Algirdas Tamošiūnas | Vilnius University (original) (raw)

Papers by Algirdas Tamošiūnas

Acta medica Lituanica, 2014

Background. The aim of our study was to assess the cardiac 123I-MIBG imaging predictive value on ... more Background. The aim of our study was to assess the cardiac 123I-MIBG imaging predictive value on the clinical outcome in HF patients with wide QRS complexes and compare its power in different treatment groups. Materials and methods. We have prospectively investigated 67 heart failure patients with the New York Heart Association (NYHA) functional class II–IV, wide QRS complexes (>120 milliseconds), reduced left ventricular ejection fraction (LV EF) eligible for CRT. 123I-MIBG planar and single photon emission computed tomography (SPECT) scans were performed in a supine position with calculation of early and late heart-to-mediastinum (H/M) ratios, washout ratio (WR), summed defect scores and scores difference from SPECT acquisition. All patients were then divided in two groups according to their clinical status – 36 patients underwent implantation of CRT, and 31 patients were continued with OMT. Initial conventional heart failure markers and NYHA were assessed at the time of 123I-M...

Diagnostics

The aim of the study was to evaluate the diagnostic utility of specific miRNAs in the preoperativ... more The aim of the study was to evaluate the diagnostic utility of specific miRNAs in the preoperative assessment of thyroid nodules. One hundred and sixty thyroid fine needle aspiration biopsy (FNAB) samples with suspected thyroid carcinoma were collected. To detect the levels of miRNA expression in FNAB, next generation small RNA sequencing was performed in 60 samples. Based on the results obtained, three miRNAs (miR125A, miR200B, miR4324) were selected for further analysis. Based on the most frequently reported miRNAs in the literature associated with thyroid papillary carcinoma (PTC), two more miRNA (miR146B, miR221) were selected for further validation, using real-time reverse transcriptase polymerase chain reaction (RT-PCR) in 36 benign and 64 PTC samples. Expression of miR125A, miR146B, miR221, and miR4324 was significantly higher in patients with PTC compared with benign thyroid nodules (p ˂ 0.05). miR125A and miR4324 were also significantly more highly expressed in patients wit...

Medicinos teorija ir praktika, Sep 1, 2013

klinikų Radiologijos ir branduolinės medicinos centras 2 Vilniaus universiteto Medicinos fakultet... more klinikų Radiologijos ir branduolinės medicinos centras 2 Vilniaus universiteto Medicinos fakulteto Radiologijos, branduolinės medicinos ir medicinos fizikos katedra 3 Vilniaus universiteto Medicinos fakulteto Gastroenterologijos, nefrourologijos ir chirurgijos klinika 4 Vilniaus universiteto ligoninės Santariškių klinikų Pilvo chirurgijos centras

Cent European J Urol, 2017

Introduction Bosniak introduced a classification of renal cysts based on imaging characteristics.... more Introduction Bosniak introduced a classification of renal cysts based on imaging characteristics. Cystic renal changes are categorised determining their risk of malignancy and further management. However, defining the malignancy of category III lesions still remains a challenge and our aim was to evaluate features of malignancy in computed tomography in this category. Material and methods Vilnius University Hospital Santariškių Klinikos information system was retrospectively searched for computed tomography examinations in which Bosniak category III lesions were reported. Data of genetic disorders and history of malignancy were collected. Longest diameter, location, shape, amount and location of calcification, contrast enhancement of Bosniak category III lesions were evaluated. The relation between collected data and malignancy was estimated. Results There were 73 patients with Bosniak category III lesions included and 43 cysts were surgically removed and histologically analyzed. Mean tumor size was significantly lower in malignant lesions. Mean enhancement in arterial and portovenous phase, change of mean enhancement in portovenous and native phases were significantly different between benign and malignant lesions. Significant difference in contrast enhancement pattern was found: septa and capsular enhancement was detected in 28.6% (n = 12) of cases in malignant lesions, while only 4.8% (n = 2) benign lesions show the same enhancement pattern. Some other features showed tendencies to be more prevalent in malignant lesions, however no significant difference was found.

Acta medica Lituanica, 2014

Background. The aim of our study was to assess the cardiac 123I-MIBG imaging predictive value on ... more Background. The aim of our study was to assess the cardiac 123I-MIBG imaging predictive value on the clinical outcome in HF patients with wide QRS complexes and compare its power in different treatment groups.

Seminars in Cardiovascular Medicine, 2012

Chirurgische Gastroenterologie, 2007

ABSTRACT Emphysematous pancreatitis is a life-threatening condition that ordinarily requires surg... more ABSTRACT Emphysematous pancreatitis is a life-threatening condition that ordinarily requires surgical management. Four cases of emphysematous pancreatitis, including one case with successful medical treatment without any surgical interventions, are described in this article. Case Reports: Four patients had pancreatic necrosis with retroperitoneal and intrapancreatic gas trapping for more than 3 years. Retroperitoneal and intrapancreatic gas trapping was found for all of them during the 1st week of their illness. Two of them underwent immediate surgery after the confirmation of the diagnosis (necrosectomy and open packing), the 3rd patient was operated (necrosectomy and closed lavage) on the 9th day after medical treatment, and the 4th patient recovered after conservative treatment without any surgery. Conclusions: If the patient�s condition is stable, antibiotic treatment without any surgical intervention could be undertaken despite the evidence of pancreatic infection. The general physical condition of the patient is an important factor for choosing a treatment rather than bacteriological or radiological findings of the infection.

Seminars in Cardiovascular Medicine, 2013

Background. Redo cardiothoracic surgery is associated with increased morbidity and mortality comp... more Background. Redo cardiothoracic surgery is associated with increased morbidity and mortality compared with primary operations. Multidetector computed tomographic angiography (MDCTA) delineates the course of previous coronary artery bypass grafts (CABG) and proximity of mediastinal structures to the chest wall. We sought to determine if high-risk preoperative MDCTA findings were associated with greater use of preventive surgical strategies during redo cardiac surgery in patients with prior CABG.

Medicina (Kaunas, Lithuania), 2013

Amyloidosis is a rare condition characterized by the deposition of abnormal protein filaments int... more Amyloidosis is a rare condition characterized by the deposition of abnormal protein filaments into the extracellular tissue. Only 16 cases of true primary idiopathic amyloidosis localized in the nose and the paranasal sinuses have previously been reported. We present a case of localized amyloidosis involving the sinonasal cavities and the nose in a 53-year-old woman. Our patient was operated on as a typical case of chronic rhinosinusitis with polyps, but after 2 years, the patient came back with severe symptoms of nasal obstruction and pain in the frontal and maxillary regions with proptosis of both eyes. Magnetic resonance imaging revealed sinonasal-intraorbital masses. Primary amyloidosis (AL type) was confirmed by tissue biopsy. A systemic workup for additional amyloid deposits revealed no evidence of other diseases. Extended surgery produced a symptomatic improvement.

Case reports in medicine, 2012

We reported a case of 68-year-old man, with a previous history of hypertension. Patient was admit... more We reported a case of 68-year-old man, with a previous history of hypertension. Patient was admitted to our institution for evaluation of a severe, constant, tearing anterior chest pain radiated to the neck with suspicion of acute aortic dissection. A multidetector computed tomography scan of thorax and abdomen demonstrated a dissection starting from the middle part of aortic arch and extending downward to the descending aorta till the middle part of the thoracic aorta. The dissection was classified as Stanford A, De Bakey I. Surgical treatment of patient was started with bypass graft from the right common carotid artery to the left common carotid with subsequent revascularization of left subclavian artery. Lower parts of above-mentioned arteries were ligated. At the second stage an emergent prosthetic stent-graft was placed distally from the truncus brachiocephalicus up to the proximal part of the descending aorta. We reported a case report to present diagnostic and possible interv...

Journal of Cardiovascular Computed Tomography, 2015

We report a case of preoperative incidental finding in a 34-year-old man with a significant aorti... more We report a case of preoperative incidental finding in a 34-year-old man with a significant aortic insufficiency. Preoperative chest x-ray was suspicious for arteriovenous malformation in the right lung. Chest CT angiography discovered an anomalous course of the left superior pulmonary vein crossing the mediastinum to the contralateral hemithorax, joining the right superior pulmonary vein before entering the right inferior pulmonary vein and forming a common trunk of right inferior pulmonary vein.

American Journal of Human Biology, 2014

Objective: Through the study of preserved human remains, it is now known that atherosclerosis, co... more Objective: Through the study of preserved human remains, it is now known that atherosclerosis, commonly thought to be a modern disease, also existed in historic and prehistoric periods. To date, however, little evidence of atherosclerosis has been reported in samples of tissues from spontaneously mummified bodies that are often found in European crypts and churches.

European Journal of Pediatrics, 2014

Our goal was to assess the natural fate of iron overload (IO) following transfusions of packed re... more Our goal was to assess the natural fate of iron overload (IO) following transfusions of packed red blood cells (PRBCs) in children treated for cancer and nonmalignant disorders according to the intensity level of their treatment. Sixty-six children were followed up from February 2010 to March 2013. The transfusion burden was compared between three treatment intensity groups assigned according to the Intensity of Treatment Rating Scale 3.0 (ITR-3). IO was assessed by serial measurements of serum ferritin (SF) (n= 66) and quantification of tissue iron by magnetic resonance imaging (MRI) (n=12). Of the children studied, 36 % (24/66) received moderately intensive treatment (level 2), 21 % (14/ 66) received very intensive treatment (level 3), and 42 % (28/ 66) received the most intensive treatment (level 4). The number of PRBC (p=0.016), the total transfused volume (p= 0.026), and transfused volume adjusted to body weight (p= 0.004) were significantly higher in the level 4 group. By the median follow-up time of 35.5 months (range 8–133), 21– 29 % of patients (including level 2 and level 3 children) had SF >1,000 μg/l 1 year after cessation of transfusions. The slowest decrease of SF was observed in the level 4 group. Initial MRI examination demonstrated either mild or moderate IO in the liver and spleen. Repetitive MRI showed significant improvement in relaxation time between the initial and follow-up MRI performances in the liver (5.9 vs. 8.6 ms, p= 0.03) and the spleen (4.3 vs. 8.8 ms, p=0.03). IO diminished over time, but in the level 4 patients, it was detectable for years after cessation of transfusions.

The Annals of Thoracic Surgery, 2008

Background. Redo cardiothoracic surgery is associated with increased morbidity and mortality comp... more Background. Redo cardiothoracic surgery is associated with increased morbidity and mortality compared with primary operations. Multidetector computed tomographic angiography (MDCTA) delineates the course of previous coronary artery bypass grafts (CABG) and proximity of mediastinal structures to the chest wall. We sought to determine if high-risk preoperative MDCTA findings were associated with greater use of preventive surgical strategies during redo cardiac surgery in patients with prior CABG.

Seminars in Cardiovascular Medicine, 2000

The aim of the paper is to evaluate the appearance of the new early ischemic lesions in the brain... more The aim of the paper is to evaluate the appearance of the new early ischemic lesions in the brain after carotid angioplasty and stenting on diffusion-weighted magnetic resonance imaging, and their relationship with clinical and procedural factors.

Acta medica Lituanica, 2014

Background. The aim of our study was to assess the cardiac 123I-MIBG imaging predictive value on ... more Background. The aim of our study was to assess the cardiac 123I-MIBG imaging predictive value on the clinical outcome in HF patients with wide QRS complexes and compare its power in different treatment groups. Materials and methods. We have prospectively investigated 67 heart failure patients with the New York Heart Association (NYHA) functional class II–IV, wide QRS complexes (>120 milliseconds), reduced left ventricular ejection fraction (LV EF) eligible for CRT. 123I-MIBG planar and single photon emission computed tomography (SPECT) scans were performed in a supine position with calculation of early and late heart-to-mediastinum (H/M) ratios, washout ratio (WR), summed defect scores and scores difference from SPECT acquisition. All patients were then divided in two groups according to their clinical status – 36 patients underwent implantation of CRT, and 31 patients were continued with OMT. Initial conventional heart failure markers and NYHA were assessed at the time of 123I-M...

Diagnostics

The aim of the study was to evaluate the diagnostic utility of specific miRNAs in the preoperativ... more The aim of the study was to evaluate the diagnostic utility of specific miRNAs in the preoperative assessment of thyroid nodules. One hundred and sixty thyroid fine needle aspiration biopsy (FNAB) samples with suspected thyroid carcinoma were collected. To detect the levels of miRNA expression in FNAB, next generation small RNA sequencing was performed in 60 samples. Based on the results obtained, three miRNAs (miR125A, miR200B, miR4324) were selected for further analysis. Based on the most frequently reported miRNAs in the literature associated with thyroid papillary carcinoma (PTC), two more miRNA (miR146B, miR221) were selected for further validation, using real-time reverse transcriptase polymerase chain reaction (RT-PCR) in 36 benign and 64 PTC samples. Expression of miR125A, miR146B, miR221, and miR4324 was significantly higher in patients with PTC compared with benign thyroid nodules (p ˂ 0.05). miR125A and miR4324 were also significantly more highly expressed in patients wit...

Medicinos teorija ir praktika, Sep 1, 2013

klinikų Radiologijos ir branduolinės medicinos centras 2 Vilniaus universiteto Medicinos fakultet... more klinikų Radiologijos ir branduolinės medicinos centras 2 Vilniaus universiteto Medicinos fakulteto Radiologijos, branduolinės medicinos ir medicinos fizikos katedra 3 Vilniaus universiteto Medicinos fakulteto Gastroenterologijos, nefrourologijos ir chirurgijos klinika 4 Vilniaus universiteto ligoninės Santariškių klinikų Pilvo chirurgijos centras

Cent European J Urol, 2017

Introduction Bosniak introduced a classification of renal cysts based on imaging characteristics.... more Introduction Bosniak introduced a classification of renal cysts based on imaging characteristics. Cystic renal changes are categorised determining their risk of malignancy and further management. However, defining the malignancy of category III lesions still remains a challenge and our aim was to evaluate features of malignancy in computed tomography in this category. Material and methods Vilnius University Hospital Santariškių Klinikos information system was retrospectively searched for computed tomography examinations in which Bosniak category III lesions were reported. Data of genetic disorders and history of malignancy were collected. Longest diameter, location, shape, amount and location of calcification, contrast enhancement of Bosniak category III lesions were evaluated. The relation between collected data and malignancy was estimated. Results There were 73 patients with Bosniak category III lesions included and 43 cysts were surgically removed and histologically analyzed. Mean tumor size was significantly lower in malignant lesions. Mean enhancement in arterial and portovenous phase, change of mean enhancement in portovenous and native phases were significantly different between benign and malignant lesions. Significant difference in contrast enhancement pattern was found: septa and capsular enhancement was detected in 28.6% (n = 12) of cases in malignant lesions, while only 4.8% (n = 2) benign lesions show the same enhancement pattern. Some other features showed tendencies to be more prevalent in malignant lesions, however no significant difference was found.

Acta medica Lituanica, 2014

Background. The aim of our study was to assess the cardiac 123I-MIBG imaging predictive value on ... more Background. The aim of our study was to assess the cardiac 123I-MIBG imaging predictive value on the clinical outcome in HF patients with wide QRS complexes and compare its power in different treatment groups.

Seminars in Cardiovascular Medicine, 2012

Chirurgische Gastroenterologie, 2007

ABSTRACT Emphysematous pancreatitis is a life-threatening condition that ordinarily requires surg... more ABSTRACT Emphysematous pancreatitis is a life-threatening condition that ordinarily requires surgical management. Four cases of emphysematous pancreatitis, including one case with successful medical treatment without any surgical interventions, are described in this article. Case Reports: Four patients had pancreatic necrosis with retroperitoneal and intrapancreatic gas trapping for more than 3 years. Retroperitoneal and intrapancreatic gas trapping was found for all of them during the 1st week of their illness. Two of them underwent immediate surgery after the confirmation of the diagnosis (necrosectomy and open packing), the 3rd patient was operated (necrosectomy and closed lavage) on the 9th day after medical treatment, and the 4th patient recovered after conservative treatment without any surgery. Conclusions: If the patient�s condition is stable, antibiotic treatment without any surgical intervention could be undertaken despite the evidence of pancreatic infection. The general physical condition of the patient is an important factor for choosing a treatment rather than bacteriological or radiological findings of the infection.

Seminars in Cardiovascular Medicine, 2013

Background. Redo cardiothoracic surgery is associated with increased morbidity and mortality comp... more Background. Redo cardiothoracic surgery is associated with increased morbidity and mortality compared with primary operations. Multidetector computed tomographic angiography (MDCTA) delineates the course of previous coronary artery bypass grafts (CABG) and proximity of mediastinal structures to the chest wall. We sought to determine if high-risk preoperative MDCTA findings were associated with greater use of preventive surgical strategies during redo cardiac surgery in patients with prior CABG.

Medicina (Kaunas, Lithuania), 2013

Amyloidosis is a rare condition characterized by the deposition of abnormal protein filaments int... more Amyloidosis is a rare condition characterized by the deposition of abnormal protein filaments into the extracellular tissue. Only 16 cases of true primary idiopathic amyloidosis localized in the nose and the paranasal sinuses have previously been reported. We present a case of localized amyloidosis involving the sinonasal cavities and the nose in a 53-year-old woman. Our patient was operated on as a typical case of chronic rhinosinusitis with polyps, but after 2 years, the patient came back with severe symptoms of nasal obstruction and pain in the frontal and maxillary regions with proptosis of both eyes. Magnetic resonance imaging revealed sinonasal-intraorbital masses. Primary amyloidosis (AL type) was confirmed by tissue biopsy. A systemic workup for additional amyloid deposits revealed no evidence of other diseases. Extended surgery produced a symptomatic improvement.

Case reports in medicine, 2012

We reported a case of 68-year-old man, with a previous history of hypertension. Patient was admit... more We reported a case of 68-year-old man, with a previous history of hypertension. Patient was admitted to our institution for evaluation of a severe, constant, tearing anterior chest pain radiated to the neck with suspicion of acute aortic dissection. A multidetector computed tomography scan of thorax and abdomen demonstrated a dissection starting from the middle part of aortic arch and extending downward to the descending aorta till the middle part of the thoracic aorta. The dissection was classified as Stanford A, De Bakey I. Surgical treatment of patient was started with bypass graft from the right common carotid artery to the left common carotid with subsequent revascularization of left subclavian artery. Lower parts of above-mentioned arteries were ligated. At the second stage an emergent prosthetic stent-graft was placed distally from the truncus brachiocephalicus up to the proximal part of the descending aorta. We reported a case report to present diagnostic and possible interv...

Journal of Cardiovascular Computed Tomography, 2015

We report a case of preoperative incidental finding in a 34-year-old man with a significant aorti... more We report a case of preoperative incidental finding in a 34-year-old man with a significant aortic insufficiency. Preoperative chest x-ray was suspicious for arteriovenous malformation in the right lung. Chest CT angiography discovered an anomalous course of the left superior pulmonary vein crossing the mediastinum to the contralateral hemithorax, joining the right superior pulmonary vein before entering the right inferior pulmonary vein and forming a common trunk of right inferior pulmonary vein.

American Journal of Human Biology, 2014

Objective: Through the study of preserved human remains, it is now known that atherosclerosis, co... more Objective: Through the study of preserved human remains, it is now known that atherosclerosis, commonly thought to be a modern disease, also existed in historic and prehistoric periods. To date, however, little evidence of atherosclerosis has been reported in samples of tissues from spontaneously mummified bodies that are often found in European crypts and churches.

European Journal of Pediatrics, 2014

Our goal was to assess the natural fate of iron overload (IO) following transfusions of packed re... more Our goal was to assess the natural fate of iron overload (IO) following transfusions of packed red blood cells (PRBCs) in children treated for cancer and nonmalignant disorders according to the intensity level of their treatment. Sixty-six children were followed up from February 2010 to March 2013. The transfusion burden was compared between three treatment intensity groups assigned according to the Intensity of Treatment Rating Scale 3.0 (ITR-3). IO was assessed by serial measurements of serum ferritin (SF) (n= 66) and quantification of tissue iron by magnetic resonance imaging (MRI) (n=12). Of the children studied, 36 % (24/66) received moderately intensive treatment (level 2), 21 % (14/ 66) received very intensive treatment (level 3), and 42 % (28/ 66) received the most intensive treatment (level 4). The number of PRBC (p=0.016), the total transfused volume (p= 0.026), and transfused volume adjusted to body weight (p= 0.004) were significantly higher in the level 4 group. By the median follow-up time of 35.5 months (range 8–133), 21– 29 % of patients (including level 2 and level 3 children) had SF >1,000 μg/l 1 year after cessation of transfusions. The slowest decrease of SF was observed in the level 4 group. Initial MRI examination demonstrated either mild or moderate IO in the liver and spleen. Repetitive MRI showed significant improvement in relaxation time between the initial and follow-up MRI performances in the liver (5.9 vs. 8.6 ms, p= 0.03) and the spleen (4.3 vs. 8.8 ms, p=0.03). IO diminished over time, but in the level 4 patients, it was detectable for years after cessation of transfusions.

The Annals of Thoracic Surgery, 2008

Background. Redo cardiothoracic surgery is associated with increased morbidity and mortality comp... more Background. Redo cardiothoracic surgery is associated with increased morbidity and mortality compared with primary operations. Multidetector computed tomographic angiography (MDCTA) delineates the course of previous coronary artery bypass grafts (CABG) and proximity of mediastinal structures to the chest wall. We sought to determine if high-risk preoperative MDCTA findings were associated with greater use of preventive surgical strategies during redo cardiac surgery in patients with prior CABG.

Seminars in Cardiovascular Medicine, 2000

The aim of the paper is to evaluate the appearance of the new early ischemic lesions in the brain... more The aim of the paper is to evaluate the appearance of the new early ischemic lesions in the brain after carotid angioplasty and stenting on diffusion-weighted magnetic resonance imaging, and their relationship with clinical and procedural factors.