Julio Cesar Gomez Fernandez | University of Warsaw (original) (raw)

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Papers by Julio Cesar Gomez Fernandez

Research paper thumbnail of Single-molecule paleoenzymology probes the chemistry of resurrected enzymes

Nature Structural & Molecular Biology, 2011

It is possible to travel back in time at the molecular level by reconstructing proteins from exti... more It is possible to travel back in time at the molecular level by reconstructing proteins from extinct organisms. Here we report the reconstruction, based on sequence predicted by phylogenetic analysis, of seven Precambrian thioredoxin enzymes (Trx) dating back between ~1.4 and ~4 billion years (Gyr). The reconstructed enzymes are up to 32 °C more stable than modern enzymes, and the

Research paper thumbnail of Probing the chemistry of thioredoxin catalysis with force

Research paper thumbnail of Single-molecule paleoenzymology probes the chemistry of resurrected enzymes

Nature Structural & Molecular Biology, 2011

It is possible to travel back in time at the molecular level by reconstructing proteins from exti... more It is possible to travel back in time at the molecular level by reconstructing proteins from extinct organisms. Here we report the reconstruction, based on sequence predicted by phylogenetic analysis, of seven Precambrian thioredoxin enzymes (Trx) dating back between ~1.4 and ~4 billion years (Gyr). The reconstructed enzymes are up to 32 °C more stable than modern enzymes, and the

Research paper thumbnail of Probing the chemistry of thioredoxin catalysis with force

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