Effect of Actinomycin D on the Expression of Nuclear Antigen SS-B/La (original) (raw)

The study investigates the impact of actinomycin D on the expression of nuclear autoantigen SS-B/La. Findings indicate that low concentrations of actinomycin D can significantly reduce the presence of SS-B/La in the nucleolus and the synthesis of associated RNAs, suggesting that actinomycin D inhibits the transcription of messenger RNA required for SS-B/La expression. The implications of these findings are relevant for understanding the mechanisms underlying autoimmune diseases where SS-B/La plays a critical role.