Isuru Wijesekara | Washington State University (original) (raw)
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Papers by Isuru Wijesekara
LWT - Food Science and Technology, 2016
Processes, Products, and Applications, 2015
Chemistry, Functionality, Interactions, and Commercialization, 2012
Applications in Human Health, 2011
Scale-Up, Processing and Automation, 2011
Biotechnology and Applied Phycology, 2011
Trends and Prospects, 2011
Biological Activities and Applications, 2013
Advances in Food and Nutrition Research, 2011
Recently, a great deal of interest has been developed in the nutraceutical and pharmaceutical ind... more Recently, a great deal of interest has been developed in the nutraceutical and pharmaceutical industries to isolate natural anticoagulant compounds from marine resources. Among marine resources, marine algae are valuable sources of novel bioactive compounds with anticoagulant effect. Phlorotannins and sulfated polysaccharides such as fucoidans in brown algae, carrageenans in red algae, and ulvans in green algae have been recognized as potential anticoagulant agents. Therefore, marine algae-derived phlorotannins and SPs have great potential for developing as anticoagulant drugs in nutraceutical and pharmaceutical areas. This chapter focuses on the potential anticoagulant agents in marine algae and presents an overview of their anticoagulant effect.
Process Biochemistry, 2013
Recently, the relationship between apoptosis and cancer has been emphasized and the induction of ... more Recently, the relationship between apoptosis and cancer has been emphasized and the induction of apoptosis is recognized as one of the key mechanisms of anti-cancer agents. Marine-derived fungi are valuable sources of structurally diverse bioactive compounds with anticancer activity. In the present study, a marine-derived fungus, Microsporum sp. was cultured and a prenylated indole alkaloid, neoechinulin A was isolated from the culture broth extract. Neoechinulin A has shown cytotoxic effect on human cervical carcinoma HeLa cells and its apoptosis induction in HeLa cells was investigated by the expressions of p53, p21, Bax, Bcl-2, Caspase 9, and Caspase 3 proteins. Western blot analysis has revealed that neoechinulin A could induce cell apoptosis through down-regulating of Bcl-2 expression, up-regulating of Bax expression, and activating the caspase-3 pathway. Collectively, these results suggest that neoechinulin A could be a potential candidate in the field of anticancer drug discovery against human cervical cancer.
Process Biochemistry, 2011
The importance of food bioactive compounds as functional ingredients has been well recognized due... more The importance of food bioactive compounds as functional ingredients has been well recognized due the effectiveness in promoting health and lead to the reduction of disease risk. Especially, nutraceuticals from seaweeds have been served as a rich source of health-promoting components. Among them, marine brown algae are a rich source of natural bioactive compounds, mainly phlorotannins and this fact implies its potential as a functional ingredient in the food products, pharmaceuticals, and cosmeceuticals. This review presents an overview of phlorotannins from marine brown algae with their health beneficial biological activities.
Microbiological Research, 2014
Please cite this article in press as: Wijesekara I, et al. Physcion from marine-derived fungus Mi... more Please cite this article in press as: Wijesekara I, et al. Physcion from marine-derived fungus Microsporum sp. induces apoptosis in human cervical carcinoma HeLa cells. Microbiol Res (2013), http://dx.
LWT - Food Science and Technology, 2016
Processes, Products, and Applications, 2015
Chemistry, Functionality, Interactions, and Commercialization, 2012
Applications in Human Health, 2011
Scale-Up, Processing and Automation, 2011
Biotechnology and Applied Phycology, 2011
Trends and Prospects, 2011
Biological Activities and Applications, 2013
Advances in Food and Nutrition Research, 2011
Recently, a great deal of interest has been developed in the nutraceutical and pharmaceutical ind... more Recently, a great deal of interest has been developed in the nutraceutical and pharmaceutical industries to isolate natural anticoagulant compounds from marine resources. Among marine resources, marine algae are valuable sources of novel bioactive compounds with anticoagulant effect. Phlorotannins and sulfated polysaccharides such as fucoidans in brown algae, carrageenans in red algae, and ulvans in green algae have been recognized as potential anticoagulant agents. Therefore, marine algae-derived phlorotannins and SPs have great potential for developing as anticoagulant drugs in nutraceutical and pharmaceutical areas. This chapter focuses on the potential anticoagulant agents in marine algae and presents an overview of their anticoagulant effect.
Process Biochemistry, 2013
Recently, the relationship between apoptosis and cancer has been emphasized and the induction of ... more Recently, the relationship between apoptosis and cancer has been emphasized and the induction of apoptosis is recognized as one of the key mechanisms of anti-cancer agents. Marine-derived fungi are valuable sources of structurally diverse bioactive compounds with anticancer activity. In the present study, a marine-derived fungus, Microsporum sp. was cultured and a prenylated indole alkaloid, neoechinulin A was isolated from the culture broth extract. Neoechinulin A has shown cytotoxic effect on human cervical carcinoma HeLa cells and its apoptosis induction in HeLa cells was investigated by the expressions of p53, p21, Bax, Bcl-2, Caspase 9, and Caspase 3 proteins. Western blot analysis has revealed that neoechinulin A could induce cell apoptosis through down-regulating of Bcl-2 expression, up-regulating of Bax expression, and activating the caspase-3 pathway. Collectively, these results suggest that neoechinulin A could be a potential candidate in the field of anticancer drug discovery against human cervical cancer.
Process Biochemistry, 2011
The importance of food bioactive compounds as functional ingredients has been well recognized due... more The importance of food bioactive compounds as functional ingredients has been well recognized due the effectiveness in promoting health and lead to the reduction of disease risk. Especially, nutraceuticals from seaweeds have been served as a rich source of health-promoting components. Among them, marine brown algae are a rich source of natural bioactive compounds, mainly phlorotannins and this fact implies its potential as a functional ingredient in the food products, pharmaceuticals, and cosmeceuticals. This review presents an overview of phlorotannins from marine brown algae with their health beneficial biological activities.
Microbiological Research, 2014
Please cite this article in press as: Wijesekara I, et al. Physcion from marine-derived fungus Mi... more Please cite this article in press as: Wijesekara I, et al. Physcion from marine-derived fungus Microsporum sp. induces apoptosis in human cervical carcinoma HeLa cells. Microbiol Res (2013), http://dx.