P934 Breast involvement in Rosai-Dorfman disease – Related case (original) (raw)
Related papers
2013
The aim of this study was to investigate the specificity and sensitivity of the conventional test combination used for the evaluation of the breast masses that included physical examination (PE), mammography (MG) and fine needle aspiration biopsy (FNAB) in evaluating the malignant or benign characteristics of the masses with respect to the data in our hospital, and to determine the specificity and sensitivity of alternative test combinations in order to compare the efficacy of these combinations. Materials and Methods: The ages and PE, ultrasonography (US), MG and FNAB findings of 636 women who were detected to have a mass breast mass in the examinations performed in the Cancer Screening Early Detection and Education Center (KETEM) between 2004 and 2009, were retrospectively investigated. Those who underwent excisional operation and follow-up were also evaluated. The specificity and sensitivity of each test or test combination were individually measured. Results: The median age of the participants was 58. All the patients were investigated with PE, USG, MG and FNAB. Excisional biopsy was performed in 448 patients and the mean follow-up period of all patients was 3 years. The sensitivity (Sn) and specificity (Sp) of the conventional triple test (PE+MG+FNAB) were 100% and 92.1% respectively, which seemed very high. It was observed that MG+US+FNAB triple test had the most successful diagnostic feature among all combinations, with a 100% Sn and 100% Sp. Conclusion: Although physical examination is essential for the evaluation of the possible masses within the breast, it is insufficient in evaluating the malignancy of the mass. Screening tests should definitely be performed in the presence of a mass. In women older than 40 years of age, US or MG alone may not be sufficient for the evaluation of the malignancy. We believe that performing these tests in conjunction, and supporting them by FNAB, can make the treatment of the mass be possible without the need for a more invasive procedure.
Clinico Pathological Study of Benign Breast Diseases in Females
IOSR Journals , 2019
Background: Benign breast ds (BBD) are common disease affecting woman mainly. These can be diagnosed by triple assessment including clinical examination, radiological imagings, and a pathological examination. Majority of the benign lesions are not associated with an increased risk for subsequent breast cancer but some may have increased risk of malignancy like atypical hyperplasia. The main problem from women’s patient of view is fear that such a lump may be a cancer. Unlike breast cancer, benign breast diseases have often been difficult to understand, in part due to variety of names that have been used to describe the various conditions. So that clinician requires in-depth knowledge to give clear explanation about breast diseases. Making an early diagnosis and planning the treatment during initial consultations, helps in alleviating unnecessary anxiety about breast cancer and unnecessary long term follow up can be avoided. So, the need for study is to analyze the spectrum of benign breast disease. Method: A total 85 patients diagnosing as benign breast diseases under the inclusion criteria were studied during the period of Oct 2014 to March 2016; in the Dept of Surgery at People’s hospital of People’s college of medical science and research center, Bhopal. Our study objectives were A. To describe the spectrum of Benign Breast Diseases with Respect to Age of incidence, Social Demography, Duration of Symptoms, Site of lumps, Clinical features specific to conditions. B. To diagnose clinically and cytologically (FNAC) Suitable patients with benign breast disease and provide either conservative or operative treatment. C. To do histopathological examination of excised specimen for the comparisons and confirmation of cytological and clinical diagnosis. Result: Fibro adenoma was the most common benign lesion encountered (65.9%) followed by Breast Abscess 18.8% disease. Fibro adenoma was presented most often in the second and third decade (75%). Lump in the breast was the commonest presentation of BBD, Lump and Mastalgia was the second commonest symptom of BBD. There was a slight preponderance of lesions in the right breast (45.9%) as compared to left breast (44.7%), shown to be significant. Most of patients belong to middle class. 100% 0f the patients were in pre menopausal group. Majority (45.9%) of lesions were of the size 2-5 cms, 31.8% were between 6-10 cms FNAC highly reliable for fibro adenoma than for other lesions. All fibro adenomas willing for surgical procedure were managed by simple excision than follow up. All 16 cases of Breast Abscess underwent incision and drainage and simple mastectomy was done in phylloide tumors. Conclusion: In the present study BBD occupy majority of total breast diseases. Fibro adenoma was the most common benign lesion (65.9%). FNAC was highly accurate and was highly reliable for fibro adenoma than for other lesions. Triple test is a prerequisite for determining management. However all fibro adenomas willing for surgical procedure were managed by simple excision than follow up. Conservative approach is acceptable in young patients, who choose conservative management, need to be informed about the limitation of the test, advised for proper follow up, and must be assessed properly if there are symptoms and clinical changes. Breast self examination should be emphasized as a part of female adult education.
Endocrinological Profiles in Benign Breast Disease
Breast Diseases, 1989
Introduction: In mammals, mammary glands or breasts are unique feature. In females growth and development of breast depend upon various hormones and various physiological statuses like lactation, pregnancy. About 30% of the women who suffer from BBDs will require treatment at some time in their lives. In female, after puberty Breast undergoes cyclical changes throughout reproductive life. From the onset of puberty till menopause there are changes in Hormones and growth factors causing significant morphological changes leading to Aberration in Normal Development and Involution (ANDI) causing majority of benign breast diseases. In benign breast disease there are most of the lesions are with variety of lesions as fibrocystic disease, cystic disease, cystic mastopathy, cystic mastitis, mammary dysplasia, benign breast disease. There are many studies which showed that the relationship between BBDs and breast cancer. According to the grading of the BBDs there is varies between Risk of cancer. Aim: The main objective of this study was nature of benign breast diseases in females with different of pathological presentations. Material and Methods: Present study was conducted in the department of surgery in collaboration with the department of pathology in our hospital in duration of one year. In this study altogether 100 women were treated for benign breast diseases attending to hospital as in patient department (IPD) and out patients department (OPD) of our hospital. In this study inclusion criteria included as only female patients with any benign diseases of the breast as breast pain, breast lump and nipple discharge. From all the patients complete clinical history was collected and also physical examinations were done. Result: The patients were divided into four groups with different symptoms or presentation such as a breast pain, breast lump, nodularity, and nipple discharge. In this study breast lump was the most common presentation as 70% followed by Nodularity of breast and Breast pain as 16 % and 12% respectively. Fibroadenoma was found as most common benign breast disease as 53% and with the age between 21 to 30 years showed more as 27 % followed by Fibroadenosis, Mastalgia and Breast abscess as 20%, 11% and 9% respectively. Whereas according to the age group followed by 31-40 years old and 41-50 years old. Other benign breast diseases include as Antibioma, Simple Cyst and Duct papilloma which was least in percentage as well as least in years also.
The hormonal profile of benign breast disease
British journal of cancer, 2013
Limited information exists about the endocrine milieu of benign breast disease (BBD), a documented breast cancer risk factor. We compared blood levels of estrogens, testosterone and insulin-like growth factor-1 (IGF-1) between BBD patients by histological type and women without breast pathology. We studied 578 BBD patients and 178 healthy women in Athens, Greece, who provided blood samples, and completed interviewer-administered questionnaires. Of the BBD patients, 254 had non-proliferative disease, 268 proliferative disease without atypia and 56 atypical hyperplasia. Comparing BBD patients with healthy women, the per cent differences (and 95% confidence intervals) for blood hormones, among pre-menopausal and peri/post-menopausal women, respectively, were: 22.4% (-4.0%, 56.1%) and 32.0% (5.6%, 65.1%) for estradiol; 26.2% (10.1%, 44.8%) and 30.9% (16.8%, 46.6%) for estrone; 19.5% (3.1%, 38.4%) and 16.5% (-5.0%, 42.9%) for testosterone; and -5.2% (-13.8%, 4.4%) and -12.1% (-19.8%, -3....
Cytological Spectrum of Female Breast Lesions in a Tertiary Centre: A Two Years Study
Journal of Evidence Based Medicine and Healthcare, 2019
BACKGROUND Palpable breast lumps are a common occurrence in women all over the world. The prevalence of non-neoplastic and neoplastic lesions varies from region to region. Fine Needle Aspiration Cytology (FNAC) is a rapid, minimally invasive, reliable and relatively simple diagnostic method. We wanted to study the frequencies of different lesions in FNAC of breast lump in our region and to observe cyto-histological correlation wherever possible. METHODS A two years prospective study was carried out in the department of pathology, RIMS, Imphal during the period January 2016-December 2017. A total of 434 cases of breast lesions were encountered during this period. RESULTS Of the total 434 cases infectious/inflammatory lesions were 100 (23.1%), benign 268 (61.7%), malignant 40 (9.2%), suspicious for malignancy 02 (0.5%), unsatisfactory 18 (4.1%), and others 6 (1.4%). The most frequent infectious/inflammatory lesion was acute mastitis in 50 (11.5%) followed by sub-areolar abscess in 17 (3.9%) and fat necrosis in 17 (3.9%). Fibroadenoma in 142 (32.7%) cases was the most common benign breast lesion followed by benign proliferative breast lesion without atypia 14 (22.1%). Among the malignant, 39 (9%) cases were carcinoma and one case (0.2%) was lymphoma. Mean age of presentation was 32.82 years. Most commonly involved age group was 21-30 years and right breast was more commonly involved. Cytohistological correlation was done in 41 cases and 35 benign and 6 malignant cases diagnosed cytologically were confirmed by histology, though there were cases with variable diagnosis. So, in differenting benign from malignant lesions, the sensitivity, specificity, positive predictive value, negative predictive value was 100%.
Pathological profile of patients with breast diseases in Shiraz
Asian Pacific journal of cancer prevention : APJCP, 2014
Around 200,000 breast disorders are annually diagnosed all over the world. Fibrocystic changes are the most common breast disorder and fibroadenoma is the most prevalent benign breast tumor. The present study aimed to determine the spectrum, type and prevalence of breast masses in women referred to Shiraz University of Medical Sciences between 2004 and 2012 . A cross-sectional study was conducted on the diagnostic reports data. A total of 640 samples were studied. Most 57.3% of masses were detected in the left breast, 65%, 28.2% and 6.1% of cases presenting with benign, malignant, and inflammatory lesions, respectively. Among all the samples the most prevalent diagnosis (37.7%) was fibroadenoma and fibrocystic lesions (17%). 174 samples (96% of the malignant cases) were invasive. 6.5% of the benign, and 37% of the malignant cases occurred in post menopause women and the differences were statistically significant. Among those with malignant tumors lymph nodes were involved in 25.6% o...
2016
Breast or mammary gland is a modified sweat gland. The mammary gland is a superficial organ. Breast carcinoma is the most common cancer in women all over India and accounts for 25% to 31% of all cancers in women in Indian cities. With the increased incidence of breast cancers every breast lump needs to be evaluated so as to assure the patient of its nature. The study was based on 50 patients who were referred to the Department of Radiodiagnosis and Imaging for evaluation of breast lesions. A detailed breast specific history was taken including menstrual history, history of mastalgia, lactational history, past and family history of any breast problem. Results showed that, highest incidence of breast lesions was found in the age group of 20-29 years containing (36%) of all cases. The second peak was seen in the age group of 40-49 years containing (18%) of all cases. Left sided lesions were slightly more common. While it was observed that of the 50 cases referred ultrasound correctly d...
Types of precancerous and cancerous breast lesions at pathology laboratory of the Buea Regional Hospital-Cameroon, 2022
Introduction: Breast cancer is the 1 st gynaecological cancer globally, with 2.100.000 cases, among which 627.000 are fatal annually. These figures are projected to get to 14.000.000 cases and 8.200.000 deaths in the next two decades. Breast cancer is a variety of different histological types of cancers. The types of cancers are ductal carcinoma in situ, lobular carcinoma in situ, invasive breast cancer, inflammatory carcinoma, papilloma, medullary carcinoma, phyllode tumours, and Paget disease. Methodology: A descriptive retrospective study was carried out based on the registry of the pathology laboratory of the Buea regional hospital, Cameroon. The period was from the 04th of March 2016 to the 25th of May 2019. Results: In terms of frequency, the following types of precancerous lesions and cancers were recorded: invasive breast carcinoma, carcinoma in situ, papilloma, inflammatory carcinoma, phyllode tumours and angiosarcoma. Their respective percentages were; 74.84, 14, 47, 6.92, 1.89, 1.57, and 0.32 Conclusion: Breast cancer is a heterogeneous malignancy made of various histological types. Our study identified the following pathologies in order of frequency: invasive breast carcinoma, ductal carcinoma in situ, papilloma, inflammatory carcinoma, phylloid tumours and angiosarcoma. Objective: the objective of the study was to find out the frequency of various types of breast cancer and precancerous lesions.