Study of dynamical behavior of magnetic nanoparticles suspension in biological fluids (original) (raw)

2020, Colloid and Interface Science Communications

The dynamical response of oleic acid (OA), oleic acid/2, 3-dimercaptosuccinic acid (OA/DMSA) and oleic/citric acid (OA/CA) coated iron oxide (Fe 3 O 4) nanoparticles in water and phosphate buffer saline (pH = 7) is investigated by dynamic light scattering (DLS). The aggregation and fragmentation rate of suspended nanoparticles at different concentration of buffers is evaluated. Iron oxide nanoparticles coated with OA, OA/DMSA and OA/CA are synthesized via thermal decomposition and ligand exchange wet chemical route. The hydrodynamic spherical diameter of OA, OA/DMSA and OA/CA coated nanoparticles, measured at room temperature are found to be 83.6, 133.7 and 147.7 nm. The formation of clusters and their distribution in the magnetic nanoparticles suspension is obtained from DLS experiments. It is correlated with the theoretical model based on diffusion dominated aggregation model. The growth rate β due to tailored aggregation and fragmentation processes at different volume fractions in different solvents, shows power law dependence as < k(t) >~t β at intermediate time scale. The slope β for OA/DMSA and OA/CA coated MNPs is obtained to be 0.09 and 0.1 respectively. These studies are therefore extremely relevant and can provide guidelines for research in biological fluids such as serum, plasma etc.