An efficient approach to the synthesis of tri-substituted iminothiazolidenes and their effects on the human neuroblastoma cell line (original) (raw)

2003, Tetrahedron Letters

Starting from cis-oriented epoxytriflate pentoses 1 and 4, an expeditious route to the chiral thioazolidene derivatives 2a-3a and 5a-6a in good yields is described. A minor amount of structural isomers 2b-3b and 5b-6b has also been observed. The newly formed compounds show activity against the human neuroblastoma cell line SK-N-LO.

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