Thalamic stimulation for tremorSubtle changes in episodic memory are related to stimulation per se and not to a microthalamotomy effect (original) (raw)

2003, Journal of Neurology

AI-generated Abstract

The aim of this study was to investigate the impact of unilateral deep brain stimulation (DBS) of the ventrointermediate (Vim) thalamic nucleus on neuropsychological functioning comparing stimulation-on with stimulation-off conditions. Nine patients with Parkinson's Disease (PD), essential tremor (ET), and multiple sclerosis (MS) underwent comprehensive neuropsychological testing for cognitive functions at least 6 months postoperatively. Results indicated improvement in tremor, but no significant differences in cognitive performance between the stimulation conditions, except for a decrease in word-recall in the stimulation-on condition related to left-sided stimulation. The findings confirm that chronic unilateral DBS is safe regarding cognitive functions, and changes in episodic memory are due to stimulation rather than a microthalamotomy effect.

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