Association of alpha1a-adrenergic receptor polymorphism and blood pressure phenotypes in the Brazilian population (original) (raw)

2008, BMC Cardiovascular Disorders

Background The alpha1A-adrenergic receptor (α1A-AR) regulates the cardiac and peripheral vascular system through sympathetic activation. Due to its important role in the regulation of vascular tone and blood pressure, we aimed to investigate the association between the Arg347Cys polymorphism in the α1A-AR gene and blood pressure phenotypes, in a large sample of Brazilians from an urban population. Methods A total of 1568 individuals were randomly selected from the general population of the Vitória City metropolitan area. Genetic analysis of the Arg347Cys polymorphism was conducted by polymerase chain reaction/restriction fragment length polymorphism. We have compared cardiovascular risk variables and genotypes using ANOVA, and Chi-square test for univariate comparisons and logistic regression for multivariate comparisons. Results Association analysis indicated a significant difference between genotype groups with respect to diastolic blood pressure (p = 0.04), but not systolic blood...

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