Dieter Mayer | University of Zurich, Switzerland (original) (raw)

Papers by Dieter Mayer

Research paper thumbnail of Technological features of advanced skin protectants and an examination of the evidence base

Journal of Wound Care, 2019

Products that provide a protective skin barrier play a vital role in defending the skin against t... more Products that provide a protective skin barrier play a vital role in defending the skin against the corrosive effect of bodily fluids, including wound exudate, urine, liquid faeces, stoma output and sweat. There are many products to choose from, which can be broadly categorised by ingredients. This article describes the differences in mechanisms of action between barrier products comprising petrolatum and/or zinc oxide, silicone film-forming polymers and cyanoacrylates, and compares the evidence on them. The literature indicates that all types of barrier product are clinically effective, with little comparative evidence indicating that any one ingredient is more efficacious than another, although film-forming polymers and cyanoacrylates have been found to be easier to apply and more cost-effective. However, laboratory evidence, albeit limited, indicates that a concentrated cyanoacrylate produced a more substantial and adherent layer on a porcine explant when compared with a diluted ...

Research paper thumbnail of Analysis of Effective Interconnectivity of DegraPol-foams Designed for Negative Pressure Wound Therapy

Research paper thumbnail of Vascular graft infections

Swiss Medical Weekly, 2013

Research paper thumbnail of CT Angiography at 24 Months Demonstrates Durability of EVAR With the Use of Chimney Grafts for Pararenal Aortic Pathologies

Journal of Endovascular Therapy, 2013

Research paper thumbnail of Multiple Periscope and Chimney Grafts to Treat Ruptured Thoracoabdominal and Pararenal Aortic Aneurysms

Journal of Endovascular Therapy, 2011

Research paper thumbnail of Surfactants and their role in wound cleansing and biofilm management

Journal of Wound Care, 2017

Surfactants are widely used as detergents, emulsifiers, wetting agents, foaming agents and disper... more Surfactants are widely used as detergents, emulsifiers, wetting agents, foaming agents and dispersants in the cosmetics, hygiene, food and oil industries. Their use in a clinical setting is also common, particularly within the field of wound care. Many wound cleansers contain surfactants and subsequently there is available data that shows the growing potential of these wound cleansers in the enhancement of wound closure. The presence of microorganisms in wounds has been recognised as a significant factor that delay healing. In complex or chronic wounds that are complicated by biofilms, persistent inflammation or the production of non-viable tissue and slough, the use of surfactants has been shown to aid in the removal of these barriers to wound healing. The use of concentrated surfactant(poloxamer) based wound dressings represent an important component of wound management. Consequently, this article will discuss the effect of clinically used surfactants, with specific focus on a con...

Research paper thumbnail of Comment on “Intra-abdominal Hypertension and Abdominal Compartment Syndrome after Endovascular Repair of Ruptured Abdominal Aortic Aneurysm”

European Journal of Vascular and Endovascular Surgery, 2011

Research paper thumbnail of Wound bed preparation

Research paper thumbnail of Die extrakorporale Stoßwellentherapie als neue Methode zur Stimulation der Heilung komplexer Wunden: eine Übersicht

Research paper thumbnail of Less Invasive (Common) Femoral Artery Aneurysm Repair Using Endografts and Limited Dissection

European Journal of Vascular and Endovascular Surgery, 2013

Research paper thumbnail of Outpatient Endovascular Aortic Aneurysm Repair

Research paper thumbnail of Periscope Endograft Technique to Revascularize the Left Subclavian Artery During Thoracic Endovascular Aortic Repair

Journal of Endovascular Therapy, 2013

Research paper thumbnail of Juxtarenale, suprarenale und Abschnitt IV-Aneurysmen der Aorta: Klinik, Diagnostik und konventionelle Therapie

Juxta-, suprarenale und Abschnitt-IV-Aneurysmen sind im Vergleich zu abdominalen Aneurysmen selte... more Juxta-, suprarenale und Abschnitt-IV-Aneurysmen sind im Vergleich zu abdominalen Aneurysmen selten. In einer grosen autoptischen Serie von Patienten mit aortoiliakalen Aneurysmen zeigte sich die folgende relative Haufigkeit nach Lokalisation: abdominale Aorta allein 65 %; thorakale Aorta allein 19 %; abdominale Aorta plus Iliakalarterien 13 %; thorakoabdominale Aorta 2 %; und isolierte Iliakalarterien 1 % (Brunkwall et al. 1989). In einer vergleichenden Studie von 429 Patienten mit abdominalen und juxtarenalen Aortenaneurysmen prasentierten sich 86 % als infrarenal, und 14 % erstreckten sich bis an oder uber die Nierenarterien (Ayari et al. 2001). Abschnitt-IV-Aneurysmen werden in 10–26 % der thorakoabdominalen Aortenaneurysmen beschrieben (Cambria 2000). Juxtarenale Aneurysmen sind etwa 3- bis 4-mal haufiger als suprarenale Aneurysmen (Nypaver et al. 1993). Populationsbasierte Studien schatzen die Inzidenz von klinisch offenkundigen abdominalen Aortenaneurysmen auf 21 pro 100.000 P...

Research paper thumbnail of Tolerance of Biofilms to Antimicrobials and Significance to Antibiotic Resistance in Wounds

A biofilm is a community of microorganisms that adhere to each other and to surfaces and secrete ... more A biofilm is a community of microorganisms that adhere to each other and to surfaces and secrete extracellular polymeric substances (EPS) encasing themselves in a matrix. Biofilms are a major healthcare concern, as they can form on medical devices leading to infection. Additionally, there is growing evidence to show their ability to form in chronic wounds, which leads to delayed wound healing and inflammation. Due to a number of reasons, such as formation of the EPS resulting in sub-inhibitory concentrations of antimicrobials reaching the bacterial cells, slow growth rate of bacterial cells rendering some antibiotics ineffective, and the presence of persister cells, biofilms show increased tolerance to many antimicrobials and antibiotics. Additionally, studies have started to emerge showing a link between resistance to antimicrobials and antibiotics. Cross-resistance can be attributed to a number of factors, for example, increased expression of multidrug efflux pumps that efflux a w...

Research paper thumbnail of Open wounds and rifampicin therapy are associated with rifampicin resistance among staphylococcal vascular graft/endograft infections

JAC-Antimicrobial Resistance

Background Optimal timing for rifampicin combination therapy in patients with staphylococcal vasc... more Background Optimal timing for rifampicin combination therapy in patients with staphylococcal vascular graft/endograft infection (S-VGEI) is unknown. Experts recommend adding rifampicin after lowering bacterial load by surgery and wound closure. Objectives To assess predictors of rifampicin resistance among staphylococci isolated from patients in the Vascular Graft Infection Cohort Study. Methods We included prospective patients with S-VGEI diagnosis from 1 January 2002 to 30 June 2020. We retrospectively assessed determinants of rifampicin resistance using exact logistic regression and described survival with Kaplan–Meier curves. Results We analysed 513 Staphylococcus spp. among 143 predominantly male (82%) patients with a median age of 68 years (IQR 60–75). Thereof, 82 (57%) received a rifampicin combination therapy and 61 (43%) received an antimicrobial therapy without rifampicin. Among 82 patients with rifampicin, 26/26 patients with any rifampicin resistance had open wounds with...

Research paper thumbnail of Wound Bed Preparation 2021

Advances in Skin & Wound Care

Research paper thumbnail of Mode of action of poloxamer-based surfactants in wound care and efficacy on biofilms

International wound journal, Jan 5, 2018

Surfactants are widely used as detergents, emulsifiers, wetting agents, foaming agents, and dispe... more Surfactants are widely used as detergents, emulsifiers, wetting agents, foaming agents, and dispersants in both the food and oil industry. Their use in a clinical setting is also common, particularly in wound care. Complicated or chronic wounds show clinical signs of delayed healing, persistent inflammation, and the production of non-viable tissue. These types of wounds also present challenges such as infection and potentially house antimicrobial-tolerant biofilms. The use of wound cleansers to aid cleaning and debridement of the wound is essential. A large proportion of skin and wound cleansers contain surfactants but there is only a small amount of data that shows the effectiveness of them in the enhancement of wound closure. This review paper aims to explore the available literature surrounding the use and mode of action of surfactants in wound healing, in particular Poloxamer 188 (Pluronic F-68) and Poloxamer 407 (Pluronic F-127), and also uncover the potential mechanisms behind...

Research paper thumbnail of Long-term Survival After Endovascular and Open Repair of Ruptured Abdominal Aortic Aneurysms

Journal of Vascular Surgery, 2010

Research paper thumbnail of Prosthetic vascular graft infections: bacterial cultures from negative pressure wound therapy foams do not improve diagnostics

Journal of Clinical Microbiology, 2016

We analyzed the diagnostic value of microorganisms cultured from negative-pressure-wound-therapy ... more We analyzed the diagnostic value of microorganisms cultured from negative-pressure-wound-therapy (NPWT) foam samples compared to that of microorganisms cultured from deep tissue samples from patients with vascular graft infections. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were 58%, 86%, 81%, and 66%, respectively. The diagnostic value of microbiological cultures from NPWT foams was poor.

Research paper thumbnail of Role of anaerobes in polymicrobial communities and biofilms complicating diabetic foot ulcers

International wound journal, 2018

Infected tissues in the feet of people with diabetes in the form of a diabetic foot ulcer (DFU) p... more Infected tissues in the feet of people with diabetes in the form of a diabetic foot ulcer (DFU) present a complex pathology for clinicians to manage. This is partly attributed to the multi-factorial nature of the disease, which may include; altered foot architecture leading to excessive plantar pressures and frictional forces peripheral arterial disease and loss of protective sensation. In addition, to the above co-morbid variables, it is understood that a delayed wound healing state may be perpetuated by the presence of microorganisms residing in the wound tissue. The microbiology of chronic DFUs has often been reported as being polymicrobial. Of growing interest is the presence and potential role of anaerobic microorganisms in the pathology of DFUs and how they may contribute to the infective process or delayed healing. The presence of anaerobes in DFUs has been greatly underestimated, largely due to the limitations of conventional culture methods in identifying them from samples....

Research paper thumbnail of Technological features of advanced skin protectants and an examination of the evidence base

Journal of Wound Care, 2019

Products that provide a protective skin barrier play a vital role in defending the skin against t... more Products that provide a protective skin barrier play a vital role in defending the skin against the corrosive effect of bodily fluids, including wound exudate, urine, liquid faeces, stoma output and sweat. There are many products to choose from, which can be broadly categorised by ingredients. This article describes the differences in mechanisms of action between barrier products comprising petrolatum and/or zinc oxide, silicone film-forming polymers and cyanoacrylates, and compares the evidence on them. The literature indicates that all types of barrier product are clinically effective, with little comparative evidence indicating that any one ingredient is more efficacious than another, although film-forming polymers and cyanoacrylates have been found to be easier to apply and more cost-effective. However, laboratory evidence, albeit limited, indicates that a concentrated cyanoacrylate produced a more substantial and adherent layer on a porcine explant when compared with a diluted ...

Research paper thumbnail of Analysis of Effective Interconnectivity of DegraPol-foams Designed for Negative Pressure Wound Therapy

Research paper thumbnail of Vascular graft infections

Swiss Medical Weekly, 2013

Research paper thumbnail of CT Angiography at 24 Months Demonstrates Durability of EVAR With the Use of Chimney Grafts for Pararenal Aortic Pathologies

Journal of Endovascular Therapy, 2013

Research paper thumbnail of Multiple Periscope and Chimney Grafts to Treat Ruptured Thoracoabdominal and Pararenal Aortic Aneurysms

Journal of Endovascular Therapy, 2011

Research paper thumbnail of Surfactants and their role in wound cleansing and biofilm management

Journal of Wound Care, 2017

Surfactants are widely used as detergents, emulsifiers, wetting agents, foaming agents and disper... more Surfactants are widely used as detergents, emulsifiers, wetting agents, foaming agents and dispersants in the cosmetics, hygiene, food and oil industries. Their use in a clinical setting is also common, particularly within the field of wound care. Many wound cleansers contain surfactants and subsequently there is available data that shows the growing potential of these wound cleansers in the enhancement of wound closure. The presence of microorganisms in wounds has been recognised as a significant factor that delay healing. In complex or chronic wounds that are complicated by biofilms, persistent inflammation or the production of non-viable tissue and slough, the use of surfactants has been shown to aid in the removal of these barriers to wound healing. The use of concentrated surfactant(poloxamer) based wound dressings represent an important component of wound management. Consequently, this article will discuss the effect of clinically used surfactants, with specific focus on a con...

Research paper thumbnail of Comment on “Intra-abdominal Hypertension and Abdominal Compartment Syndrome after Endovascular Repair of Ruptured Abdominal Aortic Aneurysm”

European Journal of Vascular and Endovascular Surgery, 2011

Research paper thumbnail of Wound bed preparation

Research paper thumbnail of Die extrakorporale Stoßwellentherapie als neue Methode zur Stimulation der Heilung komplexer Wunden: eine Übersicht

Research paper thumbnail of Less Invasive (Common) Femoral Artery Aneurysm Repair Using Endografts and Limited Dissection

European Journal of Vascular and Endovascular Surgery, 2013

Research paper thumbnail of Outpatient Endovascular Aortic Aneurysm Repair

Research paper thumbnail of Periscope Endograft Technique to Revascularize the Left Subclavian Artery During Thoracic Endovascular Aortic Repair

Journal of Endovascular Therapy, 2013

Research paper thumbnail of Juxtarenale, suprarenale und Abschnitt IV-Aneurysmen der Aorta: Klinik, Diagnostik und konventionelle Therapie

Juxta-, suprarenale und Abschnitt-IV-Aneurysmen sind im Vergleich zu abdominalen Aneurysmen selte... more Juxta-, suprarenale und Abschnitt-IV-Aneurysmen sind im Vergleich zu abdominalen Aneurysmen selten. In einer grosen autoptischen Serie von Patienten mit aortoiliakalen Aneurysmen zeigte sich die folgende relative Haufigkeit nach Lokalisation: abdominale Aorta allein 65 %; thorakale Aorta allein 19 %; abdominale Aorta plus Iliakalarterien 13 %; thorakoabdominale Aorta 2 %; und isolierte Iliakalarterien 1 % (Brunkwall et al. 1989). In einer vergleichenden Studie von 429 Patienten mit abdominalen und juxtarenalen Aortenaneurysmen prasentierten sich 86 % als infrarenal, und 14 % erstreckten sich bis an oder uber die Nierenarterien (Ayari et al. 2001). Abschnitt-IV-Aneurysmen werden in 10–26 % der thorakoabdominalen Aortenaneurysmen beschrieben (Cambria 2000). Juxtarenale Aneurysmen sind etwa 3- bis 4-mal haufiger als suprarenale Aneurysmen (Nypaver et al. 1993). Populationsbasierte Studien schatzen die Inzidenz von klinisch offenkundigen abdominalen Aortenaneurysmen auf 21 pro 100.000 P...

Research paper thumbnail of Tolerance of Biofilms to Antimicrobials and Significance to Antibiotic Resistance in Wounds

A biofilm is a community of microorganisms that adhere to each other and to surfaces and secrete ... more A biofilm is a community of microorganisms that adhere to each other and to surfaces and secrete extracellular polymeric substances (EPS) encasing themselves in a matrix. Biofilms are a major healthcare concern, as they can form on medical devices leading to infection. Additionally, there is growing evidence to show their ability to form in chronic wounds, which leads to delayed wound healing and inflammation. Due to a number of reasons, such as formation of the EPS resulting in sub-inhibitory concentrations of antimicrobials reaching the bacterial cells, slow growth rate of bacterial cells rendering some antibiotics ineffective, and the presence of persister cells, biofilms show increased tolerance to many antimicrobials and antibiotics. Additionally, studies have started to emerge showing a link between resistance to antimicrobials and antibiotics. Cross-resistance can be attributed to a number of factors, for example, increased expression of multidrug efflux pumps that efflux a w...

Research paper thumbnail of Open wounds and rifampicin therapy are associated with rifampicin resistance among staphylococcal vascular graft/endograft infections

JAC-Antimicrobial Resistance

Background Optimal timing for rifampicin combination therapy in patients with staphylococcal vasc... more Background Optimal timing for rifampicin combination therapy in patients with staphylococcal vascular graft/endograft infection (S-VGEI) is unknown. Experts recommend adding rifampicin after lowering bacterial load by surgery and wound closure. Objectives To assess predictors of rifampicin resistance among staphylococci isolated from patients in the Vascular Graft Infection Cohort Study. Methods We included prospective patients with S-VGEI diagnosis from 1 January 2002 to 30 June 2020. We retrospectively assessed determinants of rifampicin resistance using exact logistic regression and described survival with Kaplan–Meier curves. Results We analysed 513 Staphylococcus spp. among 143 predominantly male (82%) patients with a median age of 68 years (IQR 60–75). Thereof, 82 (57%) received a rifampicin combination therapy and 61 (43%) received an antimicrobial therapy without rifampicin. Among 82 patients with rifampicin, 26/26 patients with any rifampicin resistance had open wounds with...

Research paper thumbnail of Wound Bed Preparation 2021

Advances in Skin & Wound Care

Research paper thumbnail of Mode of action of poloxamer-based surfactants in wound care and efficacy on biofilms

International wound journal, Jan 5, 2018

Surfactants are widely used as detergents, emulsifiers, wetting agents, foaming agents, and dispe... more Surfactants are widely used as detergents, emulsifiers, wetting agents, foaming agents, and dispersants in both the food and oil industry. Their use in a clinical setting is also common, particularly in wound care. Complicated or chronic wounds show clinical signs of delayed healing, persistent inflammation, and the production of non-viable tissue. These types of wounds also present challenges such as infection and potentially house antimicrobial-tolerant biofilms. The use of wound cleansers to aid cleaning and debridement of the wound is essential. A large proportion of skin and wound cleansers contain surfactants but there is only a small amount of data that shows the effectiveness of them in the enhancement of wound closure. This review paper aims to explore the available literature surrounding the use and mode of action of surfactants in wound healing, in particular Poloxamer 188 (Pluronic F-68) and Poloxamer 407 (Pluronic F-127), and also uncover the potential mechanisms behind...

Research paper thumbnail of Long-term Survival After Endovascular and Open Repair of Ruptured Abdominal Aortic Aneurysms

Journal of Vascular Surgery, 2010

Research paper thumbnail of Prosthetic vascular graft infections: bacterial cultures from negative pressure wound therapy foams do not improve diagnostics

Journal of Clinical Microbiology, 2016

We analyzed the diagnostic value of microorganisms cultured from negative-pressure-wound-therapy ... more We analyzed the diagnostic value of microorganisms cultured from negative-pressure-wound-therapy (NPWT) foam samples compared to that of microorganisms cultured from deep tissue samples from patients with vascular graft infections. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were 58%, 86%, 81%, and 66%, respectively. The diagnostic value of microbiological cultures from NPWT foams was poor.

Research paper thumbnail of Role of anaerobes in polymicrobial communities and biofilms complicating diabetic foot ulcers

International wound journal, 2018

Infected tissues in the feet of people with diabetes in the form of a diabetic foot ulcer (DFU) p... more Infected tissues in the feet of people with diabetes in the form of a diabetic foot ulcer (DFU) present a complex pathology for clinicians to manage. This is partly attributed to the multi-factorial nature of the disease, which may include; altered foot architecture leading to excessive plantar pressures and frictional forces peripheral arterial disease and loss of protective sensation. In addition, to the above co-morbid variables, it is understood that a delayed wound healing state may be perpetuated by the presence of microorganisms residing in the wound tissue. The microbiology of chronic DFUs has often been reported as being polymicrobial. Of growing interest is the presence and potential role of anaerobic microorganisms in the pathology of DFUs and how they may contribute to the infective process or delayed healing. The presence of anaerobes in DFUs has been greatly underestimated, largely due to the limitations of conventional culture methods in identifying them from samples....