original ) (raw )Crystal structure of human ornithine aminotransferase complexed with the highly specific and potent inhibitor 5-fluoromethylornithine1
Paola Storici
Journal of Molecular Biology, 1999
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Mechanism of inactivation of γ-aminobutyric acid aminotransferase by ()-4-amino-5-fluoropent-2-enoic acid
dejan nikolic
Biochemical and Biophysical Research Communications, 1988
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Yoav Smith
ACS Medicinal Chemistry Letters, 2015
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Richard Van Breemen
Journal of the American Chemical Society, 1999
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Inhibition of Ornithine Aminotransferase by 5-Fluoromethylornithine: Protection Against Acute Thioacetamide Intoxication by Elevated Tissue Ornithine Levels
Shakir S K S Sarhan
Pharmacology & Toxicology, 1992
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Theodore Alston
Biochemical Pharmacology, 1982
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jacob mathew
Biochemistry, 1988
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Caroline Peneff
Journal of Biological Chemistry, 2005
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Maurizio Simmaco
Biochemistry, 1991
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David Kopečný
Plant Signaling & Behavior, 2008
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Crystal structure of human recombinant ornithine aminotransferase
Michael Hennig
Journal of Molecular Biology, 1998
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Metabolism and action of amino acid analog anti-cancer agents
Gurpreet Ahluwalia
Pharmacology & therapeutics, 1990
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Substrate specificity and protonation state of ornithine transcarbamoylase as determined by pH studies
william herzberg
Biochemistry, 1985
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Role of histidine 225 in adenosylcobalamin-dependent ornithine 4,5-aminomutase
Francois Miros
Bioorganic Chemistry, 2012
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Inhibition of plant ornithine aminotransferase by gabaculine and 4-amino-5-hexynoic acid
Frédérik Le Dily
Phytochemistry, 1993
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Overexpression of ornithine aminotransferase: consequences on amino acid homeostasis
Jean-pascal Bandt
British Journal of Nutrition, 2008
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Inhibition of human ornithine decarboxylase activity by enantiomers of difluoromethylornithine
Corey Levenson
Biochemical Journal, 2003
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Ornithine Aminotransferase, an Important Glutamate-Metabolizing Enzyme at the Crossroads of Multiple Metabolic Pathways
Ioannis Nicolis
Biology
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Use of fluorinated functionality in enzyme inhibitor development: Mechanistic and analytical advantages
kannan r
Journal of Fluorine Chemistry, 2008
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Effect of mutations at active site residues on the activity of ornithine decarboxylase and its inhibition by active site-directed irreversible inhibitors
Catherine Coleman , Bruce Stanley
Journal of Biological Chemistry, 1993
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In silico analysis of the inhibitory activities of GABA derivatives on 4-aminobutyrate transaminase
Sidra Batool
Arabian Journal of Chemistry, 2013
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Inactivation of pyridoxal 5'-phosphate-dependent enzymes by 5-nitro-L-norvaline, an analog of L-glutamate
Harold Bright , Theodore Alston
FEBS Letters, 1981
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Role of Guanidinium-Carboxylate Interaction in Enzyme Inhibition with Implication for Drug Design
Antarip Halder
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Effects of inhibition of ornithine aminotransferase or of general aminotransferases on urea and citrulline synthesis and on the levels of acetylglutamate in isolated rat hepatocytes
Fernando Aniento
Molecular and Cellular Biochemistry, 1988
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Fluorinated Aromatic Amino Acids and its Therapeutic Applications
Kiran Andra
Biochemistry & Analytical Biochemistry, 2015
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Design and Mechanism of Tetrahydrothiophene-based GABA Aminotransferase Inactivators
Hoàng Phúc Nguyễn Lê
Journal of the American Chemical Society, 2015
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Inactivation of λ-cystathionase by λ-fluorinated amino acids
Harold Bright , Theodore Alston
FEBS Letters, 1981
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A Modified Spectrophotometric and Methodical Approach to Find Novel Inhibitors of Ornithine Decarboxylase Enzyme: A Path through the Maze
Suaib Luqman
Protocol Exchange, 2013
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Fluoride-Mediated Capture of a Noncovalent Bound State of a Reversible Covalent Enzyme Inhibitor: X-ray Crystallographic Analysis of an Exceptionally Potent α-Ketoheterocycle Inhibitor of Fatty Acid Amide Hydrolase
Mauro Mileni
Journal of the American Chemical Society, 2011
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Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors
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