Bonnie Schmidt | Western University Canada (original) (raw)

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Papers by Bonnie Schmidt

In international comparisons, Canada’s education system ranks highly in terms of basic literacy, ... more In international comparisons, Canada’s education system ranks highly in terms of basic literacy, numeracy and high-school completion rates. But our country receives a much lower grade when it comes to participation in post-secondary science, technology, engineering and mathematics programs — fi elds that have been shown to have a direct impact on innovation, productivity and economic growth. If we fail to address this problem, Canada risks falling further behind in the 21st century skills race.

Public Understanding of Science, 1996

This study evaluated the effect of an outreach project, called theScientist Badge for Brownies an... more This study evaluated the effect of an outreach project, called theScientist Badge for Brownies and Girl Guides', on science attitudes and achievement of girls aged 6-12. The programme reached nearly 1500 girls and consisted of ninety minutes of hands-on ...

Progress in Brain Research, 1993

Journal of Neurochemistry, 1993

Choline acetyltransferase catalyzes the formation of acetylcholine from choline and acetyl-CoA in... more Choline acetyltransferase catalyzes the formation of acetylcholine from choline and acetyl-CoA in cholinergic neurons. The present study examined conditions for modulation of kinase-mediated phosphorylation of this enzyme. By using a monospecific polyclonal rabbit anti-human choline acetyltransferase antibody to immunoprecipitate cytosolic and mernbrane-associated subcellular pools of enzyme from rat hippocampal synaptosomes, we determined that only the cytosolic fraction of the enzyme (67,000 * 730 daltons) was phosphorylated under basal,

Brain Research, 1993

Age-related cognitive deficits in both humans and experimental animals appear to relate to dysfun... more Age-related cognitive deficits in both humans and experimental animals appear to relate to dysfunction of basal forebrain cholinerglc neuron systems. The present study assessed spatial learning performance in a water maze task as a function of choline acetyltransferase and high-affinity choline uptake specific activity (the two phenotypic markers for cholinergic neurons) in frontal cortex, hippocampus and striatum of aged male Fischer-344 rats. We observed that increased hippocampal choline acetyltransferase activity was related to better performance on the water maze task, and that, of the individual measures, hippocampal choline acetyltransferase activity was the best predictor of behavioral performance in the spatial learning task.

In international comparisons, Canada’s education system ranks highly in terms of basic literacy, ... more In international comparisons, Canada’s education system ranks highly in terms of basic literacy, numeracy and high-school completion rates. But our country receives a much lower grade when it comes to participation in post-secondary science, technology, engineering and mathematics programs — fi elds that have been shown to have a direct impact on innovation, productivity and economic growth. If we fail to address this problem, Canada risks falling further behind in the 21st century skills race.

Public Understanding of Science, 1996

This study evaluated the effect of an outreach project, called theScientist Badge for Brownies an... more This study evaluated the effect of an outreach project, called theScientist Badge for Brownies and Girl Guides', on science attitudes and achievement of girls aged 6-12. The programme reached nearly 1500 girls and consisted of ninety minutes of hands-on ...

Progress in Brain Research, 1993

Journal of Neurochemistry, 1993

Choline acetyltransferase catalyzes the formation of acetylcholine from choline and acetyl-CoA in... more Choline acetyltransferase catalyzes the formation of acetylcholine from choline and acetyl-CoA in cholinergic neurons. The present study examined conditions for modulation of kinase-mediated phosphorylation of this enzyme. By using a monospecific polyclonal rabbit anti-human choline acetyltransferase antibody to immunoprecipitate cytosolic and mernbrane-associated subcellular pools of enzyme from rat hippocampal synaptosomes, we determined that only the cytosolic fraction of the enzyme (67,000 * 730 daltons) was phosphorylated under basal,

Brain Research, 1993

Age-related cognitive deficits in both humans and experimental animals appear to relate to dysfun... more Age-related cognitive deficits in both humans and experimental animals appear to relate to dysfunction of basal forebrain cholinerglc neuron systems. The present study assessed spatial learning performance in a water maze task as a function of choline acetyltransferase and high-affinity choline uptake specific activity (the two phenotypic markers for cholinergic neurons) in frontal cortex, hippocampus and striatum of aged male Fischer-344 rats. We observed that increased hippocampal choline acetyltransferase activity was related to better performance on the water maze task, and that, of the individual measures, hippocampal choline acetyltransferase activity was the best predictor of behavioral performance in the spatial learning task.

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