Bioinspired iterative synthesis of polyketides (original) (raw)

This paper reviews the bioinspired iterative synthesis strategies of polyketides, focusing on the enzymatic assembly approach prevalent in nature. It discusses the structural diversity and medicinal significance of polyketides, emphasizing challenges in their synthesis and the need for innovative methodologies. The review highlights key examples of iterative total syntheses and the role of polyketide synthases, providing a perspective on future developments and applications in natural product synthesis.