Randy E David | Wayne State University (original) (raw)

Papers by Randy E David

Research paper thumbnail of Relationship between Δ40p53α, Δ133p53α, and p53β/γ isoforms and mitochondrial copy number, with clinical and pathological features in Mexican breast cancer patients

Research Square (Research Square), Apr 29, 2024

Research paper thumbnail of Control of SARS-CoV-2 infection in skilled nursing facilities in Detroit, Michigan: a model for emerging infectious diseases

Infection control and hospital epidemiology, Mar 20, 2024

Research paper thumbnail of Bioanthropological analysis of human remains from the archaic and classic period discovered in Puyil cave, Mexico

American journal of physical anthropology, Feb 2, 2024

Research paper thumbnail of A broad wastewater screening and clinical data surveillance for virus-related diseases in the metropolitan Detroit area in Michigan

Human genomics, Feb 6, 2024

Research paper thumbnail of Tracking the Time Lag between SARS-CoV-2 Wastewater Concentrations and Three COVID-19 Clinical Metrics: A 21-Month Case Study in the Tricounty Detroit Area, Michigan

Journal of Environmental Engineering

Research paper thumbnail of Simple methods for early warnings of COVID-19 surges: Lessons learned from 21 months of wastewater and clinical data collection in Detroit, Michigan, United States

Science of The Total Environment, Mar 1, 2023

• 21-month COVID-19 wastewater surveillance data in Detroit, USA, were presented. • Peak-defining... more • 21-month COVID-19 wastewater surveillance data in Detroit, USA, were presented. • Peak-defining methods were developed to identify peak ranges of COVID-19 cases. • Real-time and post-factum methods were developed to determine early warnings. • Hit rates were designed to evaluate the accuracy of early warning methods. • These methods can help health agencies to determine early warnings based on WBE.

Research paper thumbnail of Wastewater Monitoring for Infectious Disease: Intentional Relationships between Academia, the Private Sector, and Local Health Departments for Public Health Preparedness

International Journal of Environmental Research and Public Health

The public health emergency caused by the COVID-19 pandemic stimulated stakeholders from diverse ... more The public health emergency caused by the COVID-19 pandemic stimulated stakeholders from diverse disciplines and institutions to establish new collaborations to produce informed public health responses to the disease. Wastewater-based epidemiology for COVID-19 grew quickly during the pandemic and required the rapid implementation of such collaborations. The objective of this article is to describe the challenges and results of new relationships developed in Detroit, MI, USA among a medical school and an engineering college at an academic institution (Wayne State University), the local health department (Detroit Health Department), and an environmental services company (LimnoTech) to utilize markers of the COVID-19 virus, SARS-CoV-2, in wastewater for the goal of managing COVID-19 outbreaks. Our collaborative team resolved questions related to sewershed selection, communication of results, and public health responses and addressed technical challenges that included ground-truthing th...

Research paper thumbnail of Wastewater surveillance beyond COVID-19: a ranking system for communicable disease testing in the tri-county Detroit area, Michigan, USA

Frontiers in Public Health

IntroductionThroughout the coronavirus disease 2019 (COVID-19) pandemic, wastewater surveillance ... more IntroductionThroughout the coronavirus disease 2019 (COVID-19) pandemic, wastewater surveillance has been utilized to monitor the disease in the United States through routine national, statewide, and regional monitoring projects. A significant canon of evidence was produced showing that wastewater surveillance is a credible and effective tool for disease monitoring. Hence, the application of wastewater surveillance can extend beyond monitoring SARS-CoV-2 to encompass a diverse range of emerging diseases. This article proposed a ranking system for prioritizing reportable communicable diseases (CDs) in the Tri-County Detroit Area (TCDA), Michigan, for future wastewater surveillance applications at the Great Lakes Water Authority's Water Reclamation Plant (GLWA's WRP).MethodsThe comprehensive CD wastewater surveillance ranking system (CDWSRank) was developed based on 6 binary and 6 quantitative parameters. The final ranking scores of CDs were computed by summing the multiplicat...

Research paper thumbnail of Socio-demographic and economic inequity in the use of insecticide-treated bed nets during pregnancy: a survey-based case study of four sub-Saharan African countries with a high burden of malaria

Archives of public health, Apr 21, 2023

Research paper thumbnail of The Creation of Metropolitan Amazonia: Genetic Consequences of Migration and Urbanization

Uniparental genetic markers were analyzed in a sample of 182 individuals from the Peruvian Amazon... more Uniparental genetic markers were analyzed in a sample of 182 individuals from the Peruvian Amazonian city of Yurimaguas. The site of extensive pre-Columbian and modern migratory fluctuation, contemporary Yurimaguas is characterized by considerable population diversity. Individually unique migratory and demographic profiles were combined with population genetic methodology to cultivate a co-constitutive view of the establishment of a modern Amazonian urban center. Yurimaguas, like many cities in the Global South, continues to experience the multifarious effects of accelerated migration and urbanization on population architecture. Biodemography and population genetics are used to assess consequences and evaluate potential contributing environments and events. A nuanced, interdisciplinary perspective through both a populational and molecular lens on the creation of today's urban populations is critical to informing the following: (1) our evolutionary development, historical interactions, and prior movements, (2) the relationship between genetic diversity and the evolutionary forces of gene flow, genetic drift, and natural selection, and (3) human migratory and mating behavior.

Research paper thumbnail of International border malaria transmission in the Ethiopian district of Lare, Gambella region: implications for malaria spread into South Sudan

Malaria Journal

Background Despite notable progress in the control and prevention of malaria in the Horn of Afric... more Background Despite notable progress in the control and prevention of malaria in the Horn of Africa, the disease continues to cause significant morbidity and mortality in various regions of Ethiopia, and elsewhere in the region. The transmission of malaria is affected by genetic, sociocultural, and ecological factors. Lare is an Ethiopian district adjacent to the Ethio-South Sudan border, in Gambella region. The region currently has the highest prevalence of malaria in Ethiopia. This study assesses the burden and spatiotemporal patterns of disease transmission, including the effect of climatic factors on the occurrence of malaria, across an international border crossing. This understanding can assist in crafting informed programmatic and policy decisions for interventions. Methods This study was conducted in Lare district, Southwest Ethiopia, a temperate zone. A retrospective descriptive analysis was conducted using clinical service data collected between 2011 and 2021 from the 9 hea...

Research paper thumbnail of Simple methods for early warnings of COVID-19 surges: Lessons learned from 21 months of wastewater and clinical data collection in Detroit, Michigan, United States

Science of The Total Environment, 2023

• 21-month COVID-19 wastewater surveillance data in Detroit, USA, were presented. • Peak-defining... more • 21-month COVID-19 wastewater surveillance data in Detroit, USA, were presented. • Peak-defining methods were developed to identify peak ranges of COVID-19 cases. • Real-time and post-factum methods were developed to determine early warnings. • Hit rates were designed to evaluate the accuracy of early warning methods. • These methods can help health agencies to determine early warnings based on WBE.

Research paper thumbnail of Five-week warning of COVID-19 peaks prior to the Omicron surge in Detroit, Michigan using wastewater surveillance

Science of The Total Environment

Research paper thumbnail of Irrigation-Induced Environmental Changes Sustain Malaria Transmission and Compromise Intervention Effectiveness

The Journal of Infectious Diseases

Background Irrigated agriculture enhances food security, but it potentially promotes mosquito-bor... more Background Irrigated agriculture enhances food security, but it potentially promotes mosquito-borne disease transmission and affects vector intervention effectiveness. This study was conducted in the irrigated and nonirrigated areas of rural Homa Bay and Kisumu Counties, Kenya. Methods We performed cross-sectional and longitudinal surveys to determine Plasmodium infection prevalence, clinical malaria incidence, molecular force of infection (molFOI), and multiplicity of infection. We examined the impact of irrigation on the effectiveness of the new interventions. Results We found that irrigation was associated with >2-fold higher Plasmodium infection prevalence and 3-fold higher clinical malaria incidence compared to the nonirrigated area. Residents in the irrigated area experienced persistent, low-density parasite infections and higher molFOI. Addition of indoor residual spraying was effective in reducing malaria burden, but the reduction was more pronounced in the nonirrigated a...

Research paper thumbnail of Cell membrane enolase of Aedes albopictus C6/36 cells is involved in the entrance mechanism of dengue virus (DENV)

Journal of Asia-Pacific Entomology

Research paper thumbnail of Burden of malaria, impact of interventions and climate variability in Western Ethiopia: an area with large irrigation based farming

BMC Public Health, 2022

Background Land use change has increasingly been expanding throughout the world in the past decad... more Background Land use change has increasingly been expanding throughout the world in the past decades. It can have profound effects on the spatial and temporal distribution of vector borne diseases like malaria through ecological and habitat change. Understanding malaria disease occurrence and the impact of prevention interventions under this intense environmental modification is important for effective and efficient malaria control strategy. Methods A descriptive ecological study was conducted by reviewing health service records at Abobo district health office. The records were reviewed to extract data on malaria morbidity, mortality, and prevention and control methods. Moreover, Meteorological data were obtained from Gambella region Meteorology Service Center and National Meteorology Authority head office. Univariate, bivariate and multivariate analysis techniques were used to analyze the data. Results For the twelve-year time period, the mean annual total malaria case count in the ...

Research paper thumbnail of Genetic structure of populations of the Aleutian Archipelago based on 750,000 SNPs

Research paper thumbnail of Epidemiologic investigation of tuberculosis in a Mexican population from Chihuahua State, Mexico: a pilot study

Research paper thumbnail of Dataset on the epidemiology and genetic diversification of dengue virus (DENV) serotypes and genotypes in Mexico

Research paper thumbnail of Burden of malaria, impact of interventions and climate variability in Western Ethiopia: an area with large irrigation based farming

BMC Public Health

Background Land use change has increasingly been expanding throughout the world in the past decad... more Background Land use change has increasingly been expanding throughout the world in the past decades. It can have profound effects on the spatial and temporal distribution of vector borne diseases like malaria through ecological and habitat change. Understanding malaria disease occurrence and the impact of prevention interventions under this intense environmental modification is important for effective and efficient malaria control strategy. Methods A descriptive ecological study was conducted by reviewing health service records at Abobo district health office. The records were reviewed to extract data on malaria morbidity, mortality, and prevention and control methods. Moreover, Meteorological data were obtained from Gambella region Meteorology Service Center and National Meteorology Authority head office. Univariate, bivariate and multivariate analysis techniques were used to analyze the data. Results For the twelve-year time period, the mean annual total malaria case count in the ...

Research paper thumbnail of Relationship between Δ40p53α, Δ133p53α, and p53β/γ isoforms and mitochondrial copy number, with clinical and pathological features in Mexican breast cancer patients

Research Square (Research Square), Apr 29, 2024

Research paper thumbnail of Control of SARS-CoV-2 infection in skilled nursing facilities in Detroit, Michigan: a model for emerging infectious diseases

Infection control and hospital epidemiology, Mar 20, 2024

Research paper thumbnail of Bioanthropological analysis of human remains from the archaic and classic period discovered in Puyil cave, Mexico

American journal of physical anthropology, Feb 2, 2024

Research paper thumbnail of A broad wastewater screening and clinical data surveillance for virus-related diseases in the metropolitan Detroit area in Michigan

Human genomics, Feb 6, 2024

Research paper thumbnail of Tracking the Time Lag between SARS-CoV-2 Wastewater Concentrations and Three COVID-19 Clinical Metrics: A 21-Month Case Study in the Tricounty Detroit Area, Michigan

Journal of Environmental Engineering

Research paper thumbnail of Simple methods for early warnings of COVID-19 surges: Lessons learned from 21 months of wastewater and clinical data collection in Detroit, Michigan, United States

Science of The Total Environment, Mar 1, 2023

• 21-month COVID-19 wastewater surveillance data in Detroit, USA, were presented. • Peak-defining... more • 21-month COVID-19 wastewater surveillance data in Detroit, USA, were presented. • Peak-defining methods were developed to identify peak ranges of COVID-19 cases. • Real-time and post-factum methods were developed to determine early warnings. • Hit rates were designed to evaluate the accuracy of early warning methods. • These methods can help health agencies to determine early warnings based on WBE.

Research paper thumbnail of Wastewater Monitoring for Infectious Disease: Intentional Relationships between Academia, the Private Sector, and Local Health Departments for Public Health Preparedness

International Journal of Environmental Research and Public Health

The public health emergency caused by the COVID-19 pandemic stimulated stakeholders from diverse ... more The public health emergency caused by the COVID-19 pandemic stimulated stakeholders from diverse disciplines and institutions to establish new collaborations to produce informed public health responses to the disease. Wastewater-based epidemiology for COVID-19 grew quickly during the pandemic and required the rapid implementation of such collaborations. The objective of this article is to describe the challenges and results of new relationships developed in Detroit, MI, USA among a medical school and an engineering college at an academic institution (Wayne State University), the local health department (Detroit Health Department), and an environmental services company (LimnoTech) to utilize markers of the COVID-19 virus, SARS-CoV-2, in wastewater for the goal of managing COVID-19 outbreaks. Our collaborative team resolved questions related to sewershed selection, communication of results, and public health responses and addressed technical challenges that included ground-truthing th...

Research paper thumbnail of Wastewater surveillance beyond COVID-19: a ranking system for communicable disease testing in the tri-county Detroit area, Michigan, USA

Frontiers in Public Health

IntroductionThroughout the coronavirus disease 2019 (COVID-19) pandemic, wastewater surveillance ... more IntroductionThroughout the coronavirus disease 2019 (COVID-19) pandemic, wastewater surveillance has been utilized to monitor the disease in the United States through routine national, statewide, and regional monitoring projects. A significant canon of evidence was produced showing that wastewater surveillance is a credible and effective tool for disease monitoring. Hence, the application of wastewater surveillance can extend beyond monitoring SARS-CoV-2 to encompass a diverse range of emerging diseases. This article proposed a ranking system for prioritizing reportable communicable diseases (CDs) in the Tri-County Detroit Area (TCDA), Michigan, for future wastewater surveillance applications at the Great Lakes Water Authority's Water Reclamation Plant (GLWA's WRP).MethodsThe comprehensive CD wastewater surveillance ranking system (CDWSRank) was developed based on 6 binary and 6 quantitative parameters. The final ranking scores of CDs were computed by summing the multiplicat...

Research paper thumbnail of Socio-demographic and economic inequity in the use of insecticide-treated bed nets during pregnancy: a survey-based case study of four sub-Saharan African countries with a high burden of malaria

Archives of public health, Apr 21, 2023

Research paper thumbnail of The Creation of Metropolitan Amazonia: Genetic Consequences of Migration and Urbanization

Uniparental genetic markers were analyzed in a sample of 182 individuals from the Peruvian Amazon... more Uniparental genetic markers were analyzed in a sample of 182 individuals from the Peruvian Amazonian city of Yurimaguas. The site of extensive pre-Columbian and modern migratory fluctuation, contemporary Yurimaguas is characterized by considerable population diversity. Individually unique migratory and demographic profiles were combined with population genetic methodology to cultivate a co-constitutive view of the establishment of a modern Amazonian urban center. Yurimaguas, like many cities in the Global South, continues to experience the multifarious effects of accelerated migration and urbanization on population architecture. Biodemography and population genetics are used to assess consequences and evaluate potential contributing environments and events. A nuanced, interdisciplinary perspective through both a populational and molecular lens on the creation of today's urban populations is critical to informing the following: (1) our evolutionary development, historical interactions, and prior movements, (2) the relationship between genetic diversity and the evolutionary forces of gene flow, genetic drift, and natural selection, and (3) human migratory and mating behavior.

Research paper thumbnail of International border malaria transmission in the Ethiopian district of Lare, Gambella region: implications for malaria spread into South Sudan

Malaria Journal

Background Despite notable progress in the control and prevention of malaria in the Horn of Afric... more Background Despite notable progress in the control and prevention of malaria in the Horn of Africa, the disease continues to cause significant morbidity and mortality in various regions of Ethiopia, and elsewhere in the region. The transmission of malaria is affected by genetic, sociocultural, and ecological factors. Lare is an Ethiopian district adjacent to the Ethio-South Sudan border, in Gambella region. The region currently has the highest prevalence of malaria in Ethiopia. This study assesses the burden and spatiotemporal patterns of disease transmission, including the effect of climatic factors on the occurrence of malaria, across an international border crossing. This understanding can assist in crafting informed programmatic and policy decisions for interventions. Methods This study was conducted in Lare district, Southwest Ethiopia, a temperate zone. A retrospective descriptive analysis was conducted using clinical service data collected between 2011 and 2021 from the 9 hea...

Research paper thumbnail of Simple methods for early warnings of COVID-19 surges: Lessons learned from 21 months of wastewater and clinical data collection in Detroit, Michigan, United States

Science of The Total Environment, 2023

• 21-month COVID-19 wastewater surveillance data in Detroit, USA, were presented. • Peak-defining... more • 21-month COVID-19 wastewater surveillance data in Detroit, USA, were presented. • Peak-defining methods were developed to identify peak ranges of COVID-19 cases. • Real-time and post-factum methods were developed to determine early warnings. • Hit rates were designed to evaluate the accuracy of early warning methods. • These methods can help health agencies to determine early warnings based on WBE.

Research paper thumbnail of Five-week warning of COVID-19 peaks prior to the Omicron surge in Detroit, Michigan using wastewater surveillance

Science of The Total Environment

Research paper thumbnail of Irrigation-Induced Environmental Changes Sustain Malaria Transmission and Compromise Intervention Effectiveness

The Journal of Infectious Diseases

Background Irrigated agriculture enhances food security, but it potentially promotes mosquito-bor... more Background Irrigated agriculture enhances food security, but it potentially promotes mosquito-borne disease transmission and affects vector intervention effectiveness. This study was conducted in the irrigated and nonirrigated areas of rural Homa Bay and Kisumu Counties, Kenya. Methods We performed cross-sectional and longitudinal surveys to determine Plasmodium infection prevalence, clinical malaria incidence, molecular force of infection (molFOI), and multiplicity of infection. We examined the impact of irrigation on the effectiveness of the new interventions. Results We found that irrigation was associated with >2-fold higher Plasmodium infection prevalence and 3-fold higher clinical malaria incidence compared to the nonirrigated area. Residents in the irrigated area experienced persistent, low-density parasite infections and higher molFOI. Addition of indoor residual spraying was effective in reducing malaria burden, but the reduction was more pronounced in the nonirrigated a...

Research paper thumbnail of Cell membrane enolase of Aedes albopictus C6/36 cells is involved in the entrance mechanism of dengue virus (DENV)

Journal of Asia-Pacific Entomology

Research paper thumbnail of Burden of malaria, impact of interventions and climate variability in Western Ethiopia: an area with large irrigation based farming

BMC Public Health, 2022

Background Land use change has increasingly been expanding throughout the world in the past decad... more Background Land use change has increasingly been expanding throughout the world in the past decades. It can have profound effects on the spatial and temporal distribution of vector borne diseases like malaria through ecological and habitat change. Understanding malaria disease occurrence and the impact of prevention interventions under this intense environmental modification is important for effective and efficient malaria control strategy. Methods A descriptive ecological study was conducted by reviewing health service records at Abobo district health office. The records were reviewed to extract data on malaria morbidity, mortality, and prevention and control methods. Moreover, Meteorological data were obtained from Gambella region Meteorology Service Center and National Meteorology Authority head office. Univariate, bivariate and multivariate analysis techniques were used to analyze the data. Results For the twelve-year time period, the mean annual total malaria case count in the ...

Research paper thumbnail of Genetic structure of populations of the Aleutian Archipelago based on 750,000 SNPs

Research paper thumbnail of Epidemiologic investigation of tuberculosis in a Mexican population from Chihuahua State, Mexico: a pilot study

Research paper thumbnail of Dataset on the epidemiology and genetic diversification of dengue virus (DENV) serotypes and genotypes in Mexico

Research paper thumbnail of Burden of malaria, impact of interventions and climate variability in Western Ethiopia: an area with large irrigation based farming

BMC Public Health

Background Land use change has increasingly been expanding throughout the world in the past decad... more Background Land use change has increasingly been expanding throughout the world in the past decades. It can have profound effects on the spatial and temporal distribution of vector borne diseases like malaria through ecological and habitat change. Understanding malaria disease occurrence and the impact of prevention interventions under this intense environmental modification is important for effective and efficient malaria control strategy. Methods A descriptive ecological study was conducted by reviewing health service records at Abobo district health office. The records were reviewed to extract data on malaria morbidity, mortality, and prevention and control methods. Moreover, Meteorological data were obtained from Gambella region Meteorology Service Center and National Meteorology Authority head office. Univariate, bivariate and multivariate analysis techniques were used to analyze the data. Results For the twelve-year time period, the mean annual total malaria case count in the ...