Travis Rose - Profile on Academia.edu (original) (raw)

Papers by Travis Rose

Research paper thumbnail of Trecvid

Research paper thumbnail of Trecvid

IMPORTANT: Additional/replacement ASR. MT and Status. eMail to the mailing list trecvid2005@ nist. gov, 2005

Research paper thumbnail of MacVisSTA: A System for Multimodal Analysis of Human Communication and Interaction

The study of embodied communication requires access to multiple data sources such as multistream ... more The study of embodied communication requires access to multiple data sources such as multistream video and audio, various derived and meta-data such as gesture, head, posture, facial expression and gaze information. This thesis presents the data collection, annotation, and analysis for multiple participants engaged in planning meetings. In support of the analysis tasks, this thesis presents the multimedia Visualization for Situated Temporal Analysis for Macintosh (MacVisSTA) system. It supports the analysis of multimodal human communication through the use of video, audio, speech transcriptions, and gesture and head orientation data. The system uses a multiple linked representation strategy in which different representations are linked by the current time focus. MacVisSTA supports analysis of the synchronized data at varying timescales for coarse-to-fine observational studies. The hybrid architecture may be extended through plugins. Finally, this effort has resulted in encoding of behavioral and language data, enabling collaborative research and embodying it with the aid of, and interface to, a database management system.

Research paper thumbnail of An Exchange Format for Multimodal Annotations

Lecture Notes in Computer Science, 2009

This paper presents the results of a joint effort of a group of multimodality researchers and too... more This paper presents the results of a joint effort of a group of multimodality researchers and tool developers to improve the interoperability between several tools used for the annotation of multimodality. We propose a multimodal annotation exchange format, based on the annotation graph formalism, which is supported by import and export routines in the respective tools.

Research paper thumbnail of Delivery of peptide epitopes for HTLV-I using biodegradable microspheres

Delivery of peptide epitopes for HTLV-I using biodegradable microspheres

American Peptide Symposia, 2002

Research paper thumbnail of MacVisSTA

MacVisSTA

Proceedings of the 6th international conference on Multimodal interfaces - ICMI '04, 2004

The study of embodied communication requires access to mul-tiple data sources such as multistream... more The study of embodied communication requires access to mul-tiple data sources such as multistream video and audio, various derived and meta-data such as gesture, head, posture, facial expression and gaze information. The common element that runs through these data is the co-temporality of the multiple modes of behavior. In this paper, we present the multimedia Visualization for Situated Temporal Analysis

Research paper thumbnail of Comparing Gesture and Touch for Notification System Interactions

We explore some of the characteristics of multimodal input interaction spaces for notification sy... more We explore some of the characteristics of multimodal input interaction spaces for notification systems within a multi-tasking environment like a command and control center using two promising interaction methods: gestures and touch based input through a laboratory experiment comparing both techniques. Results of our study suggest that gestures are better suited for multi-tasking situations because they are less interruptive than touch interaction to users' primary tasks and are subjectively preferred by users in certain situations.

Research paper thumbnail of Microencapsulation of a synthetic peptide epitope for HTLV-1 in biodegradable poly(D,L-lactide-co-glycolide) microspheres using a novel encapsulation technique

Microencapsulation of a synthetic peptide epitope for HTLV-1 in biodegradable poly(D,L-lactide-co-glycolide) microspheres using a novel encapsulation technique

Journal of Microencapsulation, 2001

A novel procedure has been developed for the encapsulation of peptide antigens in poly(lactide-co... more A novel procedure has been developed for the encapsulation of peptide antigens in poly(lactide-co-glycolide) (PLGA) microspheres, which employs trifluoro-acetic acid (TFA) as a carrier solvent for both the polymer and antigen. The antigen/polymer solution is emulsified in mineral oil containing sorbitan trioleate (Span 85) as an emulsifier and a low level of cottonseed oil to extract the TFA. Fluoresceinisothiocyanate-labelled bovine serum albumin (FITC-BSA) was used as a model antigen to characterize the microencapsulation. Microspheres were of the desired size (<10 microm) for targeting to antigen-presenting cells, and released the model antigen slowly after an initial burst release (11%) in PBS/0.02% Tween 80 at 37 degrees C. Subsequently, a potential peptide vaccine, designated MVFMF2, for the human T-lymphotropic virus type 1 (HTLV-1 ) was encapsulated at 4.7% loading using the novel oil-in-oil method. In vivo immune responses were examined in rabbits immunized with (i) encapsulated MVFMF2 together with encapsulated adjuvant (N-acetyl-glucosamine-3yl-acetyl-L-alanyl-D-isoglutamine, nor-MDP, (ii) encapsulated MVFMF2 without adjuvant, and (iii) free peptide with adjuvant. Inoculation of the encapsulated peptide produced an antibody response similar to that of the free peptide emulsified in adjuvant. Moreover, the elevated immune response elicited by the encapsulated peptide was observed without multiple booster immunizations and irrespective of whether an adjuvant was used. Additionally, the antibodies raised against both free and encapsulated MVFMF2 had similar affinities, as judged by competitive enzyme-linked immunosorbant assay (ELISA), indicating that the encapsulated peptide retained a significant fraction of its epitopes. Hence, these results demonstrate that peptide vaccines can be encapsulated in PLGA microspheres using a common carrier solvent for both the peptide and polymer, which produces a desirable immune response in the absence of an adjuvant.

Research paper thumbnail of VACE Multimodal Meeting Corpus

Lecture Notes in Computer Science, 2006

In this paper, we report on the infrastructure we have developed to support our research on multi... more In this paper, we report on the infrastructure we have developed to support our research on multimodal cues for understanding meetings. With our focus on multimodality, we investigate the interaction among speech, gesture, posture, and gaze in meetings. For this purpose, a high quality multimodal corpus is being produced.

Research paper thumbnail of VACE Multimodal Meeting Corpus

In this paper, we report on the infrastructure we have developed to support our research on multi... more In this paper, we report on the infrastructure we have developed to support our research on multimodal cues for understanding meetings. With our focus on multimodality, we investigate the interaction among speech, gesture, posture, and gaze in meetings. For this purpose, a high quality multimodal corpus is being produced.

Research paper thumbnail of TRECVID 2008 workshop participants notebook papers, Gaithersburg, MD, USA, November 2008

TRECVID 2008 workshop participants notebook papers, Gaithersburg, MD, USA, November 2008

Research paper thumbnail of The CLEAR 2007 Evaluation

Lecture Notes in Computer Science, 2008

This paper is a summary of the 2007 CLEAR Evaluation on the Classification of Events, Activities,... more This paper is a summary of the 2007 CLEAR Evaluation on the Classification of Events, Activities, and Relationships which took place in early 2007 and culminated with a two-day workshop held in May 2007. CLEAR is an international effort to evaluate systems for the perception of people, their activities, and interactions. In its second year, CLEAR has developed a following from the computer vision and speech communities, spawning a more multimodal perspective of research evaluation. This paper describes the evaluation tasks, including metrics and databases used, and discusses the results achieved. The CLEAR 2007 tasks comprise person, face, and vehicle tracking, head pose estimation, as well as acoustic scene analysis. These include subtasks performed in the visual, acoustic and audio-visual domains for meeting room and surveillance data.

Research paper thumbnail of AVSS Multiple Camera Person Tracking Challenge Evaluation Overview

AVSS Multiple Camera Person Tracking Challenge Evaluation Overview

2009 Sixth IEEE International Conference on Advanced Video and Signal Based Surveillance, 2009

ABSTRACT Technologies that track a specific person as they traverse a network of surveillance cam... more ABSTRACT Technologies that track a specific person as they traverse a network of surveillance cameras can be used as the basis for a multitude of video surveillance applications including mass transit monitoring, large venue security, building security, and the like. In order to continue supporting the development robust people tracking technologies, the first AVSS Multiple Camera Person Tracking (MCPT) Challenge Evaluation was established to provide data and evaluation resources for researchers to build Single Person Tracking (SPT) technologies. This special session will focus on the AVSS MCPT Challenge Evaluation which will include a description of the evaluation task, the i-LIDS Multiple-camera tracking scenario data set used for the evaluation, and presentations by the challenge evaluation participants describing their systems.

Research paper thumbnail of The TRECVid 2008 Event Detection evaluation

The TRECVid 2008 Event Detection evaluation

2009 Workshop on Applications of Computer Vision (WACV), 2009

... It is important to complement these formative evaluations with a more realistic picture of th... more ... It is important to complement these formative evaluations with a more realistic picture of the challenges ... observations could only occur in one specific location in the camera field, (2) the size of ... the UK Home Office for contributing data for use in the TRECVid evaluation, and the ...

Research paper thumbnail of Calibrating Head Pose Estimation in Videos for Meeting Room Event Analysis

2006 International Conference on Image Processing, 2006

In this paper, we study the calibration of head pose estimation in stereo camera setting for meet... more In this paper, we study the calibration of head pose estimation in stereo camera setting for meeting room video event analysis. Head pose information infers the direction of attention of the subjects in video, therefore is valuable for video event analysis/indexing, especially in meeting room scenario. We are developing a multi-modal meeting room data analyzing system for studying meeting room interaction dynamics, in which head pose estimation is one of the key components. As each subject in the meeting room can be observed by a pair of stereo cameras, we do 2D head tracking for the subject in each camera, and the 3D coordinate of the head can be obtained by triangulation. The 3D head pose is estimated in one of the camera coordinate system, we develop a procedure to accurately convert the estimated 3D pose in the camera coordinate system to that in the world coordinate system. In the experiment, visualization of the estimated head pose and location in world coordinate system verifies the soundness of our design. The estimated head pose and 3D location of the subjects in the meeting room allows further analysis of meeting room interaction dynamics, such as F-formation, Floor-control[1], etc.

Research paper thumbnail of A Multimodal Analysis of Floor Control in Meetings

Lecture Notes in Computer Science, 2006

The participant in a human-to-human communication who controls the floor bears the burden of movi... more The participant in a human-to-human communication who controls the floor bears the burden of moving the communication process along. Change in control of the floor can happen through a number of mechanisms, including interruptions, delegation of the floor, and so on. This paper investigates floor control in multiparty meetings that are both audio and video taped; hence, we analyze patterns of speech (e.g., the use of discourse markers) and visual cues (e.g, eye gaze exchanges) that are often involved in floor control changes. Identifying who has control of the floor provides an important focus for information retrieval and summarization of meetings. Additionally, without understanding who has control of the floor, it is impossible to identify important events such as challenges for the floor. In this paper, we analyze multimodal cues related to floor control in two different meetings involving five participants each.

Research paper thumbnail of Enhanced immunogenicity of a conformational epitope of human T-lymphotropic virus type 1 using a novel chimeric peptide

Vaccine, 2000

The ability of a peptide vaccine derived from the human T-lymphotropic virus type 1 (HTLV-1) surf... more The ability of a peptide vaccine derived from the human T-lymphotropic virus type 1 (HTLV-1) surface envelope glycoprotein protein (gp46) to mimic the native protein and elicit a protective immune response has been examined. This peptide construct, designated MVFMF2, comprises amino acids (aa) 175-218 of gp46 linked by a four residue turn (GPSL) to a promiscuous T-cell epitope from the measles virus fusion protein (MVF, aa 288 -302). The peptide was structurally characterized by circular dichroism (CD) spectroscopy and was found to contain a-helical secondary structure. The immunogenicity of MVFMF2 in rabbits and mice was evaluated by direct ELISA and competitive ELISA using peptide constructs and the recombinant protein ACH-RE3 (aa 165-306). This peptide, when administered with adjuvant (N-acetyl-glucosamine-3yl-acetyl-L-alanyl-D-isoglutamine, nor-MDP) was immunogenic in an outbred population of both rabbits and mice. Furthermore, the peptide construct was encapsulated in biodegradable microspheres of poly(D,L-lactide-co-glycolide) to eliminate booster immunization and to examine adjuvant requirements. The data indicate that MVFMF2 shows enhanced immunogenicity when encapsulated in biodegradable microspheres. Inoculation of the encapsulated peptide produced a similar humoral response to that of the free peptide, but did not require the use of adjuvant. Elicited anti-rabbit and anti-mouse antibodies recognized whole viral preparations and the recombinant protein ACH-RE3 in ELISA assays. Additionally, inoculated rabbits exhibited enhanced reactivity to viral antigens by western blot compared to non-vaccinated controls. Although anti-rabbit and anti-mouse antibodies were capable of inhibiting syncytium formation at low dilutions, rabbits were not protected from cell-associated viral challenge. Future development of vaccines to HTLV-1 may need to incorporate the ability to elicit cell-mediated immune responses in order to protect against cell-associated viral infection.

Research paper thumbnail of Agent-Based Gesture Tracking

IEEE Transactions on Systems, Man, and Cybernetics - Part A: Systems and Humans, 2005

We describe an agent-based approach to the visual tracking of human hands and head that represent... more We describe an agent-based approach to the visual tracking of human hands and head that represents a very useful "middle ground" between the simple model-free tracking and the highly constrained model-based solutions. It combines the simplicity, speed and flexibility of tracking without using explicit shape models with the ability to utilize domain knowledge and to apply various constraints characteristic of more elaborate model-based tracking approaches.

Research paper thumbnail of Middleware and Metrology for the Pervasive Future

Middleware and Metrology for the Pervasive Future

IEEE Pervasive Computing, 2000

... commercial, advertising, or promotional purposes or for creating new collective works for ...... more ... commercial, advertising, or promotional purposes or for creating new collective works for ... interoperabil-ity for algorithms and hardware, collab-orative development, and performancemeasurement. ... with a robust, efficient infrastructure for reliably transporting real-time data over ...

Research paper thumbnail of TRECVID 2008 -- Goals, Tasks, Data, Evaluation Mechanisms and Metrics

Solid State Nuclear Magnetic Resonance, 2009

Research paper thumbnail of Trecvid

Research paper thumbnail of Trecvid

IMPORTANT: Additional/replacement ASR. MT and Status. eMail to the mailing list trecvid2005@ nist. gov, 2005

Research paper thumbnail of MacVisSTA: A System for Multimodal Analysis of Human Communication and Interaction

The study of embodied communication requires access to multiple data sources such as multistream ... more The study of embodied communication requires access to multiple data sources such as multistream video and audio, various derived and meta-data such as gesture, head, posture, facial expression and gaze information. This thesis presents the data collection, annotation, and analysis for multiple participants engaged in planning meetings. In support of the analysis tasks, this thesis presents the multimedia Visualization for Situated Temporal Analysis for Macintosh (MacVisSTA) system. It supports the analysis of multimodal human communication through the use of video, audio, speech transcriptions, and gesture and head orientation data. The system uses a multiple linked representation strategy in which different representations are linked by the current time focus. MacVisSTA supports analysis of the synchronized data at varying timescales for coarse-to-fine observational studies. The hybrid architecture may be extended through plugins. Finally, this effort has resulted in encoding of behavioral and language data, enabling collaborative research and embodying it with the aid of, and interface to, a database management system.

Research paper thumbnail of An Exchange Format for Multimodal Annotations

Lecture Notes in Computer Science, 2009

This paper presents the results of a joint effort of a group of multimodality researchers and too... more This paper presents the results of a joint effort of a group of multimodality researchers and tool developers to improve the interoperability between several tools used for the annotation of multimodality. We propose a multimodal annotation exchange format, based on the annotation graph formalism, which is supported by import and export routines in the respective tools.

Research paper thumbnail of Delivery of peptide epitopes for HTLV-I using biodegradable microspheres

Delivery of peptide epitopes for HTLV-I using biodegradable microspheres

American Peptide Symposia, 2002

Research paper thumbnail of MacVisSTA

MacVisSTA

Proceedings of the 6th international conference on Multimodal interfaces - ICMI '04, 2004

The study of embodied communication requires access to mul-tiple data sources such as multistream... more The study of embodied communication requires access to mul-tiple data sources such as multistream video and audio, various derived and meta-data such as gesture, head, posture, facial expression and gaze information. The common element that runs through these data is the co-temporality of the multiple modes of behavior. In this paper, we present the multimedia Visualization for Situated Temporal Analysis

Research paper thumbnail of Comparing Gesture and Touch for Notification System Interactions

We explore some of the characteristics of multimodal input interaction spaces for notification sy... more We explore some of the characteristics of multimodal input interaction spaces for notification systems within a multi-tasking environment like a command and control center using two promising interaction methods: gestures and touch based input through a laboratory experiment comparing both techniques. Results of our study suggest that gestures are better suited for multi-tasking situations because they are less interruptive than touch interaction to users' primary tasks and are subjectively preferred by users in certain situations.

Research paper thumbnail of Microencapsulation of a synthetic peptide epitope for HTLV-1 in biodegradable poly(D,L-lactide-co-glycolide) microspheres using a novel encapsulation technique

Microencapsulation of a synthetic peptide epitope for HTLV-1 in biodegradable poly(D,L-lactide-co-glycolide) microspheres using a novel encapsulation technique

Journal of Microencapsulation, 2001

A novel procedure has been developed for the encapsulation of peptide antigens in poly(lactide-co... more A novel procedure has been developed for the encapsulation of peptide antigens in poly(lactide-co-glycolide) (PLGA) microspheres, which employs trifluoro-acetic acid (TFA) as a carrier solvent for both the polymer and antigen. The antigen/polymer solution is emulsified in mineral oil containing sorbitan trioleate (Span 85) as an emulsifier and a low level of cottonseed oil to extract the TFA. Fluoresceinisothiocyanate-labelled bovine serum albumin (FITC-BSA) was used as a model antigen to characterize the microencapsulation. Microspheres were of the desired size (<10 microm) for targeting to antigen-presenting cells, and released the model antigen slowly after an initial burst release (11%) in PBS/0.02% Tween 80 at 37 degrees C. Subsequently, a potential peptide vaccine, designated MVFMF2, for the human T-lymphotropic virus type 1 (HTLV-1 ) was encapsulated at 4.7% loading using the novel oil-in-oil method. In vivo immune responses were examined in rabbits immunized with (i) encapsulated MVFMF2 together with encapsulated adjuvant (N-acetyl-glucosamine-3yl-acetyl-L-alanyl-D-isoglutamine, nor-MDP, (ii) encapsulated MVFMF2 without adjuvant, and (iii) free peptide with adjuvant. Inoculation of the encapsulated peptide produced an antibody response similar to that of the free peptide emulsified in adjuvant. Moreover, the elevated immune response elicited by the encapsulated peptide was observed without multiple booster immunizations and irrespective of whether an adjuvant was used. Additionally, the antibodies raised against both free and encapsulated MVFMF2 had similar affinities, as judged by competitive enzyme-linked immunosorbant assay (ELISA), indicating that the encapsulated peptide retained a significant fraction of its epitopes. Hence, these results demonstrate that peptide vaccines can be encapsulated in PLGA microspheres using a common carrier solvent for both the peptide and polymer, which produces a desirable immune response in the absence of an adjuvant.

Research paper thumbnail of VACE Multimodal Meeting Corpus

Lecture Notes in Computer Science, 2006

In this paper, we report on the infrastructure we have developed to support our research on multi... more In this paper, we report on the infrastructure we have developed to support our research on multimodal cues for understanding meetings. With our focus on multimodality, we investigate the interaction among speech, gesture, posture, and gaze in meetings. For this purpose, a high quality multimodal corpus is being produced.

Research paper thumbnail of VACE Multimodal Meeting Corpus

In this paper, we report on the infrastructure we have developed to support our research on multi... more In this paper, we report on the infrastructure we have developed to support our research on multimodal cues for understanding meetings. With our focus on multimodality, we investigate the interaction among speech, gesture, posture, and gaze in meetings. For this purpose, a high quality multimodal corpus is being produced.

Research paper thumbnail of TRECVID 2008 workshop participants notebook papers, Gaithersburg, MD, USA, November 2008

TRECVID 2008 workshop participants notebook papers, Gaithersburg, MD, USA, November 2008

Research paper thumbnail of The CLEAR 2007 Evaluation

Lecture Notes in Computer Science, 2008

This paper is a summary of the 2007 CLEAR Evaluation on the Classification of Events, Activities,... more This paper is a summary of the 2007 CLEAR Evaluation on the Classification of Events, Activities, and Relationships which took place in early 2007 and culminated with a two-day workshop held in May 2007. CLEAR is an international effort to evaluate systems for the perception of people, their activities, and interactions. In its second year, CLEAR has developed a following from the computer vision and speech communities, spawning a more multimodal perspective of research evaluation. This paper describes the evaluation tasks, including metrics and databases used, and discusses the results achieved. The CLEAR 2007 tasks comprise person, face, and vehicle tracking, head pose estimation, as well as acoustic scene analysis. These include subtasks performed in the visual, acoustic and audio-visual domains for meeting room and surveillance data.

Research paper thumbnail of AVSS Multiple Camera Person Tracking Challenge Evaluation Overview

AVSS Multiple Camera Person Tracking Challenge Evaluation Overview

2009 Sixth IEEE International Conference on Advanced Video and Signal Based Surveillance, 2009

ABSTRACT Technologies that track a specific person as they traverse a network of surveillance cam... more ABSTRACT Technologies that track a specific person as they traverse a network of surveillance cameras can be used as the basis for a multitude of video surveillance applications including mass transit monitoring, large venue security, building security, and the like. In order to continue supporting the development robust people tracking technologies, the first AVSS Multiple Camera Person Tracking (MCPT) Challenge Evaluation was established to provide data and evaluation resources for researchers to build Single Person Tracking (SPT) technologies. This special session will focus on the AVSS MCPT Challenge Evaluation which will include a description of the evaluation task, the i-LIDS Multiple-camera tracking scenario data set used for the evaluation, and presentations by the challenge evaluation participants describing their systems.

Research paper thumbnail of The TRECVid 2008 Event Detection evaluation

The TRECVid 2008 Event Detection evaluation

2009 Workshop on Applications of Computer Vision (WACV), 2009

... It is important to complement these formative evaluations with a more realistic picture of th... more ... It is important to complement these formative evaluations with a more realistic picture of the challenges ... observations could only occur in one specific location in the camera field, (2) the size of ... the UK Home Office for contributing data for use in the TRECVid evaluation, and the ...

Research paper thumbnail of Calibrating Head Pose Estimation in Videos for Meeting Room Event Analysis

2006 International Conference on Image Processing, 2006

In this paper, we study the calibration of head pose estimation in stereo camera setting for meet... more In this paper, we study the calibration of head pose estimation in stereo camera setting for meeting room video event analysis. Head pose information infers the direction of attention of the subjects in video, therefore is valuable for video event analysis/indexing, especially in meeting room scenario. We are developing a multi-modal meeting room data analyzing system for studying meeting room interaction dynamics, in which head pose estimation is one of the key components. As each subject in the meeting room can be observed by a pair of stereo cameras, we do 2D head tracking for the subject in each camera, and the 3D coordinate of the head can be obtained by triangulation. The 3D head pose is estimated in one of the camera coordinate system, we develop a procedure to accurately convert the estimated 3D pose in the camera coordinate system to that in the world coordinate system. In the experiment, visualization of the estimated head pose and location in world coordinate system verifies the soundness of our design. The estimated head pose and 3D location of the subjects in the meeting room allows further analysis of meeting room interaction dynamics, such as F-formation, Floor-control[1], etc.

Research paper thumbnail of A Multimodal Analysis of Floor Control in Meetings

Lecture Notes in Computer Science, 2006

The participant in a human-to-human communication who controls the floor bears the burden of movi... more The participant in a human-to-human communication who controls the floor bears the burden of moving the communication process along. Change in control of the floor can happen through a number of mechanisms, including interruptions, delegation of the floor, and so on. This paper investigates floor control in multiparty meetings that are both audio and video taped; hence, we analyze patterns of speech (e.g., the use of discourse markers) and visual cues (e.g, eye gaze exchanges) that are often involved in floor control changes. Identifying who has control of the floor provides an important focus for information retrieval and summarization of meetings. Additionally, without understanding who has control of the floor, it is impossible to identify important events such as challenges for the floor. In this paper, we analyze multimodal cues related to floor control in two different meetings involving five participants each.

Research paper thumbnail of Enhanced immunogenicity of a conformational epitope of human T-lymphotropic virus type 1 using a novel chimeric peptide

Vaccine, 2000

The ability of a peptide vaccine derived from the human T-lymphotropic virus type 1 (HTLV-1) surf... more The ability of a peptide vaccine derived from the human T-lymphotropic virus type 1 (HTLV-1) surface envelope glycoprotein protein (gp46) to mimic the native protein and elicit a protective immune response has been examined. This peptide construct, designated MVFMF2, comprises amino acids (aa) 175-218 of gp46 linked by a four residue turn (GPSL) to a promiscuous T-cell epitope from the measles virus fusion protein (MVF, aa 288 -302). The peptide was structurally characterized by circular dichroism (CD) spectroscopy and was found to contain a-helical secondary structure. The immunogenicity of MVFMF2 in rabbits and mice was evaluated by direct ELISA and competitive ELISA using peptide constructs and the recombinant protein ACH-RE3 (aa 165-306). This peptide, when administered with adjuvant (N-acetyl-glucosamine-3yl-acetyl-L-alanyl-D-isoglutamine, nor-MDP) was immunogenic in an outbred population of both rabbits and mice. Furthermore, the peptide construct was encapsulated in biodegradable microspheres of poly(D,L-lactide-co-glycolide) to eliminate booster immunization and to examine adjuvant requirements. The data indicate that MVFMF2 shows enhanced immunogenicity when encapsulated in biodegradable microspheres. Inoculation of the encapsulated peptide produced a similar humoral response to that of the free peptide, but did not require the use of adjuvant. Elicited anti-rabbit and anti-mouse antibodies recognized whole viral preparations and the recombinant protein ACH-RE3 in ELISA assays. Additionally, inoculated rabbits exhibited enhanced reactivity to viral antigens by western blot compared to non-vaccinated controls. Although anti-rabbit and anti-mouse antibodies were capable of inhibiting syncytium formation at low dilutions, rabbits were not protected from cell-associated viral challenge. Future development of vaccines to HTLV-1 may need to incorporate the ability to elicit cell-mediated immune responses in order to protect against cell-associated viral infection.

Research paper thumbnail of Agent-Based Gesture Tracking

IEEE Transactions on Systems, Man, and Cybernetics - Part A: Systems and Humans, 2005

We describe an agent-based approach to the visual tracking of human hands and head that represent... more We describe an agent-based approach to the visual tracking of human hands and head that represents a very useful "middle ground" between the simple model-free tracking and the highly constrained model-based solutions. It combines the simplicity, speed and flexibility of tracking without using explicit shape models with the ability to utilize domain knowledge and to apply various constraints characteristic of more elaborate model-based tracking approaches.

Research paper thumbnail of Middleware and Metrology for the Pervasive Future

Middleware and Metrology for the Pervasive Future

IEEE Pervasive Computing, 2000

... commercial, advertising, or promotional purposes or for creating new collective works for ...... more ... commercial, advertising, or promotional purposes or for creating new collective works for ... interoperabil-ity for algorithms and hardware, collab-orative development, and performancemeasurement. ... with a robust, efficient infrastructure for reliably transporting real-time data over ...

Research paper thumbnail of TRECVID 2008 -- Goals, Tasks, Data, Evaluation Mechanisms and Metrics

Solid State Nuclear Magnetic Resonance, 2009