Kaushal Srivastava | Vinoba Bhave University (original) (raw)
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Papers by Kaushal Srivastava
The interaction between picric acid (acceptor) and o-phenanthroline (donor) have been studied spe... more The interaction between picric acid (acceptor) and o-phenanthroline (donor) have been studied
spectrophotometrically in THF solvent for the evaluation of reliable value of association constant in
the formation of weakly bounded charge transfer complex. The value of association constant (K) was
calculated using standard equations such as Benesi-Hildebrand, Scott, Foster Hammick Waldley, Rose
Drago Ayad, El-Hati, Lang, Scatchard, Seal-Sil Mukherjee, at wavelengths358.5 378, 400 and 420
nm in THF solvent. The value of association constant of the 1:1 complex insolution, calculated by
different standard equations ranges between 1561 and 4928. The wide range of variation of the
calculated values of K led us to guest for the reliable value. The reliability of different calculated
values was examined. The Benesi- and Hildebrand method was found to give most reliable value of
K. The most reliable value of K for complex was found to be 1907. The stoichiometry of the complex
was established spectrophotometrically by Jobs’s method of constant variation.
In quest of cheap anti HIV drugs, molecular docking studies with HIV-1RT (PDB ID 1FK9) were carri... more In quest of cheap anti HIV drugs, molecular docking studies with HIV-1RT (PDB ID 1FK9) were carried out using certain succinic acid derivatives. One of the derivatives-2-(diphenylmethylene)succinic acid was found to have binding energy and docking pattern comparable to the originally docked efavirenz molecule. This molecule has been predicted theoretically to be non-toxic. Five drug molecules similar in druggability to this molecule , but used in other diseases , were identified and their molecular docking results on 1FK9 have also been reported .
The interaction between picric acid (acceptor) and o-phenanthroline (donor) have been studied spe... more The interaction between picric acid (acceptor) and o-phenanthroline (donor) have been studied
spectrophotometrically in THF solvent for the evaluation of reliable value of association constant in
the formation of weakly bounded charge transfer complex. The value of association constant (K) was
calculated using standard equations such as Benesi-Hildebrand, Scott, Foster Hammick Waldley, Rose
Drago Ayad, El-Hati, Lang, Scatchard, Seal-Sil Mukherjee, at wavelengths358.5 378, 400 and 420
nm in THF solvent. The value of association constant of the 1:1 complex insolution, calculated by
different standard equations ranges between 1561 and 4928. The wide range of variation of the
calculated values of K led us to guest for the reliable value. The reliability of different calculated
values was examined. The Benesi- and Hildebrand method was found to give most reliable value of
K. The most reliable value of K for complex was found to be 1907. The stoichiometry of the complex
was established spectrophotometrically by Jobs’s method of constant variation.
In quest of cheap anti HIV drugs, molecular docking studies with HIV-1RT (PDB ID 1FK9) were carri... more In quest of cheap anti HIV drugs, molecular docking studies with HIV-1RT (PDB ID 1FK9) were carried out using certain succinic acid derivatives. One of the derivatives-2-(diphenylmethylene)succinic acid was found to have binding energy and docking pattern comparable to the originally docked efavirenz molecule. This molecule has been predicted theoretically to be non-toxic. Five drug molecules similar in druggability to this molecule , but used in other diseases , were identified and their molecular docking results on 1FK9 have also been reported .