Histopathological pattern of adult renal tumours in a tertiary cancer center (original) (raw)
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JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
Introduction: A lot of research is available about clear cell Renal Carcinomas (ccRCC). But there are lesser known facts about other subtypes of renal malignancies. With advances in immunohistochemical and cytogenetic techniques, new variants of renal tumours are being increasingly reported. The treatment and prognosis of such rare malignancies is still an enigma. Aim: To analyse the incidence, clinicopathological features, surgical treatment, and survival of non clear cell RCC at the tertiary care centre. Materials and Methods: The present study was a retrospective study in which histopathological reports of 77 nephrectomy specimens who underwent surgical treatment for suspected renal tumours from 2013-2018 were reviewed. Of which 19 (24%) patients had documented uncommon histologic variants of RCC. The clinical, demographic, and histologic characteristics of these patients were analysed, and survival was evaluated. The characteristic light microscopy and immunohistochemical featur...
Epidemiological and Histopathological Study of Renal Cell Carcinoma: A Retrospective Study
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
Introduction: The incidence of Renal Cell Carcinomas (RCCs) has increased steadily and they have become the seventh most common histological type of cancer across the globe. Aim: To assess the profile of the patients of RCC with respect to age distribution, sex distribution, clinical presentation, site of tumour, risk factors, staging, histopathological examination, and operative complications. Materials and Methods: A retrospective descriptive study was conducted in Department of Urology, Indira Gandhi Institute of Sciences, Patna, Bihar, India, from January 2019 to June 2020, that included patients with RCC. The pathology specimens and reports of patients with RCC who underwent laparoscopic, open, cytoreductive, and partial nephrectomy were reviewed. Data related to demographic characteristics, site of tumour, risk factors, co-morbidities, clinical features, histopathology, tumour grade and stage, type of surgery, intra-and postoperative complications, and Fuhrman nuclear grading ...
Histopathological spectrum of renal tumors in nephrectomy specimens
IP innovative publication pvt. ltd, 2019
Introduction: Kidneys are the vital organs of the body which are having multiple functions. The benign or malignant diseases of the kidney result in total organ removal. Renal tumors comprises a wide spectrum of neoplastic lesions with patterns that are distinct for children and adults. In India management of chronic kidney diseases is a great challenge as the dialysis and kidney transplantations are expensive. Objectives: To study histopathological features of various renal tumors in nephrectomy specimens and to determine the age and sex distribution in various renal tumors Materials and Methods: The study was done in Mysore medical college and research institute. Total 14 nephrectomy cases were studied in a period of 2 years from 2015 to 2017. Results: Total 14 renal tumors were studied. In which RCC is the most common -10 cases, followed by SCC and Angiomyolipoma, 2 cases each. Most of the patients presented in age group of 4th to 5th decade with male to female ratio of 1.16:1. Histologically RCC-clear cell type was the most common subtype Conclusion: RCC is the most common renal tumors in which clear cell type is most common subtype.
Changing the Stage, Grade and Histological Subtypes of Renal Cell Carcinomas during 10 Years Period
Prague medical report
Renal cell carcinomas (RCCs) account 80-85% of all primary renal neoplasms and originate from the renal cortex. The patients who underwent radical or partial nephrectomy for renal tumour in our unit between January 2005 and 2015 were evaluated retrospectively. The patients were divided into two groups; group 1 includes patients who were treated between January 2005 and December 2009, group 2 those from January 2010 to 2015. There were 103 patients in group 1. The patients were between 21 and 89 years with mean age of 61.46 year. Renal cell carcinomas account 83.4% of the patients, benign renal tumours were 8.7% and transitional cell carcinomas were 7.7% of the patients in group 1. A total of 32.5% RCCs were classified as pT1a, 24.4% as pT1b, 15.1% as pT2a, 11.6% as pT2b, 15.1% as pT3a and 1.1% as pT4. There were 202 patients in group 2 and the patients were between 27 and 81 years with mean age of 58.5 year. Renal cell carcinomas comprised the main bulk of the tumours with 182 nephr...
Pattern of Renal Cell Carcinoma – A Single Center Experience in Nepal
Kathmandu University Medical Journal, 2012
Background Renal tumor is the 13th most common malignancy in the world and more than 90% of renal tumors are renal cell carcinomas. As there is no data available on renal cell carcinoma in Nepal, hence this study was undertaken to analyze the patterns of renal cell carcinoma in patients with renal mass at a tertiary level hospital in Nepal. Objectives To analyze the patterns of renal cell carcinoma in patients with renal mass at a tertiary level hospital in Nepal. Methods The case records of 50 consecutive patients with renal cell carcinoma presenting at the Tribhuvan University Teaching Hospital, Kathmandu from July 2006 to June 2011 were retrospectively evaluated for presenting symptoms, physical finding, investigation and histopathology report. Results Out of 50 patients, 64% were male and 36% were female. The age ranged between 11 to 78 years (mean ± SD: 55 ± 15 years). Fifty four percent of patients were smokers. Incidentally tumor was detected in 40% cases by ultrasonography a...
Journal of Ayub Medical College, Abbottabad : JAMC
To determine the type of malignant renal tumours subjected to radical nephrectomy at a tertiary care urology unit using the 2004 WHO classification for renal tumours. It was an observational study conducted at Department of Urology, AFIU Rawalpindi, from October 2008 to September 2010. The study included 92 patients with malignant renal tumours of both genders aged above 15 years. The histopathological types and grades were recorded along with the gross tumour presentation. The data was entered in structured proforma and analysed for descriptive statistics using SPSS-14. Over the span of 24 months study, 92 cases of malignant renal tumours were subjected to radical nephrectomy. The age was 16-82 (57.23 +/- 14.61) Years and male to female ratio was 2.1:1. The lesions were mostly unifocal (96.7%) and 58.6% affecting the right side. The commonest malignant renal tumour encountered was the conventional clear cell renal carcinoma (78.2%). The other tumours in descending order were the tr...
Journal of Kidney Cancer and VHL, 2021
Renal cell carcinoma (RCC) accounts for 3% of all adult cancers and 85% of all kidney tumours. Incidence of RCC is lower in Asian region, particularly in India, probably due to lack of reporting. Most of the data about RCC are from Western countries; and data from India are scarce, especially regarding para-neoplastic syndromes. We sought to determine the epidemiology, clinicopathological profile and management of RCCin a tertiary care centre in Western India. This was a retrospective study that involved data analysis of records of RCC patients who presented to our institution from April 2016 to February 2020. Laboratory investigations, including tests for paraneoplastic syndrome (PNS), and relevant radiologic investigations were performed and treatment was offered according to the stage, patient factors and available modalities. A total 142 RCC patients were included in the study. The median age of presentation was 58 years. Most of the patients (67%) were symptomatic, and 33% of t...
International Journal of Cancer Management, 2021
Background: Renal cell carcinoma (RCC) is the most common malignant tumor of the kidney. This tumor originates from the epithelial cells of the renal tubules and is located mainly in the cortical region of the kidney. It constitutes approximately 90% of all kidney malignancies and 2% of all cancers in adults. Objectives: The present study was conducted to determine the prevalence of RCC and its histological subtypes in samples sent to the Pathology Department of Kabul University of Medical Sciences and City Laboratory. Methods: This is a retrospective cohort study of 81 nephrectomy and partial nephrectomy samples registered in the laboratory of the Pathology Department of Kabul University of Medical Sciences and City Medical laboratory database from March 2016 to August 2020. Results: A total of 81 samples were included in this study. The mean and standard deviation (SD) age of the patients was 44.4 ± 20.5. Of 81 samples, 62 (76.6%) were malignant kidney tumors, 13 (16.0%) were infl...
The clinicopathological profile of Renal cell carcinoma at BP Koirala Memorial Cancer Hospital
Nepalese journal of cancer, 2022
Introduction Renal cell carcinoma accounts for 3-5%of all oncological diagnoses. In this study, we aim to assess the clinicopathological profile of Renal cell carcinoma in a cancer hospital of Nepal. Method This is a retrospective study conducted at BP Koirala Memorial Cancer hospital Nepal. All patients with localized and locally advanced RCC who underwent radical or partial nephrectomy at our hospital between Jan 2012 to Dec 2018 were included. Normally distributed continuous variables were expressed as median, mean ± standard deviation (SD). Categorical variables were expressed as frequencies and percentages of an appropriate denominator. Results Among 94 patients with RCC, the median age was 55 years (53.56 ±12.83). Most of the patients were male (56.4%, n=53) and Hindu by religion (67.02%, n=63). Eighty-three percent (n=78) of patients were smokers, 58.5 % (n=55) were hypertensive and 40.4% (n= 38) had history of diabetes mellitus. The most common symptom was incidental renal mass (42.55%, n=40). Ninety-five percent (n=89) of the patients underwent radical nephrectomy and five percent (n=5) of the patients underwent partial nephrectomy. The median duration of postoperative hospital stay was 8 days. The most common histological finding was Clear cell type (86.17, n=81) followed by papillary cell type (10.63%, n= 10) followed by chromophobe type (2.12%, n=2), and duct of Bellini(1.06%, n=1). Most of the patients had pathological T2 (41.48%, n=39) disease followed by T3 (26.59%, n=25) disease. Conclusion: Smoker males in the fifth to sixth decade of life are at risk for developing RCC. Radical Nephrectomy is the standard of care with Clear cell carcinoma as the most common histological subtype.
Study of Staging, Grading and Prognostic Factors of Renal Cell Carcinoma
IOSR Journals , 2019
Introduction: Renal cell carcinoma is by far the most common malignant tumor of the kidney and it accounts for 80-85% of malignant kidney tumors. All Renal cell carcinomas are adenocarcinomas derived from renal tubular epithelial cells. The prognosis of Renal cell carcinoma depends upon age, sex, race, tumor size, histological subtype, nuclear grade, distant metastasis and pathological staging. Material and Methods: The present study is both a retrospective and prospective study conducted at a tertiary care teaching hospital. Histopathological evaluation of Renal cell carcinomas was carried out for four and a half years correlating with old records, histopathology slides, special stains and immunohistochemistry. A total number of 113 nephrectomy specimens were taken into consideration in the present study. H&E stained sections of the Renal cell carcinoma specimens were studied to grade and type the tumor and to evaluate the prognostic factors. Special stains and immunohistochemistry were also used wherever required. Results: A total number of 113 nephrectomy specimens were analysed and 26 diagnosed cases of Renal cell carcinoma were included in the study. Maximum number of cases were seen in 40-49 years age group (30.7%) and also in 60-69 years age group (30.7%). Maximum number of cases diagnosed were of Clear cell Renal cell carcinoma (61.5%). Least common subtype diagnosed was Collecting duct Renal cell carcinoma (3.8%). Tumor size was >4cm in maximum number of cases i.e 20 (76%). Most of the subtypes of Renal cell carcinoma had Fuhrman nuclear grades 2 and 3. Conclusion: In the present study, among the histological subtypes of Renal cell carcinoma, Clear cell variant of Renal cell carcinoma was the most common histological subtype, accounting for 61.5% of cases. Nuclear grading is important in predicting survival of patients with Renal cell carcinoma. Nuclear grading is strongly related to both tumor size and stage. Nuclear grading and staging of the histological subtypes strongly influences the survival of patients, as thus proven in this study.