sadia anwar | Western Sydney University (original) (raw)
Papers by sadia anwar
Basic and Applied Pathology, 2010
Background and aims: Colorectal carcinoma is among the most frequently observed malignancies in P... more Background and aims: Colorectal carcinoma is among the most frequently observed malignancies in Pakistan. The HER 2/neu protein is intimately involved in tumorigenesis and its receptor has been demonstrated as a therapeutic target in several carcinomas. This study was designed to assess the clinico-pathological pattern and the HER 2/neu immunohistochemical score with respect to the histological grades of colorectal carcinoma in our population. Methods: Tissue biopsies from 100 patients, with detailed documentation of their clinical account, were subjected to immunohistochemistry utilizing monoclonal anti-HER 2/neu antibody. Positive expression was assigned a score from 0–3+. Results: A distinct positive HER 2/neu scoring pattern was observed in n= 42 cases of non-mucinous, mucinous and signet ring cell adenocarcinomas, all with a specific histological grade. An inverse correlation (P= 0.001) was observed between the two parameters. Conclusion: Colorectal carcinoma is a growing malignancy, even in the younger population and HER 2/neu protein is credibly expressed in colonic cancer cells in our patients especially where the histological grade is low or moderate. Therefore, it may be applied as a reasonably reliable immunohistochemical marker and a target for a new adjuvant monoclonal antibody-based immunotherapy.
![Research paper thumbnail of Tandem ring expansion/aldol cyclization of bicyclo[5.4.0 1,7]undecanediones](https://attachments.academia-assets.com/48670337/thumbnails/1.jpg)
](Tetrahedron Letters, 2002
Diazomethane ring expansion of 3 followed by deketalization, led to the formation of bicyclodione... more Diazomethane ring expansion of 3 followed by deketalization, led to the formation of bicyclodione intermediates 6 and 8. These intermediates underwent internal aldol cyclization to give the tricyclic adducts 7 and 9 in a 1:1 ratio, respectively.
![Research paper thumbnail of Tandem ring expansion/aldol cyclization of bicyclo[5.4.0 1,7]undecanediones](https://attachments.academia-assets.com/48670345/thumbnails/1.jpg)
](Tetrahedron Letters, 2002
Diazomethane ring expansion of 3 followed by deketalization, led to the formation of bicyclodione... more Diazomethane ring expansion of 3 followed by deketalization, led to the formation of bicyclodione intermediates 6 and 8. These intermediates underwent internal aldol cyclization to give the tricyclic adducts 7 and 9 in a 1:1 ratio, respectively.
![Research paper thumbnail of Tandem ring expansion/aldol cyclization of bicyclo[5.4.0 1,7]undecanediones](https://attachments.academia-assets.com/48670339/thumbnails/1.jpg)
](Tetrahedron Letters, 2002
Diazomethane ring expansion of 3 followed by deketalization, led to the formation of bicyclodione... more Diazomethane ring expansion of 3 followed by deketalization, led to the formation of bicyclodione intermediates 6 and 8. These intermediates underwent internal aldol cyclization to give the tricyclic adducts 7 and 9 in a 1:1 ratio, respectively.
PLOS One, 2012
Staphylococcus aureus, a major human pathogen, exacerbates allergic disorders, including atopic d... more Staphylococcus aureus, a major human pathogen, exacerbates allergic disorders, including atopic dermatitis, nasal polyps and asthma, which are characterized by tissue eosinophilia.
Clinical and Experimental Immunology, 2009
Recent developments in the study of host–pathogen interactions have fundamentally altered our und... more Recent developments in the study of host–pathogen interactions have fundamentally altered our understanding of the nature of Staphylococcus aureus infection, and previously held tenets regarding the role of the granulocyte are being cast aside. Novel mechanisms of pathogenesis are becoming evident, revealing the extent to which S. aureus can evade neutrophil responses successfully by resisting microbicides, surviving intracellularly and subverting cell death pathways. Developing a detailed understanding of these complex strategies is especially relevant in light of increasing staphylococcal virulence and antibiotic resistance, and the knowledge that dysfunctional neutrophil responses contribute materially to poor host outcomes. Unravelling the biology of these interactions is a challenging task, but one which may yield new strategies to address this, as yet, defiant organism.
Experimental Lung Research, 2007
Apoptosis, or programmed cell death, is a highly conserved cellular suicide mechanism. Apoptosis ... more Apoptosis, or programmed cell death, is a highly conserved cellular suicide mechanism. Apoptosis is critical to the effective resolution of inflammation, particularly in regulating the lifespan of the inflammatory neutrophil. Pathological dysregulation of neutrophil apoptosis prevents resolution of inflammation and is implicated in numerous inflammatory conditions. Similarly, subversion of this critical host defense mechanism by pathogens can prevent resolution of infection. Below, we describe the effects of different bacterial pathogens on regulation of neutrophil apoptosis and consider how re-engagement of these subverted mechanisms may facilitate the development of new strategies to combat infectious diseases.
Copd-journal of Chronic Obstructive Pulmonary Disease, 2008
Ejso, 2000
Colorectal cancer is the commonest cause of death due to malignancy in non-smokers in the western... more Colorectal cancer is the commonest cause of death due to malignancy in non-smokers in the western countries. The two main hereditary types of colorectal cancer are familial adenomatous polyposis (FAP) and hereditary non-polyposis colorectal cancer (HNPCC), constituting approximately 10% of all cases of colorectal cancer. The main aim of this review is to reappraise the current advances in the genetics and diagnosis of HNPCC. Methods: A Medline search was carried out to identify papers published from 1970 to 1999 on HNPCC. Embase and Cochrane databases were also searched. Reference lists of retrieved articles were carefully searched for additional articles. Results and conclusions: Recent technological advances in the genetics of HNPCC have refined the criteria for diagnosis and management of HNPCC, however current policies regarding the testing of pedigrees are not clearly established. We believe that with the rapid development in this area definitive clinical guidelines will need to be available in future for the management of HNPCC.
Ejso, 1998
Colorectal cancer results in 18,000 deaths annually in England and Wales, with 24,000 new cases d... more Colorectal cancer results in 18,000 deaths annually in England and Wales, with 24,000 new cases diagnosed each year. Despite a better understanding of the genetics, and advancement in surgical and anaesthetic techniques, there has been little reduction in mortality and morbidity from this disease over the past 25 years. Colorectal cancer fits recognized criteria for a disease that should be screened in asymptomatic individuals. The putative duration of the adenoma to carcinoma sequence gives an ample window of opportunity to detect and treat colorectal cancer.
Basic and Applied Pathology, 2010
Background and aims: Colorectal carcinoma is among the most frequently observed malignancies in P... more Background and aims: Colorectal carcinoma is among the most frequently observed malignancies in Pakistan. The HER 2/neu protein is intimately involved in tumorigenesis and its receptor has been demonstrated as a therapeutic target in several carcinomas. This study was designed to assess the clinico-pathological pattern and the HER 2/neu immunohistochemical score with respect to the histological grades of colorectal carcinoma in our population. Methods: Tissue biopsies from 100 patients, with detailed documentation of their clinical account, were subjected to immunohistochemistry utilizing monoclonal anti-HER 2/neu antibody. Positive expression was assigned a score from 0–3+. Results: A distinct positive HER 2/neu scoring pattern was observed in n= 42 cases of non-mucinous, mucinous and signet ring cell adenocarcinomas, all with a specific histological grade. An inverse correlation (P= 0.001) was observed between the two parameters. Conclusion: Colorectal carcinoma is a growing malignancy, even in the younger population and HER 2/neu protein is credibly expressed in colonic cancer cells in our patients especially where the histological grade is low or moderate. Therefore, it may be applied as a reasonably reliable immunohistochemical marker and a target for a new adjuvant monoclonal antibody-based immunotherapy.
Tetrahedron Letters, 2002
Diazomethane ring expansion of 3 followed by deketalization, led to the formation of bicyclodione... more Diazomethane ring expansion of 3 followed by deketalization, led to the formation of bicyclodione intermediates 6 and 8. These intermediates underwent internal aldol cyclization to give the tricyclic adducts 7 and 9 in a 1:1 ratio, respectively.
Tetrahedron Letters, 2002
Diazomethane ring expansion of 3 followed by deketalization, led to the formation of bicyclodione... more Diazomethane ring expansion of 3 followed by deketalization, led to the formation of bicyclodione intermediates 6 and 8. These intermediates underwent internal aldol cyclization to give the tricyclic adducts 7 and 9 in a 1:1 ratio, respectively.
Tetrahedron Letters, 2002
Diazomethane ring expansion of 3 followed by deketalization, led to the formation of bicyclodione... more Diazomethane ring expansion of 3 followed by deketalization, led to the formation of bicyclodione intermediates 6 and 8. These intermediates underwent internal aldol cyclization to give the tricyclic adducts 7 and 9 in a 1:1 ratio, respectively.
PLOS One, 2012
Staphylococcus aureus, a major human pathogen, exacerbates allergic disorders, including atopic d... more Staphylococcus aureus, a major human pathogen, exacerbates allergic disorders, including atopic dermatitis, nasal polyps and asthma, which are characterized by tissue eosinophilia.
Clinical and Experimental Immunology, 2009
Recent developments in the study of host–pathogen interactions have fundamentally altered our und... more Recent developments in the study of host–pathogen interactions have fundamentally altered our understanding of the nature of Staphylococcus aureus infection, and previously held tenets regarding the role of the granulocyte are being cast aside. Novel mechanisms of pathogenesis are becoming evident, revealing the extent to which S. aureus can evade neutrophil responses successfully by resisting microbicides, surviving intracellularly and subverting cell death pathways. Developing a detailed understanding of these complex strategies is especially relevant in light of increasing staphylococcal virulence and antibiotic resistance, and the knowledge that dysfunctional neutrophil responses contribute materially to poor host outcomes. Unravelling the biology of these interactions is a challenging task, but one which may yield new strategies to address this, as yet, defiant organism.
Experimental Lung Research, 2007
Apoptosis, or programmed cell death, is a highly conserved cellular suicide mechanism. Apoptosis ... more Apoptosis, or programmed cell death, is a highly conserved cellular suicide mechanism. Apoptosis is critical to the effective resolution of inflammation, particularly in regulating the lifespan of the inflammatory neutrophil. Pathological dysregulation of neutrophil apoptosis prevents resolution of inflammation and is implicated in numerous inflammatory conditions. Similarly, subversion of this critical host defense mechanism by pathogens can prevent resolution of infection. Below, we describe the effects of different bacterial pathogens on regulation of neutrophil apoptosis and consider how re-engagement of these subverted mechanisms may facilitate the development of new strategies to combat infectious diseases.
Copd-journal of Chronic Obstructive Pulmonary Disease, 2008
Ejso, 2000
Colorectal cancer is the commonest cause of death due to malignancy in non-smokers in the western... more Colorectal cancer is the commonest cause of death due to malignancy in non-smokers in the western countries. The two main hereditary types of colorectal cancer are familial adenomatous polyposis (FAP) and hereditary non-polyposis colorectal cancer (HNPCC), constituting approximately 10% of all cases of colorectal cancer. The main aim of this review is to reappraise the current advances in the genetics and diagnosis of HNPCC. Methods: A Medline search was carried out to identify papers published from 1970 to 1999 on HNPCC. Embase and Cochrane databases were also searched. Reference lists of retrieved articles were carefully searched for additional articles. Results and conclusions: Recent technological advances in the genetics of HNPCC have refined the criteria for diagnosis and management of HNPCC, however current policies regarding the testing of pedigrees are not clearly established. We believe that with the rapid development in this area definitive clinical guidelines will need to be available in future for the management of HNPCC.
Ejso, 1998
Colorectal cancer results in 18,000 deaths annually in England and Wales, with 24,000 new cases d... more Colorectal cancer results in 18,000 deaths annually in England and Wales, with 24,000 new cases diagnosed each year. Despite a better understanding of the genetics, and advancement in surgical and anaesthetic techniques, there has been little reduction in mortality and morbidity from this disease over the past 25 years. Colorectal cancer fits recognized criteria for a disease that should be screened in asymptomatic individuals. The putative duration of the adenoma to carcinoma sequence gives an ample window of opportunity to detect and treat colorectal cancer.