yudhiakuari sincihu | Widya Mandala Catholic University Surabaya (original) (raw)

Papers by yudhiakuari sincihu

Neuropsychiatric Disease and Treatment

Low-density polyethylene microplastics are ingested into the bloodstream and distributed to all t... more Low-density polyethylene microplastics are ingested into the bloodstream and distributed to all the organ tissue, including the hippocampus, causing toxic effects. This research aimed to elucidate the responses of hippocampal neurons to microplastic in the blood based on the expressions of superoxide dismutase (SOD), catalase (CAT) enzymes, malondialdehyde (MDA), 8-oxo-7,8-dihydro-2-deoxyguanosine (8-OHdG) in hippocampal neurons, and blood serum amyloid beta 1-42 (Aβ42) levels using SMART PLS pathway analysis. Methods: This was a pure experimental research on Wistar rats with a post-test control group design. Five experimental groups (X1, X2, X3, X4, X5) were given 0.0375 mg, 0.075 mg, 0.15 mg, 0.3 mg, and 0.6 mg of low-density polyethylene microplastics mixed in 2cc distilled water, respectively. Furthermore, except for control (C), the groups received microplastics an oral probe for 90 days. Results: The molecular response of hippocampal neurons of Wistar rats to microplastics in the blood significantly decreased SOD enzyme expression, while CAT enzyme was unaffected. It considerably increased neuronal membrane damage (expression of MDA), increased considerably neuronal deoxyribonucleic acid damage (expression of 8-OHdG), and decreased blood serum Aβ42 levels (pathway analysis, all t-value >1.96). Conclusion: The pathway analysis showed that hippocampal neurons were significantly affected by microplastic particles in the blood.

Journal of Widya Medika Junior

Introduction: Human exposure to microplastics continues to rise. Microplastics are harmful and ar... more Introduction: Human exposure to microplastics continues to rise. Microplastics are harmful and are suspected of contributing to various health problems in humans, including reduced liver function. Purpose: This study aimed to determine the effect of oral polyvinyl chloride microplastic consumption on alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) levels in Rattus norvegicus Wistar strain. Method: Male Rattus norvegicus Wistar strain experiments were separated into control and experimental groups, with the experimental group receiving a 0.5 mg/day dose of polyvinyl chloride microplastic. The experimental animals' blood was taken using the cardiac puncture technique, and the ALP and GGT levels were determined using the kinetic photometric test method. Result and Discussion: The Shapiro-Wilk normality tests showed that the ALP variable from the control group (P=0.342) and the experimental group (P=0.727) was significantly different from the GGT variable from the co...

International journal of health sciences

Microplastic particles in the blood can cause damage to organs such as the brain. This study aime... more Microplastic particles in the blood can cause damage to organs such as the brain. This study aimed to analyze the effect of microplastic particles in the blood on membrane damage (expression of malondialdehyde metabolites) and deoxyribonucleic acid damage (expression of 8-hydroxy-2′-deoxyguanosine metabolites) in hippocampus neurons of Wistar rats. Methods: Forty-two Wistar rats were used and equally divided into six groups. The study groups X1, X2, X3, X4 and X5 was given 0.0375mg, 0.075mg, 0.15mg, 0.3mg, and 0.6mg of low-density polyethylene microplastic powder mixed with 2cc distilled water respectively, while the control group only given distilled water. Microplastic administration was carried out for 90 days. Results: Microplastic particles were found in the blood of Wistar rats. The level of microplastics particle was higher along with the higher exposure dose. The mean expression of malondialdehyde and 8-hydroxy-2′-deoxyguanosine metabolites in the hippocampal neurons in CA1 ...

Medical Technology and Public Health Journal

Mikroplastik telah diketahui sebagai kontaminan rantai makanan. Polimer plastik terbanyak adalah ... more Mikroplastik telah diketahui sebagai kontaminan rantai makanan. Polimer plastik terbanyak adalah polietilen. Mikroplastik di saluran cerna akan mengalami persopsi melalui celah sel di ujung vili usus masuk ke sirkulasi darah untuk menuju keseluruh jaringan. Diduga mikroplastik akan memicu inflamasi kronis. Tujuan penelitian adalah menganalisis dampak paparan mikroplastik polietilen peroral terhadap jumlah sel leukosit darah. Penelitian eksperimental murni dengan post-test only control group design. Alokasi random digunakan untuk membagi 30 ekor Rattus norvegicus strain wistar kedalam tiap kelompok sejumlah sama banyak. Terdapat 4 kelompok paparan dengan dosis D1=0,0375mg, D2=0,075mg, D3=0,15mg, D4=0,6mg partikel mikroplastik perhari melalui sonde oral dan 1 kelompok kontrol yang tidak diberikan mikroplastik. Paparan diberikan selama 90 hari. Uji ANOVA satu arah digunakan untuk analisis perbedaan nilai antar kelompok. Hasil penelitian nenunjukan tren peningkatan nilai rerata pada bio...

Jurnal Widya Medika, Apr 1, 2013

Gross National Product (GNP) is one indicator of the socioeconomic development system. Its influe... more Gross National Product (GNP) is one indicator of the socioeconomic development system. Its influence on people's health status, including quality of life, there are still many disputed, especially on the implementation in the region. Some of the indicator that could be used againts the public health impact assessment, among others Human Development Index (HDI), Physical Quality of Life Index (PQLI), and etc. effect of GNP on health effect, among others depending on how far equitable distribution of quality among the various strata of the population. The article with the above title aims to discuss the effectiveness of GNP effect on improvement public heatlh in general.

Jurnal Ilmiah Kedokteran Wijaya Kusuma, Mar 30, 2018

Angka kematian neonatus merupakan salah satu indikator untuk menilai kesehatan di masyarakat. Ber... more Angka kematian neonatus merupakan salah satu indikator untuk menilai kesehatan di masyarakat. Berdasarkan WHO, penyebab utama kematian neonatus diantaranya adalah prematuritas, asfiksia neonatorum dan sepsis neonatorum. Faktor penyebab terjadinya asfiksia neonatorum salah satunya KPD. Tujuan penelitian ini untuk mengetahui apakah lamanya KPD pada persalinan aterm berhubungan terhadap tingkat asfiksia bayi baru lahir. Penelitian ini bersifat observasional analitik menggunakan data sekunder dengan pendekatan retrospektif, rancangan cross-sectional. Teknik pengambilan sampel menggunakan purposive sampling. Data diambil selama 18 bulan yaitu periode 1 Januari 2016 hingga 30 Juni 2017.Populasi pada penelitian ini adalah 1594 ibu yang melahirkan dan 1619 bayi yang dilahirkan. Data ibu bersalin dengan riwayat KPD terdapat sebanyak 168 dan 80 ibu dan bayinya yang memenuhi kriteria. Data dianalisis menggunakan uji korelasi Spearman's rho. Hasil penelitian menunjukkan terdapat hubungan antara lamanya KPD dengan tingkat asfiksia nonatorum, dengan nilai signifikansi p = 0,029 (p < 0,050) dan nilai koefisien korelasi (C)-0,244 yang termasuk koefisien korelasi rendah hubungan terbalik. Interpretasi hubungan terbalik menunjukkan bahwa semakin meningkat lama KPD maka nilai APGAR semakin menurun atau tingkat asfiksia semakin berat.

Journal Of Widya Medika Junior, Mar 4, 2019

Introduction: Asphyxia neonatorum occupies second place in the cause of death of babies in East J... more Introduction: Asphyxia neonatorum occupies second place in the cause of death of babies in East Java in 2010 and still in the top three of the cause of death of babies in Surabaya until 2016. One of the risk factors of asphyxia neonatorum was the delivery method, one of which is caesarean section delivery. Aim: The purpose of this study was to determine the correlation between asphyxia neonatorum incidence and caesarean section delivery. Methods: This is an observational analytical study using secondary data with retrospective approach. This study used case control design. Total population in this study were 1112 birthing mother and 1134 babies born during 1 January 2016 until 31 December 2016. A total of 125 case samples (Asphyxia) were chosen using purposive sampling technique, while 125 control samples (No asphyxia) were chosen using simple random sampling technique. Data were analysed with Chi-Square test. Results: Results showed that there were no significant correlation between asphyxia neonatorum incidence and caesarean section delivery (p = 0.591) Conclusion: This study showed that caesarean section delivery was not the main risk factor of asphyxia neonatorum.

Indian Journal of Public Health Research & Development, 2020

Antihypertensive drugs involved in many sexual problems, particularly erectile dysfunction, and b... more Antihypertensive drugs involved in many sexual problems, particularly erectile dysfunction, and being the main cause of non compliance toward antihypertensive medication. Patient who has hypertension, even the disease progression and medication maybe have some detrimental effects to the sexual function. The aim of this study is identify the effect of hypertension and antihypertensive drugs to the erectile function. A cross-sectional and analytic observational study was conducted in adult community at Redemptor Mundi church, Surabaya, East Java, obtained 30 samples of men aged ≥ 45 years. Research data Included are measuring result of blood pressure, the medication history of antihypertensive and erectile function measured by International Index of Erectile Function (IIEF) questionnaire recorded. Outcome of the study show significant correlation between hypertensive condition and IIEF questionnaire result (p = 0.010) with negative and moderate strength correlation (r =-0.466). While antihypertensive medication history not showing the difference of questionnaire result between two groups (p = 0.273). The conclusion that hypertensive condition have effect toward erectile function, while antihypertensive medication history did not have effect to the erectile function.

Jurnal Kesehatan Masyarakat, 2018

Every human is getting old and we must attempt to be happy in the old time. The problem is 17.5% ... more Every human is getting old and we must attempt to be happy in the old time. The problem is 17.5% of elderly people have poor quality of life and 62.5% are sufficient. Elderly at this level needs immediate intervention because it will be a burden for families. communities and governments. This study aims to analyze the family participation on improving the quality of life. An observational study with cross sectional approach with population study at Posyandu Lansia Mekar Sari Surabaya. We used purposive sampling method. We took 54 samples elderly aged ≥ 60 years out of 96 elderly who enrolled in Posyandu year 2016. Data were obtained from WHOQoL-BREF and family role questionnaire. We analyzed the data with Rank Spearman’s Correlation. There was a positive correlation between the family role and the quality of life (p=0.000.. r=0.568). mainly by environmental domain (p=0.000. r=0.561). psychological domain (p=0.008. r=0.358). and social relations domain (p=0.011. r=0.345). but not for...

The Influence of Aphrodisiac Food Consumption Patterns on Elderly Sexual Functions Background. Li... more The Influence of Aphrodisiac Food Consumption Patterns on Elderly Sexual Functions Background. Life expectancy in Indonesia is increasing so that the number of elderly people is also increasing. One of the factors that influence the happiness of elderly marriage is the harmony of husband and wife relationships. Aphrodisiac food is known to improve sexual function. The aim of the study was to determine the effect of aphrodisiac food consumption patterns on the elderly on sexual function. The research method was a cross sectional study with 35 samples (12 males and 23 females) measured for sexual function by using the International Index of Erectile Function (IIEF) and Female Sexual Function Index (FSFI). The pattern of consumption of aphrodisiac foods was measured by the Food Frequency Questionaire (FFQ). The results of the study found that there was no influence of the consumption pattern of aphrodisiac food on male sexual function. In women there was a significant effect (p = 0.001...

Osteoarthritis (OA) is a common joint disease. Pain has a profound effect on the quality of life ... more Osteoarthritis (OA) is a common joint disease. Pain has a profound effect on the quality of life of a person by affecting physical and psychological functions. According to World Health Organization (WHO), the quality of one's life is determined by several dimensions: physical, environmental, psychological and social dimension. The purpose of this researchwasto analyze the relationship between pain intensity in patients with knee OA and physical dimensions in quality of life. This researchwas an analytical study of correlation, using cross-sectional approach. Sample was taken using consecutive technique with inclusion and exclusion criteria. The population in this research were 180 patients with knee OA as many as 70 patients were taken into the sample. There wasa correlation between pain intensity and physical dimension in quality of life of patients with knee OA with p = 0,000 (p <0,050) and R Square = 0,573 which meant pain had impact on physical dimension in quality of life as much as 57.30%, while the remaining of 42.70% was influenced by other variables such as swelling, joint stiffness and muscle weakness. This finding meant that pain was the main focus of treatment giventopatients with knee OAin order to improve their quality of life.

SURABAYAABSTRAKAkupunktur sebagai terapi komplementer formal bagi kedokteran modern semakin diken... more SURABAYAABSTRAKAkupunktur sebagai terapi komplementer formal bagi kedokteran modern semakin dikenal dan diminati sebagai metode pengobatan. Metode ini mengadopsi prinsip keseimbangan Yin-Yang, sehingga mempunyai frekuensi pengobatan yang berbeda pada tiap kasus penyakit. Analisis Customer Value merupakan salah satu strategi pemasaran dalam upaya pencapaian kepuasan layanan dari sudut pandang pasien sebagai user, buyer dan payer, sehingga tercipta prilaku patuh. Kepatuhan pasien diklinik LP3A masih rendah.Diharapkan dengan upayaanalisis customer value ini dapat meningkatkan prilaku kepatuhanpengobatan.Penelitian ini bertujuanmenyusun rekomendasi peningkatan kepatuhan pasien dalam mengikuti seri pengobatan akupunktur berdasarkan analisis customer value yang memberi added value di Klinik LP3A, Surabaya. Merupakanpenelitian diskriptif dengan pendekatan kuantitatif dan rancang bangun penelitiannya yaitu cross sectional. Data hasil penelitian dijadikan sebagai isu strategis dan menjadi po...

Majalah Kesehatan, 2018

Kemampuan kognitif sangat diperlukan pekerja dalam menjalankan aktivitas pekerjaannya sehingga pr... more Kemampuan kognitif sangat diperlukan pekerja dalam menjalankan aktivitas pekerjaannya sehingga produktifitas dapat maksimal. Perusahaan galangan kapal selalu menghasilkan bising sebagai risiko bahaya kesehatan bagi pekerjanya. Pemeriksaan audiometri tahun 2018 menemukan 81,2% dengan kelainan tuli sensorineural akibat bising pada pekerja galangan kapal. Penelitian ini bertujuan untuk menganalisis hubungan ketulian sensorineural akibat bising dengan kemampuan kognitif (seperti fungsi visiokontruksi, penamaan, memori, atensi, berbahasa, berpikir abstrak, memori tertunda, dan orientasi). Penelitian ini adalah penelitian observasional dengan pendekatan cross-sectional. Lokasi penelitian di perusahaan galangan kapal di Surabaya. Populasi adalah pekerja bagian produksi galangan kapal, sebanyak 314 orang, dan ditemukan 49 subjek sebagai sampel yang memenuhi kriteria inklusi dan eksklusi. Data fungsi kognitif diambil menggunakan kuesioner Moca-Ina. Hasil penelitian menunjukan 79,6% subjek mengalami gangguan fungsi kognitif, 57,1% tuli derajat ringan, 16,3% tuli derajat sedang, 2,1% tuli derajat sedang-berat, dan 2,1% tuli derajat berat. Analisis statistik non-parametrik dengan uji Spearman antara derajat ketulian dengan skor kognitif subjek penelitian menunjukan hubungan yang rendah namun bermakna (r = 0,306, p = 0,032). Kesimpulan penelitian ini adalah semakin berat derajat ketulian yang diderita pekerja berhubungan dengan semakin rendahnya kemampuan kognitif mereka. Kata kunci: bising, gangguan kognitif, tuli sensorineural.

Indian Journal of Public Health Research & Development, 2020

Cognitive ability is important for the elderly to be able to live independently. Many factors infl... more Cognitive ability is important for the elderly to be able to live independently. Many factors influence this ability in elderly, one of them being occupational history. The purpose of this study was to analyze occupational history as a cause of decreased cognitive ability. An observational analytic study with a cross-sectional approach. 87 subjects who met the inclusion criteria were recruited from Nursing Homes in Surabaya. 71.3% of the subjects have a history of physical-dominated occupation and 28.7% have intelectual-dominated occupation. There were no differences regarding duration of work and perception of workload in both groups. The average cognitive score is 18.57 (SD 5.939). The ANOVA test between occupational history and cognitive abilities shows p=0.001, R Square=0.172, and estimated standard of error of 5.501. This study concluded that occupational history can be used as a predictor of cognitive ability in elderly.

Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya, 2018

Elderly are often considered as a burden because of their physical limitations. The reduced cogni... more Elderly are often considered as a burden because of their physical limitations. The reduced cognitive function is one of the important causes for this physical limitation. Quality of sleep used to be associated with changes in cognitive function. A comparative analytic research to assess insomnia as a risk factor for the incidence of cognitive function impairment in the elderly. A case-control study in elderly community at the nursing home St.Yosef, Surabaya. Fifty respondents were taken by consecutive sampling and meeting the inclusion criteria. This study also excluded people with depression, schizophrenia, and users of psychotropic drugs. Eighty four percent of respondents have impaired cognitive function. Not much difference in percentage of insomnia disturbance in control group (37,5%) and case group (35,8%). Fisher's Exact Test show Sig.0,609 and OR=0.926 on CI [(0,194),(4,425)]. It was concluded that insomnia alone was not a risk factor for impaired cognitive modalities. Elderly exposed to sleep disorders have the same tendency to suffer cognitive impairment with unexposed.

The Indonesian Journal of Occupational Safety and Health, 2019

Introduction: Noise is a health risk that cannot be avoided in production process. Noise has the ... more Introduction: Noise is a health risk that cannot be avoided in production process. Noise has the potential to cause hearing loss for workers. The bad news, noise damage due to noise is permanent. Audiometric screening at shipyard company employees found 81.2% experienced Sensory-Neural Hearing Loss. 61.5% of employees experience deafness in both ears. The research objective was to find the cause of deafness at shipyard company. Methods: A Quantitative research with cross sectional approach in 64 subjects who worked in the ship repair production unit. The sample is chosen with a simple random technique according to inclusion and exclusion criteria. Assessment was carried out using questionnaires, measurement, and direct observations. Result: The bad habit of wearing ear protectors on employees as a cause of deafness (p

Jurnal Ilmiah Kedokteran Wijaya Kusuma, 2018

Anxiety is a mental disorder common in elderly people. In the process of becoming elderly, feelin... more Anxiety is a mental disorder common in elderly people. In the process of becoming elderly, feelings of anxiety arise as a normal response to situations that accompany development, change, new experiences and find meaning in life. Anxious looks from physiological symptoms such as shaking, sweating, heart work increases and psychological symptoms such as panic, tension, confusion, unable to concentrate. This condition will inhibit the elderly's bio-psycho-social condition in living the rest of his life. One effect is seen from their sleep problems. This is observational research with cross-sectional approach. Samples were taken by consecutive sampling technique. 43 elderly who met the exclusion criteria. Research location at Posyandu Lansia Mojo, Surabaya. Data collection using Hamilton Rating Scale for Anxiety and Insomnia Severity Index questionnaires. the results of the study described 41.9% of subjects with anxiety disorders and 67.4% of subjects had insomnia disorders. The cr...

Aging Medicine and Healthcare, 2019

The improvement in health and education sector within the national development context has an imp... more The improvement in health and education sector within the national development context has an impact on the increase of life expectancy the elderly people. The Law Number 13, 1998 about elderly welfare stated that Indonesian citizen who are categorizedas the elderly are those who aged over 60 years. 1 From the social-health demography perspective, increasing the elderly's life expectancy has become a ABSTRACT Backgroud/Purpose: The data showed that 62.5% of the elderly's quality of life in the community is at the medium level, which have a tendency to downgrade to a lower level over the aging process in the future if there is no immediate intervention. As expected, analyzes of the individual determinants of the elderly can produce insights that will reinforce the improvement of their quality of life. Methods: An analytical study of correlation, using crosssectional approach. The population were the elderly in Surabaya, Indonesia who joined the gemeinschaft (n=120). The sample was taken using consecutive sampling technique among those who the aged ≥60 years. Results: The data indicated that the elderly's dissatisfaction regarding their quality of life mainly comes from psychological domain (26.7%), environmental domain (15.0%), physical domain (14.7%), and social relationships domain (10,8%). There are correlations found between age (p=0.006), education level (p=0.035), health condition (p=0.001), and financial condition (p=0.005) with the elderly's quality of life. However, the determinants of gender, ethnicity, workload, marital status, and living conditions are found to have no influence upon their quality of life. Conclusion: The specific characteristics of the elderly that need to be targeted are those who aged ≥71 years with education level of or below senior high school, have physical health problems, elderly whose retirement income is not sufficient for their daily living expenses, and who are still forced to work.

Journal of Public Health in Africa

Introduction. Microplastics are plastic particles with a microscopic size of <5 mm in diameter... more Introduction. Microplastics are plastic particles with a microscopic size of <5 mm in diameter. Microplastics are new contamination of the environment and can be bad for health. Objective. This paper aims to examine the presence of microplastics in the Indonesian environment based on the results of research in 2022 and its effects on health. Materials and Methods. Systematic review based on the results of research journals published in 2022. Journal obtained from a search on Google Scholar with keywords “microplastics”, “microplastics in Indonesia”, and “effect microplastic to health”. Results. The results of a review showed that the research location was dominated in East Jawa. The presence of microplastics in the environment in Indonesia is most widely studied, namely in river and sea sediments. The forms of microplastics identified are fiber, fragment, film, pellets, granule, foam, filament, and bead. In microplastic research on the environment in Indonesia in 2022, as much as...

Neuropsychiatric Disease and Treatment

Low-density polyethylene microplastics are ingested into the bloodstream and distributed to all t... more Low-density polyethylene microplastics are ingested into the bloodstream and distributed to all the organ tissue, including the hippocampus, causing toxic effects. This research aimed to elucidate the responses of hippocampal neurons to microplastic in the blood based on the expressions of superoxide dismutase (SOD), catalase (CAT) enzymes, malondialdehyde (MDA), 8-oxo-7,8-dihydro-2-deoxyguanosine (8-OHdG) in hippocampal neurons, and blood serum amyloid beta 1-42 (Aβ42) levels using SMART PLS pathway analysis. Methods: This was a pure experimental research on Wistar rats with a post-test control group design. Five experimental groups (X1, X2, X3, X4, X5) were given 0.0375 mg, 0.075 mg, 0.15 mg, 0.3 mg, and 0.6 mg of low-density polyethylene microplastics mixed in 2cc distilled water, respectively. Furthermore, except for control (C), the groups received microplastics an oral probe for 90 days. Results: The molecular response of hippocampal neurons of Wistar rats to microplastics in the blood significantly decreased SOD enzyme expression, while CAT enzyme was unaffected. It considerably increased neuronal membrane damage (expression of MDA), increased considerably neuronal deoxyribonucleic acid damage (expression of 8-OHdG), and decreased blood serum Aβ42 levels (pathway analysis, all t-value >1.96). Conclusion: The pathway analysis showed that hippocampal neurons were significantly affected by microplastic particles in the blood.

Journal of Widya Medika Junior

Introduction: Human exposure to microplastics continues to rise. Microplastics are harmful and ar... more Introduction: Human exposure to microplastics continues to rise. Microplastics are harmful and are suspected of contributing to various health problems in humans, including reduced liver function. Purpose: This study aimed to determine the effect of oral polyvinyl chloride microplastic consumption on alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) levels in Rattus norvegicus Wistar strain. Method: Male Rattus norvegicus Wistar strain experiments were separated into control and experimental groups, with the experimental group receiving a 0.5 mg/day dose of polyvinyl chloride microplastic. The experimental animals' blood was taken using the cardiac puncture technique, and the ALP and GGT levels were determined using the kinetic photometric test method. Result and Discussion: The Shapiro-Wilk normality tests showed that the ALP variable from the control group (P=0.342) and the experimental group (P=0.727) was significantly different from the GGT variable from the co...

International journal of health sciences

Microplastic particles in the blood can cause damage to organs such as the brain. This study aime... more Microplastic particles in the blood can cause damage to organs such as the brain. This study aimed to analyze the effect of microplastic particles in the blood on membrane damage (expression of malondialdehyde metabolites) and deoxyribonucleic acid damage (expression of 8-hydroxy-2′-deoxyguanosine metabolites) in hippocampus neurons of Wistar rats. Methods: Forty-two Wistar rats were used and equally divided into six groups. The study groups X1, X2, X3, X4 and X5 was given 0.0375mg, 0.075mg, 0.15mg, 0.3mg, and 0.6mg of low-density polyethylene microplastic powder mixed with 2cc distilled water respectively, while the control group only given distilled water. Microplastic administration was carried out for 90 days. Results: Microplastic particles were found in the blood of Wistar rats. The level of microplastics particle was higher along with the higher exposure dose. The mean expression of malondialdehyde and 8-hydroxy-2′-deoxyguanosine metabolites in the hippocampal neurons in CA1 ...

Medical Technology and Public Health Journal

Mikroplastik telah diketahui sebagai kontaminan rantai makanan. Polimer plastik terbanyak adalah ... more Mikroplastik telah diketahui sebagai kontaminan rantai makanan. Polimer plastik terbanyak adalah polietilen. Mikroplastik di saluran cerna akan mengalami persopsi melalui celah sel di ujung vili usus masuk ke sirkulasi darah untuk menuju keseluruh jaringan. Diduga mikroplastik akan memicu inflamasi kronis. Tujuan penelitian adalah menganalisis dampak paparan mikroplastik polietilen peroral terhadap jumlah sel leukosit darah. Penelitian eksperimental murni dengan post-test only control group design. Alokasi random digunakan untuk membagi 30 ekor Rattus norvegicus strain wistar kedalam tiap kelompok sejumlah sama banyak. Terdapat 4 kelompok paparan dengan dosis D1=0,0375mg, D2=0,075mg, D3=0,15mg, D4=0,6mg partikel mikroplastik perhari melalui sonde oral dan 1 kelompok kontrol yang tidak diberikan mikroplastik. Paparan diberikan selama 90 hari. Uji ANOVA satu arah digunakan untuk analisis perbedaan nilai antar kelompok. Hasil penelitian nenunjukan tren peningkatan nilai rerata pada bio...

Jurnal Widya Medika, Apr 1, 2013

Gross National Product (GNP) is one indicator of the socioeconomic development system. Its influe... more Gross National Product (GNP) is one indicator of the socioeconomic development system. Its influence on people's health status, including quality of life, there are still many disputed, especially on the implementation in the region. Some of the indicator that could be used againts the public health impact assessment, among others Human Development Index (HDI), Physical Quality of Life Index (PQLI), and etc. effect of GNP on health effect, among others depending on how far equitable distribution of quality among the various strata of the population. The article with the above title aims to discuss the effectiveness of GNP effect on improvement public heatlh in general.

Jurnal Ilmiah Kedokteran Wijaya Kusuma, Mar 30, 2018

Angka kematian neonatus merupakan salah satu indikator untuk menilai kesehatan di masyarakat. Ber... more Angka kematian neonatus merupakan salah satu indikator untuk menilai kesehatan di masyarakat. Berdasarkan WHO, penyebab utama kematian neonatus diantaranya adalah prematuritas, asfiksia neonatorum dan sepsis neonatorum. Faktor penyebab terjadinya asfiksia neonatorum salah satunya KPD. Tujuan penelitian ini untuk mengetahui apakah lamanya KPD pada persalinan aterm berhubungan terhadap tingkat asfiksia bayi baru lahir. Penelitian ini bersifat observasional analitik menggunakan data sekunder dengan pendekatan retrospektif, rancangan cross-sectional. Teknik pengambilan sampel menggunakan purposive sampling. Data diambil selama 18 bulan yaitu periode 1 Januari 2016 hingga 30 Juni 2017.Populasi pada penelitian ini adalah 1594 ibu yang melahirkan dan 1619 bayi yang dilahirkan. Data ibu bersalin dengan riwayat KPD terdapat sebanyak 168 dan 80 ibu dan bayinya yang memenuhi kriteria. Data dianalisis menggunakan uji korelasi Spearman's rho. Hasil penelitian menunjukkan terdapat hubungan antara lamanya KPD dengan tingkat asfiksia nonatorum, dengan nilai signifikansi p = 0,029 (p < 0,050) dan nilai koefisien korelasi (C)-0,244 yang termasuk koefisien korelasi rendah hubungan terbalik. Interpretasi hubungan terbalik menunjukkan bahwa semakin meningkat lama KPD maka nilai APGAR semakin menurun atau tingkat asfiksia semakin berat.

Journal Of Widya Medika Junior, Mar 4, 2019

Introduction: Asphyxia neonatorum occupies second place in the cause of death of babies in East J... more Introduction: Asphyxia neonatorum occupies second place in the cause of death of babies in East Java in 2010 and still in the top three of the cause of death of babies in Surabaya until 2016. One of the risk factors of asphyxia neonatorum was the delivery method, one of which is caesarean section delivery. Aim: The purpose of this study was to determine the correlation between asphyxia neonatorum incidence and caesarean section delivery. Methods: This is an observational analytical study using secondary data with retrospective approach. This study used case control design. Total population in this study were 1112 birthing mother and 1134 babies born during 1 January 2016 until 31 December 2016. A total of 125 case samples (Asphyxia) were chosen using purposive sampling technique, while 125 control samples (No asphyxia) were chosen using simple random sampling technique. Data were analysed with Chi-Square test. Results: Results showed that there were no significant correlation between asphyxia neonatorum incidence and caesarean section delivery (p = 0.591) Conclusion: This study showed that caesarean section delivery was not the main risk factor of asphyxia neonatorum.

Indian Journal of Public Health Research & Development, 2020

Antihypertensive drugs involved in many sexual problems, particularly erectile dysfunction, and b... more Antihypertensive drugs involved in many sexual problems, particularly erectile dysfunction, and being the main cause of non compliance toward antihypertensive medication. Patient who has hypertension, even the disease progression and medication maybe have some detrimental effects to the sexual function. The aim of this study is identify the effect of hypertension and antihypertensive drugs to the erectile function. A cross-sectional and analytic observational study was conducted in adult community at Redemptor Mundi church, Surabaya, East Java, obtained 30 samples of men aged ≥ 45 years. Research data Included are measuring result of blood pressure, the medication history of antihypertensive and erectile function measured by International Index of Erectile Function (IIEF) questionnaire recorded. Outcome of the study show significant correlation between hypertensive condition and IIEF questionnaire result (p = 0.010) with negative and moderate strength correlation (r =-0.466). While antihypertensive medication history not showing the difference of questionnaire result between two groups (p = 0.273). The conclusion that hypertensive condition have effect toward erectile function, while antihypertensive medication history did not have effect to the erectile function.

Jurnal Kesehatan Masyarakat, 2018

Every human is getting old and we must attempt to be happy in the old time. The problem is 17.5% ... more Every human is getting old and we must attempt to be happy in the old time. The problem is 17.5% of elderly people have poor quality of life and 62.5% are sufficient. Elderly at this level needs immediate intervention because it will be a burden for families. communities and governments. This study aims to analyze the family participation on improving the quality of life. An observational study with cross sectional approach with population study at Posyandu Lansia Mekar Sari Surabaya. We used purposive sampling method. We took 54 samples elderly aged ≥ 60 years out of 96 elderly who enrolled in Posyandu year 2016. Data were obtained from WHOQoL-BREF and family role questionnaire. We analyzed the data with Rank Spearman’s Correlation. There was a positive correlation between the family role and the quality of life (p=0.000.. r=0.568). mainly by environmental domain (p=0.000. r=0.561). psychological domain (p=0.008. r=0.358). and social relations domain (p=0.011. r=0.345). but not for...

The Influence of Aphrodisiac Food Consumption Patterns on Elderly Sexual Functions Background. Li... more The Influence of Aphrodisiac Food Consumption Patterns on Elderly Sexual Functions Background. Life expectancy in Indonesia is increasing so that the number of elderly people is also increasing. One of the factors that influence the happiness of elderly marriage is the harmony of husband and wife relationships. Aphrodisiac food is known to improve sexual function. The aim of the study was to determine the effect of aphrodisiac food consumption patterns on the elderly on sexual function. The research method was a cross sectional study with 35 samples (12 males and 23 females) measured for sexual function by using the International Index of Erectile Function (IIEF) and Female Sexual Function Index (FSFI). The pattern of consumption of aphrodisiac foods was measured by the Food Frequency Questionaire (FFQ). The results of the study found that there was no influence of the consumption pattern of aphrodisiac food on male sexual function. In women there was a significant effect (p = 0.001...

Osteoarthritis (OA) is a common joint disease. Pain has a profound effect on the quality of life ... more Osteoarthritis (OA) is a common joint disease. Pain has a profound effect on the quality of life of a person by affecting physical and psychological functions. According to World Health Organization (WHO), the quality of one's life is determined by several dimensions: physical, environmental, psychological and social dimension. The purpose of this researchwasto analyze the relationship between pain intensity in patients with knee OA and physical dimensions in quality of life. This researchwas an analytical study of correlation, using cross-sectional approach. Sample was taken using consecutive technique with inclusion and exclusion criteria. The population in this research were 180 patients with knee OA as many as 70 patients were taken into the sample. There wasa correlation between pain intensity and physical dimension in quality of life of patients with knee OA with p = 0,000 (p <0,050) and R Square = 0,573 which meant pain had impact on physical dimension in quality of life as much as 57.30%, while the remaining of 42.70% was influenced by other variables such as swelling, joint stiffness and muscle weakness. This finding meant that pain was the main focus of treatment giventopatients with knee OAin order to improve their quality of life.

SURABAYAABSTRAKAkupunktur sebagai terapi komplementer formal bagi kedokteran modern semakin diken... more SURABAYAABSTRAKAkupunktur sebagai terapi komplementer formal bagi kedokteran modern semakin dikenal dan diminati sebagai metode pengobatan. Metode ini mengadopsi prinsip keseimbangan Yin-Yang, sehingga mempunyai frekuensi pengobatan yang berbeda pada tiap kasus penyakit. Analisis Customer Value merupakan salah satu strategi pemasaran dalam upaya pencapaian kepuasan layanan dari sudut pandang pasien sebagai user, buyer dan payer, sehingga tercipta prilaku patuh. Kepatuhan pasien diklinik LP3A masih rendah.Diharapkan dengan upayaanalisis customer value ini dapat meningkatkan prilaku kepatuhanpengobatan.Penelitian ini bertujuanmenyusun rekomendasi peningkatan kepatuhan pasien dalam mengikuti seri pengobatan akupunktur berdasarkan analisis customer value yang memberi added value di Klinik LP3A, Surabaya. Merupakanpenelitian diskriptif dengan pendekatan kuantitatif dan rancang bangun penelitiannya yaitu cross sectional. Data hasil penelitian dijadikan sebagai isu strategis dan menjadi po...

Majalah Kesehatan, 2018

Kemampuan kognitif sangat diperlukan pekerja dalam menjalankan aktivitas pekerjaannya sehingga pr... more Kemampuan kognitif sangat diperlukan pekerja dalam menjalankan aktivitas pekerjaannya sehingga produktifitas dapat maksimal. Perusahaan galangan kapal selalu menghasilkan bising sebagai risiko bahaya kesehatan bagi pekerjanya. Pemeriksaan audiometri tahun 2018 menemukan 81,2% dengan kelainan tuli sensorineural akibat bising pada pekerja galangan kapal. Penelitian ini bertujuan untuk menganalisis hubungan ketulian sensorineural akibat bising dengan kemampuan kognitif (seperti fungsi visiokontruksi, penamaan, memori, atensi, berbahasa, berpikir abstrak, memori tertunda, dan orientasi). Penelitian ini adalah penelitian observasional dengan pendekatan cross-sectional. Lokasi penelitian di perusahaan galangan kapal di Surabaya. Populasi adalah pekerja bagian produksi galangan kapal, sebanyak 314 orang, dan ditemukan 49 subjek sebagai sampel yang memenuhi kriteria inklusi dan eksklusi. Data fungsi kognitif diambil menggunakan kuesioner Moca-Ina. Hasil penelitian menunjukan 79,6% subjek mengalami gangguan fungsi kognitif, 57,1% tuli derajat ringan, 16,3% tuli derajat sedang, 2,1% tuli derajat sedang-berat, dan 2,1% tuli derajat berat. Analisis statistik non-parametrik dengan uji Spearman antara derajat ketulian dengan skor kognitif subjek penelitian menunjukan hubungan yang rendah namun bermakna (r = 0,306, p = 0,032). Kesimpulan penelitian ini adalah semakin berat derajat ketulian yang diderita pekerja berhubungan dengan semakin rendahnya kemampuan kognitif mereka. Kata kunci: bising, gangguan kognitif, tuli sensorineural.

Indian Journal of Public Health Research & Development, 2020

Cognitive ability is important for the elderly to be able to live independently. Many factors infl... more Cognitive ability is important for the elderly to be able to live independently. Many factors influence this ability in elderly, one of them being occupational history. The purpose of this study was to analyze occupational history as a cause of decreased cognitive ability. An observational analytic study with a cross-sectional approach. 87 subjects who met the inclusion criteria were recruited from Nursing Homes in Surabaya. 71.3% of the subjects have a history of physical-dominated occupation and 28.7% have intelectual-dominated occupation. There were no differences regarding duration of work and perception of workload in both groups. The average cognitive score is 18.57 (SD 5.939). The ANOVA test between occupational history and cognitive abilities shows p=0.001, R Square=0.172, and estimated standard of error of 5.501. This study concluded that occupational history can be used as a predictor of cognitive ability in elderly.

Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya, 2018

Elderly are often considered as a burden because of their physical limitations. The reduced cogni... more Elderly are often considered as a burden because of their physical limitations. The reduced cognitive function is one of the important causes for this physical limitation. Quality of sleep used to be associated with changes in cognitive function. A comparative analytic research to assess insomnia as a risk factor for the incidence of cognitive function impairment in the elderly. A case-control study in elderly community at the nursing home St.Yosef, Surabaya. Fifty respondents were taken by consecutive sampling and meeting the inclusion criteria. This study also excluded people with depression, schizophrenia, and users of psychotropic drugs. Eighty four percent of respondents have impaired cognitive function. Not much difference in percentage of insomnia disturbance in control group (37,5%) and case group (35,8%). Fisher's Exact Test show Sig.0,609 and OR=0.926 on CI [(0,194),(4,425)]. It was concluded that insomnia alone was not a risk factor for impaired cognitive modalities. Elderly exposed to sleep disorders have the same tendency to suffer cognitive impairment with unexposed.

The Indonesian Journal of Occupational Safety and Health, 2019

Introduction: Noise is a health risk that cannot be avoided in production process. Noise has the ... more Introduction: Noise is a health risk that cannot be avoided in production process. Noise has the potential to cause hearing loss for workers. The bad news, noise damage due to noise is permanent. Audiometric screening at shipyard company employees found 81.2% experienced Sensory-Neural Hearing Loss. 61.5% of employees experience deafness in both ears. The research objective was to find the cause of deafness at shipyard company. Methods: A Quantitative research with cross sectional approach in 64 subjects who worked in the ship repair production unit. The sample is chosen with a simple random technique according to inclusion and exclusion criteria. Assessment was carried out using questionnaires, measurement, and direct observations. Result: The bad habit of wearing ear protectors on employees as a cause of deafness (p

Jurnal Ilmiah Kedokteran Wijaya Kusuma, 2018

Anxiety is a mental disorder common in elderly people. In the process of becoming elderly, feelin... more Anxiety is a mental disorder common in elderly people. In the process of becoming elderly, feelings of anxiety arise as a normal response to situations that accompany development, change, new experiences and find meaning in life. Anxious looks from physiological symptoms such as shaking, sweating, heart work increases and psychological symptoms such as panic, tension, confusion, unable to concentrate. This condition will inhibit the elderly's bio-psycho-social condition in living the rest of his life. One effect is seen from their sleep problems. This is observational research with cross-sectional approach. Samples were taken by consecutive sampling technique. 43 elderly who met the exclusion criteria. Research location at Posyandu Lansia Mojo, Surabaya. Data collection using Hamilton Rating Scale for Anxiety and Insomnia Severity Index questionnaires. the results of the study described 41.9% of subjects with anxiety disorders and 67.4% of subjects had insomnia disorders. The cr...

Aging Medicine and Healthcare, 2019

The improvement in health and education sector within the national development context has an imp... more The improvement in health and education sector within the national development context has an impact on the increase of life expectancy the elderly people. The Law Number 13, 1998 about elderly welfare stated that Indonesian citizen who are categorizedas the elderly are those who aged over 60 years. 1 From the social-health demography perspective, increasing the elderly's life expectancy has become a ABSTRACT Backgroud/Purpose: The data showed that 62.5% of the elderly's quality of life in the community is at the medium level, which have a tendency to downgrade to a lower level over the aging process in the future if there is no immediate intervention. As expected, analyzes of the individual determinants of the elderly can produce insights that will reinforce the improvement of their quality of life. Methods: An analytical study of correlation, using crosssectional approach. The population were the elderly in Surabaya, Indonesia who joined the gemeinschaft (n=120). The sample was taken using consecutive sampling technique among those who the aged ≥60 years. Results: The data indicated that the elderly's dissatisfaction regarding their quality of life mainly comes from psychological domain (26.7%), environmental domain (15.0%), physical domain (14.7%), and social relationships domain (10,8%). There are correlations found between age (p=0.006), education level (p=0.035), health condition (p=0.001), and financial condition (p=0.005) with the elderly's quality of life. However, the determinants of gender, ethnicity, workload, marital status, and living conditions are found to have no influence upon their quality of life. Conclusion: The specific characteristics of the elderly that need to be targeted are those who aged ≥71 years with education level of or below senior high school, have physical health problems, elderly whose retirement income is not sufficient for their daily living expenses, and who are still forced to work.

Journal of Public Health in Africa

Introduction. Microplastics are plastic particles with a microscopic size of <5 mm in diameter... more Introduction. Microplastics are plastic particles with a microscopic size of <5 mm in diameter. Microplastics are new contamination of the environment and can be bad for health. Objective. This paper aims to examine the presence of microplastics in the Indonesian environment based on the results of research in 2022 and its effects on health. Materials and Methods. Systematic review based on the results of research journals published in 2022. Journal obtained from a search on Google Scholar with keywords “microplastics”, “microplastics in Indonesia”, and “effect microplastic to health”. Results. The results of a review showed that the research location was dominated in East Jawa. The presence of microplastics in the environment in Indonesia is most widely studied, namely in river and sea sediments. The forms of microplastics identified are fiber, fragment, film, pellets, granule, foam, filament, and bead. In microplastic research on the environment in Indonesia in 2022, as much as...