Prognostic significance of Ki 67 labelling index and P63 immunoreactivity in intra cranial and intra spinal meningiomas (original) (raw)

Annals of Pathology and Laboratory Medicine, 2016

Abstract

Background: Meningiomas are indolent tumors and their grading is based on histopathological parameters which have inherent limitations. Adjunct immunohistochemical markers are often used to overcome these limitations. Objective: To investigate the role of Ki67 and P63 immunoexpression in various grades of meningiomas. Methods: A retrospective analysis of 144 biopsies of intracranial and spinal meningothelial and nonmeningothelial tumors operated from January 2011 to May 2016 was carried out. Intraoperative squash smears were stained by 1% aqueous toluidine blue and rapid H&E method. Ki67 and p63 immunohistochemical staining was performed on paraffin sections of 125 histologically proven meningiomas cases. Grading was done according to the modified 2016 World Health Organization classification of CNS neoplasms .The results were analysed using statistical methods. Results: The total number of biopsy samples received was from144 cases. There was a female preponderance accounting for 68...

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