Amphetamine Microinfusion in the Dorso-Ventral Axis of the Prefrontal Cortex Differentially Modulates Dopamine Neurotransmission in the Shell-Core Subterritories of the Nucleus Accumbens (original) (raw)

This research investigates how amphetamine (AMPHE) microinfusion affects dopamine (DA) neurotransmission in distinct subterritories (shell and core) of the nucleus accumbens, influenced by projections from the prefrontal cortex (PFC). A dual-probe microdialysis method was utilized on male Wistar rats, revealing that AMPHE microinfusion into the ventral PFC induces a dose-dependent decrease in dialysate DA levels, a contrast to the dorsal PFC which shows no significant changes. Findings highlight the differential modulation of DA dynamics in the NAC's subregions, significantly affected by the PFC's influence and basal DA levels.