Case report: A rare presentation of high risk epithelioid hemangioendothelioma on leg treated with surgical excision (original) (raw)

Cutaneous Epitheloid Hemangioendothelioma: A Rare Tumor

International Journal of Advanced Research, 2020

Epithelioid hemangioendothelioma is a rare, slowly unfavorable vascular tumor. It is considered to be a malignant tumor. Localization in the skin is very rare and often part of a multi-systemic disorder. It has the potential for local recurrence, lymph node metastasis and at a distance and it's not frequently accompanied by death. We report the observation of a 57-years-old patient, who is presented with an epithelioid hemangioendothelioma of the left buttock with a 1-year follow-up without recurrence.

Epithelioid hemangioendothelioma of the forearm with radius involvement. Case report

Diagnostic Pathology, 2011

Epithelioid hemangioendothelioma (EHE) is a rare, well-differentiated endothelial tumor with intermediate malignancy which develops more frequently from the peripheral veins, generally in the lower limb. Bone EHE comprises less than 1% of the bone neoplasms. We present the case of a young man, 24-year-old, with EHE of the forearm with secondary involvement of the distal radius. The location and the extension of the tumor allowed a wide excision, without the reconstruction of radius, followed by adjuvant radiotherapy, with a subsequent favorable evolution. Based on the clinical, radiographic, and pathological features of the EHE review, we concluded that it is difficult to adopt a standardized therapeutic approach due to the extremely low incidence of the bone involvement in EHE and the variable tendencies towards malignancy of this tumor. To our knowledge this is the third case of EHE with the involvement of the radius.

Multifocal epithelioid hemangioendothelioma of the foot and ankle: a case report

Journal of Orthopaedic Surgery, 2014

We report on a 41-year-old man with multiple epithelioid hemangioendothelioma of the left foot and ankle. The patient was treated with curettage and fixation with 2 separate plates, but later developed local infection. Owing to the potential for malignancy, below-knee amputation was suggested, but the patient declined and was treated symptomatically with close monitoring. The patient underwent removal of the plates, excision of the distal fourth of the fibula, intralesional curettage of all lesions, and fusion of the ankle and subtalar joints with a retrograde intramedullary nail. After 5.5 years, the patient had recovered well and had no evidence of malignancy. The tumour was considered definitively benign.

A Rare Case of Hemangioendothelioma of Upper Thigh

Cureus

Baliga et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Epithelioid Hemangioendothelioma of Tibia and Talus: A Case Report

Oman medical journal, 2015

Epithelioid hemangioendothelioma (EHE) of the bone is extremely uncommon and consists of less than 1% of primary bone tumors. It is characterized by epithelioid endothelial cells and has variable biological behavior. EHE is more likely to occur between 20 and 30 years of age. Approximately half of EHE present with multifocal disease. Since the behavior of these tumors is intermediate, it is important to not misdiagnose EHE as an angiosarcoma. Here we describe the case of a 43-year-old male who presented with pain and swelling of the leg and ankle to Dr. Ram Manohar Lohia Hospital, India. Radiography and computed tomography of the ankle and leg were performed and suggested an expansile lytic lesion involving the distal tibia and talus bone. The lesion was excised and ankle arthrodesis performed. Histological evaluation of the lesion demonstrated the presence of EHE of the tibia and talus.

An unusual case of aggressive malignant spread of epithelioid hemangioendothelioma

Rare Tumors, 2021

Epithelioid hemangioendothelioma (EHE) is a rare vascular neoplasm which typically originates from liver, lung, or bone. Due to the low incidence of disease, the most effective treatment is not easily studied and much of the information known about EHE has been learned through case reports and case series. In this case, we will present an uncommon form of primary soft tissue EHE with local recurrence, bone metastasis, and lymphangitic spread to the lungs leading to respiratory failure. Imaging of the chest was atypical for EHE with intraseptal thickening and hilar lymphadenopathy. Respiratory failure was progressive despite aggressive multimodal treatment. This case highlights an unusually aggressive recurrence and metastasis of primary soft tissue EHE with atypical pulmonary imaging findings.

Epithelioid hemangioendothelioma of the femur

European Radiology Supplements, 2004

A 27-year-old man presented at the orthopedic department with a 3-year history of severe limitation on his locomotor capacity and persistent pain at the anteromedial side of the right thigh. These symptoms had been diagnosed and treated as a psychosomatic disorder because of his known mental illness.

Metastatic Epithelioid Hemangioendothelioma of the Bone: A Case Report and Literature Review

Curēus, 2024

Epithelioid hemangioendothelioma (EHE) is an extremely rare vascular tumor, which can pose a diagnostic dilemma. It affects women more than men and is mainly found in the liver, lung, and bone. To date, there are no known predisposing factors. Limited data are available on the management of EHE at metastatic stages. The only optimal treatments to prevent metastatic dissemination are surgical resection and amputation in addition to radiotherapy at early stages. The oncologist in this rare entity plays an important role in the guided and standardized management of this disease, especially for advanced stages. In this article, we report the case of a 74-year-old patient admitted with swelling on the outer aspect of the right calf associated with pain and total functional impairment of the limb. The diagnosis favored a high-risk vascular tumor resembling EHE, confirmed by bone (tibia) and soft tissue biopsy. The patient underwent staging investigations, revealing diffuse metastases to the liver, bones, and lungs. The objective of this article is to advocate for oncological intervention in this entity, particularly in the advanced stages of the disease. Despite its rarity, the advancement of clinical trials and therapeutic recommendations remains crucial for optimal treatment.

Common Presentation with Uncommon Diagnosis: Multifocal Epithelioid Hemangioendothelioma

Oman Medical Journal, 2015

pithelioid hemangioendothelioma (EHE) is a rare vascular tumor with an estimated prevalence of less than one in one million. It has an intermediate malignant potential and clinically behaves in an intermediate way between a benign hemangioma and a highly malignant angiosarcoma. It usually involves the liver, bone, lungs, skin, and other soft tissue. 1,2 Single organ involvement is more common than multi-organ involvement (64%). 2 Together the liver and lung (51%) were the most commonly involved organs in those who presented with multi-organ disease, as reported in a series of 264 patients of EHE. 2 The distribution of EHE involving soft tissue as described in a series of 49 cases are extremities (n=32), head and neck (n=6), mediastinum and trunk (n=4, each), genitals (n=2), and the retroperitoneum (n=1).