Michele Grimm | Wayne State University (original) (raw)

Papers by Michele Grimm

Research paper thumbnail of Use of ultrasound attenuation and velocity to estimate Young's modulus in trabecular bone

Measurements were made of ultrasound transmission velocity (UTV) and attenuation (BUA) in cores o... more Measurements were made of ultrasound transmission velocity (UTV) and attenuation (BUA) in cores of human trabecular bone. The Young's modulus and apparent density were also determined for each specimen. Analysis of the correlation between the ultrasonic parameters and the mechanical property was conducted. The highest coefficient of determination was found for a linear combination model of UTV and BUA. It

Research paper thumbnail of Childbirth Computational Models: Characteristics and Applications

Journal of biomechanical engineering, Feb 19, 2021

Research paper thumbnail of Design as a Feature of Biomedical Engineering Education—Satisfying ABET and Preparing Students to Address Clinical Needs

Journal of biomechanical engineering, Sep 22, 2020

Design is an important aspect of biomedical engineering education. It prepares students to work a... more Design is an important aspect of biomedical engineering education. It prepares students to work as part of a team to develop systems that address medical and health-related needs—and it is required to be part of an accredited undergraduate engineering program. This work looks at the history of design requirements in the U.S. and the current state of biomedical engineering curricula with respect to design. As a growing number of programs have expanded their design program beyond the capstone project, some examples of innovative programs are described. There is no single way to address design education within an undergraduate biomedical engineering program. However, intentional development of this component of the curriculum can enhance the impact on student learning and outcomes.

Research paper thumbnail of Effect of clinician applied maneuvers on fetal brachial plexus strain during shoulder dystocia delivery

American Journal of Obstetrics and Gynecology, Dec 1, 2003

Research paper thumbnail of Defining forces that are associated with shoulder dystocia: The use of a mathematic dynamic computer model

American Journal of Obstetrics and Gynecology, Apr 1, 2003

Research paper thumbnail of Potential role of nuclear magnetic resonance for the evaluation of trabecular bone quality

Calcified Tissue International, Feb 1, 1993

This paper discusses two novel applications of nuclear magnetic resonance (NMR) as an investigati... more This paper discusses two novel applications of nuclear magnetic resonance (NMR) as an investigational tool for the assessment of cancellous bone microarchitecture. It further outlines extensions of the method for in vivo clinical evaluation of bone strength in patients with skeletal disorders such as osteoporosis. The first method relies on the hypothesis that the presence of two phases of different magnetic permeability, i.e., bone and bone marrow, causes a spatial nonuniformity of the magnetic field across the measurement volume. The resulting spread in resonance frequency shortens the decay time constant (T2*) of the time domain proton signal in bone marrow or its substitute (water). Increased trabecular spacing, such as it occurs in osteoporosis, reduces the spatial field inhomogeneity and thus prolongs T2*, which has been shown both in vitro and in vivo. Subjects with osteoporosis, characterized by either low bone mineral density and/or spine compression fractures, have T2* values that are significantly prolonged. The second method focuses on a direct measurement of micromorphometric parameters of cancellous bone, using the principles of proton NMR microscopy in conjunction with computer processing of the resulting digital images. Image contrast between the trabeculae and the intertrabecular space is based on the marrow protons providing a signal, as opposed to bone, which appears with background intensity. Once tissues have been classified (into bone and marrow), for example, by means of a histogram-based segmentation algorithm, bone area fraction, mean trabecular plate density (MTPD), and mean trabecular plate thickness (MTPT) can be computed without the need for further operator intervention.(ABSTRACT TRUNCATED AT 250 WORDS)

Research paper thumbnail of Effect of clinician-applied maneuvers on brachial plexus stretch during a shoulder dystocia event: investigation using a computer simulation model

American Journal of Obstetrics and Gynecology, Oct 1, 2010

Research paper thumbnail of Ultrasound Propagation Through the Calcaneus: Dependence on "bone Quality" and Prediction by Biot's Theory

Research paper thumbnail of Smart Steering Sleeve (S3): A Non-Intrusive and Integrative Sensing Platform for Driver Physiological Monitoring

Research paper thumbnail of Mathematic modeling of forces associated with shoulder dystocia: A comparison of endogenous and exogenous sources

American Journal of Obstetrics and Gynecology, Mar 1, 2000

Research paper thumbnail of How to Build Your Mentoring Tree—Insight Gained From a 36-Year Career in Biomedical Engineering

Journal of biomechanical engineering, May 22, 2023

Mentoring is often viewed as a unidirectional relationship, with the senior, more seasoned indivi... more Mentoring is often viewed as a unidirectional relationship, with the senior, more seasoned individual imparting knowledge, guidance, and experience to more junior individuals. But this structure limits our ability to recognize that the mentoring relationship can bring benefits and opportunities for growth to the mentor as well. On the occasion of receiving the 2022 Robert M. Nerem Education and Mentorship Medal, I have had the opportunity to reflect on the mentoring that I have been lucky enough to participate in—both as mentor and mentee—during my academic career. This paper discusses some of those insights and presents the concept of a mentoring tree—through which we can identify multiple mentors and mentees, each of whom can provide mutual support and insight as we progress through our careers. Each individual who is part of our mentoring tree can play a role at different times and with different challenges within our professional path. This everchanging and growing structure provides continuous mentoring without overtaxing any single relationship.

Research paper thumbnail of 489 Defining forces associated with shoulder dystocia (SD): Use of a dynamic computer model (MADYMO)

American Journal of Obstetrics and Gynecology, Dec 1, 2001

Research paper thumbnail of Forces Involved with Labor and Delivery—A Biomechanical Perspective

Annals of Biomedical Engineering, Jan 11, 2021

Childbirth is a primarily biomechanical process of physiology, and one that engineers have recent... more Childbirth is a primarily biomechanical process of physiology, and one that engineers have recently begun to address in a broader fashion. Computational models are being developed to address the biomechanical effects of parturition on both maternal and fetal tissues. Experimental research is being conducted to understand how maternal tissues adapt to intrauterine forces near the onset of labor. All of this research requires an understanding of the forces that are developed through maternal efforts-both uterine contractions and semi-voluntary pushing-and that can be applied by the clinician to assist with the delivery. This work reviews the current state of knowledge regarding forces of labor and delivery, with a focus on macro-level biomechanics.

Research paper thumbnail of Maternal Endogenous Forces and Shoulder Dystocia

Clinical Obstetrics and Gynecology, Dec 1, 2016

Research paper thumbnail of Prediction of frequency and pore size dependent attenuation of ultrasound in trabecular bone using Biot’s theory

Solid mechanics and its applications, 1996

Biot’s theory is applied to trabecular bone using the Johnson-Koplik-Dashen (JKD) theory of perme... more Biot’s theory is applied to trabecular bone using the Johnson-Koplik-Dashen (JKD) theory of permeability and tortuosity. This may be the first instance in which the critical physical constants for bone, as determined from experiments, are used with Biot’ theory, incorporating the JKD permeability and tortuosity, to calculate velocities and attenuations and compare the results with experimentally determined velocities and attenuations. The velocities are correctly predicted by the theory and there is qualitative agreement with the experimental attenuations. The predicted magnitudes of the attenuations calculated for internal Biot losses due to relative motion of the solid and fluid phases are smaller than the experimentally measured attenuations, which include losses due to porous surface reflection at the front and back of the specimen, scattering due to macroscopic pores, as well as attenuation due to intrinsic losses in the bone and in the marrow phase, which are not directly accounted for by Biot’s theory.

Research paper thumbnail of Assessment of bone quantity and ‘quality’ by ultrasound attenuation and velocity in the heel

Clinical Biomechanics, Jul 1, 1997

Research paper thumbnail of Work in Progress: Creative Biomechanics Project Using an Interactive Digital Experience as an Alternative Laboratory (IDEAL) – Phase 2

2021 ASEE Virtual Annual Conference Content Access, Jul 26, 2021

Research paper thumbnail of The effect of clinician-applied maneuvers on delivery force and brachial plexus strain during shoulder dystocia deliveries — assessment through mathematical modeling

Journal of Biomechanics, 2006

Research paper thumbnail of Transcranial sonothrombolysis using high-intensity focused ultrasound: impact of increasing output power on clot fragmentation

Journal of therapeutic ultrasound, Nov 1, 2013

Research paper thumbnail of A Computational Procedure to Derive the Curve of Carus for Childbirth Computational Modeling

Journal of Biomechanical Engineering

Computational modeling serves an important role in childbirth-related research. Prescribed fetal ... more Computational modeling serves an important role in childbirth-related research. Prescribed fetal descent trajectory is a key characteristic in childbirth simulations. Two major types of fully prescribed fetal descent trajectories can be identified in the literature: straight descent trajectories and curve of Carus. The straight descent trajectory has the advantage of being simpler and can serve as a reasonable approximation for relatively small fetal movements during labor, but it cannot be used to simulate the entire childbirth process. The curve of Carus is the well-recognized fetal descent trajectory with physiological significance. However, no detailed procedure to geometrically define the curve of Carus can be found in existing computational studies. This status of curve of Carus simulation in the literature hinders the direct comparison of results across different studies and the advancement of computational techniques built upon previous research. The goals of this study are:...

Research paper thumbnail of Use of ultrasound attenuation and velocity to estimate Young's modulus in trabecular bone

Measurements were made of ultrasound transmission velocity (UTV) and attenuation (BUA) in cores o... more Measurements were made of ultrasound transmission velocity (UTV) and attenuation (BUA) in cores of human trabecular bone. The Young's modulus and apparent density were also determined for each specimen. Analysis of the correlation between the ultrasonic parameters and the mechanical property was conducted. The highest coefficient of determination was found for a linear combination model of UTV and BUA. It

Research paper thumbnail of Childbirth Computational Models: Characteristics and Applications

Journal of biomechanical engineering, Feb 19, 2021

Research paper thumbnail of Design as a Feature of Biomedical Engineering Education—Satisfying ABET and Preparing Students to Address Clinical Needs

Journal of biomechanical engineering, Sep 22, 2020

Design is an important aspect of biomedical engineering education. It prepares students to work a... more Design is an important aspect of biomedical engineering education. It prepares students to work as part of a team to develop systems that address medical and health-related needs—and it is required to be part of an accredited undergraduate engineering program. This work looks at the history of design requirements in the U.S. and the current state of biomedical engineering curricula with respect to design. As a growing number of programs have expanded their design program beyond the capstone project, some examples of innovative programs are described. There is no single way to address design education within an undergraduate biomedical engineering program. However, intentional development of this component of the curriculum can enhance the impact on student learning and outcomes.

Research paper thumbnail of Effect of clinician applied maneuvers on fetal brachial plexus strain during shoulder dystocia delivery

American Journal of Obstetrics and Gynecology, Dec 1, 2003

Research paper thumbnail of Defining forces that are associated with shoulder dystocia: The use of a mathematic dynamic computer model

American Journal of Obstetrics and Gynecology, Apr 1, 2003

Research paper thumbnail of Potential role of nuclear magnetic resonance for the evaluation of trabecular bone quality

Calcified Tissue International, Feb 1, 1993

This paper discusses two novel applications of nuclear magnetic resonance (NMR) as an investigati... more This paper discusses two novel applications of nuclear magnetic resonance (NMR) as an investigational tool for the assessment of cancellous bone microarchitecture. It further outlines extensions of the method for in vivo clinical evaluation of bone strength in patients with skeletal disorders such as osteoporosis. The first method relies on the hypothesis that the presence of two phases of different magnetic permeability, i.e., bone and bone marrow, causes a spatial nonuniformity of the magnetic field across the measurement volume. The resulting spread in resonance frequency shortens the decay time constant (T2*) of the time domain proton signal in bone marrow or its substitute (water). Increased trabecular spacing, such as it occurs in osteoporosis, reduces the spatial field inhomogeneity and thus prolongs T2*, which has been shown both in vitro and in vivo. Subjects with osteoporosis, characterized by either low bone mineral density and/or spine compression fractures, have T2* values that are significantly prolonged. The second method focuses on a direct measurement of micromorphometric parameters of cancellous bone, using the principles of proton NMR microscopy in conjunction with computer processing of the resulting digital images. Image contrast between the trabeculae and the intertrabecular space is based on the marrow protons providing a signal, as opposed to bone, which appears with background intensity. Once tissues have been classified (into bone and marrow), for example, by means of a histogram-based segmentation algorithm, bone area fraction, mean trabecular plate density (MTPD), and mean trabecular plate thickness (MTPT) can be computed without the need for further operator intervention.(ABSTRACT TRUNCATED AT 250 WORDS)

Research paper thumbnail of Effect of clinician-applied maneuvers on brachial plexus stretch during a shoulder dystocia event: investigation using a computer simulation model

American Journal of Obstetrics and Gynecology, Oct 1, 2010

Research paper thumbnail of Ultrasound Propagation Through the Calcaneus: Dependence on "bone Quality" and Prediction by Biot's Theory

Research paper thumbnail of Smart Steering Sleeve (S3): A Non-Intrusive and Integrative Sensing Platform for Driver Physiological Monitoring

Research paper thumbnail of Mathematic modeling of forces associated with shoulder dystocia: A comparison of endogenous and exogenous sources

American Journal of Obstetrics and Gynecology, Mar 1, 2000

Research paper thumbnail of How to Build Your Mentoring Tree—Insight Gained From a 36-Year Career in Biomedical Engineering

Journal of biomechanical engineering, May 22, 2023

Mentoring is often viewed as a unidirectional relationship, with the senior, more seasoned indivi... more Mentoring is often viewed as a unidirectional relationship, with the senior, more seasoned individual imparting knowledge, guidance, and experience to more junior individuals. But this structure limits our ability to recognize that the mentoring relationship can bring benefits and opportunities for growth to the mentor as well. On the occasion of receiving the 2022 Robert M. Nerem Education and Mentorship Medal, I have had the opportunity to reflect on the mentoring that I have been lucky enough to participate in—both as mentor and mentee—during my academic career. This paper discusses some of those insights and presents the concept of a mentoring tree—through which we can identify multiple mentors and mentees, each of whom can provide mutual support and insight as we progress through our careers. Each individual who is part of our mentoring tree can play a role at different times and with different challenges within our professional path. This everchanging and growing structure provides continuous mentoring without overtaxing any single relationship.

Research paper thumbnail of 489 Defining forces associated with shoulder dystocia (SD): Use of a dynamic computer model (MADYMO)

American Journal of Obstetrics and Gynecology, Dec 1, 2001

Research paper thumbnail of Forces Involved with Labor and Delivery—A Biomechanical Perspective

Annals of Biomedical Engineering, Jan 11, 2021

Childbirth is a primarily biomechanical process of physiology, and one that engineers have recent... more Childbirth is a primarily biomechanical process of physiology, and one that engineers have recently begun to address in a broader fashion. Computational models are being developed to address the biomechanical effects of parturition on both maternal and fetal tissues. Experimental research is being conducted to understand how maternal tissues adapt to intrauterine forces near the onset of labor. All of this research requires an understanding of the forces that are developed through maternal efforts-both uterine contractions and semi-voluntary pushing-and that can be applied by the clinician to assist with the delivery. This work reviews the current state of knowledge regarding forces of labor and delivery, with a focus on macro-level biomechanics.

Research paper thumbnail of Maternal Endogenous Forces and Shoulder Dystocia

Clinical Obstetrics and Gynecology, Dec 1, 2016

Research paper thumbnail of Prediction of frequency and pore size dependent attenuation of ultrasound in trabecular bone using Biot’s theory

Solid mechanics and its applications, 1996

Biot’s theory is applied to trabecular bone using the Johnson-Koplik-Dashen (JKD) theory of perme... more Biot’s theory is applied to trabecular bone using the Johnson-Koplik-Dashen (JKD) theory of permeability and tortuosity. This may be the first instance in which the critical physical constants for bone, as determined from experiments, are used with Biot’ theory, incorporating the JKD permeability and tortuosity, to calculate velocities and attenuations and compare the results with experimentally determined velocities and attenuations. The velocities are correctly predicted by the theory and there is qualitative agreement with the experimental attenuations. The predicted magnitudes of the attenuations calculated for internal Biot losses due to relative motion of the solid and fluid phases are smaller than the experimentally measured attenuations, which include losses due to porous surface reflection at the front and back of the specimen, scattering due to macroscopic pores, as well as attenuation due to intrinsic losses in the bone and in the marrow phase, which are not directly accounted for by Biot’s theory.

Research paper thumbnail of Assessment of bone quantity and ‘quality’ by ultrasound attenuation and velocity in the heel

Clinical Biomechanics, Jul 1, 1997

Research paper thumbnail of Work in Progress: Creative Biomechanics Project Using an Interactive Digital Experience as an Alternative Laboratory (IDEAL) – Phase 2

2021 ASEE Virtual Annual Conference Content Access, Jul 26, 2021

Research paper thumbnail of The effect of clinician-applied maneuvers on delivery force and brachial plexus strain during shoulder dystocia deliveries — assessment through mathematical modeling

Journal of Biomechanics, 2006

Research paper thumbnail of Transcranial sonothrombolysis using high-intensity focused ultrasound: impact of increasing output power on clot fragmentation

Journal of therapeutic ultrasound, Nov 1, 2013

Research paper thumbnail of A Computational Procedure to Derive the Curve of Carus for Childbirth Computational Modeling

Journal of Biomechanical Engineering

Computational modeling serves an important role in childbirth-related research. Prescribed fetal ... more Computational modeling serves an important role in childbirth-related research. Prescribed fetal descent trajectory is a key characteristic in childbirth simulations. Two major types of fully prescribed fetal descent trajectories can be identified in the literature: straight descent trajectories and curve of Carus. The straight descent trajectory has the advantage of being simpler and can serve as a reasonable approximation for relatively small fetal movements during labor, but it cannot be used to simulate the entire childbirth process. The curve of Carus is the well-recognized fetal descent trajectory with physiological significance. However, no detailed procedure to geometrically define the curve of Carus can be found in existing computational studies. This status of curve of Carus simulation in the literature hinders the direct comparison of results across different studies and the advancement of computational techniques built upon previous research. The goals of this study are:...