Current perspectives on quinazolines with potent biological activities: A review (original) (raw)

Recent advances in the biological activity of quinazoline

International Journal of Pharmaceutical Chemistry and Analysis

The aim of this review is to produce an outline of numerous pharmacologic activities of quinazoline moiety. Quinazoline has become a famous topic up of two fused six-membered simple aromatic rings, a benzene ring and a pyrimidine ring because of its manifold uses. various quinazoline derivatives have been found to gives a broad spectrum of biological activities, which stimulated the research activity in this field. Quinazolines and its derivatives represent one in all the foremost active categories of compounds, that possess wide selection of biological activities like anti-bacterial, analgesic, anti-microbial, anti-inflammatory drug, anticancer, and anti-hypertensive, antifungal, anti-HIV, inhibitor, analgesic, medicament, antiprotozoal, antitumor, anti-tubercular activities. This review is an effort to magnify the immense potentiality of this ring system. This study may accelerate the designing process to come up with a lot of range of therapeutically viable clinical candidates.

ROLE OF QUINAZOLINE IN BIOLOGICAL ACTIVITY: A REVIEW

European Chemical Bulletin, 2023

Due to its diverse applicability in the realm of medicine, the heterocyclic fused nucleus quinazoline has attracted a lot of attention in recent years research in chemistry. A number of patents and studies on the discovery and development of novel potential quinazoline compounds have been published in the literature. Quinazoline and their derivatives are a type of chemical substance that is very prevalent. Chemicals that are the most active and have a wide variety of biological effects actions such as antibacterial, antifungal, and antiviral properties antifungal, anti-HIV, analgesic, antimicrobial, anti-inflammatory, anticancer, and antihypertensive antioxidant, analgesic, anticonvulsant, anti-malarial, anticancer, and anti-tubercular properties. The goal of this review was to compile research on Quinazoline for its diverse pharmacological effects described by researcher's activities, as well as recent attempts on this subject.

Enhancement of Different Biomedical Activities of Newly Synthesized Quinazoline Derivatives

A series of newly synthesized compounds of quinazolinone by various substituents was screened for its pharmacological activities. These included their action as antibacterial agents against pathogenic bacteria (Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa) and as antifungal agents against Aspergillus niger and pathogenic yeast (Candida albicans). The presently investigated compounds were synthesized in higher yields, and the structure features were elucidated on the basis of IR, 1 H-NMR, and mass and elemental analysis data. These compounds were also evaluated as antioxidant agent. The results revealed that six compounds (2a, 11b, 11a, 2b, 13a, and 3c) exhibited higher antimicrobial activity against the tested pathogenic strains. In addition, it was found that compound 6a exhibited a radical scavenging activity higher than other studied compounds. activity, respectively, compound 3c changed by interfering phenyl group.

Quinazoline pharmacophore in therapeutic medicine

Bangladesh Journal of Pharmacology, 2016

This present study comprehensively expatiates the functionalized utilization of quinazoline scaffolds in drug development and furnishes latest updates in pharmacological appositeness of its derivatives in order to reveal novel pathways for therapeutic targets. It traverses numerous biological potentials of quinazoline in the contemporary time to allow researchers’ unhindered access to the beneficial role of quinazoline in fighting infectious diseases for future drug discovery. This work provides broad overview of medicinal survey of quinazoline chemistry valuable in the discovery of more efficient clinical trials and to summarize the most promising molecular targets for drug design.

Biological Activity of Quinazolinones

Quinazolinone and Quinazoline Derivatives [Working Title]

The chemical structure of quinazolinones includes benzene ring fused with 2-pyrimidinone (1), 4-pyrimidinone (2) or 2,4-pyrimidinedione (3) ring, and are named as quinazolin-2(1H)-one, quinazolin-4(3H)-one or quinazolin-2,4(1H, 3H)-one, respectively. The chemical structure of quinazolinones constitutes a crucial scaffold of natural and synthetic compounds with various therapeutic and biological activities. Quinazolinones are first synthesized by Stefan Niementowski (1866-1925) and named after Niementowski quinazolinone synthesis. Quinazolinones have strongly attracted the interest of medicinal chemist as they constitute a large class of compounds that exhibited broad spectrum of biological activities including antimicrobial, antimalarial, anticonvulsant, anticancer, antileishmanial, anti-inflammatory, etc. This chapter provides a brief overview on the recent advances on chemical and pharmacological aspects of quinazolinone derivatives published in the last decade.

Quinazoline compounds for antitumor treatment

Experimental Oncology, 2019

Quinazolines are among the most useful heterocyclic compounds due to their diverse chemical reactivity and a wide range of biological activity. Despite a large number of publications devoted to quinazolines and their derivatives, information is presented predominantly regarding the features of the synthesis of these compounds and their structure. The studies of specific pharmacological activity and antitumor activity of these compounds are mainly limited to primary screening using enzyme systems and cell lines. In this mini review information concerning the potential targets for antitumor action of quinazoline compounds is summarized and discussed.

Biological Activity of Quinazolinone Derivatives: A Review

International Journal of Current Pharmaceutical Research

The heterocyclic compounds have a great importance in medicinal chemistry. Quinazolinone is a heterocyclic chemical compound. A quinazolinone with a carbonyl group in the C4N2 ring. The two isomers are possible: 2-Quinazolinone and 4-Quinazolinone, with the 4-isomer being the more common. These compounds are of interest in medicinal chemistry. Quinazolinone derivatives were reported to possess analgesic and anti-inflammatory activity, Antibacterial, Diuretic, Antihypertensive, Anti-diabetics, Anticancer, Antitumor, Anti-fungal, Anti-malarial, Anti-protozoal agent and many other biological Action. This skeleton is an important pharmacophore considered as a privileged structure.