Floating Drug Delivery System: As A Novel Approach for Drug Delivery (original) (raw)
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Floating Drug Delivery System:- a Review
World Journal of Pharmacy and Pharmaceutical Sciences, 2017
Oral controlled release delivery systems are programmed to deliver the drug in predictable time frame that will increase the efficacy and minimize the adverse effects and increase the bioavailability of drugs. It is most widely utilized route of administration among all the routes that have been explored for systemic delivery of drugs via pharmaceutical products of different dosage form. Recent technological and scientific research has been devoted to the development of rate controlled drug delivery systems to overcome physiological adversities such as short gastric residence times and unpredictable gastric emptying times. Differences in gastric physiology such as gastric pH and motility exhibit both intra and inter subject variability demonstrating significant impact on gastric residence time and drug delivery behavior. This triggered an increased interest towards formulation of novel delivery systems which retained in the stomach for prolonged and predictable period of time. Several approaches such as floating drug delivery systems (FDDS), swelling and expanding systems, bioadhesive systems, modified shape systems, high density systems or other delayed gastric emptying devices have been discovered till now. FDDS are of particular interest for drugs that are locally active and have narrow absorption window in stomach or upper small intestine, unstable in the intestinal or colonic environment, and exhibit low solubility at high pH values. This review article is in pursuit of giving detailed information on the pharmaceutical basis of their design, classification, advantages, in vitro and in vivo evaluation parameters, and the future potential of FDDS.
2021
Current pharmaceutical situation focuses on the preparation of gastro-retentive floating drug delivery system (GRFDDS). This systems has gained noteworthy interest in the past decades. These are the low density systems that float over the gastric contents and remain buoyant in the stomach for a prolonged period of time without affecting the gastric emptying rate. GRFDDS is used to delay the residence time of delivery in stomach. The controlled gastric retention of solid dosage forms may be achieved by the mechanism of mucoadhesion, floatation, sedimentation, expansion, modified shape systems or by the administration of pharmacological agents that delaying gastric emptying. This results in targeting of release of drug at a specific site for the systemic or local effects. GRDDS is used to overcome challenges associated with conventional oral dosage forms and to release the drug at a specific absorption site to improve bioavailability of particular drug substance. Some floating drug de...
NEW INSIGHTS INTO GASTRO-RETENTIVE FLOATING DRUG DELIVERY SYSTEMS
In recent year, considerable attention has been focused on the formulation and development of new drug for orally targeted drug delivery systems. The oral route is most popular route of drug administration. Conventional dosage forms are unable to control either the rate or site of action. When a drug is delivered as a conventional dosage form they show very short gastric retention time. As such the drug which act locally in the stomach or get degraded by the colonic bacteria or/ and alkaline pH of the small intestine cannot be formulate as conventional dosage form. In conventional dosage forms, fluctuating drug level may lead to some side effect and dosing interval is short, this leads to poor patient compliance. At present a number of approaches are utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), swelling and expanding system, mucoadhesive system, high density system, modified system and other delayed gastric emptying systems.
A Review on the Floating Drug Delivery System -Its Evaluations and Recent Works Done in 4-5 Years
International Journal of Pharmaceutical Sciences Review and Research, 2024
Since floating drug delivery systems may solve the disadvantages associated with traditional drug delivery systems, such as frequent dosing, limited bioavailability, etc., in comparison to quick stomach emptying time, they have attracted a lot of attention in recent decades. A system that stays in the stomach for an adequate amount of time and delivers the active medication continuously is known as an ideal floating drug delivery system. These continue to float over the stomach contents. prolonging the pharmacological effects and enhancing the drug's bioavailability. This overview of gastroretentive and floating tablets was written to gather recent research on the topic, as well as information on the floating tablets' principles, benefits, categorization, preparation, and assessment methods, and a list of medications that have been developed as floating tablets. formulation evaluation and future scope of floating tablets. The review concentrated on the types of floating medication delivery systems and the formulation aspect of effervescent floating drug delivery systems. The review's objective is to gather the research being done on this floating medicine delivery device. The review addresses several aspects that impact stomach retention (long duration) and offers useful information about the pharmaceutical formulation side of it.
Floating Drug Delivery System: An Overview
sphinxsai.com
Floating drug delivery systems (FDDS) was to organize the recently focus on the principalmechanism of floatation to achieve gastric retention time. The recent developments of FDDS including thephysiological and formulation variables affecting gastric retention, approaches to design floating systems, and their classification and formulation aspects are covered in detail. Gastric emptying ofdosage forms is an extremely variable process and ability to prolong and control the gastric emptying time is a valuable asset for dosage forms, which reside in the stomach for a longer period of time than conventional dosage forms. Gastroretentive systems can remain in the gastric region for several hours for significantly prolong residence time of drugs by which improves bioavailability, reduces drug waste, and improves solubility for drugs that are less soluble in a high pH environment.. The present review addresses briefly about the floating drug delivery systems.
A Review on Gastroretentive Floating Drug Delivery System
One of the most feasible approaches for achieving prolonged and predictable drug delivery profiles in gastrointestinal tract is to control the Gastric Residence Time (GRT) using gastro retentive dosage forms (GRDFs) that offer a new and better option for drug therapy. Oral delivery of drugs is by far the most preferable route of drug delivery. Oral-rate controlled drug delivery systems have an important area among novel drug delivery system. But these oral sustained release drug delivery systems suffer greatly due to their short gastric residence time/ gastric emptying time. Whereas prolonged gastric residence increases duration of drug release, reduces drug waste, and improves drug solubility in gastric pH. In order to overcome these drawbacks novel dosage forms that can be retained in the stomach for a prolonged and predictable period of time were discovered and they successfully exists today as gastro retentive dosage forms, in academic and industrial research groups. The objective of our review is to compile the recent advancements and literatures regarding the novel dosage form i.e. the floating drug delivery systems (FDDS) that can be retained in the stomach for a prolonged period of time and gives therapeutic action in a predetermined manner. Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), swelling and expanding systems, polymeric bioadhesive systems, high-density systems, modified-shape systems and other delayed gastric emptying devices. In this review, current & recent developments of Stomach Specific FDDS are discussed. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail.
A REVIEW: FLOATING DRUG DELIVERY SYSTEM AS A TOOL TO IMPROVE DISSOLUTION RATE IN GASTRIC
International Journal of Applied Pharmaceutics, 2020
Floating drugs are an effective way to lift the absorption of the drug in the stomach. Drugs made drugs last longer in the stomach so that the solubility process will occur effectively in the stomach. This review-journal was created by extracting indexed journals with the floating drug as journal keywords of 40 journals. This assessment of a floating drug for a new drug delivery system (NDDS) is established to elucidate the floating drugs delivery system (FDDS) based on existing literature. The most recent progress of FDDS includes the formulation and physiological variables that could affect gastric retention and formulation are dealt with in detail. This review also summarizes some approaches to prepare a floating system, evaluation methods and characterization for FDDS pharmaceutical dosage form and also its classification.
Floating drug delivery systems: A better approach
International Current Pharmaceutical Journal, 2012
The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. It is known that differences in gastric physiology (such as, gastric pH, motility) exhibit both intra- as well as inter-subject variability demonstrating significant impact on gastric retention time and drug delivery behaviour. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail. This review also summarizes the studies to evaluate the performance and application of floating systems, and applications of these systems.DOI: http://dx.doi.org/10.3329/icpj.v1i5.10283International Current Pharmaceutical Journal 2012, 1(5): 110-118
Floating drug delivery systems: A review
Aaps Pharmscitech, 2005
The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail. This review also summarizes the in vitro techniques, in vivo studies to evaluate the performance and application of floating systems, and applications of these systems. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques, 2015
Gastric retentive drug delivery provides a promising technology exhibiting an extended gastric residence and a drug release independent of patient related variables. It is usually useful in improving local gastric treatment as well as overcoming drug-related problems .i.e. drugs having narrow absorption window, short half-life or low intestinal solubility. Buoyancy is considered one of the most promising approaches for gastro-retention of dosage forms. Floating drug delivery systems have a bulk density lower than gastric fluids and thus remain buoyant in the stomach causing an increase in gastric residence time. The buoyancy of these systems is attained by the aid of substances responsible to generate the low density. Various agents with different mechanisms were adopted either gas-generating agents, air entrapping swellable polymers, inherent low density substances, porous excipients, hollow/porous particles inducing preparation techniques or sublimating agents. Therefore, this rev...