Buschke-Lowenstein Tumor (original) (raw)
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Giant Condyloma Acuminatum (GCA; Buschke-Löwenstein Tumor): A New Case and Review
Giant Condyloma Acuminatum (GCA; Buschke-Löwenstein Tumor) is a rare sexually transmitted human-papillomavirus (HPV)-induced, large, exophytic, and cauliflower-like lesion of the anogenital region with a potentially fatal course. We report a case on a 57-year-old male with a 9-year history of a large slow-growing right inguinal/abdominal wall giant condyloma acuminatum.
Perianal Giant Condyloma Acuminatum—Buschke-Löwenstein Tumor: A Case Report
Case Reports in Surgery, 2012
Condyloma acuminatum caused by Human Papillomavirus is the most commonly occurring sexually transmitted infection in the anogenital region. Buschke-Löwenstein tumor (BLT) known also as giant condyloma acuminatum is a rare disease. The disease, for which the most important treatment method is the surgical excision, differs from normal condyloma acuminatum cases with its high degree of malignancy. The purpose of this paper is to present the case that reached huge dimensions in the perianal region and that was treated with wide resection in the literature.
Buschke–Löwenstein Tumor mimics Carcinoma Vulva
Journal of SAFOMS
Giant condylomata are uncommon in developed countries; however, they are prevalent in developing nations. Condylomata acuminata are maximally transmitted by sexual contact. Giant condyloma acuminata, also called Buschke-Löwenstein tumor, is known to be a slow-growing cauliflower-like tumor, which is locally aggressive, with possible malignant transformation. Common management is conservative on medical lines. However, in extreme cases, surgical excision is required. A case of a 68-yearold nulliparous lady with giant condyloma acuminata is reviewed. She presented with a 3-year history of slowly progressive lesion on the vulva, with associated itching and another complaint of difficulty in walking. The growth measured 6 × 5 cm on left labia and was successfully excised with no evidence of malignancy. Concomitant reconstruction was also done.
Acta Medica Bulgarica
Buschke-Löwenstein tumours are a relatively rare clinicopathological entity. However, due to their malignant potential and frequent association with some types of Human Papillomaviruses (HPV), their diagnosis should be promptly confirmed and appropriate management should be planned (according to the condition). In this article we present a middle-aged patient with long-standing tumoural lesions located in the anogenital area, which were confirmed clinically and histopathologically as well-differentiated squamous cell carcinomas of Buschke-Löwenstein type, in combination with disseminated anogenital condylomata acuminata. Histologically, large tumour nests of well-differentiated squamous cell carcinoma were observed, as well as a marked mononuclear cell infiltrate and conspicuous koilocytosis. Immunohistochemistry for Ki-67 revealed a relatively high proliferative index, and was strongly positive for HPV with a pan-HPV antibody (AK), confirming the presence of the virus in the tiss...
Giant Cumulated Condyloma (Tumor of Buschke Lõwenstein) Presentation of a Case
Biomedical Journal of Scientific & Technical Research, 2019
The condylomataacuminataor genital warts are produced by the human papiloma virus. Infection typically occurs when host basal cells are exposed to viral infection through a damaged epitelial barrier, such as during sexual inter course or as a product of other minor skin abrasions. In few occasions they can evolve with a marked growth and cause the well-known Buschke-Löwenste in síndrome or Giant Condiloma Acuminado. We present a patient with Giant Condyloma Accumulated in the inguinal and anal regions that was surgically treated with exeresis of the inguinal lesions and electro fulguration of the annals with satisfactory evolution, without tumor recurrence at three months.
Giant Perineal Condyloma Acuminatum (Buschke-Lowenstein Tumour): A Case Report
Chirurgia, 2016
Condilom acuminat gigant perineal (Tumora Buschke-Löwenstein): prezentare de caz Condilomul acuminat gigant, cunoscut aei sub numele de tumora Buschke-Löwenstein (BLT), reprezintã o afecåiune cu transmitere sexualã rar întâlnitã. În acelaaei timp, condilomul acuminat produs de infecåia cu HPV (Human Papilloma Virus) devine una dintre cele mai comune infecåii transmise pe cale sexualã ce afecteazã regiunea perinealã. În aceste situaåii, opåiunea terapeuticã de prima intenåie este excizia chirurgicalã. Obiectivul acestui articol este de a prezenta un caz în care tumora a atins dimensiuni gigante, ce afecteazã calitatea vieåii aei de a accentua importanåa unei intervenåii chirurgicale largi, având în vedere rata ridicatã de recurenåã aei potenåialul semnificativ de transformare malignã a BLT.
Perianal giant condyloma acuminatum (Buschke-Lowenstein tumor): report of 3 cases
tion at the level of the penis, the most frequent area of the onset of disease,3 while only rarely does it involve the anorectal and perianal regions. In fact, from a review of English medicalliterature from 1958 to 2000 only 51 cases were reported with anorectal and perianallocalization. Case I.-T.W., a 57-year-old heterosexual white male, with a history of neoformations in the anal and perianal site that caused itchiness, burning, mucohematic oozing and sporadic pain with defecation. Over the last 6 months these lesions had grown in size and were associated with an accentuation of the subjective symp-tomatology (Figure l). The labtests were alI norma!. In particular, the HIV test and the screening tests for other sexually transmitted diseases were negative. Apre-operative pancolonscopy was carri ed out which was also norma!. Extensive surgery of anal and perianal masses was performed in two steps; the histological examination of which revealed the presence of a verrucous type squa...
Giant Condyloma (Buschke-Loewenstein Tumor) in a 16-year-old Patient: Case Report
Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics, 2016
The Buschke-Loewenstein tumor is characterized by excessive growth of verrucous lesions on the genitals and/or perianal region. It is considered benign despite the high rate of recurrence and the possibility of malignant transformation. It is commonly associated with subtypes 6 and 11 of the human papillomavirus (HPV), and host's immunity plays an important role in the development of the disease. Surgical excision is the recommended treatment in most cases. We present the case of a 16 years old female patient with extensive vulvar lesions successfully treated surgically.
The Pathogenesis of Giant Condyloma Acuminatum (Buschke-Lowenstein Tumor): An Overview
International Journal of Molecular Sciences
Giant condyloma acuminatum, also known as Buschke-Lowenstein tumor (BLT), is a rare disease of the anogenital region. BLT is considered a locally aggressive tumor of benign histological appearance, but with the potential for destructive growth and high recurrence rates. BLT development is strongly associated with infection with low-risk human papillomaviruses (HPVs), mostly HPV-6 and -11. Immunity to HPVs plays a crucial role in the natural control of various HPV-induced lesions. Large condyloma acuminata are frequently reported in patients with primary (e.g., DOCK8 or SPINK5 deficiencies) and secondary (e.g., AIDS, solid organ transplantation) immune defects. Individuals with extensive anogenital warts, including BLT in particular, should therefore be tested for inherited or acquired immunodeficiency. Research into the genetic basis of unexplained cases is warranted. An understanding of the etiology of BLT would lead to improvements in its management. This review focuses on the rol...