Joe Arévalo S | U.T.P.L. (original) (raw)
Papers by Joe Arévalo S
Nuclear Fusion, 2011
This paper presents an overview of experimental results and progress made in investigating densit... more This paper presents an overview of experimental results and progress made in investigating density control using Li-coating, transport and L-H transitions in TJ-II. The Li-coating changes drastically the plasma-wall interaction, decreasing the recycling, and enlarges substantially the operational range of the device delaying the appearance of radiative collapse that happens for higher densities, which permits confinement properties of much denser plasmas to be studied. Moreover, L-H mode transition has only been achieved after Li-coating in TJ-II. The effect of rational surfaces on heat transport is studied showing a decrease in heat diffusivity close to their position, and it is also seen that rational surfaces located in the edge make L-H transition easier. TJ-II findings provide a new guideline for understanding the trigger mechanism of the L-H transition pointing out the importance of low frequency fluctuating sheared E × B flows. The properties of fast-ion confinement are described as well as the effects of impurities on radiation profiles, showing two types of profiles the bell and the dome shape, the latter being more prone to radiative collapse.
Journal of Ethnicity in Substance Abuse, 2012
This study examined variations by race and ethnicity in initiation and engagement, two performanc... more This study examined variations by race and ethnicity in initiation and engagement, two performance measures of treatment for substance use disorders that focus on the timely receipt of services during the early stage of substance abuse treatment. Administrative data from the Oklahoma Department of Mental Health and Substance Abuse Services were linked with facility-level information from the National Survey of Substance Abuse Treatment Services. We found that Black clients were least likely to initiate treatment, but no race or ethnic differences in treatment engagement were found when compared by race or ethnicity. Most client and facility characteristics' association with initiation or engagement did not differ across racial or ethnic groups. Increased attention is needed to understand what may contribute to the differences and how to address them. This study also offers an approach that state agencies may implement for monitoring treatment quality and examining racial and ethnic disparities in substance abuse treatment services.
Journal of Popular Music Studies, 2003
European Journal of Immunology, 2008
The vaccine potential of Plasmodium falciparum liver stage antigen-3 (LSA3) was investigated in A... more The vaccine potential of Plasmodium falciparum liver stage antigen-3 (LSA3) was investigated in Aotus monkeys using two long synthetic peptides corresponding respectively to an N-terminal non-repeat peptide (NRP) and repeat 2 (R2) region of the LSA3, adjuvanted by ASO2. Both 100–222 (NRP) and 501–596 repeat peptides induced effector B- and T-cell responses in terms of antigen-driven antibodies and/or specific IFN-γ secretion. Animals challenged with P. falciparum sporozoites were protected following immunization with either the NRP region alone or the NRP combined with the R2 repeat region, as compared with controls receiving the adjuvant alone. These results indicate that the NRP may be sufficient to induce full, sterile protection and confirm the vaccine potential of LSA3 previously demonstrated in chimpanzees and in Aotus.
Social Work in Health Care, 2010
This study investigated association between post-traumatic stress disorder (PTSD) and a 1-year fo... more This study investigated association between post-traumatic stress disorder (PTSD) and a 1-year follow-up heroin use among female clients in methadone clinics in Israel. Participants were 104 Israeli female clients from four methadone clinics (Mean age = 39.09, SD = 8.61) who reported victimization to childhood sexual abuse. We tested traces in urine of these female clients for heroin a year preceding and a year following the assessment of their PTSD. Results show that 54.2% reported symptoms that accedes the DSM-IV criteria for PTSD. We found that among childhood victimized women PTSD is associated with more frequent use of heroin at a 1-year follow-up even after controlling for duration of the stay at the clinic, background, other traumatic experiences and heroin use a year prior the assessment of their PTSD. This study shows the potential long-run negative consequences of childhood sexual abuse. Not only are these sexually abused women trapped into drug dependence and addiction, they cannot break the vicious cycle of continuing the use of illicit drugs even when treated for their addiction. One major practice implication is that treatment for PTSD proven efficacious will be provided in the methadone and other drug treatment services.
The recent availability of significantly increased levels of funding for unmet medical needs in t... more The recent availability of significantly increased levels of funding for unmet medical needs in the developing world, made available by newly created public-private-partnerships, has proven to be a powerful driver for stimulating clinical development of candidate vaccines for malaria. This new way forward promises to greatly increase the likelihood of bringing a safe and effective vaccine to licensure. The investigators bring together important published and unpublished information that illuminates the status of malaria vaccine development. They focus their comments on those candidate vaccines that are currently in or expected to enter clinical trials in the next 12 months.
Journal of Men's Health, 2009
BackgroundRacial and ethnic minorities have lower cardiovascular disease (CVD) risk factor contro... more BackgroundRacial and ethnic minorities have lower cardiovascular disease (CVD) risk factor control and lower awareness of their CVD risk status despite being at higher risk for the disease. We sought to understand the reach and potential impact of delivering a CVD risk reduction program by Community Health Workers (CHW) in 15 Denver, Colorado barbershops.
Journal of Dietary Supplements, 2010
Therapeutic options for Duchenne muscular dystrophy (DMD), the most common and lethal neuromuscul... more Therapeutic options for Duchenne muscular dystrophy (DMD), the most common and lethal neuromuscular disorder in children, remain elusive. Oxidative damage is implicated as a pertinent factor involved in its pathogenesis. Protandim ® is an over-the-counter supplement with the ability to induce antioxidant enzymes. In this study we investigated whether Protandim ® provided benefit using surrogate markers and functional measures in the dystrophin-deficient (mdx)mouse model of DMD. Male 3-week-old mdx mice were randomized into two treatment groups: control (receiving standard rodent chow) and Protandim ® -supplemented standard rodent chow. The diets were continued for 6-week and 6-month studies. The endpoints included the oxidative stress marker thiobarbituric acid-reactive substances (TBARS), plasma osteopontin (OPN), plasma paraoxonase (PON1) activity, H&E histology, gadolinium-enhanced magnetic resonance imaging (MRI) of leg muscle and motor functional measurements. The Protandim ® chow diet in mdx mice for 6 months was safe and well tolerated. After 6 months of Protandim ® , a 48% average decrease in plasma TBARS was seen; 0.92 nmol/mg protein in controls versus 0.48 nmol/mg protein in the Protandim ® group (p = .006). At 6 months, plasma OPN was decreased by 57% (p = .001) in the Protandim ® -treated mice. Protandim ® increased the plasma antioxidant enzyme PON1 activity by 35% (p = .018). After 6 months, the mdx mice with Protandim ® showed 38% less MRI signal abnormality (p = .07) than mice on control diet. In this 6-month mdx mouse study, Protandim ® did not significantly alter motor function nor histological criteria.
Advances in Contraception, 1998
Nuclear Fusion, 2011
This paper presents an overview of experimental results and progress made in investigating densit... more This paper presents an overview of experimental results and progress made in investigating density control using Li-coating, transport and L-H transitions in TJ-II. The Li-coating changes drastically the plasma-wall interaction, decreasing the recycling, and enlarges substantially the operational range of the device delaying the appearance of radiative collapse that happens for higher densities, which permits confinement properties of much denser plasmas to be studied. Moreover, L-H mode transition has only been achieved after Li-coating in TJ-II. The effect of rational surfaces on heat transport is studied showing a decrease in heat diffusivity close to their position, and it is also seen that rational surfaces located in the edge make L-H transition easier. TJ-II findings provide a new guideline for understanding the trigger mechanism of the L-H transition pointing out the importance of low frequency fluctuating sheared E × B flows. The properties of fast-ion confinement are described as well as the effects of impurities on radiation profiles, showing two types of profiles the bell and the dome shape, the latter being more prone to radiative collapse.
Journal of Ethnicity in Substance Abuse, 2012
This study examined variations by race and ethnicity in initiation and engagement, two performanc... more This study examined variations by race and ethnicity in initiation and engagement, two performance measures of treatment for substance use disorders that focus on the timely receipt of services during the early stage of substance abuse treatment. Administrative data from the Oklahoma Department of Mental Health and Substance Abuse Services were linked with facility-level information from the National Survey of Substance Abuse Treatment Services. We found that Black clients were least likely to initiate treatment, but no race or ethnic differences in treatment engagement were found when compared by race or ethnicity. Most client and facility characteristics' association with initiation or engagement did not differ across racial or ethnic groups. Increased attention is needed to understand what may contribute to the differences and how to address them. This study also offers an approach that state agencies may implement for monitoring treatment quality and examining racial and ethnic disparities in substance abuse treatment services.
Journal of Popular Music Studies, 2003
European Journal of Immunology, 2008
The vaccine potential of Plasmodium falciparum liver stage antigen-3 (LSA3) was investigated in A... more The vaccine potential of Plasmodium falciparum liver stage antigen-3 (LSA3) was investigated in Aotus monkeys using two long synthetic peptides corresponding respectively to an N-terminal non-repeat peptide (NRP) and repeat 2 (R2) region of the LSA3, adjuvanted by ASO2. Both 100–222 (NRP) and 501–596 repeat peptides induced effector B- and T-cell responses in terms of antigen-driven antibodies and/or specific IFN-γ secretion. Animals challenged with P. falciparum sporozoites were protected following immunization with either the NRP region alone or the NRP combined with the R2 repeat region, as compared with controls receiving the adjuvant alone. These results indicate that the NRP may be sufficient to induce full, sterile protection and confirm the vaccine potential of LSA3 previously demonstrated in chimpanzees and in Aotus.
Social Work in Health Care, 2010
This study investigated association between post-traumatic stress disorder (PTSD) and a 1-year fo... more This study investigated association between post-traumatic stress disorder (PTSD) and a 1-year follow-up heroin use among female clients in methadone clinics in Israel. Participants were 104 Israeli female clients from four methadone clinics (Mean age = 39.09, SD = 8.61) who reported victimization to childhood sexual abuse. We tested traces in urine of these female clients for heroin a year preceding and a year following the assessment of their PTSD. Results show that 54.2% reported symptoms that accedes the DSM-IV criteria for PTSD. We found that among childhood victimized women PTSD is associated with more frequent use of heroin at a 1-year follow-up even after controlling for duration of the stay at the clinic, background, other traumatic experiences and heroin use a year prior the assessment of their PTSD. This study shows the potential long-run negative consequences of childhood sexual abuse. Not only are these sexually abused women trapped into drug dependence and addiction, they cannot break the vicious cycle of continuing the use of illicit drugs even when treated for their addiction. One major practice implication is that treatment for PTSD proven efficacious will be provided in the methadone and other drug treatment services.
The recent availability of significantly increased levels of funding for unmet medical needs in t... more The recent availability of significantly increased levels of funding for unmet medical needs in the developing world, made available by newly created public-private-partnerships, has proven to be a powerful driver for stimulating clinical development of candidate vaccines for malaria. This new way forward promises to greatly increase the likelihood of bringing a safe and effective vaccine to licensure. The investigators bring together important published and unpublished information that illuminates the status of malaria vaccine development. They focus their comments on those candidate vaccines that are currently in or expected to enter clinical trials in the next 12 months.
Journal of Men's Health, 2009
BackgroundRacial and ethnic minorities have lower cardiovascular disease (CVD) risk factor contro... more BackgroundRacial and ethnic minorities have lower cardiovascular disease (CVD) risk factor control and lower awareness of their CVD risk status despite being at higher risk for the disease. We sought to understand the reach and potential impact of delivering a CVD risk reduction program by Community Health Workers (CHW) in 15 Denver, Colorado barbershops.
Journal of Dietary Supplements, 2010
Therapeutic options for Duchenne muscular dystrophy (DMD), the most common and lethal neuromuscul... more Therapeutic options for Duchenne muscular dystrophy (DMD), the most common and lethal neuromuscular disorder in children, remain elusive. Oxidative damage is implicated as a pertinent factor involved in its pathogenesis. Protandim ® is an over-the-counter supplement with the ability to induce antioxidant enzymes. In this study we investigated whether Protandim ® provided benefit using surrogate markers and functional measures in the dystrophin-deficient (mdx)mouse model of DMD. Male 3-week-old mdx mice were randomized into two treatment groups: control (receiving standard rodent chow) and Protandim ® -supplemented standard rodent chow. The diets were continued for 6-week and 6-month studies. The endpoints included the oxidative stress marker thiobarbituric acid-reactive substances (TBARS), plasma osteopontin (OPN), plasma paraoxonase (PON1) activity, H&E histology, gadolinium-enhanced magnetic resonance imaging (MRI) of leg muscle and motor functional measurements. The Protandim ® chow diet in mdx mice for 6 months was safe and well tolerated. After 6 months of Protandim ® , a 48% average decrease in plasma TBARS was seen; 0.92 nmol/mg protein in controls versus 0.48 nmol/mg protein in the Protandim ® group (p = .006). At 6 months, plasma OPN was decreased by 57% (p = .001) in the Protandim ® -treated mice. Protandim ® increased the plasma antioxidant enzyme PON1 activity by 35% (p = .018). After 6 months, the mdx mice with Protandim ® showed 38% less MRI signal abnormality (p = .07) than mice on control diet. In this 6-month mdx mouse study, Protandim ® did not significantly alter motor function nor histological criteria.
Advances in Contraception, 1998