Disequilibrium of Mental Health Status in the Patient with Pemphigus Vulgaris (original) (raw)
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Pemphigus vulgaris triggered by psychological stress
Buletin de psihiatrie integrativă, 2019
Pemphigus vulgaris (PV) is a rare but severe autoimmune disease caused by autoantibodies directed against desmosomes, and clinically characterized by bullae and painful erosions of the skin and mucous membranes. While the morphology is well defined, its etiopathogenesis remains a subject of research. PV, the most frequent and representative form of the autoimmune bullous dermatoses, has a poor prognosis in the absence of medical treatment. The onset and course of PV depend on a variable interaction between predisposing and inducing factors. Thus, drugs, viral infections (herpes simplex virus), physical agents, contact allergens, vaccinations, dietary factors, and psychological stress have been implicated in the disease. Stressful life events have been associated with the course of several autoimmune skin diseases and reported a possible factor in triggering and aggravating for pemphigus in predisposed patients. Psychological care, 90/Bulletin of Integrative Psychiatry New Series December 2019 Year XXV No. 4 (83) associated with the immunosuppressive treatment, should entail a better management of these patients.
General Health Status of Patients with Pemphigus Vulgaris
Journal of Skin and Stem Cell, 2021
Background: Pemphigus vulgaris is a severe autoimmune disease that involves skin and mucosal membranes by blistering lesions of varying sizes. Pemphigus is often associated with psychological stress. Objectives: This study aimed to show the status of general health in patients suffering from this disease. Methods: A descriptive study was conducted on 35 new cases of pemphigus vulgaris that were referred to the tertiary level hospital from March 2017 to March 2018. Personal and clinical data were gathered by interviewing. Assessment of severity of the disease was done by the Ikeda index, and GHQ-28 questionnaires were used to measure their general health status. Results: A total of 35 new cases of non-treated pemphigus vulgaris (16 females and 19 males; mean age of 48.3 years, range 25 - 84 years) participated in this study. Median severity score of pemphigus was 4.1. Moreover, GHQ-28 positivity was detected in 65.7%o the patients. Social dysfunction and anxiety/insomnia had higher s...
Pemphigus and psychological stress: a review of the literature
Our Dermatology Online, 2013
Introduction: Psychological stress has been associated with the course of several autoimmune skin diseases and reported a possible factor in triggering and aggravating for pemphigus in predisposed patients. Aim: The aim of this study is to present an upgrade of the scientific literature on the relation between pemphigus and psychological stress. Methods: To assure a comprehensive investigation, we have performed searches on LILACS, MedLine, PEPSIC, PubMed, SCOPUS and Web of Science databases. The terms used were pemphigus, psychological stress and psychological distress. We have selected works published on journals indexed in different online databases, without distinction as to language and date of the studies. Results and Discussion: Initially, 22 works had fulfilled the selection criteria. After discarding publications which deviated from the subject, 9 works were selected for analysis. Among the selected articles, one was a theoretical review, five case studies, two case-control studies and one documental analysis. Publications discuss the importance of recognizing the influence of exogenous factors, such as psychological stress, on the development and evolution of pemphigus, since the health condition of the patients can be improved through the recognition, validation and treatment of their psychological issues, associating psychological assistance to the immunosuppressive treatment. Conclusion: The report of stressor events by patients at the Dermatology Clinical is frequently observed, however, the relation between psychological stress and the development or aggravation of pemphigus is a recent subject among researchers of the field.
Introduction: Pemphigus vulgaris (PV) is an autoimmune disease with vesiculobullous lesions that attack the skin and mucosa including oral mucosa. There are some factors that can trigger the recurrence of PV; one of them is psychological stress. PV is treated using immunosuppressant agents like corticosteroids or other immunosuppressant drugs. Complete remission in PV often hard to achieve because of some trigger factors that is hard to control and systemic disease like diabetes mellitus (DM). Objective: to discuss the management of oral lesions in persistent PV with psychological stress and DM as triggers. Case report: A 46 years old female diagnosed with PV had oral lesions that recurrent every time she had problems in her family. The patient also known to have DM. PV was treated in collaboration with Department of Dermatoveneorology, and she received corticosteroids and mycophenolate mofetil. We prescribed corticosteroid oral rinse with the dose according to oral condition and corticosteroid given for skin lesions. Oral lesions resolved after the patient was consulted to Department of Psychiatric for counselling and DM was controlled. Conclusions: Systemic and psychological factors have important roles in remission of PV. Comprehensive treatment in collaboration with related departments is mandatory to achieve maximum benefits of healing.
Pemphigus: a disease stamped in the skin
Our Dermatology Online, 2013
Introduction: Pemphigus are autoimmune blistering diseases that affect the skin and mucous membranes. The blisters characteristics of pemphigus tend to break, causing painful erosions that easily bleed. This study aimed to identify the experiences involved in the triggering of pemphigus and how patients face the illness and treatment. Material and Methods: The study included 31 patients diagnosed with pemphigus foliaceus and vulgaris, under a standardized pulsetherapy treatment. Data collection was through semi-structured interviews, which were audio-recorded, transcribed and analyzed using a qualitative approach. Results: During the journey in search of the phenomenon, were defined two thematic categories, subdivided into eleven subcategories. Months before the triggering of the illness, patients experienced feelings of losses, familiar conflicts and concerns; also showed an experience permeated by heartache and disappointments. After the first signs of pemphigus, patients experienced a long journey until the correct diagnose; worsening of the lesions after the communication of the diagnosis; feelings of isolation, shame and prejudgment; interruptions of the future plans; lack of information about the disease and treatment; difficult adherence to the pulsetherapy and the appearance of new lesions or worse by stressful events. Discussion: It might be observed that the disease is not just a biological deviation, but also a social deviance, which explicit the need to adapt to the new reality of the disease and face the isolation, prejudgment and shame of living with a stigmatizing disease.
Pemphigus Vulgaris about a Case and Review of the Literature
Scholars Journal of Medical Case Reports
Introduction: Pemphigus vulgaris (PV) is a serious autoimmune disorder of the skin, which accounts for 80% of all pemphigus cases. Observation: This article describes the case of a 27-year-old woman with multiple skin wounds who was diagnosed with PV. The article also reviews the existing literature on the diagnosis and treatment of the disease. Conclusion: PV is a serious pathology with complex diagnosis and therapy, it requires multidisciplinary care associated with therapeutic education.
Acta dermato-venereologica, 2021
Data on the impact of psychological factors on quality of life in patients with pemphigus are sparse. This study evaluated illness perception and perceived social support and their influence on quality of life in 58 patients with pemphigus. The results showed that patients had realistic illness perceptions and high perceived social support. Higher beliefs in personal control, chronic course, and accidental cause predicted higher quality of life, while higher beliefs in cyclical course, psychological cause, and risk factors predicted lower quality of life. The results indicate a significant influence of psychological factors on quality of life in patients with pemphigus. Data regarding the impact of psychological factors in patients with pemphigus is sparse. This study evaluat ed the correlation of demographic, clinical, and psycho logical parameters with quality of life in 58 patients with pemphigus. Illness perception showed a realis tic view, with the highest scores for cyclical course (3.35 ± 0.09) and treatment control (3.08 ± 0.06). Mean scores for perceived social support were relatively high from family and significant others (5.89 ± 0.18 and 5.66 ± 0.23, accordingly), and relatively low from friends (4.55 ± 0.24). There were no correlations be tween demographic, clinical parameters, perceived social support, and Dermatology Life Quality Index. Beliefs in cyclical course, emotional influence, psychological cause, and treatment control correlated significantly with quality of life. Stronger beliefs in selfcontrol, chronicity, and accidental cause predicted higher qua lity of life, while stronger beliefs in cyclical course, psychological cause, and risk factors predicted lower quality of life. In order to enhance QoL, dermatologists should deliver the message to the patients that pem phigus is a chronic disease rather than cyclical and un expected, and stress the patients' role in controlling it.
IP innovative publication pvt ltd, 2020
Pemphigus is an autoimmune inter epidermal blistering disorder. it is characterized by mucosal and cutaneous vesicles, bullae, erosions. It has an array of maifesations and symptoms. Systemic corticosteroids have remained the mainstay of treatment for pemphigus, recent years are focusing on use of other immunomodulators as well. This review looks at the etiology, clinical features, management, complications of the condition.
A Clinical Profile and Co-morbidities of Pemphigus Vulgaris Patients: A Study of 35 Cases
KYAMC Journal, 2019
Background: Pemphigus vulgaris (PV), an autoimmune blistering disease involving the skin and mucosa. PV frequently begins with oral lesions and progresses to skin lesions. Autoimmune bullous skin disorders are associated with IgG or IgA auto- antibodies against distinct adhesion molecules of the epidermis and dermal epidermal basement membrane zone, respectively. These auto- antibodies lead to a loss of skin adhesion which shows up clinically as the formation of blisters or erosions. Objectives: To characterize the clinical parameters and co-morbidities of PV patients from a single tertiary medical centre in Bangladesh. Material and Methods: This observational study was done including 35 PV patients attending in the department of Dermatology and Venereology, Khwaja Yunus Ali Medical College Khawja Eunus Ali Medical College from 2010 to 2014. Thirty patients of pemphigus diagnosed clinically confirmed and treated over a 4-year period (2010-2014). Results: Majority of the patients 45....