormal corpus callosum in neonates after hypoxic-ischemic injury

Pediatric Radiology, Sep 21, 2011

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Research paper thumbnail of Barriers to High Risk Maternal Transfer < 32 Weeks Gestation

Paediatrics and Child Health, May 1, 2010

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Outcome of Infants 23–26 Weeks’ Gestation Pre and Post Surfactant

Obstetrical & Gynecological Survey, Apr 1, 2001

To describe mortality and neurodevelopmental outcome before and after the introduction of rescue ... more To describe mortality and neurodevelopmental outcome before and after the introduction of rescue therapy with natural surfactant in two neonatal units in Toronto, Canada, a retrospective cohort study of 891 liveborn 23-26 wk gestational age infants, 421 presurfactant (1982-1987) and 470 postsurfactant (1990-1994) was performed. Overall mortality was stable over time (41% vs 35%, p = 0.077), but declined for inborn 24 (71% vs 43%, p = 0.03) and 26 wk (26% vs 13%, p = 0.01) gestational age infants and was higher in surfactant-treated infants (p &amp;amp;lt; 0.0001). Chronic lung disease (61% vs 34%, p &amp;amp;lt; 0.0001) and bilateral blindness (8% vs 4%, p = 0.004) declined over time, with stable rates of cerebral palsy (12% vs 15%), cognitive deficit (27% vs 26%) and aided sensorineural hearing loss (5% vs 4%). Sixty-five percent of surviving infants in both eras were free from neurodevelopmental impairment, and severe impairment declined over time (p = 0.035). This study shows no secular change in overall mortality in a large cohort of 23-26 wk gestational age infants since the introduction of rescue therapy with natural surfactant. However, it does suggest that maternal transfer to and delivery of all extremely preterm infants in high risk perinatal centres is justified.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Outcomes of children at 2 years after planned cesarean section versus planned vaginal birth for breech presentation at term : The internal randomized Term Breech Trial

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Index of suspicion in the nursery

Neoreviews, Apr 1, 2005

A 2,216-g baby boy is born at 37 weeks’ gestation to a 34-year-old gravida 2, para 1 female. The ... more A 2,216-g baby boy is born at 37 weeks’ gestation to a 34-year-old gravida 2, para 1 female. The pregnancy was uncomplicated until the day prior to delivery, when a biophysical profile score of 4/8 was obtained on assessment. Fetal heart rate decelerations to 80 beats/min and multiple late decelerations were noted the evening of delivery, and an emergent cesarean section is planned. The male infant is delivered precipitously prior to entering the operating room. Placental abruption is evident after delivery. At birth, the baby is limp but has spontaneous respirations, with a respiratory rate of 60 breaths/min. Mild intercostal retractions are evident. Femoral pulses are weak, but the heart rate is detected at 130 beats/min. On auscultation, heart sounds are not audible. Apgar scores are 7, 7, and 8 at 1, 5, and 10 minutes, respectively. Shortly after initial assessment, continuous positive airway pressure (CPAP) is applied at 4 to 5 cm H2O, and the baby is transported to the neonatal intensive care unit where the blood pressure is 44/16 mm Hg (mean, 27 mm Hg) and the oxygen saturation is 98% (with CPAP). Color and tone are poor, and the baby subsequently receives bag-and-mask ventilation and a bolus of 10 mL/kg normal saline via a peripheral intravenous …

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Research paper thumbnail of Imaging Case of the Month

American Journal of Perinatology, Jul 1, 1988

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Mortality Rates and Nicu Outcomes of Neonates Born at the Limits of Viability in in born Vs Outborn Centres

Paediatrics and Child Health, 2010

Bookmarks Related papers MentionsView impact

Research paper thumbnail of The interfacility transport of critically ill newborns

Paediatrics & Child Health, 2015

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Comparison of Findings on Head Ultrasound Scans (U/S) With Early Advanced Magnetic Resonance Imaging (Mri) in Preterm Brains

Paediatrics and Child Health, May 1, 2010

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Periventricular Hemorrhagic Infarction in Very Preterm Infants: Characteristic Sonographic Findings and Association with Neurodevelopmental Outcome at Age 2 Years

The Journal of Pediatrics, Feb 1, 2020

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Resilience and Vulnerability: Neurodevelopment of Very Preterm Children at Four Years of Age

Frontiers in Human Neuroscience, Jul 14, 2020

Bookmarks Related papers MentionsView impact