Eman Egept | Virginia Commonwealth University (original) (raw)

Papers by Eman Egept

Journal of …, 2002

Jigrine a polypharmaceutical herbal formulation containing aqueous extracts of 14 medicinal plant... more Jigrine a polypharmaceutical herbal formulation containing aqueous extracts of 14 medicinal plants developed on the principles of unani system of medicine is used for liver ailments. The hepatoprotective potential of jigrine post-treatment at the dose of 0.5 ml/kg per day p.o. for 21 days was evaluated against thiocetamide induced liver damage in rats. Biochemical parameters like AST, ALT in serum and TBARS and glutathione in tissues were estimated to assess liver function. Data on the biochemical parameters revealed hepatoprotective potential of jigrine post-treatment against thioacetamide induced hepatotoxicity in rats. Silymarin used as reference standard also exhibited significant hepatoprotective activity on post-treatment against thioacetamide-induced hepatotoxity in rats. The biochemical observations were supplemented with histopathological examination of rat liver sections.

… Research Journal of …, 2011

Abstract: Liver is the principle organ for maintaining the body's in... more Abstract: Liver is the principle organ for maintaining the body's internal environment. Its major influence on the flow of nutrients, & control the metabolism of carbohydrate, proteins and fats. It is also the major reticulo-endothelial organ in the body as such has important ...

Ind J Phar Sci Res, 2011

A phytotherapeutic approach to modern drug development can provide many invaluable drugs from tra... more A phytotherapeutic approach to modern drug development can provide many invaluable drugs from traditional medicinal plants. Search for pure phytochemicals as drugs is time consuming and expensive. Numerous plants and polyherbal formulations are used for the treatment of liver diseases. However, in most of the severe cases, the treatments are not satisfactory. Although experimental evaluations were carried out on a good number of these plants and formulations, the studies were mostly incomplete and insufficient. The therapeutic values were tested against a few chemicals-induced subclinical levels of liver damages in rodents. Even common dietary antioxidants can provide such protection from liver damage caused by oxidative mechanisms of toxic chemicals. However, experiments have clearly shown that plants such as Picrorrhiza kurroa, Andrographis paniculata, Eclipta alba, Silibum marianum, Phyllanthus maderaspatensis and Trichopus zeylanicus are sufficiently active against, at least, certain hepatotoxins. Screening plants for antihepatitis activities remains in its infancy. P.kurroa, E. alba, Glycyrrhiza glabra, A. paniculata and P. amarus are likely to be active against Hepatitis B virus. In the case of severe liver damage, most of the liver cells die or turn into fibrotic state. In this case, the treatment should include in addition to the therapeutic agents, agents which can stimulate liver cell proliferation. For developing satisfactory herbal combinations to treat severe liver diseases, plants have to be evaluated systematically for properties such as antiviral activity (Hepatitis B, Hepatitis C, etc), antihepatotoxicity (antioxidants and others), stimulation of liver regeneration and choleretic activity. The plants with remarkable activities for each of the above properties have to be identified. Single plant may not have all the desired activities. A combination of different herbal extracts/'fractions is likely to provide desired activities to cure severe liver diseases. Development of such medicines with standards of safety and efficacy can revitalise treatment of liver disorders and hepatoprotective activity.

Food Reviews International, 2005

... the link if you wish to visit the database now. Food Reviews International. ... Protective Ef... more ... the link if you wish to visit the database now. Food Reviews International. ... Protective Effect of Ganoderma (a Mushroom with Medicinal Properties) Against Various Liver Injuries. ... DOI: 10.1081/FRI-200040586 Yihuai Gao a , He Gao b , Eli Chan c , Wenbo Tang b , Xiaotian Li d ...

International Journal of Medicinal Mushrooms, 2003

Journal of …, 2002

Jigrine a polypharmaceutical herbal formulation containing aqueous extracts of 14 medicinal plant... more Jigrine a polypharmaceutical herbal formulation containing aqueous extracts of 14 medicinal plants developed on the principles of unani system of medicine is used for liver ailments. The hepatoprotective potential of jigrine post-treatment at the dose of 0.5 ml/kg per day p.o. for 21 days was evaluated against thiocetamide induced liver damage in rats. Biochemical parameters like AST, ALT in serum and TBARS and glutathione in tissues were estimated to assess liver function. Data on the biochemical parameters revealed hepatoprotective potential of jigrine post-treatment against thioacetamide induced hepatotoxicity in rats. Silymarin used as reference standard also exhibited significant hepatoprotective activity on post-treatment against thioacetamide-induced hepatotoxity in rats. The biochemical observations were supplemented with histopathological examination of rat liver sections.

… Research Journal of …, 2011

Abstract: Liver is the principle organ for maintaining the body's in... more Abstract: Liver is the principle organ for maintaining the body's internal environment. Its major influence on the flow of nutrients, & control the metabolism of carbohydrate, proteins and fats. It is also the major reticulo-endothelial organ in the body as such has important ...

Ind J Phar Sci Res, 2011

A phytotherapeutic approach to modern drug development can provide many invaluable drugs from tra... more A phytotherapeutic approach to modern drug development can provide many invaluable drugs from traditional medicinal plants. Search for pure phytochemicals as drugs is time consuming and expensive. Numerous plants and polyherbal formulations are used for the treatment of liver diseases. However, in most of the severe cases, the treatments are not satisfactory. Although experimental evaluations were carried out on a good number of these plants and formulations, the studies were mostly incomplete and insufficient. The therapeutic values were tested against a few chemicals-induced subclinical levels of liver damages in rodents. Even common dietary antioxidants can provide such protection from liver damage caused by oxidative mechanisms of toxic chemicals. However, experiments have clearly shown that plants such as Picrorrhiza kurroa, Andrographis paniculata, Eclipta alba, Silibum marianum, Phyllanthus maderaspatensis and Trichopus zeylanicus are sufficiently active against, at least, certain hepatotoxins. Screening plants for antihepatitis activities remains in its infancy. P.kurroa, E. alba, Glycyrrhiza glabra, A. paniculata and P. amarus are likely to be active against Hepatitis B virus. In the case of severe liver damage, most of the liver cells die or turn into fibrotic state. In this case, the treatment should include in addition to the therapeutic agents, agents which can stimulate liver cell proliferation. For developing satisfactory herbal combinations to treat severe liver diseases, plants have to be evaluated systematically for properties such as antiviral activity (Hepatitis B, Hepatitis C, etc), antihepatotoxicity (antioxidants and others), stimulation of liver regeneration and choleretic activity. The plants with remarkable activities for each of the above properties have to be identified. Single plant may not have all the desired activities. A combination of different herbal extracts/'fractions is likely to provide desired activities to cure severe liver diseases. Development of such medicines with standards of safety and efficacy can revitalise treatment of liver disorders and hepatoprotective activity.

Food Reviews International, 2005

... the link if you wish to visit the database now. Food Reviews International. ... Protective Ef... more ... the link if you wish to visit the database now. Food Reviews International. ... Protective Effect of Ganoderma (a Mushroom with Medicinal Properties) Against Various Liver Injuries. ... DOI: 10.1081/FRI-200040586 Yihuai Gao a , He Gao b , Eli Chan c , Wenbo Tang b , Xiaotian Li d ...

International Journal of Medicinal Mushrooms, 2003